Experimental studies of erythropoietin protection following traumatic brain injury in rats

Experimental and Therapeutic Medicine

Volumn 4, Issue 6, 2012, Pages 977-982

  Xu, Feng ^a   Yu, Zheng Yuan ^a   Ding, Li ^a   Zheng, Shi Ying ^a  

^a THE FIRST AFFILIATED HOSPITAL OF SOOCHOW UNIVERSITY   (China)

Author keywords

Apoptosis; CD68 + cells; Erythropoietin; Monocyte chemotactic protein 1; Traumatic brain injury

Indexed keywords

CD68 ANTIGEN; ERYTHROPOIETIN; MONOCYTE CHEMOTACTIC PROTEIN 1;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BRAIN EDEMA; BRAIN WATER; CONTROLLED STUDY; DRUG EFFECT; EXPERIMENTAL STUDY; LYMPHOCYTIC INFILTRATION; MALE; NEUROPROTECTION; NONHUMAN; PROTEIN EXPRESSION; RAT; TRAUMATIC BRAIN INJURY;

EID: 84867264894     PISSN: 17920981     EISSN: 17921015     Source Type: Journal    
DOI: 10.3892/etm.2012.723     Document Type: Article

References (27)

1. Bernaudin M, Marti HH, Roussel S, Divoux D, Nouvelot A, MacKenzie ET and Petit E: A potential role for erythropoietin in focal permanent cerebral ischemia in mice. J Cereb Blood Flow Metab 19: 643-651, 1999.
2. Sakanaka M, Wen TC, Matsuda S, Masuda S, Morishita E, Nagao M and Sasaki R: In vivo evidence that erythropoietin protects neurons from ischemic damage. Proc Natl Acad Sci USA 95: 4635-4640, 1998.
3. Siren AL, Fratelli M, Brines M, Goemans C, Casagrande S, Lewczuk P, Keenan S, Gleiter C, Pasquali C, Capobianco A, et al: Erythropoietin prevents neuronal apoptosis after cerebral ischemia and metabolic stress. Proc Natl Acad Sci USA 98: 4044-4049, 2001.
4. Brines M and Cerami A: Emerging biological roles for erythropoietin in the nervous system. Nat Rev Neurosci 6: 484-494, 2005.
5. Eid T and Brines M: Recombinant human erythropoietin for neuroprotection: what is the evidence? Clin Breast Cancer 3 (Suppl 3): S109-S115, 2002.
6. Tan CC, Eckardt KU, Firth JD and Ratcliffe PJ: Feedback modulation of renal and hepatic erythropoietin mRNA in response to graded anemia and hypoxia. Am J Physiol 263: F474-F481, 1992.
7. Marti HH, Wenger RH, Rivas LA, Straumann U, Digicaylioglu M, Henn V, Yonekawa Y, Bauer C and Gassmann M: Erythropoietin gene expression in human, monkey and murine brain. Eur J Neurosci 8: 666-676, 1996.
8. Kilic E, Kilic U, Soliz J, Bassetti CL, Gassmann M and Hermann DM: Brain-derived erythropoietin protects from focal cerebral ischemia by dual activation of ERK-1/-2 and Akt pathways. FASEB J 19: 2026-2028, 2005.
9. Yatsiv I, Grigoriadis N, Simeonidou C, Stahel PF, Schmidt OI, Alexandrovitch AG, Tsenter J and Shohami E: Erythropoietin is neuroprotective, improves functional recovery, and reduces neuronal apoptosis and inflammation in a rodent model of experimental closed head injury. FASEB J 19: 1701-1703, 2005.
10. Boran BO, Colak A and Kutlay M: Erythropoietin enhances neurological recovery after experimental spinal cord injury. Restor Neuro Neurosci 23: 341-345, 2005.
11. Gorio A, Gokmen N, Erbayraktar S, Yilmaz O, Madaschi L, Cichetti C, Di Giulio AM, Vardar E, Cerami A and Brines M: Recombinant human erythropoietin counteracts secondary injury and markedly enhances neurological recovery from experimental spinal cord trauma. Proc Natl Acad Sci USA 99: 9450-9455, 2002.
12. Lu D, Mahmood A, Qu C, Goussev A, Schallert T and Chopp M: Erythropoietin enhances neurogenesis and restores spatial memory in rats after traumatic brain injury. J Neurotrauma 22: 1011-1017, 2005.
13. Kalialis LV and Olsen NV: Erythropoietin - a new therapy in cerebral ischemia? Ugeskr Laeger 165: 2477-2481, 2003 (In Danish).
14. Buemi M, Cavallaro E, Floccari F, Sturiale A, Aloisi C, Trimarchi M, Grasso G, Corica F and Frisina N: Erythropoietin and the brain: from neurodevelopment to neuroprotection. Clin Sci (Lond.) 103: 275-282, 2002.
15. Feeney DM, Boyeson MG, Linn RT, Murray HM and Dail WG: Responses to cortical injury: I. Methodology and local effects of contusions in the rat. Brain Res 211: 67-77, 1981.
16. Mammis A, McIntosh TK and Maniker AH: Erythropoietin as a neuroprotective agent in traumatic brain injury Review. Surg Neurol 71: 527-531, 2009.
17. Hartley CE, Varma M, Fischer JP, Riccardi R, Strauss JA, Shah S, Zhang S and Yang ZJ: Neuroprotective effects of erythropoietin on acute metabolic and pathological changes in experimentally induced neurotrauma. J Neurosurg 109: 708-714, 2008.
18. Agnello D, Bigini P, Villa P, Mennini T, Cerami A, Brines ML and Ghezzi P: Erythropoietin exerts an anti-inflammatory effect on the CNS in a model of experimental autoimmune encephalomyelitis. Brain Res 952: 128-134, 2002.
19. Chong ZZ, Kang JQ and Maiese K: Erythropoietin fosters both intrinsic and extrinsic neuronal protection through modulation of microglia, Akt1, Bad, and caspase-mediated pathways. Br J Pharmacol 138: 1107-1118, 2003.
20. Chen G, Shi JX, Hang CH, Xie W, Liu J and Liu X: Inhibitory effect on cerebral inflammatory agents that accompany traumatic brain injury in a rat model: a potential neuroprotective mechanism of recombinant human erythropoietin (rhEPO). Neurosci Lett 425: 177-182, 2007.
21. Digicaylioglu M and Lipton SA: Erythropoietin-mediated neuroprotection involves cross-talk between Jak2 and NF-kappaB signalling cascades. Nature 412: 641-647, 2001.
22. Chong ZZ, Kang JQ and Maiese K: Essential cellular regulatory elements of oxidative stress in early and late phases of apoptosis in the central nervous system. Antioxid Redox Signal 6: 277-287, 2004.
23. Xiong Y, Mahmood A, Qu C, Kazmi H, Zhang ZG, Noguchi CT, Schallert T and Chopp M: Erythropoietin improves histological and functional outcomes after traumatic brain injury in mice in the absence of the neural erythropoietin receptor. J Neurotrauma 27: 205-215, 2010.
24. Gourmala NG, Buttini M, Limonta S, Sauter A and Boddeke HW: Differential and time-dependent expression of monocyte chemoattractant protein-1 mRNA by astrocytes and macrophages in rat brain: effects of ischemia and peripheral lipopolysaccharide administration. J Neuroimmunol 74: 35-44, 1997.
25. Xiong Y, Lu D, Qu C, Goussev A, Schallert T, Mahmood A and Chopp M: Effects of erythropoietin on reducing brain damage and improving functional outcome after traumatic brain injury in mice. J Neurosurg 109: 510-521, 2008.
26. Chong ZZ, Kang JQ and Maiese K: Erythropoietin is a novel vascular protectant through activation of Akt1 and mitochondrial modulation of cysteine proteases. Circulation 106: 2973-2979, 2002.
27. Martínez-Estrada OM, Rodríguez-Millán E, González-De Vicente E, Reina M, Vilaró S and Fabre M: Erythropoietin protects the in vitro blood-brain barrier against VEGF-induced permeability. Eur J Neurosci 18: 2538-2544, 2003.