Targeted protein engineering provides insights into binding mechanism and affinities of bacterial collagen adhesins

Journal of Biological Chemistry

Volumn 287, Issue 41, 2012, Pages 34856-34865

  Ross, Caná L ^a   Liang, Xiaowen ^a   Liu, Qing ^a   Murray, Barbara E ^b   Höök, Magnus ^a   Ganesh, Vannakambadi K ^a  

^a UNIVERSITY OF TEXAS   (United States)

^b UNIVERSITY OF TEXAS MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADHESIVE MATRICES; BACTERIAL PROTEIN; BINDING ANALYSIS; BINDING KINETICS; BINDING MECHANISMS; BINDING RATIO; COLLAGEN TYPE I; IN-VITRO; INVERSE CORRELATION; LIGAND BINDING DOMAIN; MICROBIAL SURFACES; PROTEIN ENGINEERING; STRUCTURAL ELEMENTS; STRUCTURAL SIMILARITY; STRUCTURE-BASED; SUB-DOMAINS; SURFACE PLASMONS; WEAK INTERACTIONS;

GENETIC ENGINEERING; LIGANDS;

COLLAGEN;

ADHESIN; COLLAGEN; PROTEIN ACE; PROTEIN CNA; UNCLASSIFIED DRUG;

ARTICLE; BACTERIAL STRAIN; BACTERIUM CULTURE; BINDING AFFINITY; CONTROLLED STUDY; ESCHERICHIA COLI; IN VITRO STUDY; LIGAND BINDING; MOLECULAR MODEL; MUTATION; NONHUMAN; PLASMID; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN ENGINEERING; PROTEIN PURIFICATION; SURFACE PLASMON RESONANCE;

ADHESINS, BACTERIAL; AMINO ACID MOTIFS; BACTERIAL PROTEINS; CARRIER PROTEINS; COLLAGEN; ENTEROCOCCUS FAECALIS; PROTEIN BINDING; PROTEIN ENGINEERING; PROTEIN STRUCTURE, TERTIARY; STAPHYLOCOCCUS AUREUS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84867261136     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.371054     Document Type: Article

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