Chitosan-based nanocapsules: Physical characterization, stability in biological media and capsaicin encapsulation

Colloid and Polymer Science

Volumn 290, Issue 14, 2012, Pages 1423-1434

  Goycoolea, Francisco M ^a,f   Valle Gallego, Angela ^a   Stefani, Rossana ^b   Menchicchi, Bianca ^a   David, Laurent ^d   Rochas, Cyrille ^e   Santander Ortega, Manuel J ^a,c   Alonso, María J ^a  

^a UNIVERSITY OF SANTIAGO DE COMPOSTELA   (Spain)

^b UNIVERSITY OF GENOA   (Italy)

^c UNIVERSITY OF LONDON   (United Kingdom)

^d UNIVERSITÉ DE LYON   (France)

^e CENTRE DE RECHERCHES SUR LES MACROMOLÉCULES VÉGÉTALES CERMAV CNRS   (France)

^f UNIVERSITY OF MÜNSTER   (Germany)

Author keywords

Capsaicin; Chitosan; Nanocapsules; Stability; Synchrotron SAXS

Indexed keywords

AVERAGE DIAMETER; BIOLOGICAL MEDIA; BIOPHYSICAL PROPERTIES; CAPSAICIN; COLLOIDAL STABILITY; CRYSTALLINE STATE; ENCAPSULATION EFFICIENCY; HYDRATION FORCE; HYDROPHOBIC DOMAINS; INTERPLANAR DISTANCE; LIPOPHILIC DRUGS; N-ACETYLATION; PHOSPHOLIPIDIC MEMBRANES; PHYSICAL CHARACTERIZATION; REPULSIVE INTERACTIONS;

CELL CULTURE; CHITOSAN; CONVERGENCE OF NUMERICAL METHODS; CRYSTALLINE MATERIALS; DRUG THERAPY; NANOCAPSULES; STABILITY; ZETA POTENTIAL;

ENCAPSULATION;

CAPSAICIN; CHITOSAN; PHOSPHOLIPID;

ARTICLE; COLLOID; CONTROLLED STUDY; HUMAN; HUMAN CELL; HYDROPHILICITY; HYDROPHOBICITY; MOLECULAR WEIGHT; NANOEMULSION; NANOENCAPSULATION; PARTICLE SIZE; PHOSPHOLIPID MEMBRANE; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; SURFACE PROPERTY; SYNCHROTRON; TRANSMISSION ELECTRON MICROSCOPY; TREND STUDY; ZETA POTENTIAL;

EID: 84867248159     PISSN: 0303402X     EISSN: 14351536     Source Type: Journal    
DOI: 10.1007/s00396-012-2669-z     Document Type: Article

References (29)

1. Calvo P, Remuñan-Lopez C, Vila-Jato JL, Alonoso MJ (1997) Development of positively charged colloidal carriers: chitosancoated polyester nanocapsules and submicron emulsions. Colloid Polymer Sci 275:46-53
2. Prego C, Fabre M, Torres D, Alonso MJ (2006) Efficacy and mechanism of action of chitosan nanocapsules for oral peptide delivery. Pharm Res 23(3):549-556
3. Prego C, Torres D, Alonso MJ (2006) Chitosan nanocapsules as carriers for oral peptide delivery: effect of chitosan molecular weight and type of salt on the in vitro behaviour and in vivo effectiveness. J Nanosci Nanotechnol 6(9-10):2921-2928
4. Prego C, Torres D, Alonoso MJ (2006) Chitosan nanocapsules: a new carrier for nasal peptide delivery. J Drug Deliv Sci Tech 16:331-337
5. Lozano MV, Torrecilla D, Torres D, Vidal A, Domínguez F, Alonso MJ (2008) Highly efficient system to deliver taxanes into tumor cells: docetaxel-loaded chitosan oligomer colloidal carriers. Biomacromolecules 9:2186-2193
6. Vicente S, Diaz B, Sanchez A, Gonzalez-Fernandez A, Alonso MJ Polysaccharide-based nanocapsules as vehicles for nasal immunization against hepatitis B. 2nd PharmSciFair, Premier European Platform for Advancing Pharmaceutical Sciences, 2010
7. López-Montilla JC, Herrera-Morales PE, Pandey S, Shah DO (2002) Spontaneous emulsification: mechanisms, physicochemical aspects, modeling, and applications. J Dispers Sci Technol 23:219-268
8. Santander-Ortega MJ, Peula-García JM, Goycoolea FM, Ortega- Vinuesa JL (2011) Chitosan nanocapsules: effect of chitosan molecular weight and acetylation degree on their electrokinetic and stability behaviour. Colloids Surf B Biointerfaces 82:571-580
9. Cortright DN, Zallasi A (2004) Biochemical pharmacology of the vanilloid receptor TRPV1. An update. Eur J Biochem 271:814-819
10. Bevan S, Szolcsányi J (1990) Sensory neuron-specific actions of capsaicin: mechanisms and applications. Trends Pharmacol Sci 11:330-333
11. Prego C, Garcia M, Torres D, Alonso MJ (2005) Transmucosal macromolecular drug delivery. J Contr Release 101(1-3):151-162
12. Calvo P, Vila-Jato JL, Alonso MJ (1997) Evaluation of cationic polymer-coated nanocapsules as ocular drug carriers. Int J Pharm 153:41-50, 41
13. Quemeneur F, Rammal A, Rinaudo M, Pepin-Donat B (2007) Large and giant vesicles "decorated" with chitosan: effects of pH, salt or glucose stress, and surface adhesion. Biomacromolecules 8:2512- 2519
14. van der Lubben IM, Verhoef JC, Borchard G, Junginger HE (2001) Chitosan and its derivatives in mucosal drug and vaccine delivery. Eur J Pharm Sci 14:201-207
15. Quemeneur F, Rinaudo M, Pepin-Donat B (2008) Influence of molecular weight and ph on adsorption of chitosan at the surface of large and giant vesicles. Biomacromolecules 9:396-402
16. Fang N, Chan V (2003) Chitosan-induced restructuration of a mica-supported phospholipid bilayer: an atomic force microscopy study. Biomacromolecules 4:1596-1604
17. Fang N, Chan V, Mao HQ, Leong KW (2001) Interactions of phospholipid bilayer with chitosan: effect of molecular weight and pH. Biomacromolecules 2:1161-1168
18. Pavinatto FJ, Caseli L, Pavinatto A, dos Santos DS, Nobre TM, Zaniquelli MED, Silva HS, Miranda PB, de Oliveira ON (2007) Probing chitosan and phospholipid interactions using Langmuir and Langmuir-Blodgett films as cell membrane models. Langmuir 23:7666-7671
19. Nervo R, Konovalov O, Rinaudo M (2012) Chitosan-behenic acid monolayer interaction at the air-water interface: characterization of the adsorbed polymer layers by X-ray reflectivity. Int J Polymer Anal Char 17:11-20. doi:10.1080/1023666x.2011.628780
20. Santander-Ortega MJ, Lozano-Lopez MV, Bastos-Gonzalez D, Peula-Garcia JM, Ortega-Vinuesa JL (2009) Novel core-shell lipid-chitosan and lipid-poloxamer nanocapsules: stability by hydration forces. Colloid Polymer Sci 288:159-172
21. Alonso-Sande M, Cuna M, Remuñán-López C, Alonoso MJ (2006) Formation of new glucomannan-chitosan nanoparticles and study of their ability to associate and deliver proteins. Macromolecules 39:4152-4158
22. Santander-Ortega MJ, Jodar-Reyes AB, Csaba N, Bastos-Gonzalez D, Ortega-Vinuesa JL (2006) Colloidal stability of pluronic F68- coated PLGA nanoparticles: a variety of stabilisation mechanisms. J Colloid Interface Sci 302:522-529
23. Santander-Ortega MJ, Stauner T, Loretz B, Ortega-Vinuesa JL, Bastos-Gonzalez D, Wenz G, Schaefer UF, Lehr CM (2010) Nanoparticles made from novel starch derivatives for transdermal drug delivery. J Contr Release 141:85-92
24. López-León T, Santander-Ortega MJ, Ortega-Vinuesa JL, Bastos- González D (2008) Hofmeister effects in colloidal systems: influence of the surface nature. J Phys Chem C 112:16060-16069
25. Anackearn EW, Ghose DHM (1963) Counterions and micelle size. I. Light scattering by solutions of dodecyltrimethylammonium salts. J Am Chem Soc 67:1713-1715
26. Allan GG, Peyron M (1995) Molecular weight manipulation of chitosan I: kinetics of depolymerization by nitrous acid. Carbohydr Res 277:257-272
27. Lamarque G, Lucas JL, Viton C, Domard A (2005) Physicochemical behavior of homogeneous series of acetylated chitosans in aqueous solution: role of various structural parameters. Biomacromolecules 6:131-146
28. Muzzarelli RAA (1998) Colorimetric determination of chitosan. Anal Biochem 260:255-257
29. Wang YY, Hong CT, Chiu WT, Fang JY (2001) In vitro and in vivo evaluations of topically applied capsaicin and nonivamide from hydrogels. Int J Pharm 224:89-104