Identification of Type-II Inhibitors Using Kinase Structures

Chemical Biology and Drug Design

Volumn 80, Issue 5, 2012, Pages 657-664

  Lovering, Frank ^a   McDonald, Joseph ^a   Whitlock, Gavin A ^b   Glossop, Paul A ^b   Phillips, Chris ^b   Bent, Andrew ^b   Sabnis, Yogesh ^b   Ryan, Mark ^a   Fitz, Lori ^a   Lee, Julie ^a   Chang, Jeanne S ^a   Han, Seungil ^a   Kurumbail, Ravi ^a   Thorarensen, Atli ^a  

^a PFIZER INC   (United States)

^b PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United Kingdom)

Author keywords

Cheminformatics; Kinase; X ray crystallography

Indexed keywords

CYCLOPROPANE DERIVATIVE; PHOSPHOTRANSFERASE; PROTEIN KINASE INHIBITOR; PROTEIN KINASE SYK;

ARTICLE; BINDING SITE; CRYSTAL STRUCTURE; DRUG CONFORMATION; DRUG IDENTIFICATION; DRUG SCREENING; DRUG STRUCTURE; HYDROGEN BOND; PRIORITY JOURNAL; PROTEIN STRUCTURE;

CRYSTALLOGRAPHY, X-RAY; DATABASES, PROTEIN; DRUG DESIGN; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; LIGANDS; MODELS, MOLECULAR; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN KINASE INHIBITORS; PROTEIN-TYROSINE KINASES; SPLEEN;

EID: 84867233413     PISSN: 17470277     EISSN: 17470285     Source Type: Journal    
DOI: 10.1111/j.1747-0285.2012.01443.x     Document Type: Article

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