Comorbidity and metabolic context are crucial factors determining neurological sequelae of hypoglycaemia

Developmental Medicine and Child Neurology

Volumn 54, Issue 11, 2012, Pages 1012-1017

  Gataullina, Svetlana ^a   Dellatolas, Georges ^b   Perdry, Hervé ^c   Robert, Jean Jacques ^a,b   Valayannopoulos, Vassili ^a   Touati, Guy ^a   Ottolenghi, Chris ^a   Dulac, Olivier ^b,d   De Lonlay, Pascale ^a,b  

^a HÔPITAL NECKER ENFANTS MALADES   (France)

^b UNIVERSITÉ PARIS DESCARTES   (France)

^c UNIVERSITÉ PARIS SACLAY   (France)

^d INSERM   (France)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE; LACTIC ACID;

ARTICLE; CHILD; COMORBIDITY; CONVULSION; EPILEPTIC STATE; ESSENTIAL FATTY ACID DEFICIENCY; FATTY ACID OXIDATION; FEMALE; FEVER; GLUCOSE BLOOD LEVEL; GLYCOGEN STORAGE DISEASE TYPE 1; HUMAN; HYPERINSULINISM; HYPOGLYCEMIA; HYPOXIA; INFANT; ISCHEMIA; LACTATE BLOOD LEVEL; MAJOR CLINICAL STUDY; MALE; NEUROLOGIC DISEASE; ONSET AGE; OUTCOME ASSESSMENT; PRESCHOOL CHILD; PRIORITY JOURNAL; RISK ASSESSMENT; RISK FACTOR; SCHOOL CHILD; VIRUS INFECTION;

CHILD; CHILD, PRESCHOOL; COMORBIDITY; GLYCOGEN STORAGE DISEASE TYPE I; HUMANS; HYPERINSULINISM; HYPOGLYCEMIA; INFANT; LOGISTIC MODELS; NERVOUS SYSTEM DISEASES; RISK FACTORS; SEIZURES;

EID: 84867230778     PISSN: 00121622     EISSN: 14698749     Source Type: Journal    
DOI: 10.1111/j.1469-8749.2012.04400.x     Document Type: Article

References (26)

1. Burns CM, Rutherford MA, Boardman JP, Cowan FM. Patterns of cerebral injury and neurodevelopmental outcomes after symptomatic neonatal hypoglycemia. Pediatrics 2008; 122: 65-74.
2. Menni F, de Lonlay P, Sevin C, et al. Neurologic outcomes of 90 neonates and infants with persistent hyperinsulinaemic hypoglycemia. Pediatrics 2001; 107: 476-9.
3. Vannucci RC, Vannucci SJ. Hypoglycemic brain injury. Semin Neonatol 2001; 6: 147-55.
4. Yager JY. Hypoglycemic injury to the immature brain. Clin Perinatol 2002; 29: 651-74.
5. Montassir H, Maegaki Y, Ogura K, et al. Associated factors in neonatal hypoglycaemic brain injury. Brain Dev 2009; 31: 649-56.
6. Chou JY, Mansfield BC. Mutations in the glucose-6-phosphatase-alpha (G6PC) gene that cause type Ia glycogen storage disease. Hum Mutat 2008; 29: 921-30.
7. Saudubray JM, Martin D, de Lonlay P, et al. Recognition and management of fatty acid oxidation defects: a series of 107 patients. J Inherit Metab Dis 1999; 22: 488-502.
8. Bellanné-Chantelot C, Saint-Martin C, Ribeiro MJ, et al. ABCC8 and KCNJ11 molecular spectrum of 109 patients with diazoxide-unresponsive congenital hyperinsulinism. J Med Genet 2010; 47: 752-9.
9. RDC Team (R Development Core Team). R: A Language and Environment for Statistical Computing. Vienna: R Foundation for Statistical Computing, 2006.
10. Tam EW, Widjaja E, Blaser SI, Macgregor DL, Satodia P, Moore AM. Occipital lobe injury and cortical visual outcomes after neonatal hypoglycemia. Pediatrics 2008; 122: 507-12.
11. Hawdon JM, Platt Ward MP, Aynsley-Gree A. Patterns of metabolic adaptation for preterm and term infants in the first neonatal week. Arch Dis Child 1992; 67: 357-65.
12. Nehlig A. Respective roles of glucose and ketone bodies as substrates for cerebral energy metabolism in the suckling rat. Dev Neurosci 1996; 18: 426-33.
13. Vannucci SJ, Simpson IA. Developmental switch in brain nutrient transporter expression in the rat. Am J Physiol Endocrinol Metab 2003; 285: E1127-34.
14. Hussain K, Blankenstein O, De Lonlay P, Christesen HT. Hyperinsulinaemic hypoglycemia: biochemical basis and the importance of maintaining normoglycaemia during management. Arch Dis Child 2007; 92: 568-70.
15. Willamson DH. Mechanisms for the regulation of ketogenesis. Proc Nutr Soc 1981; 40: 93-8.
16. Tanaka M, Nakamura F, Mizokawa S, et al. Role of lactate in the brain energy metabolism: revealed by bioradiography. Neurosci Res 2004; 48: 13-20.
17. Vezzani A, Granata T. Brain inflammation in epilepsy: experimental and clinical evidence. Epilepsia 2005; 46: 1724-43.
18. Nehlig A, Rudolf G, Leroy C, Rigoulot MA, Simpson IA, Vannucci SJ. Pentylenetetrazol-induced status epilepticus up-regulates the expression of glucose transporter mRNA but not proteins in the immature rat brain. Brain Res 2006; 1082: 32-42.
19. El Sabbagh S, Lebre AS, Bahi-Buisson N, et al. Epileptic phenotypes in children with respiratory chain disorders. Epilepsia 2010; 51: 1225-35.
20. Somjen GG. Ion regulation in the brain: implications for pathophysiology. Neuroscientist 2002; 8: 254-67.
21. Vannucci RC, Yager JY, Vannucci SJ. Cerebral glucose and energy utilization during the evolution of hypoxic-ischemic brain damage in the immature rat. J Cereb Blood Flow Metab 1994; 14: 279-88.
22. Stenninger E, Flink R, Eriksson B, Sahlèn C. Long-term neurological dysfunction and neonatal hypoglycemia after diabetic pregnancy. Arch Dis Child Fetal Neonatal Ed 1998; 79: F174-9.
23. Feingold KR, Moser A, Patsek SM, Shigenaga JK, Grunfeld C. Infection decreases fatty acid oxidation and nuclear hormone receptors in the diaphragm. J Lipid Res 2009; 50: 2055-63.
24. Wang X, Rousset CI, Hagberg H, Mallard C. Lipopolysaccaride-induced inflammation and perinatal brain injury. Semin Fetal Neonatal Med 2006; 11: 343-53.
25. Nabbout R, Vezzani A, Dulac O, Chiron C. Acute encephalopathy with inflammation-mediated status epilepticus. Lancet Neurol 2011; 10: 99-108.
26. Brochu ME, Girard S, Lavoie K, Sébire G. Developmental regulation of the neuroinflammatory responses to LPS and/or hypoxia-ischaemia between preterm and term neonates: an experimental study. J Neuroinflammation 2011; 8: 55.