Bead-size directed distribution of Pseudomonas aeruginosa results in distinct inflammatory response in a mouse model of chronic lung infection

Clinical and Experimental Immunology

Volumn 170, Issue 2, 2012, Pages 222-230

  Christophersen, L J ^a   Trostrup H ^a   Malling Damlund, D S ^a   Bjarnsholt, T ^a   Thomsen, K ^a   Jensen, P O ^a   Hougen, H P ^b   Hoiby N ^a   Moser, C ^a  

^a Rigshospitalet   (Denmark)

^b UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

Animal models studies mice rats; Cystic fibrosis (CF); Cytokines interleukins; Lung immunology disease

Indexed keywords

ALCIAN BLUE; ALGINIC ACID; CXCL3 CHEMOKINE; GRANULOCYTE COLONY STIMULATING FACTOR;

AIRWAY; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOFILM; BRONCHUS; COLONY FORMING UNIT; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; EXPERIMENTAL MODEL; FEMALE; HISTOPATHOLOGY; IMMUNE RESPONSE; INFLAMMATION; LEUKOCYTE MOTILITY; LUNG PARENCHYMA; MOUSE; NEUTROPHIL; NONHUMAN; PRIORITY JOURNAL; PSEUDOMONAS AERUGINOSA; PSEUDOMONAS PNEUMONIA; QUANTITATIVE ANALYSIS;

ALGINATES; ANIMALS; BIOFILMS; CHEMOKINE CXCL2; CHRONIC DISEASE; CYSTIC FIBROSIS; FEMALE; GLUCURONIC ACID; GRANULOCYTE COLONY-STIMULATING FACTOR; HEXURONIC ACIDS; INFLAMMATION; LUNG; LUNG DISEASES; MICE; MICE, INBRED BALB C; NEUTROPHILS; PSEUDOMONAS AERUGINOSA; PSEUDOMONAS INFECTIONS; RESPIRATORY TRACT INFECTIONS;

EID: 84867221050     PISSN: 00099104     EISSN: 13652249     Source Type: Journal    
DOI: 10.1111/j.1365-2249.2012.04652.x     Document Type: Article

References (21)

1. Jensen PO, Givskov M, Bjarnsholt T, Moser C. The immune system vs. Pseudomonas aeruginosa biofilms. FEMS Immunol Med Microbiol 2010; 59:292-305.
2. Knowles MR, Boucher RC. Mucus clearance as a primary innate defense mechanism for mammalian airways. J Clin Invest 2002; 109:571-7.
3. Craig A, Mai J, Cai S, Jeyaseelan S. Neutrophil recruitment to the lungs during bacterial pneumonia. Infect Immun 2009; 77:568-75.
4. Schmiedl A, Kerber-Momot T, Munder A, Pabst R, Tschernig T. Bacterial distribution in lung parenchyma early after pulmonary infection with Pseudomonas aeruginosa. Cell Tissue Res 2010; 342:67-73.
5. McCullagh A, Rosenthal M, Wanner A, Hurtado A, Padley S, Bush A. The bronchial circulation - worth a closer look: a review of the relationship between the bronchial vasculature and airway inflammation. Pediatr Pulmonol 2010; 45:1-13.
6. Pedersen SS, Moller H, Espersen F, Sorensen CH, Jensen T, Høiby N. Mucosal immunity to Pseudomonas aeruginosa alginate in cystic fibrosis. APMIS 1992; 100:326-34.
7. Bjarnsholt T, Jensen PO, Fiandaca MJ etal. Pseudomonas aeruginosa biofilms in the respiratory tract of cystic fibrosis patients. Pediatr Pulmonol 2009; 44:547-58.
8. Moser C, PØ J, Kobayashi O etal. Improved outcome of chronic Pseudomonas aeruginosa lung infection is associated with induction of a Th1-dominated cytokine response. Clin Exp Immunol 2002; 127:206-13.
9. Moser C, Johansen HK, Song Z, Hougen HP, Rygaard J, Høiby N. Chronic Pseudomonas aeruginosa lung infection is more severe in Th2 responding BALB/c mice compared to Th1 responding C3H/HeN mice. APMIS 1997; 105:838-42.
10. Wörlitzsch D, Tarran R, Ulrich M etal. Effects of reduced mucus oxygen concentration in airway Pseudomonas infections of cystic fibrosis patients. J Clin Invest 2002; 109:317-25.
11. Kolpen M, Hansen CR, Bjarnsholt T etal. Polymorphonuclear leucocytes consume oxygen in sputum from chronic Pseudomonas aeruginosa pneumonia in cystic fibrosis. Thorax 2010; 65:57-62.
12. Lee B, Schjerling CK, Kirkby N etal. Mucoid Pseudomonas aeruginosa isolates maintain the biofilm formation capacity and the gene expression profiles during the chronic lung infection of CF patients. APMIS 2011; 119:263-74.
13. West JB. Pulmonary physiology and pathophysiology. An integrated case-based approach. Philadelphia, PA: Lippincott Williams & Wilkins, 2001.
14. Moser C, Van Gennip M, Bjarnsholt T etal. Novel experimental Pseudomonas aeruginosa lung infection model mimicking long-term host-pathogen interactions in cystic fibrosis. APMIS 2009; 117:95-107.
15. Janeway CA. Immunobiology. Garland Sci 2011; 6 (Part IV): Chapter 9.
16. Plantinga M, Hammad H, Lambrecht BN. Origin and functional specializations of DC subsets in the lung. Eur J Immunol 2010; 40:2112-8.
17. Rohmann K, Tschernig T, Pabst R, Goldmann T, Dromann D. Innate immunity in the human lung: pathogen recognition and lung disease. Cell Tissue Res 2011; 343:167-74.
18. Jensen PO, Moser C, Kharazmi A, Presler T, Koch C, Hoiby N. Increased serum concentration of G-CSF in cystic fibrosis patients with chronic Pseudomonas aeruginosa pneumonia. J Cyst Fibros 2006; 5:145-51.
19. Høiby N, Ciofu O, Bjarnsholt T. Pseudomonas aeruginosa biofilms in cystic fibrosis. Future Microbiol 2010; 5:1663-74.
20. Thiberville L, Moreno-Swirc S, Vercauteren T, Peltier E, Cave C, Bourg Heckly G. In vivo imaging of the bronchial wall microstructure using fibered confocal fluorescence microscopy. Am J Respir Crit Care Med 2007; 175:22-31.
21. Høiby N. Recent advances in the treatment of Pseudomonas aeruginosa infections in cystic fibrosis. BMC Med 2011; 9:32 (pp. 1-7).