Synthesis and biological activities of 1α,4α,25- and 1α,4β,25-trihydroxyvitamin D3 and their metabolism by human CYP24A1 and UDP-glucuronosyltransferase

Chemical and Pharmaceutical Bulletin

Volumn 60, Issue 10, 2012, Pages 1343-1346

  Sawada, Daisuke ^a   Tsukuda, Yuya ^a   Yasuda, Kaori ^b   Sakaki, Toshiyuki ^b   Saito, Hiroshi ^c   Takagi, Ken Ichiro ^c   Takenouchi, Kazuya ^c   Chen, Tai C ^d   Reddy, G Satyanarayana ^e,f   Kittaka, Atsushi ^a  

^a TEIKYO UNIVERSITY   (Japan)

^b TOYAMA PREFECTURAL UNIVERSITY   (Japan)

^c TEIJIN PHARMA LIMITED   (Japan)

^d BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^e Epimer LLC   (United States)

^f BROWN UNIVERSITY   (United States)

Author keywords

Human CYP24A1; Human liver microsome; Metabolism; Trihydroxyvitamin D3; UDP glucuronosyltransferase; Vitamin D receptor

Indexed keywords

1ALPHA,4ALPHA,25 TRIHYDROXYCOLECALCIFEROL; 1ALPHA,4BETA,25 TRIHYDROXYCOLECALCIFEROL; COLECALCIFEROL DERIVATIVE; CYTOCHROME P450 24A1; CYTOCHROME P450 ISOENZYME; GLUCURONOSYLTRANSFERASE; HYDROXYL GROUP; OSTEOCALCIN; PALLADIUM; UNCLASSIFIED DRUG; VITAMIN D RECEPTOR;

ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; DIASTEREOISOMER; DRUG METABOLISM; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG SYNTHESIS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; LIVER MICROSOME METABOLISM; PROMOTER REGION; STRUCTURE ACTIVITY RELATION;

CELL LINE; GLUCURONOSYLTRANSFERASE; HUMANS; HYDROXYCHOLECALCIFEROLS; MICROSOMES, LIVER; OSTEOCALCIN; RECEPTORS, CALCITRIOL; STEROID HYDROXYLASES; TRANSCRIPTIONAL ACTIVATION;

EID: 84867199841     PISSN: 00092363     EISSN: 13475223     Source Type: Journal    
DOI: 10.1248/cpb.c12-00526     Document Type: Article

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