The three clades of the telomere-associated Tlo gene family of Candida albicans have different splicing, localization, and expression features

Eukaryotic Cell

Volumn 11, Issue 10, 2012, Pages 1268-1275

  Anderson, Matthew Z ^a   Baller, Joshua A ^a   Dulmage, Keely ^a,c   Wigen, Lauren ^a   Berman, Judith ^a,b  

^a UNIVERSITY OF MINNESOTA   (United States)

^b TEL AVIV UNIVERSITY   (Israel)

^c DUKE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FUNGAL PROTEIN; MEDIATOR COMPLEX; TELOMERE BINDING PROTEIN;

ARTICLE; CANDIDA ALBICANS; CELL NUCLEUS; GENETIC TRANSCRIPTION; GENETICS; INTRON; METABOLISM; MITOCHONDRION; MULTIGENE FAMILY; PHYLOGENY; PROTEIN SUBUNIT; RNA SPLICING;

CANDIDA ALBICANS; CELL NUCLEUS; FUNGAL PROTEINS; INTRONS; MEDIATOR COMPLEX; MITOCHONDRIA; MULTIGENE FAMILY; PHYLOGENY; PROTEIN SUBUNITS; RNA SPLICING; TELOMERE-BINDING PROTEINS; TRANSCRIPTION, GENETIC;

CANDIDA; CANDIDA ALBICANS;

EID: 84867187155     PISSN: 15359778     EISSN: None     Source Type: Journal    
DOI: 10.1128/EC.00230-12     Document Type: Article

References (49)

1. Beve J, et al. 2005. The structural and functional role of Med5 in the yeast Mediator tail module. J. Biol. Chem. 280:41366-41372.
2. Bourbon HM. 2008. Comparative genomics supports a deep evolutionary origin for the large, four-module transcriptional mediator complex. Nucleic Acids Res. 36:3993-4008.
3. Brown CA, Murray AW, Verstrepen KJ. 2010. Rapid expansion and functional divergence of subtelomeric gene families in yeasts. Curr. Biol. 20:895-903.
4. Bruno VM, et al. 2010. Comprehensive annotation of the transcriptome of the human fungal pathogen Candida albicans using RNA-seq. Genome Res. 20:1451-1458.
5. Burge C, Karlin S. 1997. Prediction of complete gene structures in human genomic DNA. J. Mol. Biol. 268:78-94.
6. Butler G, et al. 2009. Evolution of pathogenicity and sexual reproduction in eight Candida genomes. Nature 459:657-662.
7. Carreto L, et al. 2008. Comparative genomics of wild type yeast strains unveils important genome diversity. BMC Genomics 9:524. doi:10.1186/1471-2164-9-524.
8. Conaway RC, Conaway JW. 2011. Function and regulation of the Mediator complex. Curr. Opin. Genet. Dev. 21:225-230.
9. Dreszer TR, Wall GD, Haussler D, Pollard KS. 2007. Biased clustered substitutions in the human genome: the footprints of male-driven biased gene conversion. Genome Res. 17:1420-1430.
10. Dujon B, et al. 2004. Genome evolution in yeasts. Nature 430:35-44.
11. Edgar RC. 2004. MUSCLE: multiple sequence alignment with high accuracy and high throughput. Nucleic Acids Res. 32:1792-1797.
12. Farman ML, Kim YS. 2005. Telomere hypervariability in Magnaporthe oryzae. Mol. Plant Pathol. 6:287-298.
13. Gerami-Nejad M, Berman J, Gale CA. 2001. Cassettes for PCR-mediated construction of green, yellow, and cyan fluorescent protein fusions in Candida albicans. Yeast 18:859-864.
14. Greenbaum D, Colangelo C, Williams K, Gerstein M. 2003. Comparing protein abundance and mRNA expression levels on a genomic scale. Genome Biol. 4:117. doi:10.1186/gb-2003-4-9-117.
15. Gresham D, et al. 2008. The repertoire and dynamics of evolutionary adaptations to controlled nutrient-limited environments in yeast. PLoS Genet. 4:e1000303. doi:10.1371/journal.pgen.1000303.
16. Gustafsson CM, Samuelsson T. 2001. Mediator-a universal complex in transcriptional regulation. Mol. Microbiol. 41:1-8.
17. Hoffman CS, Winston F. 1987. A ten-minute DNA preparation from yeast efficiently releases autonomous plasmids for transformation of Escherichia coli. Gene 57:267-272.
18. Huh WK, et al. 2003. Global analysis of protein localization in budding yeast. Nature 425:686-691.
19. Jackson AP, et al. 2009. Comparative genomics of the fungal pathogens Candida dubliniensis and Candida albicans. Genome Res. 19:2231-2244.
20. Kagey MH, et al. 2010. Mediator and cohesin connect gene expression and chromatin architecture. Nature 467:430-435.
21. Kaiser B, Munder T, Saluz HP, Kunkel W, Eck R. 1999. Identification of a gene encoding the pyruvate decarboxylase gene regulator CaPdc2p from Candida albicans. Yeast 15:585-591.
22. Kellis M, Birren BW, Lander ES. 2004. Proof and evolutionary analysis of ancient genome duplication in the yeast Saccharomyces cerevisiae. Nature 428:617-624.
23. Kondoh H, Mizutani T. 1998. Expression of the glutathione peroxidase gene lacking its 3= untranslated region. Mol. Biol. Rep. 25:121-125.
24. Kornberg RD. 2005. Mediator and the mechanism of transcriptional activation. Trends Biochem. Sci. 30:235-239.
25. Kyes SA, Kraemer SM, Smith JD. 2007. Antigenic variation in Plasmodium falciparum: gene organization and regulation of the var multigene family. Eukaryot. Cell 6:1511-1520.
26. Lebrun E, et al. 2001. Protosilencers in Saccharomyces cerevisiae subtelomeric regions. Genetics 158:167-176.
27. Louis EJ, Haber JE. 1992. The structure and evolution of subtelomeric Y' repeats in Saccharomyces cerevisiae. Genetics 131:559-574.
28. Mathur S, Vyas S, Kapoor S, Tyagi AK. 2011. The Mediator complex in plants: structure, phylogeny, and expression profiling of representative genes in a dicot (Arabidopsis) and a monocot (rice) during reproduction and abiotic stress. Plant Physiol. 157:1609-1627.
29. Maxwell PH, Burhans WC, Curcio MJ. 2011. Retrotransposition is associated with genome instability during chronological aging. Proc. Natl. Acad. Sci. U. S. A. 108:20376-20381.
30. Mishra PK, Baum M, Carbon J. 2007. Centromere size and position in Candida albicans are evolutionarily conserved independent of DNA sequence heterogeneity. Mol. Genet. Genomics 278:455-465.
31. Nolan T, Hands RE, Bustin SA. 2006. Quantification of mRNA using real-time RT-PCR. Nat. Protoc. 1:1559-1582. doi:10.1038/ nprot.2006.236.
32. Novatchkova M, Eisenhaber F. 2004. Linking transcriptional mediators via the GACKIX domain super family. Curr. Biol. 14:R54-R55.
33. Pavelka N, Rancati G, Li R. 2010. Dr Jekyll and Mr Hyde: role of aneuploidy in cellular adaptation and cancer. Curr. Opin. Cell Biol. 22:809-815.
34. Peng J, Zhou JQ. 2012. The tail-module of yeast Mediator complex is required for telomere heterochromatin maintenance. Nucleic Acids Res. 40:581-593.
35. Ramirez-Zavala B, Reuss O, Park YN, Ohlsen K, Morschhauser J. 2008. Environmental induction of white-opaque switching in Candida albicans. PLoS Pathog. 4:e1000089. doi:10.1371/journal.ppat.1000089.
36. Sanglard D, Ischer F, Monod M, Bille J. 1996. Susceptibilities of Candida albicans multidrug transporter mutants to various antifungal agents and other metabolic inhibitors. Antimicrob. Agents Chemother. 40:2300-2305.
37. Schuller D, et al. 2012. Genetic diversity and population structure of Saccharomyces cerevisiae strains isolated from different grape varieties and winemaking regions. PLoS One 7:e32507. doi:10.1371/ journal.pone.0032507.
38. Selmecki A, Bergmann S, Berman J. 2005. Comparative genome hybridization reveals widespread aneuploidy in Candida albicans laboratory strains. Mol. Microbiol. 55:1553-1565.
39. Sherman F. 1991. Getting started with yeast. Methods Enzymol. 194:3-21.
40. Taylor JE, Rudenko G. 2006. Switching trypanosome coats: what's in the wardrobe? Trends Genet. 22:614-620.
41. Thakur JK, et al. 2009. Mediator subunit Gal11p/MED15 is required for fatty acid-dependent gene activation by yeast transcription factor Oaf1p. J. Biol. Chem. 284:4422-4428.
42. Torres EM, et al. 2010. Identification of aneuploidy-tolerating mutations. Cell 143:71-83.
43. Turakainen H, Naumov G, Naumova E, Korhola M. 1993. Physical mapping of the MEL gene family in Saccharomyces cerevisiae. Curr. Genet. 24:461-464.
44. van het Hoog M, et al. 2007. Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes. Genome Biol. 8:R52. doi:10.1186/gb-2007-8-4-r52.
45. Verstrepen KJ, Klis FM. 2006. Flocculation, adhesion and biofilm formation in yeasts. Mol. Microbiol. 60:5-15.
46. Xiao H, Jiang N, Schaffner E, Stockinger EJ, van der Knaap E. 2008. A retrotransposon-mediated gene duplication underlies morphological variation of tomato fruit. Science 319:1527-1530.
47. Yamada M, Hayatsu N, Matsuura A, Ishikawa F. 1998. Y'-Help1, a DNA helicase encoded by the yeast subtelomeric Y' element, is induced in survivors defective for telomerase. J. Biol. Chem. 273:33360-33366.
48. Zhang A, et al. 2012. The Tlo proteins are stoichiometric components of Candida albicans Mediator anchored via the Med3 subunit. Eukaryot. Cell 11:874-884.
49. Zhang F, Sumibcay L, Hinnebusch AG, Swanson MJ. 2004. A triad of subunits from the Gal11/tail domain of Srb mediator is an in vivo target of transcriptional activator Gcn4p. Mol. Cell. Biol. 24:6871-6886.