Increased fibroblast telomerase expression precedes myofibroblastα-smooth muscle actin expression in idiopathic pulmonary fibrosis

Clinics

Volumn 67, Issue 9, 2012, Pages 1039-1046

  Waisberg, Daniel Reis ^a   Parra, Edwin Roger ^a   Barbas Filho, João Valente ^a   Fernezlian, Sandra ^a   Capelozzi, Vera Luiza ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

smooth Muscle Actin; Fibroblasts; Idiopathic Pulmonary Fibrosis; Interleukin 4; Telomerase

Indexed keywords

ACTA2 PROTEIN, HUMAN; ACTIN; BIOLOGICAL MARKER; FIBROBLAST GROWTH FACTOR; INTERLEUKIN 4; TELOMERASE; TRANSFORMING GROWTH FACTOR BETA;

AGED; ARTICLE; BIOPSY; CELL DIFFERENTIATION; FEMALE; FIBROSING ALVEOLITIS; HUMAN; LUNG; MALE; METABOLISM; MIDDLE AGED; MYOFIBROBLAST; PATHOLOGY; PROPORTIONAL HAZARDS MODEL; RETROSPECTIVE STUDY; SURVIVAL;

ACTINS; AGED; BIOLOGICAL MARKERS; BIOPSY; CELL DIFFERENTIATION; FEMALE; FIBROBLAST GROWTH FACTORS; HUMANS; IDIOPATHIC PULMONARY FIBROSIS; INTERLEUKIN-4; LUNG; MALE; MIDDLE AGED; MYOFIBROBLASTS; PROPORTIONAL HAZARDS MODELS; RETROSPECTIVE STUDIES; SURVIVAL ANALYSIS; TELOMERASE; TRANSFORMING GROWTH FACTOR BETA;

EID: 84867185713     PISSN: 18075932     EISSN: None     Source Type: Journal    
DOI: 10.6061/clinics/2012(09)10     Document Type: Article

References (35)

1. Gross TJ, Hunninghake GW. Idiopathic pulmonary fibrosis. NEngl J Med. 2001;16;345(7):517-25.
2. Raghu G, Weycker D, Edelsberg J, Bradford WZ, Oster G. Incidence and prevalence of idiopathic pulmonary fibrosis. Am J Respir Crit Care Med. 2006;174(7):810-6, http://dx.doi.org/10.1164/rccm.200602-163OC.
3. Katzenstein AA, Myers JL. Idiopathic pulmonary fibrosis: clinical relevance of pathological classification. Am J Respir Crit Care Med. 1998;157(4 Pt 1):1301-15.
4. Ramos C, Montano M, Garcia-Alvarez J, Ruiz V, Uhal BD, Selman M, et al. Fibroblasts from idiopathic pulmonary fibrosis and normal lungs differ in growth rate, apoptosis, and tissue inhibitor of metalloproteinases expression. Am J Respir Cell Mol Biol. 2001;24(5):591-8.
5. Scotton C, Chambers RC. Molecular targets in pulmonary fibrosis: the myofibroblasts in focus. Chest. 2007;132(4):1311-21, http://dx.doi.org/ 10.1378/chest.06-2568.
6. King TE Jr, Schwarz MI, Brown K, Tooze JA, Colby TV, Waldron JA Jr, Flint A, Thurlbeck W, Cherniack RM. Idiopathic pulmonary fibrosis: relationship between histopathologic features and mortality. Am J Respir Crit Care Med. 2001;164(6):1025-32.
7. Zhang HY, Gharaee-Kermani M, Zhang K, Karmiol S, Phan SH. Lung fibroblast alpha-smooth muscle actin expression and contractile phenotype in bleomycin-induced pulmonary fibrosis. Am J Pathol. 1996;148(2):527-37.
8. Selman M, Pardo A. Role of epithelial cells in idiopathic pulmonary fibrosis: from innocent targets to serial killers. Proc Am Thorac Soc. 2006;3(4):364-72, http://dx.doi.org/10.1513/pats.200601-003TK.
9. Barbas-Filho JV, Ferreira MA, Sesso A, Kairalla RA, Carvalho CR, Capelozzi VL. Evidence of type II pneumocyte apoptosis in the pathogenesis of idiopathic pulmonary fibrosis (IPF)/usual interstitial pneumonia (UIP). J Clin Pathol. 2001;54(2):132-8, http://dx.doi.org/ 10.1136/jcp.54.2.132.
10. Waisberg DR, Barbas-Filho JV, Parra ER, Fernezlian S, Carvalho CR, Kairalla RA, et al. Abnormal expression of telomerase/apoptosis limits type II alveolar epithelial cell replication in the early remodeling of usual interstitial pneumonia/idiopathic pulmonary fibrosis. Human Pathology. 2010;41(3):385-91, http://dx.doi.org/10.1016/j.humpath.2009.08.019.
11. Armanios MY, Chen JLLJ, Cogan JD, Alder JK, Ingersoll RG, Markin C, et al. N Engl J Med. 2007;356(13):1317-26.
12. Tsakiri KD, Cronkhite JT, Kuan PJ, Xing C, Raghu G, Weissler JC, et al. Adult-onset pulmonary fibrosis caused by mutations in telomerase. Proc Natl Acad Sci USA. 2007;104(18):7552-7, http://dx.doi.org/10.1073/ pnas.0701009104.
13. Alder JK, Chen JJ, Lancaster L, Danoff S, Su SC, Cogan JD, et al. Short telomeres are a risk factor for idiopathic pulmonary fibrosis. Proc Natl Acad Sci USA. 2008;105(35):13051-6, http://dx.doi.org/10.1073/ pnas.0804280105.
14. Cronkhite JT, Xing C, Raghu G, Chin KM, Torres F, Rosenblatt RL, et al. Telomere shortening in familial and sporadic pulmonary fibrosis. Am J Respir Crit Care Med. 2008;178(7):729-37, http://dx.doi.org/ 10.1164/rccm.200804-550OC.
15. Greider CW. Telomere length regulation. Annu Rev Biochem. 1996;65:337-65, http://dx.doi.org/10.1146/annurev.bi.65.070196.002005.
16. Greider CW. Telomerase activity, cell proliferation, and cancer. Proc Natl Acad Sci U S A. 1998;95(1):90-2, http://dx.doi.org/10.1073/pnas.95.1.90.
17. Nozaki Y, Liu T, Hatano K, Gharaee-Kermani M, Phan SH. Induction of telomerase activity in fibroblasts from bleomycin-injured lungs. American journal of respiratory cell and molecular biology. 2000;23(4):460-5.
18. Liu T, Hu B, Chung MJ, Ullenbruch M, Jin H, Phan SH. Telomerase regulation of myofibroblast differentiation. Am J Resp Cell Mol Biol. 2006;34(5):625-33, http://dx.doi.org/10.1165/rcmb.2005-0252OC.
19. Liu T, Nozaki Y, Phan SH. Regulation of Telomerase Activity in Rat Lung Fibroblasts. Am J Respir Cell Mol. Biol. 2002;26(5):534-40.
20. American Thoracic Society, European Respiratory Society. American Thoracic Society/European Respiratory Society International Multidisciplinary Consensus Classification of the Idiopathic Interstitial Pneumonias. This joint statement of the American Thoracic Society (ATS), and the European Respiratory Society (ERS) was adopted by the ATS board of directors, June 2001 and by the ERS Executive Committee, June 2001. Am J Respir Crit Care Med. 2002;165(2):277-304.
21. Gundersen HJG, Bendtesen TF, Korbo L, Marcussen N, Moller A, Nielsen K, et al. Some new, simple and efficient stereological methods and their use in pathological research and diagnosis. APMIS. 1988;96(5):379-94, http://dx.doi.org/10.1111/j.1699-0463.1988.tb05320.x.
22. Jordana M, Schulman J, McSharry C, Irving LB, Newhouse MT, Jordana G, et al. Heterogeneous proliferative characteristics of human adult lung fibroblast lines and clonally derived fibroblasts from control and fibrotic tissue. Am Rev Respir Dis. 1988;137(5): 579-84.
23. Zhang HY, Gharaee-Kermani M, Zhang K, Karmiol S, Phan SH. Lung fibroblast alpha-smooth muscle actin expression and contractile phenotype in bleomycin-induced pulmonary fibrosis. Am J Pathol. 1996;148(2):527-37.
24. Uhal BD, Ramos C, Joshi I, Bifero A, Pardo A, Selman M. Cell size, cell cycle, and alpha-smooth muscle actin expression by primary human lung fibroblasts. Am J Physiol. 1998;275(5 Pt 1):L998-L1005.
25. Raghu G, Chen YY, Rusch V, Rabinivitch PS. Differential proliferation of fibroblast cultured and fibrotic human lungs. Am Rev Respir Dis. 1988;138(3):703-8.
26. Goodwin A, Jenkins G. Role of integrin-mediated TGFb activation in the pathogenesis of pulmonary fibrosis. Biochem Soc Trans. 2009;37(Pt 4):849-54.
27. Desmouliere A, Geinoz A, Gabbiani F, Gabbiani G. Transforming growth factor-b1 induces a-smooth muscle actin expression in granulation tissue myofibroblasts and in quiescent and growing cultured fibroblasts. J Cell Biol. 1993;122(1):103-11, http://dx.doi.org/10.1083/ jcb.122.1.103.
28. Strieter RM. What differentiates normal lung repair and fibrosis? Proc Am Thorac Soc. 2008;5(3):305-10, http://dx.doi.org/10.1513/ pats.200710-160DR.
29. Lopes AJ, Capone D, Mogami R, Lanzillotti RS, Melo PL, Jansen JM. Severity classification for idiopathic pulmonary fibrosis by using fuzzy logic. Clinics. 2011;66(6):1015-9, http://dx.doi.org/10.1590/S1807-59322011000600016.
30. Postlethwaite AE, Holness MA, Katai H, Raghow R. Human fibroblasts synthesize elevated levels of extracellular matrix proteins in response to interleukin 4. J Clin Invest. 1992;90(4):1479-85, http://dx.doi.org/ 10.1172/JCI116015.
31. Hogaboam CM, Bone-Larson CL, Lipinski S, Lukacs NW, Chensue SW, Strieter RM, et al. Differential monocyte chemoattractant protein-1 and chemokine receptor 2 expression by murine lung fibroblasts derived from Th1-and Th2-type pulmonary granuloma models. J Immunol. 1999;163(4):2193-201.
32. Wallace WA, Ramage EA, Lamb D, Howie SE. A type 2 (Th2-like) pattern of immune response predominates in the pulmonary interstitium of patients with cryptogenic fibrosing alveolitis (CFA). Clin Exp Immunol. 1995;101(3):436-41.
33. Barata LT, Ying S, Meng Q, Barkans J, Rajakulasingam K, Durham SR, Kay AB. IL-4-and IL-5-positive T lymphocytes, eosinophils, and mast cells in allergen-induced late-phase cutaneous reactions in atopic subjects. J Allergy Clin Immunol. 1998;101(2Pt 1):222-30.
34. Vasakova M, Striz I, Slavcev A, Jandova S, Kolesar L, Sulc J. Th1/Th2 cytokine gene polymorphisms in patients with idiopathic pulmonary fibrosis. Tissue Antigens. 2006;67(3):229-32, http://dx.doi.org/10.1111/ j.1399-0039.2006.00560.x.
35. Ando M, Miyazaki E, Fukami T, Kumamoto T, Tsuda T. Interleukin-4-producing cells in idiopathic pulmonary fibrosis: an immunohistochemical study. Respirology. 1999;4(4):383-91, http://dx.doi.org/10.1046/ j.1440-1843.1999.00209.x.