Empirical antibiotic therapy for suspected early-onset bacterial sepsis

Pediatrics

Volumn 130, Issue 4, 2012, Pages

  Cotten, C Michael ^a   Benjamin, Daniel K ^a,b   Smith, P Brian ^b   Stoll, Barbara J ^c,d,e   Spitzer, Alan R ^f   Clark, Reese H ^g  

^a DUKE UNIVERSITY   (United States)

^b DUKE CLINICAL RESEARCH INSTITUTE   (United States)

^c EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d Emory Children's Pediatric Institute   (United States)

^e CHILDREN'S HEALTHCARE OF ATLANTA   (United States)

^f American Anesthesiology   (United States)

^g PEDIATRIX MEDICAL GROUP   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTIC AGENT; C REACTIVE PROTEIN;

ALGORITHM; ANTIBIOTIC PROPHYLAXIS; ANTIBIOTIC THERAPY; BACTERIUM CULTURE; BLOOD CULTURE; CHORIOAMNIONITIS; DRUG INDICATION; GROUP B STREPTOCOCCAL INFECTION; HIGH RISK INFANT; HUMAN; INFANT; INFECTION PREVENTION; LETTER; LEUKOCYTOSIS; NEWBORN; NEWBORN SEPSIS; PRACTICE GUIDELINE; PRIORITY JOURNAL; RISK BENEFIT ANALYSIS; SCREENING TEST; UNITED STATES;

EID: 84867154398     PISSN: 00314005     EISSN: 10984275     Source Type: Journal    
DOI: 10.1542/peds.2012-2302A     Document Type: Letter

References (9)

1. Polin RA; Committee on Fetus and Newborn. Management of neonates with suspected or proven early-onset bacterial sepsis. Pediatrics. 2012;129(5):1006-1015
2. Stoll BJ, Hansen NI, Sánchez PJ, et al Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network. Early onset neonatal sepsis: the burden of group B Streptococcal and E. coli disease continues. Pediatrics. 2011;127(5):817-826
3. Verani JR, McGee L, Schrag SJ; Division of Bacterial Diseases, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention (CDC). Prevention of perinatal group B streptococcal disease - revised guidelines from CDC, 2010. MMWR Recomm Rep. 2010;59(RR-10):1-36
4. Jackson GL, Engle WD, Sendelbach DM, et al. Are complete blood cell counts useful in the evaluation of asymptomatic neonates exposed to suspected chorioamnionitis? Pediatrics. 2004;113(5):1173-1180 (Pubitemid 38580677)
5. Benitz WE, Han MY, Madan A, Ramachandra P. Serial serum C-reactive protein levels in the diagnosis of neonatal infection. Pediatrics. 1998;102(4). Available at: www.pediatrics.org/cgi/content/full/102/4/e41
6. Centers for Disease Control and Prevention. 12-Step Program to Prevent Antimicrobial Resistance in Health Care Settings. Available at: www.cdc.gov/drugresistance/healthcare/default.html. Accessed May 15, 2012
7. Cotten CM, Taylor S, Stoll B, et al NICHD Neonatal Research Network. Prolonged duration of initial empirical antibiotic treatment is associated with increased rates of necrotizing enterocolitis and death for extremely low birth weight infants. Pediatrics. 2009;123(1):58-66
8. Kuppala VS, Meinzen-Derr J, Morrow AL, Schibler KR. Prolonged initial empirical antibiotic treatment is associated with adverse outcomes in premature infants. J Pediatr. 2011;159(5):720-725
9. Patel SJ, Saiman L. Antibiotic resistance in neonatal intensive care unit pathogens: mechanisms, clinical impact, and prevention including antibiotic stewardship. Clin Perinatol. 2010;37(3):547-563