Enhanced Ca 2+binding of cardiac troponin reduces sarcomere length dependence of contractile activation independently of strong crossbridges

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 303, Issue 7, 2012, Pages

  Steven Korte, F ^a   Feest, Erik R ^a   Razumova, Maria V ^a   Tu, An Yue ^a   Regnier, Michael ^a  

^a University of Washington   (United States)

Author keywords

Ca 2+ sensitivity; Frank Starling relationship; Length dependent activation; Sarcomere length; Trabeculae

Indexed keywords

DEXTRAN; DIACETYL OXIME; TROPONIN; TROPONIN C; 2,3 BUTANEDIONE; CALCIUM; DRUG DERIVATIVE; RECOMBINANT PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; BINDING SITE; CALCIUM BINDING; CALCIUM HOMEOSTASIS; CONTROLLED STUDY; FORCE; HEART MUSCLE CONTRACTILITY; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; SARCOMERE LENGTH; STEADY STATE; THIN FILAMENT; WILD TYPE; ANIMAL; BIOLOGICAL MODEL; COMPARATIVE STUDY; DRUG EFFECT; EXCITATION CONTRACTION COUPLING; GENETICS; HEART CONTRACTION; HEART MUSCLE CELL; METABOLISM; MUSCLE STRENGTH; MUTATION; OSMOTIC PRESSURE; SARCOMERE; SPRAGUE DAWLEY RAT;

ANIMALS; CALCIUM; DIACETYL; EXCITATION CONTRACTION COUPLING; MALE; MODELS, BIOLOGICAL; MUSCLE STRENGTH; MUTATION; MYOCARDIAL CONTRACTION; MYOCYTES, CARDIAC; OSMOTIC PRESSURE; RATS; RATS, SPRAGUE-DAWLEY; RECOMBINANT PROTEINS; SARCOMERES; TROPONIN C;

EID: 84867145508     PISSN: 03636135     EISSN: 15221539     Source Type: Journal    
DOI: 10.1152/ajpheart.00395.2012     Document Type: Article

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