The impact of gender on urine C-peptide creatinine ratio interpretation

Annals of Clinical Biochemistry

Volumn 49, Issue 4, 2012, Pages 363-368

  Thomas, Nicholas J ^a   Shields, Beverley M ^a   Besser, Rachel E J ^a   Jones, Angus G ^a   Rawlingson, Andrew ^a   Goodchild, Emily ^a   Leighton, Christopher ^a   Bowman, Pamela ^a   Shepherd, Maggie ^a   Knight, Bridget A ^a   McDonald, Timothy J ^a   Hattersley, Andrew T ^a  

^a UNIVERSITY OF EXETER   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

C PEPTIDE; CREATININE; HEPATOCYTE NUCLEAR FACTOR 1; HEPATOCYTE NUCLEAR FACTOR 4ALPHA; INSULIN; ORAL ANTIDIABETIC AGENT;

ACCURACY; ADULT; ARTICLE; CHEMOLUMINESCENCE; CONTROLLED STUDY; CREATININE URINE LEVEL; DISEASE CLASSIFICATION; DISEASE DURATION; ELECTROIMMUNOASSAY; FEMALE; HUMAN; INSULIN DEPENDENT DIABETES MELLITUS; MAJOR CLINICAL STUDY; MALE; MIXED MEAL TOLERANCE TEST; MUSCLE MASS; NON INSULIN DEPENDENT DIABETES MELLITUS; POSTPRANDIAL STATE; PRIORITY JOURNAL; PROTEIN SECRETION; PROTEIN URINE LEVEL; SEX DIFFERENCE; TEST MEAL; URINARY C PEPTIDE CREATININE RATIO;

ADULT; AGED; C-PEPTIDE; CREATININE; FEMALE; HUMANS; MALE; MIDDLE AGED;

EID: 84867127388     PISSN: 00045632     EISSN: 17581001     Source Type: Journal    
DOI: 10.1258/acb.2011.011164     Document Type: Article

References (16)

1. Hoekstra JB, Van Rijn HJM, Erkelens DW, Thijssen JHH. C-peptide. Diabetes Care 1982;5:438-46
2. Hoogwerf BJ, Barbosa JJ, Bantle JP, Dawn Laine RD, Frederick C, Goetz MD. Urinary C-peptide as a measure of beta-cell function after a mixed meal in healthy subjects: comparison of four-hour urine C-peptide with serum insulin and plasma C-peptide. Diabetes Care 1983;6:488-92
3. Jones AG, Besser REJ, McDonald TJ, et al. Urine C-peptide creatinine ratio (UCPCR) is an alternative to stimulated serum C-peptide measurement in late-onset insulin-treated diabetes. Diabet Med 2011;28:1034-8
4. Besser REJ, Ludvigsson J, Jones AG, et al. Urine C-peptide creatinine ratio is a noninvasive alternative to the mixed-meal tolerance test in children and adults with type 1 diabetes. Diabetes Care 2011;34:607-9
5. Bowman P, McDonald TJ, Shields BM, Knight BA, Hattersley AT. Validation of a single sample urinary C-peptide creatinine ratio (UCPCR) is a reproducible alternative to serum C-peptide in patients with type 2 diabetes. Diabet Med 2012;29:90-3
6. McDonald TJ, Knight BA, Shields BM, Bowman P, Salzmann MB, Hattersley AT. Stability and reproducibility of a single-sample urinary C-peptide/creatinine ratio and its correlation with 24-h urinary C-peptide. Clini Chem 2009;55:2035-9
7. Besser REJ, Shepherd MJ, McDonald TJ, et al. Urinary C-peptide creatinine ratio is a practical outpatient tool for identifying hepatocyte nuclear factor 1-falphag/hepatocyte nuclear factor 4-falphag maturity-onset diabetes of the young from long-duration type 1 diabetes. Diabetes Care 2011;34:286-91
8. Parag KB, Seedat YK. The protein/creatinine index. A semiquantitative assessment of 24-h protein excretion. S Afr Med J 1986;69:42-3 9 The Renal Association. Proteinuria. See http://www.renal.org/whatwedo/InformationResources/CKDeGUIDE/Proteinuria.aspx (last checked 4 March 2012)
9. National Institute of Clinical Excellence. Type 2 diabetes. 2008. See http://www.nice.org.uk/nicemedia/live/11983/40803/40803.pdf
10. Mattix HJ, Hsu C, Shaykevich S, Curhan G. Use of the albumin/creatinine ratio to detect microalbuminuria: implications of sex and race. J Am Soc Nephrol 2002;13:1034-9
11. Greenbaum CJ, Mandrup-Poulsen T, McGee F, et al. Mixed-meal tolerance test versus glucagon stimulation test for the assessment of beta-cell function in therapeutic trials in type 1 diabetes. Diabetes Care 2008;31:1966-71
12. Bristow AF, Das RE. WHO international reference reagents for human proinsulin and human insulin C-peptide. J Biol Stand 1988;16:179-86
13. Connell SJ, Hollis JS, Tieszen KL, McMurray JR, Dornan TL. Gender and the clinical usefulness of the albumin:creatinine ratio. Diabet Med 1994;11:32-6
14. Jacobs DR, Murtaugh MA, Steffes M, Yu X, Roseman J, Goez FC. Gender- and race-specific determination of albumin excretion rate using albumin-to-creatinine ratio in single, untimed urine specimens: the coronary artery risk development in young adults study. Am J Epidemiol 2002;155:1114-9
15. James GD, Sealey JE, Alderman M, et al. A longitudinal study of urinary creatinine and creatinine clearance in normal subjects. Race, sex, and age differences. Am J Hypertens 1988;1:124-31
16. Iozzo P, Beck-Nielsen H, Laakso M, et al. Independent influence of age on basal insulin secretion in nondiabetic humans. European group for the study of insulin resistance. J Clin Endocrinol Metab 1999;84:863-8