Tukey's contrast test versus two-sample test in a dose-response clinical trial

Statistics in Biopharmaceutical Research

Volumn 3, Issue 1, 2011, Pages 31-39

  Aras, Girish ^a   Xue, Allen ^a   Liu, Thomas ^a  

^a AMGEN INC   (United States)

Author keywords

Dose finding study; Dose response study; Ordered alternatives; Relative efficiency; Tukey's linear trend test

Indexed keywords

ANALYSIS OF VARIANCE; ARTICLE; CALCULATION; DOSE RESPONSE; DRUG EFFICACY; STATISTICAL ANALYSIS; STATISTICAL DISTRIBUTION; TUKEY CONTRAST TEST;

EID: 84867113336     PISSN: None     EISSN: 19466315     Source Type: Journal    
DOI: 10.1198/sbr.2010.09036     Document Type: Article

References (5)

1. Capizzi, T., Survill, T. T., Heyse, J. F., and Malani, H. (1992), "An Empirical and Simulated Comparison of Some Tests for Detecting Progressiveness of Response with Increasing Dose of a Compound, " Biometrical Journal, 34, 3, 275-289. 32
2. ICH (1994), ICH topic E4: Dose-Response Information to Support Drug Registration. 32
3. Rom, D. M., Costello, R. J., and Connell, L. T. (1994), "On Closed Test Procedures for Dose Response Analysis, " Statistics in Medicine, 13, 1583-1596. 32
4. Ruberg, S. J. (1995), "Dose Response Studies. I. Some Design Considerations, " Journal of Biopharmaceutical Statistics, 5, 1, 1-14. 32
5. Tukey, J. W., Ciminera, J. L., and Heyse, J. F. (1985), "Testing the Statistical Certainty of a Response to Increasing Doses of a Drug, " Biometrics, 41, 295-301. 31, 32