A combination of taxol infusion and human umbilical cord mesenchymal stem cells transplantation for the treatment of rat spinal cord injury

Brain Research

Volumn 1481, Issue , 2012, Pages 79-89

  Zhilai, Zhou ^a   Hui, Zhang ^a   Anmin, Jin ^a   Shaoxiong, Min ^a   Bo, Yu ^a   Yinhai, Chen ^a  

^a SOUTHERN MEDICAL UNIVERSITY   (China)

Author keywords

Mesenchymal stem cells; Spinal cord injury; Taxol; Transplantation; Umbilical cord

Indexed keywords

CASPASE 3; PACLITAXEL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; ASTROCYTE; CELL ACTIVATION; CELL COUNT; CELL DIVISION; CELL MIGRATION; CELL PROLIFERATION; CELL SURVIVAL; CONTROLLED STUDY; CONVALESCENCE; CORD BLOOD STEM CELL TRANSPLANTATION; FEMALE; GLIOSIS; HISTOLOGY; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; LOCOMOTION; MESENCHYMAL STEM CELL TRANSPLANTATION; MICROGLIA; MOTOR PERFORMANCE; NERVE FIBER; NONHUMAN; OUTCOME ASSESSMENT; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SPINAL CORD INJURY; TREATMENT DURATION; UMBILICAL CORD MESENCHYMAL STEM CELL TRANSPLANTATION;

ANIMALS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; AXONS; CELL MOVEMENT; CELL SURVIVAL; COMBINED MODALITY THERAPY; CORD BLOOD STEM CELL TRANSPLANTATION; FEMALE; GLIOSIS; HUMANS; MACROPHAGES; MESENCHYMAL STEM CELL TRANSPLANTATION; MICROGLIA; MOTOR ACTIVITY; PACLITAXEL; RATS; RATS, SPRAGUE-DAWLEY; RECOVERY OF FUNCTION; SPINAL CORD INJURIES; TRANSPLANTATION, HETEROLOGOUS;

RATTUS;

EID: 84867096919     PISSN: 00068993     EISSN: 18726240     Source Type: Journal    
DOI: 10.1016/j.brainres.2012.08.051     Document Type: Article

References (38)

1. M.C. Arufe, A. De la Fuente, J. Mateos, I. Fuentes, F.J. De Toro, and F.J. Blanco Analysis of the chondrogenic potential and secretome of mesenchymal stem cells derived from human umbilical cord stroma Stem Cells Dev. 20 2011 1199 1212
2. D.M. Basso, M.S. Beattie, and J.C. Bresnahan A sensitive and reliable locomotor rating scale for open field testing in rats J. Neurotrauma. 12 1995 1 21
3. P.S. Cho, D.J. Messina, E.L. Hirsh, N. Chi, S.N. Goldman, D.P. Lo, I.R. Harris, S.H. Popma, D.H. Sachs, and C.A. Huang Immunogenicity of umbilical cord tissue derived cells Blood 111 2008 430 438
4. J.V. Coumans, T.T. Lin, H.N. Dai, L. MacArthur, M. McAtee, C. Nash, and B.S. Bregman Axonal regeneration and functional recovery after complete spinal cord transection in rats by delayed treatment with transplants and neurotrophins J. Neurosci. 21 2001 9334 9344
5. D.M. Deshpande, Y.S. Kim, T. Martinez, J. Carmen, S. Dike, I. Shats, L.L. Rubin, J. Drummond, C. Krishnan, A. Hoke, N. Maragakis, J. Shefner, J.D. Rothstein, and D.A. Kerr Recovery from paralysis in adult rats using embryonic stem cells Ann. Neurol. 60 2006 32 44
6. C. Dong, Z. Li, R.J. Alvarez, X.H. Feng, and P.J. Goldschmidt-Clermont Microtubule binding to Smads may regulate TGF beta activity Mol. Cell 5 2000 27 34
7. A. Erturk, F. Hellal, J. Enes, and F. Bradke Disorganized microtubules underlie the formation of retraction bulbs and the failure of axonal regeneration J. Neurosci. 27 2007 9169 9180
8. W. Gong, Z. Han, H. Zhao, Y. Wang, J. Wang, J. Zhong, B. Wang, S. Wang, Y. Wang, L. Sun, and Z. Han Banking human umbilical cord-derived mesenchymal stromal cells for clinical use Cell Transplant 21 2012 207 216
9. J.D. Guest, E.D. Hiester, and R.P. Bunge Demyelination and Schwann cell responses adjacent to injury epicenter cavities following chronic human spinal cord injury Exp. Neurol. 192 2005 384 393
10. B.C. Hains, C.Y. Saab, A.C. Lo, and S.G. Waxman Sodium channel blockade with phenytoin protects spinal cord axons, enhances axonal conduction, and improves functional motor recovery after contusion SCI Exp. Neurol. 188 2004 365 377
11. F. Hellal, A. Hurtado, J. Ruschel, K.C. Flynn, C.J. Laskowski, M. Umlauf, L.C. Kapitein, D. Strikis, V. Lemmon, J. Bixby, C.C. Hoogenraad, and F. Bradke Microtubule stabilization reduces scarring and causes axon regeneration after spinal cord injury Science 331 2011 928 931
12. S.Q. Hong, H.T. Zhang, J. You, M.Y. Zhang, Y.Q. Cai, X.D. Jiang, and R.X. Xu Comparison of transdifferentiated and untransdifferentiated human umbilical mesenchymal stem cells in rats after traumatic brain injury Neurochem. Res 2011
13. S.L. Hu, H.S. Luo, J.T. Li, Y.Z. Xia, L. Li, L.J. Zhang, H. Meng, G.Y. Cui, Z. Chen, N. Wu, J.K. Lin, G. Zhu, and H. Feng Functional recovery in acute traumatic spinal cord injury after transplantation of human umbilical cord mesenchymal stem cells Crit. Care Med. 38 2010 2181 2189
14. C. Ide, Y. Nakai, N. Nakano, T.B. Seo, Y. Yamada, K. Endo, T. Noda, F. Saito, Y. Suzuki, M. Fukushima, and T. Nakatani Bone marrow stromal cell transplantation for treatment of sub-acute spinal cord injury in the rat Brain Res. 1332 2010 32 47
15. S.C. Jefferson, N.J. Tester, and D.R. Howland Chondroitinase ABC promotes recovery of adaptive limb movements and enhances axonal growth caudal to a spinal hemisection J. Neurosci. 31 2011 5710 5720
16. S.R. Jeong, M.J. Kwon, H.G. Lee, E.H. Joe, J.H. Lee, S.S. Kim, H. Suh-Kim, and B.G. Kim Hepatocyte growth factor reduces astrocytic scar formation and promotes axonal growth beyond glial scars after spinal cord injury Exp. Neurol. 2011
17. B.G. Kim, D.H. Hwang, S.I. Lee, E.J. Kim, and S.U. Kim Stem cell-based cell therapy for spinal cord injury Cell Transplant 16 2007 355 364
18. S.H. Koh, K.S. Kim, M.R. Choi, K.H. Jung, K.S. Park, Y.G. Chai, W. Roh, S.J. Hwang, H.J. Ko, Y.M. Huh, H.T. Kim, and S.H. Kim Implantation of human umbilical cord-derived mesenchymal stem cells as a neuroprotective therapy for ischemic stroke in rats Brain Res. 1229 2008 233 248
19. G.C. Koopmans, R. Deumens, W.M. Honig, F.P. Hamers, H.W. Steinbusch, and E.A. Joosten The assessment of locomotor function in spinal cord injured rats: the importance of objective analysis of coordination J. Neurotrauma 22 2005 214 225
20. W. Liao, J. Zhong, J. Yu, J. Xie, Y. Liu, L. Du, S. Yang, P. Liu, J. Xu, J. Wang, Z. Han, and Z.C. Han Therapeutic benefit of human umbilical cord derived mesenchymal stromal cells in intracerebral hemorrhage rat: implications of anti-inflammation and angiogenesis Cell Physiol. Biochem. 24 2009 307 316
21. A. Logan, M. Berry, A.M. Gonzalez, S.A. Frautschy, M.B. Sporn, and A. Baird Effects of transforming growth factor beta 1 on scar production in the injured central nervous system of the rat Eur. J. Neurosci. 6 1994 355 363
22. I. Majore, P. Moretti, F. Stahl, R. Hass, and C. Kasper Growth and differentiation properties of mesenchymal stromal cell populations derived from whole human umbilical cord Stem Cell Rev. 7 2011 17 31
23. H. Nakajima, K. Uchida, G.A. Rodriguez, S. Watanabe, D. Sugita, N. Takeura, A. Yoshida, G. Long, K. Wright, E. Johnson, and H. Baba Transplantation of mesenchymal stem cells promotes the alternative pathway of macrophage activation and functional recovery after spinal cord injury J. Neurotrauma 2012
24. L.N. Novikova, M. Brohlin, P.J. Kingham, L.N. Novikov, and M. Wiberg Neuroprotective and growth-promoting effects of bone marrow stromal cells after cervical spinal cord injury in adult rats Cytotherapy 2011
25. K. Sakai, A. Yamamoto, K. Matsubara, S. Nakamura, M. Naruse, M. Yamagata, K. Sakamoto, R. Tauchi, N. Wakao, S. Imagama, H. Hibi, K. Kadomatsu, N. Ishiguro, and M. Ueda Human dental pulp-derived stem cells promote locomotor recovery after complete transection of the rat spinal cord by multiple neuro-regenerative mechanisms J. Clin. Invest. 2011
26. J. Schira, M. Gasis, V. Estrada, M. Hendricks, C. Schmitz, T. Trapp, F. Kruse, G. Kogler, P. Wernet, H.P. Hartung, and H.W. Muller Significant clinical, neuropathological and behavioural recovery from acute spinal cord trauma by transplantation of a well-defined somatic stem cell from human umbilical cord blood Brain 2011
27. V. Sengottuvel, M. Leibinger, M. Pfreimer, A. Andreadaki, and D. Fischer Taxol facilitates axon regeneration in the mature CNS J. Neurosci. 31 2011 2688 2699
28. V. Sengottuvel, and D. Fischer Facilitating axon regeneration in the injured CNS by microtubules stabilization Commun. Integr. Biol. 4 2011 391 393
29. A.J. Shang, S.Q. Hong, Q. Xu, H.Y. Wang, Y. Yang, Z.F. Wang, B.N. Xu, X.D. Jiang, and R.X. Xu NT-3-secreting human umbilical cord mesenchymal stromal cell transplantation for the treatment of acute spinal cord injury in rats Brain Res. 1391 2011 102 113
30. M.H. Tuszynski, R. Grill, L.L. Jones, A. Brant, A. Blesch, K. Low, S. Lacroix, and P. Lu NT-3 gene delivery elicits growth of chronically injured corticospinal axons and modestly improves functional deficits after chronic scar resection Exp. Neurol. 181 2003 47 56
31. D.M. Vyas, and J.F. Kadow Paclitaxel: a unique tubulin interacting anticancer agent Prog. Med. Chem. 32 1995 289 337
32. S.G. Waxman, B.R. Ransom, and P.K. Stys Non-synaptic mechanisms of Ca(2)-mediated injury in CNS white matter Trends Neurosci. 14 1991 461 468
33. T. Williamson, P.R. Gordon-Weeks, M. Schachner, and J. Taylor Microtubule reorganization is obligatory for growth cone turning Proc. Natl. Acad. Sci. U S A 93 1996 15221 15226
34. C.C. Yang, Y.H. Shih, M.H. Ko, S.Y. Hsu, H. Cheng, and Y.S. Fu Transplantation of human umbilical mesenchymal stem cells from Wharton's jelly after complete transection of the rat spinal cord PLoS ONE 3 2008 e3336
35. D. Yang, Y. Han, J. Zhang, A. Seyda, M. Chopp, and D.M. Seyfried Therapeutic effect of human umbilical tissue-derived cell treatment in rats with experimental intracerebral hemorrhage Brain Res. 1444 2012 1 10
36. A. Yasuda, O. Tsuji, S. Shibata, S. Nori, M. Takano, Y. Kobayashi, Y. Takahashi, K. Fujiyoshi, C.M. Hara, A. Miyawaki, H.J. Okano, Y. Toyama, M. Nakamura, and H. Okano Significance of remyelination by neural stem/progenitor cells transplanted into the injured spinal cord Stem Cells 29 2011 1983 1994
37. L. Zhang, Y. Li, C. Zhang, M. Chopp, A. Gosiewska, and K. Hong Delayed administration of human umbilical tissue-derived cells improved neurological functional recovery in a rodent model of focal ischemia Stroke 42 2011 1437 1444
38. B. Zheng, J. Atwal, C. Ho, L. Case, X.L. He, K.C. Garcia, O. Steward, and M. Tessier-Lavigne Genetic deletion of the Nogo receptor does not reduce neurite inhibition in vitro or promote corticospinal tract regeneration in vivo Proc. Natl. Acad. Sci. U S A 102 2005 1205 1210