A randomized, controlled, multicenter study comparing intensity-modulated radiotherapy plus concurrent chemotherapy with chemotherapy alone in gastric cancer patients with D2 resection

Radiotherapy and Oncology

Volumn 104, Issue 3, 2012, Pages 361-366

  Zhu, Wei Guo ^a   Xua, Da Fu ^a   Pu, Jun ^b   Zong, Cheng Dong ^c   Li, Tao ^a   Tao, Guang Zhou ^a   Ji, Fu Zhi ^a   Zhou, Xi Lei ^a   Han, Ji Hua ^a   Wang, Cheng Shi ^b   Yu, Chang Hua ^a   Yi, Jiang Guo ^c   Su, Xi Long ^d   Ding, Jin Xia ^a  

^a NANJING MEDICAL UNIVERSITY   (China)

^b Department of Radiation Oncology   (China)

^c Department of Radiation Oncology   (China)

^d Huai'An No 2 People's Hospital   (China)

Author keywords

Chemotherapy; D2 resection; Gastric cancer; Intensity modulated radiotherapy (IMRT); Prognosis

Indexed keywords

FLUOROURACIL; FOLINIC ACID;

ADULT; AGED; ARTICLE; BODY SURFACE; CANCER CHEMOTHERAPY; CANCER PATIENT; CANCER PROGNOSIS; CANCER STAGING; CHEMORADIOTHERAPY; CONTROLLED STUDY; DIARRHEA; DRUG DOSE REGIMEN; FEMALE; FOLLOW UP; GASTRECTOMY; HAZARD RATIO; HUMAN; INTENSITY MODULATED RADIATION THERAPY; LIVER METASTASIS; LYMPH NODE DISSECTION; LYMPH NODE METASTASIS; MAJOR CLINICAL STUDY; MALE; MULTICENTER STUDY; NAUSEA; OVERALL SURVIVAL; POSTOPERATIVE PERIOD; PRIORITY JOURNAL; RADIATION DOSE; RANDOMIZED CONTROLLED TRIAL; RECURRENCE FREE SURVIVAL; STOMACH CANCER; TREATMENT DURATION; VOMITING;

ADULT; AGED; CHEMORADIOTHERAPY; FEMALE; HUMANS; LYMPH NODE EXCISION; LYMPHATIC METASTASIS; MALE; MIDDLE AGED; RADIOTHERAPY, INTENSITY-MODULATED; STOMACH NEOPLASMS;

EID: 84867084252     PISSN: 01678140     EISSN: 18790887     Source Type: Journal    
DOI: 10.1016/j.radonc.2012.08.024     Document Type: Article

References (35)

1. J.R. Kelley, and J.M. Duggan Gastric cancer epidemiology and risk factors J Clin Epidemiol 56 2003 1 9
2. F. Kamangar, G.M. Dores, and W.F. Anderson Patterns of cancer incidence, mortality, and prevalence across five continents: defining priorities to reduce cancer disparities in different geographic regions of the world J Clin Oncol 24 2006 2137 2150
3. J. Kulig, P. Kolodziejczyk, and M. Sierzega Adjuvant chemotherapy with etoposide, adriamycin and cisplatin compared with surgery alone in the treatment of gastric cancer: a phase III randomized, multicenter, clinical trial Oncology 78 2010 54 61
4. F. Di Costanzo, S. Gasperoni, and L. Manzione Adjuvant chemotherapy in completely resected gastric cancer: a randomized phase III trial conducted by GOIRC J Natl Cancer Inst 100 2008 388 398
5. J.S. Macdonald, S.R. Smalley, and J. Benedetti Chemoradiotherapy after surgery compared with surgery alone for adenocarcinoma of the stomach or gastroesophageal junction N Engl J Med 345 2001 725 730
6. J.J. Bonenkamp, I. Songun, and J. Hermans Randomised comparison of morbidity after D1 and D2 dissection for gastric cancer in 996 Dutch patients Lancet 345 1995 745 748
7. A. Cuschieri, S. Weeden, and J. Fielding Patient survival after D1 and D2 resections for gastric cancer: long-term results of the MRC randomized surgical trial. Surgical Co-operative Group Br J Cancer 79 1999 1522 1530
8. S. Kim, D.H. Lim, and J. Lee An observational study suggesting clinical benefit for adjuvant postoperative chemoradiation in a population of over 500 cases after gastric resection with D2 nodal dissection for adenocarcinoma of the stomach Int J Radiat Oncol Biol Phys 63 2005 1279 1285
9. J. Lee, H. Limdo, and S. Kim Phase III trial comparing capecitabine plus cisplatin versus capecitabine plus cisplatin with concurrent capecitabine radiotherapy in completely resected gastric cancer with D2 lymph node dissection: the ARTIST trial J Clin Oncol 30 2012 268 273
10. M.T. Milano, M.C. Garofalo, and S.J. Chmura Intensity modulated radiation therapy in the treatment of gastric cancer: early clinical outcome and dosimetric comparison with conventional techniques Br J Radiol 79 2006 497 503
11. J. Ringash, G. Perkins, and J. Brierley IMRT for adjuvant radiation in gastric cancer: a preferred plan? Int J Radiat Oncol Biol Phys 63 2005 732 738
12. C. Yu, R. Yu, and W. Zhu Intensity-modulated radiotherapy combined with chemotherapy for the treatment of gastric cancer patients after standard D1/D2 surgery J Cancer Res Clin Oncol 138 2012 255 259
13. L. Sobin, M. Gospodarowicz, and C. Wittekind International union against cancer (UICC) TNM classification of malignant tumours 7th ed. 2010 Wiley-Liss New York p. 117-26
14. International Commission on Radiation Units and Measurements (ICRU) Report Number 50. Prescribing, recording and reporting photon beam therapy 1993 International Commission on Radiation Units and Measurements (ICRU) Washington, DC
15. A. Trotti, A.D. Colevas, and A. Setser CTCAE v3.0: development of a comprehensive grading system for the adverse effects of cancer treatment Semin Radiat Oncol 13 2003 176 181
16. S.R. Smalley, J.K. Benedetti, and D.G. Haller Updated analysis of SWOG-directed intergroup study 0116: a phase III trial of adjuvant radiochemotherapy versus observation after curative gastric cancer resection J Clin Oncol 30 2012 2327 2333
17. S.H. Park, D.Y. Kim, and J.S. Heo Postoperative chemoradiotherapy for gastric cancer Ann Oncol 14 2003 1373 1377
18. B.G. Hughes, D. Yip, and M. Chao Audit of postoperative chemoradiotherapy as adjuvant therapy for resected gastroesophageal adenocarcinoma: an Australian multicentre experience ANZ J Surg 74 2004 951 956
19. V. Vincenzo, F. Cellini, and B.D. Minsky Survival after radiotherapy in gastric cancer: systematic review and meta-analysis Radiother Oncol 92 2009 176 183
20. J.S. Macdonald Adjuvant therapy for gastric cancer Semin Oncol 30 2003 19 25
21. J.S. Macdonald Clinical overview: adjuvant therapy of gastrointestinal cancer Cancer Chemother Pharmacol 54 2004 S4 S11
22. C. Gemici, A. Mayadagli, and T. Salepci Impact of INT-0116 trial on adjuvant treatment of gastric cancer [Abstract] Proc Am Soc Clin Oncol 22 2004 376s
23. M. Sasako Principles of surgical treatment for curable gastric cancer J Clin Oncol 21 2003 274s 275s
24. A. Nashimoto, T. Nakajima, and H. Furukawa Randomized trial of adjuvant chemotherapy with mitomycin, fluorouracil, and cytosine arabinoside followed by oral fluorouracil in serosa-negative gastric cancer: Japan Clinical Oncology Group9206-1 J Clin Oncol 21 2003 2282 2287
25. S.A. Hundahl Surgical quality in trials of adjuvant cancer therapy J Surg Oncol 80 2002 177 180
26. T. Leong, D. Willis, and D.L. Joon 3D conformal radiotherapy for gastric cancer results of a comparative planning study Radiother Oncol 74 2005 301 306
27. M.K. Kam, R.M. Chau, and J. Suen Intensity- modulated radiotherapy in nasopharyngeal carcinoma: dosimetric advantage over conventional plans and feasibility of dose escalation Int J Radiat Oncol Biol Phys 56 2003 145 157
28. W.G. Zhu, K. Zhou, and C.H. Yu Efficacy analysis of simplified intensity-modulated radiotherapy with high or conventional dose and concurrent chemotherapy for patients with neck and upper thoracic esophageal carcinoma Asian Pac J Cancer Prev 13 2012 803 807
29. N.M. Reddy, D. Nori, and H. Chang Prostate and seminal vesicle volume based consideration of prostate cancer patients for treatment with 3D-conformal or intensity modulated radiation therapy Med Phys 37 2010 3791 3801
30. A.Y. Minn, A. Hsu, and T. La Comparison of intensity modulated radiotherapy and 3-dimensional conformal radiotherapy as adjuvant therapy for gastric cancer Cancer 116 2010 3943 3952
31. M. Dahele, M. Skinner, and B. Schultz Adjuvant radiotherapy for gastric cancer: a dosimetric comparison of 3-dimensional conformal radiotherapy, tomotherapy and conventional intensity modulated radiotherapy treatment plans Med Dosim 35 2010 115 121
32. S. Chae, A. Lee, and J.H. Lee The effectiveness of the new 7th UICC N classification in the prognosis evaluation of gastric cancer patients: a comparative study between the 5th/6th and 7th UICC N classification Gastric Cancer 14 2011 166 171
33. W. Wang, X.W. Sun, and C.F. Li Comparison of the 6th and 7th editions of UICC TNM staging for gastric cancer: results of a Chinese single-institution study of 1503 patients Ann Surg Oncol 18 2011 1060 1067
34. H.S. Ahn, H.J. Lee, and S. Hahn Evaluation of the seventh American Joint Committee on Cancer/International Union Against Cancer classification of gastric adenocarcinoma in comparison with the sixth classification Cancer 116 2010 5592 5598
35. M.Z. Qiu, Z.Q. Wang, and D.S. Zhang Comparison of 6th and 7th AJCC TNM staging classification for carcinoma of the stomach in China Ann Surg Oncol 18 2011 1869 1876