Galanin and its three receptors in human pituitary adenoma

Neuropeptides

Volumn 46, Issue 5, 2012, Pages 195-201

  Tofighi, Roshan ^a   Barde, Swapnali ^a   Palkovits, Miklos ^c   Höög, Anders ^a   Hökfelt, Tomas ^a   Ceccatelli, Sandra ^a   Hulting, Anna Lena ^b  

^a KAROLINSKA INSTITUTE   (Sweden)

^b KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^c SEMMELWEIS UNIVERSITY   (Hungary)

Author keywords

G protein coupled receptor; Galanin receptors; Neuroendocrine peptide; Pituitary tumor; Tumor recurrence

Indexed keywords

GALANIN; GALANIN RECEPTOR 1; GALANIN RECEPTOR 2; GALANIN RECEPTOR 3;

ADULT; AGED; ARTICLE; AUTOPSY; CANCER PROGNOSIS; CLINICAL ARTICLE; CONTROLLED STUDY; DIAGNOSTIC PROCEDURE; FEMALE; HUMAN; HUMAN TISSUE; HYPOPHYSIS ADENOMA; MALE; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ADENOMA; ADULT; AGED; FEMALE; GALANIN; HUMANS; MALE; MIDDLE AGED; PITUITARY GLAND; PITUITARY NEOPLASMS; RECEPTORS, GALANIN;

EID: 84867074203     PISSN: 01434179     EISSN: 15322785     Source Type: Journal    
DOI: 10.1016/j.npep.2012.07.003     Document Type: Article

References (50)

1. Barde, S., Tofighi, R., Hoog, A., Hökfelt, T., Ceccatelli, S., Hulting, A.L., 2011. Galanin and its receptors in human pituitary adenoma: Evidence for association of GalR3 with tumor relapse. 2nd Workshop, Aggressive pituitary tumors, Munich, Germany p. 60, 68.
2. Bauer F.E., Ginsberg L., Venetikou M., MacKay D.J., Burrin J.M., Bloom S.R. Growth hormone release in man induced by galanin, a new hypothalamic peptide. Lancet 1986, 2:192-195.
3. Bennet W.M., Hill S.F., Ghatei M.A., Bloom S.R. Galanin in the normal human pituitary and brain and in pituitary adenomas. J. Endocrinol. 1991, 130:463-467.
4. Berger A., Lang R., Moritz K., Santic R., Hermann A., Sperl W., Kofler B. Galanin receptor subtype GalR2 mediates apoptosis in SH-SY5Y neuroblastoma cells. Endocrinology 2004, 145:500-507.
5. Bernard P.S., Wittwer C.T. Real-time PCR technology for cancer diagnostics. Clin. Chem. 2002, 48:1178-1185.
6. Bersani M., Johnsen A.H., Hojrup P., Dunning B.E., Andreasen J.J., Holst J.J. Human galanin: Primary structure and identification of two molecular forms. FEBS Lett. 1991, 283:189-194.
7. Branchek T.A., Smith K.E., Gerald C., Walker M.W. Galanin receptor subtypes. Trends Pharmacol. Sci. 2000, 2000(21):109-117.
8. Evans H.F., Shine J. Human galanin: Molecular cloning reveals a unique structure. Endocrinology 1991, 129:1682-1684.
9. Gaffey T.A., Scheithauer B.W., Leech R.W., Blick K., Kovacs K., Horvath E., Weaver A.L., Lloyd R.V., Ebersold M., Laws E.R., DeBault L.E. Pituitary adenoma: A DNA flow cytometric study of 192 clinicopathologically characterized tumors. Clin. Neuropathol. 2005, 24:56-63.
10. Grenbäck E., Bjellerup P., Wallerman E., Lundblad L., Anggard A., Ericson K., Aman K., Landry M., Schmidt W.E., Hökfelt T., Hulting A.L. Galanin in pituitary adenomas. Regul. Pept. 2004, 117:127-139.
11. Henson B.S., Neubig R.R., Jang I., Ogawa T., Zhang Z., Carey T.E., D'Silva N.J. Galanin receptor 1 has anti-proliferative effects in oral squamous cell carcinoma. J. Biol. Chem. 2005, 280:22564-22571.
12. Hsu D.W., Hooi S.C., Hedley-Whyte E.T., Strauss R.M., Kaplan L.M. Coexpression of galanin and adrenocorticotropic hormone in human pituitary and pituitary adenomas. Am. J. Pathol. 1991, 138:897-909.
13. Hulting A.L., Meister B., Grimelius L., Wersäll J., Änggård A., Hökfelt T. Production of a galanin-like peptide by a human pituitary adenoma: Immunohistochemical evidence. Acta Physiol. Scand. 1989, 137:561-562.
14. Invitti C., Pecori Giraldi F., Dubini A., Moroni P., Losa M., Piccoletti R., Cavagnini F. Galanin is released by adrenocorticotropin-secreting pituitary adenomas in vivo and in vitro. J. Clin. Endocrinol. Metab. 1999, 84:1351-1356.
15. Kanazawa T., Iwashita T., Kommareddi P., Nair T., Misawa K., Misawa Y., Ueda Y., Tono T., Carey T.E. Galanin and galanin receptor type 1 suppress proliferation in squamous carcinoma cells: Activation of the extracellular signal regulated kinase pathway and induction of cyclin-dependent kinase inhibitors. Oncogene 2007, 26:5762-5771.
16. Kanazawa T., Kommareddi P.K., Iwashita T., Kumar B., Misawa K., Misawa Y., Jang J., Nair T.S., Iino Y., Carey T.E. Galanin receptor subtype 2 suppresses cell proliferation and induces apoptosis in p53 mutant head and neck cancer cells. Clin. Cancer Res. 2009, 15:2222-2230.
17. Kanazawa T., Misawa K., Carey T.E. Galanin receptor subtypes 1 and 2 as therapeutic targets in head and neck squamous cell carcinoma. Expert Opin. Ther. Targets 2010, 14:289-302.
18. Lamberts S.W., Hofland L.J. Future treatment strategies of aggressive pituitary tumors. Pituitary 2009, 12:261-264.
19. Lang R., Gundlach A.L., Kofler B. The galanin peptide family: receptor pharmacology, pleiotropic biological actions, and implications in health and disease. Pharmacol. Ther. 2007, 115:177-207.
20. Leung B., Iisma T.P., Leung K.C., Hort Y.J., Turner J., Sheehy J.P., Ho K.K. Galanin in human pituitary adenomas: Frequency and clinical significance. Clin. Endocrinol. (Oxf) 2002, 56:397-403.
21. Lu X., Bartfai T. Analyzing the validity of GalR1 and GalR2 antibodies using knockout mice. Naunyn Schmiedebergs Arch. Pharmacol. 2009, 379(4):417-420.
22. Mainprize T.G., Taylor M.D., Rutka J.T., Dirks P.B. Cip/Kip cell-cycle inhibitors: A neuro-oncological perspective. J. Neurooncol. 2001, 51:205-218.
23. Meister B., Ceccatelli S., Hökfelt T., Anden N.E., Anden M., Theodorsson E. Neurotransmitters, neuropeptides and binding sites in the rat mediobasal hypothalamus: Effects of monosodium glutamate (MSG) lesions. Exp. Brain Res. 1989, 76:343-368.
24. Meister B., Scanlon M.F., Hökfelt T. Occurrence of galanin-like immunoreactivity in growth hormone-releasing factor (GRF)-containing neurons of the monkey (Macaca fascicularis) infundibular nucleus and median eminence. Neurosci. Lett. 1990, 119:136-139.
25. Melander T., Hökfelt T., Rökaeus A. Distribution of galanin like immunoreactivity in the rat central nervous system. J. Comp. Neurol. 1986, 248:475-517.
26. Merchenthaler I. Galanin and the neuroendocrine axes. EXS 2010, 102:71-85.
27. Michel M., Wieland T., Tsujimoto How reliable are G-protein-coupled receptor antibodies?. Naunyn Schmiedebergs Arch. Pharmacol. 2009, 379:385-388.
28. Misawa K., Ueda Y., Kanazawa T., Misawa Y., Jang I., Brenner J.C., Ogawa T., Takebayashi S., Grenman R.A., Herman J.G., Mineta H., Carey T.E. Epigenetic inactivation of galanin receptor 1 in head and neck cancer. Clin. Cancer Res. 2008, 14:7604-7613.
29. Moore J.P., Morrison D.G., Hyde J.F. Galanin gene expression is increased in the anterior pituitary gland of the human growth hormone-releasing hormone transgenic mouse. Endocrinology 1994, 134:2005-2010.
30. O'Donnell D., Mennicken F., Hoffert C., Hubatsch M., Pelletier P., Walker, Ahmad S. Localization of galanin receptor subtypes in the rat CNS. Handbook of Chemical Neuroanatomy Peptide Receptors, Part II 2003, 195-244. Elsevier, Amsterdam. R. Quirion, A. Björklund, T. Hökfelt (Eds.).
31. Polak, J.M., Gibson, S., Gentleman, S., Steel, J., Van Noorden, S., 1991. Galanin: distribution, ontogeny and expression following manipulation of the endocrine and nervous system. In: Hökfelt, T., Bartfai, T, Jacobowitz, D.M., Ottoson, D., (Eds.), Galanin a New Multifunctional Peptide in The Neuro-Endocrine System, Macmillan, London, pp. 117-134.
32. Rauch I., Kofler B. The galanin system in cancer. Galanin 2010, 223-241. Springer, Basel. T. Hökfelt (Ed.).
33. Reubi J.C. Regulatory peptide receptors as molecular targets for cancer diagnosis and therapy. Q. J. Nucl. Med. 1997, 41:63-70.
34. Reubi J.C., Maecke H.R. Peptide-based probes for cancer imaging. J. Nucl. Med. 2008, 49:1735-1738.
35. Sano T., Vrontakis M.E., Kovacs K., Asa S.L., Friesen H.G. Galanin immunoreactivity in neuroendocrine tumors. Arch. Pathol. Lab. Med. 1991, 115:926-929.
36. Schmidt W.E., Kratzin H., Eckart K., Drevs D., Mundkowski G., Clemens A., Katsoulis S., Schafer H., Gallwitz B., Creutzfeldt W. Isolation and primary structure of pituitary human galanin, a 30-residue nonamidated neuropeptide. Proc. Natl. Acad. Sci. USA 1991, 88:11435-11439.
37. Skofitsch G., Jacobowitz D.M. Immunohistochemical mapping of galanin-like neurons in the rat central nervous system. Peptides 1985, 6:509-546.
38. Sugimoto T., Seki N., Shimizu S., Kikkawa N., Tsukada J., Shimada H., Sasaki K., Hanazawa T., Okamoto Y., Hata A. The galanin signaling cascade is a candidate pathway regulating oncogenesis in human squamous cell carcinoma. Genes Chromosomes Cancer 2009, 48:132-142.
39. Swanson C.J., Blackburn T.P., Zhang X., Zheng K., Xu Z.Q., Hökfelt T., Wolinsky T.D., Konkel M.J., Chen H., Zhong H., Walker M.W., Craig D.A., Gerald C.P., Branchek T.A. Anxiolytic- and antidepressant-like profiles of the galanin-3 receptor (Gal3) antagonists SNAP 37889 and SNAP 398299. Proc. Natl. Acad. Sci. USA 2005, 102:17489-17494.
40. Tatemoto K., Rokaeus A., Jornvall H., McDonald T.J., Mutt V. Galanin - a novel biologically active peptide from porcine intestine. FEBS Lett. 1983, 164:124-128.
41. Tofighi, R., Hulting, AL., Grenbäck, E., Hökfelt, T., Ceccatelli, S., 2008a. Expression of galanin and its receptors in different types of pituitary tumours. Soc. Neurosci. Abstracts C12c, E01i.
42. Tofighi R., Joseph B., Xia S., Xu Z.Q., Hamberger B., Hökfelt T., Ceccatelli S. Galanin decreases proliferation of PC12 cells and induces apoptosis via its subtype 2 receptor (GalR2). Proc. Natl. Acad. Sci. USA 2008, 105:2717-2722.
43. Vrontakis M.E., Sano T., Kovacs K., Friesen H.G. Presence of galanin-like immunoreactivity in nontumorous corticotrophs and corticotroph adenomas of the human pituitary. J. Clin. Endocrinol. Metab. 1990, 70:747-751.
44. Wang S., Hwa J., Varty G. Galanin receptors and their therapeutic potential. Emerg. Drugs 2000, 5:415-440.
45. Waters S.M., Krause J.E. Distribution of galanin-1, -2 and -3 receptor messenger RNAs in central and peripheral rat tissues. Neuroscience 2000, 95:265-271.
46. Whitelaw C.M., Robinson J.E., Chambers G.B., Hastie P., Padmanabhan V., Thompson R.C., Evans N.P. Expression of mRNA for galanin, galanin-like peptide and galanin receptors 1-3 in the ovine hypothalamus and pituitary gland: effects of age and gender. Reproduction 2009, 137:141-150.
47. Wittau N., Grosse R., Kalkbrenner F., Gohla A., Schultz G., Gudermann T. The galanin receptor type 2 initiates multiple signaling pathways in small cell lung cancer cells by coupling to G(q), G(i) and G(12) proteins. Oncogene 2000, 19:4199-4209.
48. Wynick D., Hammond P.J., Akinsanya K.O., Bloom S.R. Galanin regulates basal and oestrogen-stimulated lactotroph function. Nature 1993, 364:529-532.
49. Xia S., Dun X.P., Hu P.S., Kjaer S., Zheng K., Qian Y., Solen C., Xu T., Fredholm B., Hökfelt T., Xu Z.Q. Postendocytotic traffic of the galanin R1 receptor: a lysosomal signal motif on the cytoplasmic terminus. Proc. Natl. Acad. Sci. USA 2008, 105:5609-5613.
50. Xia S., Kjaer S., Zheng K., Hu P.S., Bai L., Jia J.Y., Rigler R., Pramanik A., Xu T., Hökfelt T., Xu Z.Q. Visualization of a functionally enhanced GFP-tagged galanin R2 receptor in PC12 cells: constitutive and ligand-induced internalization. Proc. Natl. Acad. Sci. USA 2004, 101:15207-15212.