Computational and experimental analyses reveal the essential roles of interdomain linkers in the biological function of chemotaxis histidine kinase CheA

Journal of the American Chemical Society

Volumn 134, Issue 39, 2012, Pages 16107-16110

  Wang, Xiqing ^a   Wu, Chun ^a   Vu, Anh ^a   Shea, Joan Emma ^a   Dahlquist, Frederick W ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOPHOSPHORYLATION; BACTERIAL CHEMOTAXIS; BIOLOGICAL FUNCTIONS; CHEMICAL SIGNALS; ENVIRONMENTAL STIMULI; EXPERIMENTAL ANALYSIS; FUNCTIONAL DEPENDENCE; HISTIDINE KINASE; INTER-DOMAIN; KINASE ACTIVITY; NETWORKED INTERACTIONS; REPLICA-EXCHANGE MOLECULAR DYNAMICS SIMULATIONS; SENSORY SIGNALS; SIGNAL INFORMATION; STRUCTURAL INFORMATION; STRUCTURAL MODELS; SWIMMING BEHAVIOR; TERNARY COMPLEX; TWO-COMPONENT SIGNAL TRANSDUCTION;

AMINO ACIDS; BIOCHEMISTRY; BIOLOGICAL SYSTEMS; CATALYST ACTIVITY; MODEL STRUCTURES; MOLECULAR DYNAMICS; SIGNAL TRANSDUCTION;

ENZYMES;

CHEMOTAXIS ACTIVATOR; PROTEIN HISTIDINE KINASE;

ARTICLE; AUTOPHOSPHORYLATION; BIOLOGICAL FUNCTIONS; CHEMORECEPTOR; ENZYME ACTIVITY; EXPERIMENTAL STUDY; MATHEMATICAL ANALYSIS; MOLECULAR DYNAMICS; PROTEIN INTERACTION; SIGNAL TRANSDUCTION; STRUCTURE ANALYSIS;

BACTERIAL PROTEINS; CHEMOTAXIS; MEMBRANE PROTEINS; MOLECULAR DYNAMICS SIMULATION; MUTAGENESIS; PHOSPHORYLATION; POINT MUTATION; PROTEIN STRUCTURE, TERTIARY;

EID: 84867051096     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/ja3056694     Document Type: Article

References (28)

1. Gao, R.; Mack, T. T.; Stock, A. M. Trends Biochem. Sci. 2007, 32, 225
2. Parkinson, J. S.; Kofoid, E. C. Annu. Rev. Genet. 1992, 26, 71
3. Watanabe, T.; Okada, A.; Gotoh, Y.; Utsumi, R. Adv. Exp. Med. Biol. 2008, 631, 229
4. Barrett, J. F.; Hoch, J. A. Antimicrob. Agents Chemother. 1998, 42, 1529
5. Kurosu, M.; Begari, E. Drug Dev. Res. 2010, 71, 168
6. Wadhams, G. H.; Armitage, J. P. Nat. Rev. Mol. Cell Biol. 2004, 5, 1024
7. Gegner, J. A.; Graham, D. R.; Roth, A. F.; Dahlquist, F. W. Cell 1992, 70, 975
8. Surette, M. G.; Levit, M.; Liu, Y.; Lukat, G.; Ninfa, E. G.; Ninfa, A.; Stock, J. B. J. Biol. Chem. 1996, 271, 939
9. Swanson, R. V.; Bourret, R. B.; Simon, M. I. Mol. Microbiol. 1993, 8, 435
10. Borkovich, K. A.; Kaplan, N.; Hess, J. F.; Simon, M. I. Proc. Natl. Acad. Sci. U.S.A. 1989, 86, 1208
11. Bourret, R. B.; Davagnino, J.; Simon, M. I. J. Bacteriol. 1993, 175, 2097
12. Garzón, A.; Parkinson, J. S. J. Bacteriol. 1996, 178, 6752
13. Bilwes, A. M.; Alex, L. A.; Crane, B. R.; Simon, M. I. Cell 1999, 96, 131
14. Park, S.; Borbat, P. P.; Gonzalez-Bonet, G.; Bhatnagar, J.; Pollard, A. M.; Freed, J. H.; Bilwes, A. M.; Crane, B. R. Nat. Struct. Mol. Biol. 2006, 13, 400
15. Wang, X.; Vu, A.; Lee, K.; Dahlquist, F. W. J. Mol. Biol. 2012, 422, 282
16. Zhao, J.; Parkinson, J. S. J. Bacteriol. 2006, 188, 4321
17. Miller, A. S.; Kohout, S. C.; Gilman, K. A.; Falke, J. J. Biochemistry 2003, 42, 2952
18. Briegel, A.; Li, X.; Bilwes, A. M.; Hughes, K. T.; Jensen, G. J.; Crane, B. R. Proc. Natl. Acad. Sci. U.S.A. 2012, 109, 3766
19. Francis, N. R.; Wolanin, P. M.; Stock, J. B.; Derosier, D. J.; Thomas, D. R. Proc. Natl. Acad. Sci. U.S.A. 2004, 101, 17480
20. Liu, J.; Hu, B.; Morado, D. R.; Jani, S.; Manson, M. D.; Margolin, W. Proc. Natl. Acad. Sci. U.S.A. 2012, 109, E1481
21. Bhatnagar, J.; Borbat, P. P.; Pollard, A. M.; Bilwes, A. M.; Freed, J. H.; Crane, B. R. Biochemistry 2010, 49, 3824
22. Bilwes, A. M.; Quezada, C. M.; Croal, L. R.; Crane, B. R.; Simon, M. I. Nat. Struct. Biol. 2001, 8, 353
23. Gloor, S. L.; Falke, J. J. Biochemistry 2009, 48, 3631
24. Vu, A.; Wang, X.; Zhou, H.; Dahlquist, F. W. J. Mol. Biol. 2012, 415, 759
25. Ma, B.; Tsai, C.; Haliloglu, T.; Nussinov, R. Structure 2011, 19, 907
26. Nussinov, R.; Tsai, C. J.; Csermley, P. Trends Pharmacol. Sci. 2011, 32, 686
27. Apic, G.; Huber, W.; Teichmann, S. A. J. Struct. Funct. Genomics 2003, 4, 67
28. Marcotte, E. M.; Pellegrini, M.; Ng, H. L.; Rice, D. W.; Yeates, T. O.; Eisenberg, D. Science 1999, 285, 751