Timing and route of exposure affects crystal formation in melamine and cyanuric exposed male and female rats: Gavage vs. feeding

Food and Chemical Toxicology

Volumn 50, Issue 12, 2012, Pages 4389-4397

  Sprando, Robert L ^a   Reimschuessel, Renate ^a   Stine, Cynthia B ^a   Black, Thomas ^a   Olejnik, Nicholas ^a   Scott, Michael ^a   Keltner, Zachary ^a   Bandele, Omari ^a   Ferguson, Martine ^a   Nemser, Sarah M ^a   Tkachenko, Andriy ^a   Evans, Eric ^a   Crosby, Tina ^a   Woodling, Kellie ^b   Loukotková, Lucie ^b   da Costa, Gonçalo Gamboa ^b  

^a CENTER FOR DRUG EVALUATION AND RESEARCH   (United States)

^b NATIONAL CENTER FOR TOXICOLOGICAL RESEARCH   (United States)

Author keywords

Cyanuric acid; Gavage vs. feeding; Kidney; Melamine; Renal crystal formation

Indexed keywords

CARBOXYMETHYLCELLULOSE; CREATININE; CYANURIC ACID; MELAMINE; NITROGEN; UREA; URIC ACID;

ACUTE KIDNEY FAILURE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; EXPOSURE; FEEDING; FEMALE; FLUID INTAKE; FOOD INTAKE; HISTOPATHOLOGY; KIDNEY MASS; MALE; NEPHROTOXICITY; NONHUMAN; RAT; RENAL CRYSTAL FORMATION; TESTIS WEIGHT; UREA NITROGEN BLOOD LEVEL; URINALYSIS; URINE VOLUME; WEIGHT GAIN;

ADMINISTRATION, ORAL; ANIMALS; BLOOD UREA NITROGEN; BODY WEIGHT; CREATININE; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; FOOD CONTAMINATION; KIDNEY; MALE; ORGAN SIZE; RATS; RATS, INBRED F344; RISK ASSESSMENT; SEX FACTORS; TRIAZINES; URIC ACID;

ANIMALIA; RATTUS;

EID: 84867036465     PISSN: 02786915     EISSN: 18736351     Source Type: Journal    
DOI: 10.1016/j.fct.2012.07.051     Document Type: Article

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