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Volumn 39, Issue 2, 2012, Pages 318-325

Anxiolytic effects of the melatonin MT2 receptor partial agonist UCM765: Comparison with melatonin and diazepam

Author keywords

Anxiety; Elevated plus maze test; Melatonin; Novelty suppressed feeding test; UCM765

Indexed keywords

DIAZEPAM; HORMONE RECEPTOR STIMULATING AGENT; LUZINDOLE; MELATONIN; MELATONIN 2 RECEPTOR; N [2 [(3 METHOXYPHENYL)PHENYLAMINO]ETHYL]ACETAMIDE; UCM 765; UNCLASSIFIED DRUG;

EID: 84867010418     PISSN: 02785846     EISSN: 18784216     Source Type: Journal    
DOI: 10.1016/j.pnpbp.2012.07.003     Document Type: Article
Times cited : (61)

References (49)
  • 2
    • 75949092239 scopus 로고    scopus 로고
    • Chronic exposure to cannabinoids during adolescence but not during adulthood impairs emotional behaviour and monoaminergic neurotransmission
    • Bambico F.R., Nguyen N.-T., Katz N., Gobbi G. Chronic exposure to cannabinoids during adolescence but not during adulthood impairs emotional behaviour and monoaminergic neurotransmission. Neurobiol Dis 2010, 37:641-655.
    • (2010) Neurobiol Dis , vol.37 , pp. 641-655
    • Bambico, F.R.1    Nguyen, N.-T.2    Katz, N.3    Gobbi, G.4
  • 4
    • 0036053186 scopus 로고    scopus 로고
    • Do animal models of anxiety predict anxiolytic-like effects of antidepressants?
    • Borsini F., Podhorna J., Marazziti D. Do animal models of anxiety predict anxiolytic-like effects of antidepressants?. Psychopharmacology (Berl) 2002, 163:121-141.
    • (2002) Psychopharmacology (Berl) , vol.163 , pp. 121-141
    • Borsini, F.1    Podhorna, J.2    Marazziti, D.3
  • 5
    • 0028385717 scopus 로고
    • The role of serotonin and melatonin in gastrointestinal physiology: ontogeny, regulation of food intake, and mutual serotonin-melatonin feedback
    • Bubenik G.A., Pang S.F. The role of serotonin and melatonin in gastrointestinal physiology: ontogeny, regulation of food intake, and mutual serotonin-melatonin feedback. J Pineal Res 1994, 16:91-99.
    • (1994) J Pineal Res , vol.16 , pp. 91-99
    • Bubenik, G.A.1    Pang, S.F.2
  • 6
    • 58049211820 scopus 로고    scopus 로고
    • Preoperative anxiolytic effect of melatonin and clonidine on postoperative pain and morphine consumption in patients undergoing abdominal hysterectomy: a double-blind, randomized, placebo-controlled study
    • Caumo W., Levandovski R., Hidalgo M.P.L. Preoperative anxiolytic effect of melatonin and clonidine on postoperative pain and morphine consumption in patients undergoing abdominal hysterectomy: a double-blind, randomized, placebo-controlled study. J Pain 2009, 10:100-108.
    • (2009) J Pain , vol.10 , pp. 100-108
    • Caumo, W.1    Levandovski, R.2    Hidalgo, M.P.L.3
  • 7
    • 77955167934 scopus 로고    scopus 로고
    • Melatonin treatment mimics the antidepressant action in chronic corticosterone-treated mice
    • Crupi R., Mazzon E., Marino A., La Spada G., Bramanti P., Cuzzocrea S., et al. Melatonin treatment mimics the antidepressant action in chronic corticosterone-treated mice. J Pineal Res 2010, 49:123-129.
    • (2010) J Pineal Res , vol.49 , pp. 123-129
    • Crupi, R.1    Mazzon, E.2    Marino, A.3    La Spada, G.4    Bramanti, P.5    Cuzzocrea, S.6
  • 8
    • 0027932914 scopus 로고
    • Ethopharmacological analysis of rat behavior on the elevated plus-maze
    • Cruz A.P., Frei F., Graeff F.G. Ethopharmacological analysis of rat behavior on the elevated plus-maze. Pharmacol Biochem Behav 1994, 49:171-176.
    • (1994) Pharmacol Biochem Behav , vol.49 , pp. 171-176
    • Cruz, A.P.1    Frei, F.2    Graeff, F.G.3
  • 10
    • 33646714421 scopus 로고    scopus 로고
    • Clinical efficacy of agomelatine in depression: the evidence
    • den Boer J., Bosker F., Meesters Y. Clinical efficacy of agomelatine in depression: the evidence. Int Clin Psychopharmacol 2006, 21(Suppl. 1):S21-S24.
    • (2006) Int Clin Psychopharmacol , vol.21 , Issue.SUPPL. 1
    • den Boer, J.1    Bosker, F.2    Meesters, Y.3
  • 12
    • 27644449587 scopus 로고    scopus 로고
    • Functional MT1 and MT2 melatonin receptors in mammals
    • Dubocovich M., Markowska M. Functional MT1 and MT2 melatonin receptors in mammals. Endocrine 2005, 27:101-110.
    • (2005) Endocrine , vol.27 , pp. 101-110
    • Dubocovich, M.1    Markowska, M.2
  • 13
    • 0028951675 scopus 로고
    • Melatonin agonists modulate 5-HT2A receptor-mediated neurotransmission: behavioral and biochemical studies in the rat
    • Eison A.S., Freeman R.P., Guss V.B., Mullins U.L., Wright R.N. Melatonin agonists modulate 5-HT2A receptor-mediated neurotransmission: behavioral and biochemical studies in the rat. J Pharmacol Exp Ther 1995, 273:304-308.
    • (1995) J Pharmacol Exp Ther , vol.273 , pp. 304-308
    • Eison, A.S.1    Freeman, R.P.2    Guss, V.B.3    Mullins, U.L.4    Wright, R.N.5
  • 14
    • 0019814668 scopus 로고
    • The half life-life of melatonin from rat plasma
    • Gibbs F.P., Vriend J. The half life-life of melatonin from rat plasma. Endocrinology 1981, 109:1796-1798.
    • (1981) Endocrinology , vol.109 , pp. 1796-1798
    • Gibbs, F.P.1    Vriend, J.2
  • 15
    • 0027163991 scopus 로고
    • Melatonin as an anxiolytic in rats: time dependence and interaction with the central GABAergic system
    • Golombek D., Martini M., Cardinali D. Melatonin as an anxiolytic in rats: time dependence and interaction with the central GABAergic system. Eur J Pharmacol 1993, 237:231-236.
    • (1993) Eur J Pharmacol , vol.237 , pp. 231-236
    • Golombek, D.1    Martini, M.2    Cardinali, D.3
  • 16
    • 0019784619 scopus 로고
    • The effects of melatonin on open field behavior
    • Golus P., King M.G. The effects of melatonin on open field behavior. Pharmacol Biochem Behav 1981, 15:883-885.
    • (1981) Pharmacol Biochem Behav , vol.15 , pp. 883-885
    • Golus, P.1    King, M.G.2
  • 17
    • 0026088961 scopus 로고
    • Benzodiazepines, putative anxiolytics and animal models of anxiety
    • Green S. Benzodiazepines, putative anxiolytics and animal models of anxiety. Trends Neurosci 1991, 14:101-104.
    • (1991) Trends Neurosci , vol.14 , pp. 101-104
    • Green, S.1
  • 19
    • 61449183663 scopus 로고    scopus 로고
    • Ramelteon for insomnia symptoms in a community sample of adults with generalized anxiety disorder: an open label study
    • Gross P., Nourse R., Wasser T. Ramelteon for insomnia symptoms in a community sample of adults with generalized anxiety disorder: an open label study. J Clin Sleep Med 2009, 5:28-33.
    • (2009) J Clin Sleep Med , vol.5 , pp. 28-33
    • Gross, P.1    Nourse, R.2    Wasser, T.3
  • 20
    • 0034097926 scopus 로고    scopus 로고
    • Anxiolytic-like properties of melatonin receptor agonists in mice: involvement of MT1 and/or MT2 receptors in the regulation of emotional responsiveness
    • Kopp C., Vogel E., Rettori M.-C., Delagrange P., Misslin R. Anxiolytic-like properties of melatonin receptor agonists in mice: involvement of MT1 and/or MT2 receptors in the regulation of emotional responsiveness. Neuropharmacology 2000, 39:1865-1871.
    • (2000) Neuropharmacology , vol.39 , pp. 1865-1871
    • Kopp, C.1    Vogel, E.2    Rettori, M.-C.3    Delagrange, P.4    Misslin, R.5
  • 21
    • 84857088430 scopus 로고    scopus 로고
    • Prolonged-release melatonin for insomnia - an open-label long-term study of efficacy, safety, and withdrawal
    • Lemoine P., Garfinkel D., Laudon M., Nir T., Zisapel N. Prolonged-release melatonin for insomnia - an open-label long-term study of efficacy, safety, and withdrawal. Ther Clin Risk Manag 2011, 7:301-311.
    • (2011) Ther Clin Risk Manag , vol.7 , pp. 301-311
    • Lemoine, P.1    Garfinkel, D.2    Laudon, M.3    Nir, T.4    Zisapel, N.5
  • 22
    • 33745669873 scopus 로고    scopus 로고
    • Effects of melatonin and agomelatine in anxiety-related procedures in rats: interaction with diazepam
    • Loiseau F., Le Bihan C., Hamon M., Thiébot M.-H. Effects of melatonin and agomelatine in anxiety-related procedures in rats: interaction with diazepam. Eur Neuropsychopharmacol 2006, 16:417-428.
    • (2006) Eur Neuropsychopharmacol , vol.16 , pp. 417-428
    • Loiseau, F.1    Le Bihan, C.2    Hamon, M.3    Thiébot, M.-H.4
  • 23
    • 0037717094 scopus 로고    scopus 로고
    • Melatonin exerts an antidepressant-like effect in the tail suspension test in mice: evidence for involvement of N-methyl-d-aspartate receptors and the l-arginine-nitric oxide pathway
    • Mantovani M., Pertile R., Calixto J., Santos A., Rodrigues A. Melatonin exerts an antidepressant-like effect in the tail suspension test in mice: evidence for involvement of N-methyl-d-aspartate receptors and the l-arginine-nitric oxide pathway. Neurosci Lett 2003, 343:1-4.
    • (2003) Neurosci Lett , vol.343 , pp. 1-4
    • Mantovani, M.1    Pertile, R.2    Calixto, J.3    Santos, A.4    Rodrigues, A.5
  • 24
    • 0142216081 scopus 로고    scopus 로고
    • The neurobiology and control of anxious states
    • Millan M.J. The neurobiology and control of anxious states. Prog Neurobiol 2003, 70:83-244.
    • (2003) Prog Neurobiol , vol.70 , pp. 83-244
    • Millan, M.J.1
  • 25
    • 13644250791 scopus 로고    scopus 로고
    • Anxiolytic properties of agomelatine, an antidepressant with melatoninergic and serotonergic properties: role of 5-HT2C receptor blockade
    • Millan M.J., Brocco M., Gobert A., Dekeyne A. Anxiolytic properties of agomelatine, an antidepressant with melatoninergic and serotonergic properties: role of 5-HT2C receptor blockade. Psychopharmacology (Berl) 2005, 177:448-458.
    • (2005) Psychopharmacology (Berl) , vol.177 , pp. 448-458
    • Millan, M.J.1    Brocco, M.2    Gobert, A.3    Dekeyne, A.4
  • 26
    • 83455199095 scopus 로고    scopus 로고
    • Promotion of non-rapid eye movement sleep and activation of reticular thalamic neurons by a novel MT2 melatonin receptor ligand
    • Ochoa-Sanchez R., Comai S., Lacoste B., Bambico F.R., Domínguez-Lopez S., Spadoni G., et al. Promotion of non-rapid eye movement sleep and activation of reticular thalamic neurons by a novel MT2 melatonin receptor ligand. J Neurosci 2011, 31:18439-18452.
    • (2011) J Neurosci , vol.31 , pp. 18439-18452
    • Ochoa-Sanchez, R.1    Comai, S.2    Lacoste, B.3    Bambico, F.R.4    Domínguez-Lopez, S.5    Spadoni, G.6
  • 27
    • 30344467797 scopus 로고    scopus 로고
    • Anxiolytic-like activity of agomelatine and melatonin in three animal models of anxiety
    • Papp M., Litwa E., Gruca P., Mocaër E. Anxiolytic-like activity of agomelatine and melatonin in three animal models of anxiety. Behav Pharmacol 2006, 17:9-18.
    • (2006) Behav Pharmacol , vol.17 , pp. 9-18
    • Papp, M.1    Litwa, E.2    Gruca, P.3    Mocaër, E.4
  • 28
    • 0022374863 scopus 로고
    • Validation of open: closed arm entries in an elevated plus-maze as a measure of anxiety in the rat
    • Pellow S., Chopin P., File S.E., Briley M. Validation of open: closed arm entries in an elevated plus-maze as a measure of anxiety in the rat. J Neurosci Methods 1985, 14:149-167.
    • (1985) J Neurosci Methods , vol.14 , pp. 149-167
    • Pellow, S.1    Chopin, P.2    File, S.E.3    Briley, M.4
  • 29
    • 0037470154 scopus 로고    scopus 로고
    • The open field as a paradigm to measure the effects of drugs on anxiety-like behaviors: a review
    • Prut L., Belzung C. The open field as a paradigm to measure the effects of drugs on anxiety-like behaviors: a review. Eur J Pharmacol 2003, 463:3-33.
    • (2003) Eur J Pharmacol , vol.463 , pp. 3-33
    • Prut, L.1    Belzung, C.2
  • 30
    • 0033662501 scopus 로고    scopus 로고
    • Anti-depressant action of melatonin in chronic forced swimming-induced behavioral despair in mice, role of peripheral benzodiazepine receptor modulation
    • Raghavendra V., Kaur G., Kulkarni S. Anti-depressant action of melatonin in chronic forced swimming-induced behavioral despair in mice, role of peripheral benzodiazepine receptor modulation. Eur Neuropsychopharmacol 2000, 10:473-481.
    • (2000) Eur Neuropsychopharmacol , vol.10 , pp. 473-481
    • Raghavendra, V.1    Kaur, G.2    Kulkarni, S.3
  • 32
    • 0025960866 scopus 로고
    • Pineal gland interface between the photoperiodic environment and the endocrine system
    • Reiter R. Pineal gland interface between the photoperiodic environment and the endocrine system. Trends Endocrinol Metab 1991, 2:13-19.
    • (1991) Trends Endocrinol Metab , vol.2 , pp. 13-19
    • Reiter, R.1
  • 33
    • 0031297742 scopus 로고    scopus 로고
    • Melatonin receptors: molecular biology of a new family of g protein-coupled receptors
    • Reppert S.M. Melatonin receptors: molecular biology of a new family of g protein-coupled receptors. J Biol Rhythms 1997, 12:528-531.
    • (1997) J Biol Rhythms , vol.12 , pp. 528-531
    • Reppert, S.M.1
  • 34
    • 0029968882 scopus 로고    scopus 로고
    • Anxiolytic action of diazepam and abecarnil in a modified open field test
    • Rex A., Stephens D.N., Fink H. Anxiolytic action of diazepam and abecarnil in a modified open field test. Pharmacol Biochem Behav 1996, 53:1005-1011.
    • (1996) Pharmacol Biochem Behav , vol.53 , pp. 1005-1011
    • Rex, A.1    Stephens, D.N.2    Fink, H.3
  • 36
    • 37349076564 scopus 로고    scopus 로고
    • N-(substituted-anilinoethyl)amides: design, synthesis, and pharmacological characterization of a new class of melatonin receptor ligands
    • Rivara S., Lodola A., Mor M., Bedini A., Spadoni G., Lucini V., et al. N-(substituted-anilinoethyl)amides: design, synthesis, and pharmacological characterization of a new class of melatonin receptor ligands. J Med Chem 2007, 50:6618-6626.
    • (2007) J Med Chem , vol.50 , pp. 6618-6626
    • Rivara, S.1    Lodola, A.2    Mor, M.3    Bedini, A.4    Spadoni, G.5    Lucini, V.6
  • 37
    • 70349777464 scopus 로고    scopus 로고
    • N-(anilinoethyl)amides: design and synthesis of metabolically stable, selective melatonin receptor ligands
    • Rivara S., Vacondio F., Fioni A., Silva C., Carmi C., Mor M., et al. N-(anilinoethyl)amides: design and synthesis of metabolically stable, selective melatonin receptor ligands. ChemMedChem 2009, 4:1746-1755.
    • (2009) ChemMedChem , vol.4 , pp. 1746-1755
    • Rivara, S.1    Vacondio, F.2    Fioni, A.3    Silva, C.4    Carmi, C.5    Mor, M.6
  • 38
    • 0023022057 scopus 로고
    • Melatonin increases in vivo GABA accumulation in rat hypothalamus, cerebellum, cerebral cortex and pineal gland
    • Rosenstein R.E., Cardinali D.P. Melatonin increases in vivo GABA accumulation in rat hypothalamus, cerebellum, cerebral cortex and pineal gland. Brain Res 1986, 398:403-406.
    • (1986) Brain Res , vol.398 , pp. 403-406
    • Rosenstein, R.E.1    Cardinali, D.P.2
  • 39
    • 0033944784 scopus 로고    scopus 로고
    • Effects of buspirone, diazepam, and zolpidem on open field behavior, and brain [3H]muscimol binding after buspirone pretreatment
    • Siemiatkowski M., Sienkiewicz-Jarosz H., CzŁonkowska A.I., Bidziński A., PŁaźnik A. Effects of buspirone, diazepam, and zolpidem on open field behavior, and brain [3H]muscimol binding after buspirone pretreatment. Pharmacol Biochem Behav 2000, 66:645-651.
    • (2000) Pharmacol Biochem Behav , vol.66 , pp. 645-651
    • Siemiatkowski, M.1    Sienkiewicz-Jarosz, H.2    CzŁonkowska, A.I.3    Bidziński, A.4    PŁaźnik, A.5
  • 40
    • 0038621817 scopus 로고    scopus 로고
    • Generation of the melatonin endocrine message in mammals: a review of the complex regulation of melatonin synthesis by norepinephrine, peptides, and other pineal transmitters
    • Simonneaux V., Ribelayga C. Generation of the melatonin endocrine message in mammals: a review of the complex regulation of melatonin synthesis by norepinephrine, peptides, and other pineal transmitters. Pharmacol Rev 2003, 55:325-395.
    • (2003) Pharmacol Rev , vol.55 , pp. 325-395
    • Simonneaux, V.1    Ribelayga, C.2
  • 41
    • 33644543348 scopus 로고    scopus 로고
    • Prevalence and incidence studies of anxiety disorders: a systematic review of the literature
    • Somers J., Goldner E., Waraich P., Hsu L. Prevalence and incidence studies of anxiety disorders: a systematic review of the literature. Can J Psychiatry 2006, 51:100-113.
    • (2006) Can J Psychiatry , vol.51 , pp. 100-113
    • Somers, J.1    Goldner, E.2    Waraich, P.3    Hsu, L.4
  • 43
    • 0026678029 scopus 로고
    • The comparison of benzodiazepine derivatives and serotonergic agonists and antagonists in two animal models of anxiety
    • Stefański R., Pazxllejko W., Kostowski W., Pałźnik A. The comparison of benzodiazepine derivatives and serotonergic agonists and antagonists in two animal models of anxiety. Neuropharmacology 1992, 31:1251-1258.
    • (1992) Neuropharmacology , vol.31 , pp. 1251-1258
    • Stefański, R.1    Pazxllejko, W.2    Kostowski, W.3    Pałźnik, A.4
  • 44
    • 58149129754 scopus 로고    scopus 로고
    • Efficacy of agomelatine in generalized anxiety disorder: a randomized, double-blind, placebo-controlled study
    • Stein D., Ahokas A., de Bodinat C. Efficacy of agomelatine in generalized anxiety disorder: a randomized, double-blind, placebo-controlled study. J Clin Psychopharmacol 2008, 28:561-566.
    • (2008) J Clin Psychopharmacol , vol.28 , pp. 561-566
    • Stein, D.1    Ahokas, A.2    de Bodinat, C.3
  • 46
    • 77954511022 scopus 로고    scopus 로고
    • Antidepressant- and anxiolytic effects of the novel melatonin agonist Neu-P11 in rodent models
    • Tian S., Laudon M., Han L., Gao J., Huang F., Yang Y., et al. Antidepressant- and anxiolytic effects of the novel melatonin agonist Neu-P11 in rodent models. Acta Pharmacol Sin 2010, 31:775-783.
    • (2010) Acta Pharmacol Sin , vol.31 , pp. 775-783
    • Tian, S.1    Laudon, M.2    Han, L.3    Gao, J.4    Huang, F.5    Yang, Y.6
  • 48
    • 30844442386 scopus 로고    scopus 로고
    • GABA-A receptors: a viable target for novel anxiolytics?
    • Whiting P. GABA-A receptors: a viable target for novel anxiolytics?. Curr Opin Pharmacol 2006, 6:24-29.
    • (2006) Curr Opin Pharmacol , vol.6 , pp. 24-29
    • Whiting, P.1
  • 49
    • 0037418623 scopus 로고    scopus 로고
    • Melatonin receptors and their regulation: biochemical and structural mechanisms
    • Witt-Enderby P.A., Bennett J., Jarzynka M.J., Firestine S., Melan M.A. Melatonin receptors and their regulation: biochemical and structural mechanisms. Life Sci 2003, 72:2183-2198.
    • (2003) Life Sci , vol.72 , pp. 2183-2198
    • Witt-Enderby, P.A.1    Bennett, J.2    Jarzynka, M.J.3    Firestine, S.4    Melan, M.A.5


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