Reversible acute encephalopathy with mutism, induced by calcineurin inhibitors after renal transplantation

Journal of Nephrology

Volumn 25, Issue 5, 2012, Pages 839-842

  Perdomo, Katia Toledo ^a   Cabello, María Dolores Navarro ^a   Sáez, María José Pérez ^a   Pérez, Manuel José Ramos ^a   Morales, Maria Luisa Agüera ^a   García, Pedro Aljama ^a  

^a HOSPITAL UNIVERSITARIO REINA SOFÍA   (Spain)

Author keywords

Akinetic mutism; Calcineurin inhibitors; Neurotoxicity; Tacrolimus

Indexed keywords

CREATININE; HEPATITIS C ANTIBODY; MAGNESIUM; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; PREDNISONE; SODIUM; TACROLIMUS;

ACUTE BRAIN DISEASE; ADULT; ARTICLE; CASE REPORT; CHRONIC KIDNEY FAILURE; COMA; CONFUSION; CREATININE CLEARANCE; DRUG BLOOD LEVEL; DRUG SAFETY; DRUG WITHDRAWAL; ELECTROENCEPHALOGRAPHY; FEMALE; GAZE; GLOMERULUS FILTRATION RATE; HEMODIALYSIS; HUMAN; KIDNEY TRANSPLANTATION; MAGNESIUM BLOOD LEVEL; MUTISM; NEUROIMAGING; NUCLEAR MAGNETIC RESONANCE IMAGING; SODIUM BLOOD LEVEL; TONIC CLONIC SEIZURE;

AKINETIC MUTISM; BIOLOGICAL MARKERS; BRAIN; CALCINEURIN; DRUG SUBSTITUTION; FEMALE; HUMANS; IMMUNOSUPPRESSIVE AGENTS; KIDNEY TRANSPLANTATION; MAGNETIC RESONANCE IMAGING; MIDDLE AGED; NEUROLOGIC EXAMINATION; NEUROTOXICITY SYNDROMES; SIROLIMUS; TACROLIMUS; TREATMENT OUTCOME;

EID: 84867006294     PISSN: 11218428     EISSN: 17246059     Source Type: Journal    
DOI: 10.5301/jn.5000080     Document Type: Article

References (12)

1. Wijdicks EF. Neurotoxicity of immunosuppressive drugs. Liver Transpl. 2001;7(11):937-942.
2. Bechstein WO. Neurotoxicity of calcineurin inhibitors: impact and clinical management. Transpl Int. 2000;13(5):313-326.
3. Coley SC, Porter DA, Calamante F, Chong WK, Connelly A. Quantitative MR diffusion mapping and cyclosporine-induced neurotoxicity. AJNR Am J Neuroradiol. 1999;20(8):1507-1510.
4. Wu Q, Marescaux C, Wolff V, et al. Tacrolimus-associated posterior reversible encephalopathy syndrome after solid organ transplantation. Eur Neurol. 2010;64(3):169-177. Published online August 12, 2010.
5. Lin JT, Wang SJ, Fuh JL, Hsiao LT, Lirng JF, Chen PM. Prolonged reversible vasospasm in cyclosporin A-induced encephalopathy. AJNR Am J Neuroradiol. 2003;24(1):102-104.
6. Ducros A, Boukobza M, Porcher R, Sarov M, Valade D, Bousser MG. The clinical and radiological spectrum of reversible cerebral vasoconstriction syndrome: a prospective series of 67 patients. Brain. 2007;130(Pt 12):3091-3101.
7. de Groen PC, Aksamit AJ, Rakela J, Forbes GS, Krom RA. Central nervous system toxicity after liver transplantation: the role of cyclosporine and cholesterol. N Engl J Med. 1987;317(14):861-866.
8. Thompson CB, June CH, Sullivan KM, Thomas ED. Association between cyclosporin neurotoxicity and hypomagnesaemia. Lancet. 1984;2(8412):1116-1120.
9. Bronster DJ, Gurkan A, Buchsbaum MS, Emre S. Tacrolimusassociated mutism after orthotopic liver transplantation. Transplantation. 2000;70(6):979-982.
10. Sokol DK, Molleston JP, Filo RS, Van Valer J, Edwards-Brown M. Tacrolimus (FK506)-induced mutism after liver transplant. Pediatr Neurol. 2003;28(2):156-158.
11. Ahn KJ, Lee JW, Hahn ST, et al. Diffusion-weighted MRI and ADC mapping in FK506 neurotoxicity. Br J Radiol. 2003;76(912):916-919.
12. Sierra-Hidalgo F, Martínez-Salio A, Moreno-García S, de Pablo-Fernández E, Correas-Callero E, Ruiz-Morales J. Akinetic mutism induced by tacrolimus. Clin Neuropharmacol. 2009;32(5):293-294.