Production and evaluation of a chromatographically purified Vero cell rabies vaccine (PVRV) in China using microcarrier technology

Human Vaccines and Immunotherapeutics

Volumn 8, Issue 9, 2012, Pages 1230-1235

  Yu, Pengcheng ^a   Huang, Ying ^a   Zhang, Yibin ^b   Tang, Qing ^a   Liang, Guodong ^a  

^a Institute for Viral Disease Control and Prevention   (China)

^b Liaoning Chengda Biology Co Ltd   (China)

Author keywords

Immunogenicity; Microcarrier; Neutralizing antibody; Rabies vaccine; Vero cells

Indexed keywords

NEUTRALIZING ANTIBODY; PURIFIED VERO CELL RABIES VACCINE; RABIES VACCINE; UNCLASSIFIED DRUG;

ADOLESCENT; ADULT; ANTIBODY TITER; ARTICLE; BIOREACTOR; CHILD; CHINA; CHROMATOGRAPHY; CONTROLLED STUDY; DRUG EFFICACY; DRUG FEVER; DRUG INDUCED HEADACHE; DRUG POTENCY; DRUG SAFETY; FEMALE; HUMAN; IMMUNOGENICITY; IMMUNOPROPHYLAXIS; INJECTION SITE PAIN; INJECTION SITE SWELLING; INOCULATION; MALAISE; MALE; OUTCOME ASSESSMENT; POST EXPOSURE PROPHYLAXIS; PRURITUS; RABIES; SCHOOL CHILD; VACCINATION; VERO CELL;

ANIMALS; BIOREACTORS; CERCOPITHECUS AETHIOPS; CHINA; CHROMATOGRAPHY; HUMANS; RABIES VACCINES; VERO CELLS;

EID: 84867000954     PISSN: None     EISSN: 2164554X     Source Type: Journal    
DOI: 10.4161/hv.20985     Document Type: Article

References (18)

1. Cui-ping Y, Hang Z, Hui W, Xinxin S, Lihua W, Wenwu Y, et al. Epidemiological analysis of rabies in 2010, China. Chinese Journal of Experimental and Clinical Virology 2011; 25:434-6.
2. Situation of rabies prevention and control in China. Ministry of Health of the People's Republic of China 2009.
3. Yongxin Y. Development of the current situation of the domestic and foreign rabies vaccine. Shanghai Journal of Preventive Medicine 2006; 18:216-8.
4. Li C, Jun G, Jianying H, Zhumu B, Deming Y, Junwei Y, et al. Preparation of Rabies Vaccine for Human Use by Cell Culture in Bioreactor. Chinese Journal of Biologicals 2006; 19:288-90.
5. CytodexTM 1: Beaded microcarriers for cell culture, Pharmacia Fine Chemicals, Technical Booklet Series, Uppsala, Sweden 1978.
6. Kruse PF Patterson MK. Tissue culture, methods and applications. New York: Academic Press, 1973; 372-377.
7. van Wezel AL, van Herwaarden JA, van de Heuvel-de Rijk EW. Large-scale concentration and purification of virus suspension from microcarrier culture for the preparation of inactivated virus vaccines. Dev Biol Stand 1979; 42:65-9; PMID:223923.
8. Yan-ping L, Li C, Rong-cheng L, Jiongxian T, Yi N, Fusheng C, et al. Safety and immunogenicity of a new inactivated rabies vaccine (Vero Cell) in healthy adult. Guangxi Prev Med 2005; 11:193-5.
9. WHO expert consultation on rabies: first report. WHO technical report series 931. Geneva: WHO; 2004.
10. Smith JS, Yager PA, Baer GM. A rapid reproducible test for determining rabies neutralizing antibody. Bull World Health Organ 1973; 48:535-41; PMID:4544144.
11. WHO expert consultation on rabies, 1st report. Geneva 2005; 88.
12. WHO tech Rep Ser No. 700, 1984.
13. WHO tech Rep Ser No. 747, 1987.
14. Wang LY, Sun MP, Zhang XC, Suo LD, Xu RH, Zou YJ, et al. Safety and immunogenicity of two freeze-dried Vero cell rabies vaccines for human use in post-exposure prophylaxis. Vaccine 2011; 29:2679-81; PMID:21296694; http://dx.doi.org/10.1016/j.vaccine.2011.01.053.
15. Liu H, Huang G, Tang Q, Li J, Cao S, Fu C, et al. The immunogenicity and safety of vaccination with purified Vero cell rabies vaccine (PVRV) in China under a 2-1-1 regimen. Hum Vaccin 2011; 7:220-4; PMID:21311216; http://dx.doi.org/10.4161/hv.7.2.14003.
16. Meslin FX, Kaplan MM, Koprowski H. Laboratory techniques in rabies. 4th edition. Geneva: World Health Organization, 1996: 7.
17. Fishbein DB, Yenne KM, Dreesen DW, Teplis CF, Mehta N, Briggs DJ. Risk factors for systemic hypersensitivity reactions after booster vaccinations with human diploid cell rabies vaccine: a nationwide prospective study. Vaccine 1993; 11:1390-4; PMID:8310759; http://dx.doi.org/10.1016/0264-410X(93)90167-V.
18. Suntharasamai P, Chaiprasithikul P, Wasi C, Supanaranond W, Auewarakul P, Chanthavanich P, et al. A simplified and economical intradermal regimen of purified chick embryo cell rabies vaccine for postexposure prophylaxis. Vaccine 1994; 12:508-12; PMID:8036824; http://dx.doi.org/10.1016/0264-410X(94)90308-5.