Normal fractional urate excretion identifies hyponatremic patients with reset osmostat

Journal of Nephrology

Volumn 25, Issue 5, 2012, Pages 833-838

  Imbriano, Louis J ^a,b   Ilamathi, Ekambaram ^a,b   Ali, Nicole M ^a,b   Miyawaki, Nobuyuki ^a,b   Maesaka, John K ^a,b  

^a WINTHROP UNIVERSITY HOSPITAL   (United States)

^b STONY BROOK UNIVERSITY   (United States)

Author keywords

Fractional urate excretion; Hyponatremia; Reset osmostat

Indexed keywords

SODIUM; URATE; VASOPRESSIN;

ADULT; AGED; ARTICLE; CLINICAL ARTICLE; COMORBIDITY; CONTROLLED STUDY; DILUTION; HUMAN; HYPONATREMIA; HYPOURICEMIA; SODIUM URINE LEVEL; URIC ACID BLOOD LEVEL; URIC ACID URINE LEVEL; URINARY EXCRETION; URINE OSMOLALITY; VASOPRESSIN BLOOD LEVEL; WATER LOADING;

AGED; AGED, 80 AND OVER; BIOLOGICAL MARKERS; COMORBIDITY; HUMANS; HYPONATREMIA; INAPPROPRIATE ADH SYNDROME; KIDNEY CONCENTRATING ABILITY; MIDDLE AGED; NEUROPHYSINS; NEW YORK; OSMOLAR CONCENTRATION; PREDICTIVE VALUE OF TESTS; PROTEIN PRECURSORS; SODIUM; URIC ACID; URINALYSIS; VASOPRESSINS;

EID: 84866999230     PISSN: 11218428     EISSN: 17246059     Source Type: Journal    
DOI: 10.5301/jn.5000074     Document Type: Article

References (35)

1. Zerbe R, Stropes L, Robertson G. Vasopressin function in the syndrome of inappropriate antidiuresis. Annu Rev Med. 1980;31(1):315-327.
2. Saghafi D. Water loading test in the reset osmostat variant of SIADH. Am J Med. 1993;95(3):343.
3. Sterns RH. Treatment of hyponatremia: syndrome of inappropriate antidiuretic hormone secretion (SIADH) and reset osmostat. In: Emmett M, Sheridan AM, eds. Up To Date. Waltham, MA: Up To Date; February 08, 2011.
4. Renneboog B, Musch W, Vandemergel X, Manto MU, Decaux G. Mild chronic hyponatremia is associated with falls, unsteadiness, and attention deficits. Am J Med. 2006;119(1): 711-718.
5. Arieff AI, Llach F, Massry SG. Neurological manifestations and morbidity of hyponatremia: correlation with brain water and electrolytes. Medicine (Baltimore). 1976;55(2):121-129.
6. Gankam Kengne F, Andres C, Sattar L, Melot C, Decaux G. Mild hyponatremia and risk of fracture in the ambulatory elderly. QJM. 2008;101(7):583-588.
7. Decaux G. Is asymptomatic hyponatremia really asymptomatic? Am J Med. 2006;119(7)(Suppl 1):S79-S82.
8. Sterns RH, Nigwekar SU, Hix JK. The treatment of hyponatremia. Semin Nephrol. 2009;29(3):282-299.
9. Berl T, Quittnat-Pelletier F, Verbalis JG, et al; SALTWATER Investigators. Oral tolvaptan is safe and effective in chronic hyponatremia. J Am Soc Nephrol. 2010;21(4):705-712.
10. Schrier RW. Does 'asymptomatic hyponatremia' exist? Nat Rev Nephrol. 2010;6(4):185.
11. Maesaka JK, Fishbane S. Regulation of renal urate excretion: a critical review. Am J Kidney Dis. 1998;32(6):917-933.
12. Maesaka JK, Gupta S, Fishbane S. Cerebral salt-wasting syndrome: does it exist? Nephron. 1999;82(2):100-109.
13. Maesaka JK, Imbriano LJ, Ali NM, Ilamathi E. Is it cerebral or renal salt wasting? Kidney Int. 2009;76(9):934-938.
14. Maesaka JK, Miyawaki N, Palaia T, Durham J. Renal salt wasting without cerebral disease: value of determining urate in hyponatremia. Kidney Int. 2007;71:822-826.
15. Beck LH. Hypouricemia in the syndrome of inappropriate secretion of antidiuretic hormone. N Engl J Med. 1979;301(10): 28-530.
16. Sonnenblick M, Rosin A. Increased uric acid clearance in the syndrome of inappropriate secretion of antidiuretic hormone. Isr J Med Sci. 1988;24(1):20-23.
17. Decaux G, Dumont I, Waterlot Y, Hanson B. Mechanisms of hypouricemia in the syndrome of inappropriate secretion of antidiuretic hormone. Nephron. 1985;39(3):164-168.
18. Dorhout Mees EJ, Blom van Assendelft P, Nieuwenhuis MG. Elevation of uric aicd clearance caused by inappropriate antidiuretic hormone secretion. Acta Med Scand. 1971;189(1-2):69-72.
19. Bitew S, Imbriano L, Miyawaki N, Fishbane S, Maesaka JK. More on renal salt wasting without cerebral disease: response to saline infusion. Clin J Am Soc Nephrol. 2009;4(2):309-315.
20. Fenske W, Störk S, Koschker AC, et al. Value of fractional uric acid excretion in differential diagnosis of hyponatremic patients on diuretics. J Clin Endocrinol Metab. 2008;93(8):2991-2997.
21. Berl T. Impact of solute intake on urine flow and water excretion. J Am Soc Nephrol. 2008;19(6):1076-1078.
22. Milionis HJ, Kakafika AI, Tsouli SG, et al. Effects of statin treatment on uric acid homeostasis in patient with primary hyperlipidemia. Am Heart J. 2004;148:635-640.
23. Yamamoto T, Moriwaki Y, Takahashi S, Tsutsumi Z, Hada T. Effect of losartan potassium, an angiotensin II receptor antagonist, on renal excretion of oxypurinol and purine bases. J Rheumatol. 2000;27(9):2232-2236.
24. Steele TH, Oppenheimer S. Factors affecting urate excretion following diuretic administration in man. Am J Med. 1969;47(4):564-574.
25. Sonnenblick M, Rosin AJ. Significance of the measurement of uric acid fractional clearance in diuretic induced hyponatraemia. Postgrad Med J. 1986;62(728):449-452.
26. DeFronzo RA, Goldberg M, Agus ZS. Normal diluting capacity in hyponatremic patients. Reset osmostat or a variant of the syndrome of inappropriate antidiuretic hormone secretion. Ann Intern Med. 1976;84(5):538-542.
27. Kahn T. Reset osmostat and salt and water retention in the course of severe hyponatremia. Medicine (Baltimore). 2003;82(3):170-176.
28. Elisaf MS, Konstantinides A, Siamopoulos KC. Chronic hyponatremia due to reset osmostat in a patient with colon cancer. Am J Nephrol. 1996;16(4):349-351.
29. Wall BM, Crofton JT, Share L, Cooke CR. Chronic hyponatremia due to resetting of the osmostat in a patient with gastric carcinoma. Am J Med. 1992;93(2):223-228.
30. Hill AR, Uribarri J, Mann J, Berl T. Altered water metabolism in tuberculosis: role of vasopressin. Am J Med. 1990;88(4): 357-364.
31. Lipschutz JH, Arieff AI. Reset osmostat in a healthy patient. Ann Intern Med. 1994;120(7):574-576.
32. Robertson GL. Thirst and vasopressin function in normal and disordered states of water balance. J Lab Clin Med. 1983; 101(3):351-371.
33. Saghafi D. Water loading test in the reset osmostat variant of SIADH. Am J Med. 1993;95(3):343.
34. Ali N, Imbriano LJ, Maesaka JK, Maesaka JK. The case of a 66-year-old male with hyponatremia. Kidney Int. 2009;76(2): 233-234.
35. Steele TH. Evidence for altered renal urate reabsorption during changes in volume of the extracellular fluid. J Lab Clin Med. 1969;74(2):288-299.