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European Journal of Medicinal Chemistry

Volumn 57, Issue , 2012, Pages 112-125

Synthesis and biological activities of polyquinoline derivatives: New Bcl-2 family protein modulators

(5) Saugues, Emmanuelle a,b Debaud, Anne Laure c,d,e Anizon, Fabrice a,b Bonnefoy, Nathalie c,d,e Moreau, Pascale a,b

a UNIVERSITÉ CLERMONT AUVERGNE (France)

b ICCF (France)

c UNIVERSITÉ DE LYON (France)

d INSERM (France)

e University Lyon i (France)

Author keywords

Bcl 2 family protein interactions modulators; In vitro pro apoptotic activities; Quinoline; Suzuki coupling

Indexed keywords

2' ETHOXY 5' ISOPROPYL 2 MORPHOLIN 4 YL 3,7' BIQUINOLINE; 4 [4 (4' CHLORO 2 BIPHENYLYLMETHYL) 1 PIPERAZINYL] N [4 [3 DIMETHYLAMINO 1 (PHENYLTHIOMETHYL)PROPYLAMINO] 3 NITROBENZENESULFONYL]BENZAMIDE; 5' ISOPROPYL 2' ETHOXY 2 PYRROLIDIN 1 YL 3,7' BIQUINOLINE; BCL2 RELATED PROTEIN A1; BH3 PROTEIN; DIMER; GAMBOGIC ACID; OBATOCLAX; PROTEIN BCL 2; PROTEIN BCL XL; PROTEIN MCL 1; QUINOLINE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CANCER THERAPY; CONTROLLED STUDY; DRUG PROTEIN BINDING; DRUG SYNTHESIS; HUMAN; HUMAN CELL; LYMPHATIC SYSTEM TUMOR; NONHUMAN; PERIPHERAL BLOOD MONONUCLEAR CELL; PROTEIN EXPRESSION; STRUCTURE ACTIVITY RELATION;

3T3 CELLS; ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS REGULATORY PROTEINS; BCL-2-ASSOCIATED X PROTEIN; BCL-X PROTEIN; CELL DEATH; CELL SURVIVAL; DIMERIZATION; GENE EXPRESSION; HUMANS; INHIBITORY CONCENTRATION 50; LEUKOCYTES, MONONUCLEAR; MEMBRANE PROTEINS; MICE; PROTEIN BINDING; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-BCL-2; QUINOLINES;

EID: 84866978408 PISSN: 02235234 EISSN: 17683254 Source Type: Journal
DOI: 10.1016/j.ejmech.2012.09.012 Document Type: Article

Times cited : (11)

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