Is DNA damage response ready for action anywhere?

International Journal of Molecular Sciences

Volumn 13, Issue 9, 2012, Pages 11569-11583

  Terradas, Mariona ^a   Martín, Marta ^a   Hernández, Laia ^a   Tusell, Laura ^a   Genescà, Anna ^a  

^a UNIVERSITAT AUTÒNOMA DE BARCELONA   (Spain)

Author keywords

Chromosome instability; DSB repair; Micronuclei; NER pathway

Indexed keywords

CELL NUCLEUS DNA; CHROMATIN; DNA;

BULK DENSITY; CELL NUCLEUS MEMBRANE; CHROMOSOMAL INSTABILITY; DNA DAMAGE; DNA HELIX; DNA REPLICATION; DNA RESPONSIVE ELEMENT; DOUBLE STRANDED DNA BREAK; EXCISION REPAIR; HUMAN; MICRONUCLEUS; REVIEW; CHROMATIN; CHROMOSOME; DNA REPAIR; GENETICS; METABOLISM; PATHOLOGY;

CHROMATIN; CHROMOSOMAL INSTABILITY; CHROMOSOMES; DNA; DNA BREAKS, DOUBLE-STRANDED; DNA DAMAGE; DNA REPAIR; MICRONUCLEI, CHROMOSOME-DEFECTIVE; NUCLEAR ENVELOPE;

EID: 84866948000     PISSN: 16616596     EISSN: 14220067     Source Type: Journal    
DOI: 10.3390/ijms130911569     Document Type: Review

References (58)

1. Fenech, M.; Kirsch-Volders, M.; Natarajan, A.T.; Surralles, J.; Crott, J.W.; Parry, J.; Norppa, H.; Eastmond, D.A.; Tucker, J.D.; Thomas, P. Molecular Mechanisms of Micronucleus, Nucleoplasmic Bridge and Nuclear Bud Formation in Mammalian and Human Cells. Mutagenesis 2011, 26, 125-132.
2. Shay, J.W.; Wright, W.E. Senescence and Immortalization: Role of Telomeres and Telomerase. Carcinogenesis 2005, 26, 867-874.
3. Hande, M.P.; Samper, E.; Lansdorp, P.; Blasco, M.A. Telomere Length Dynamics and Chromosomal Instability in Cells Derived from Telomerase Null Mice. J. Cell Biol. 1999, 144, 589-601.
4. Latre, L.; Tusell, L.; Martin, M.; Miro, R.; Egozcue, J.; Blasco, M.A.; Genesca, A. Shortened Telomeres Join to DNA Breaks Interfering with their Correct Repair. Exp. Cell Res. 2003, 287, 282-288.
5. Hoffelder, D.R.; Luo, L.; Burke, N.A.; Watkins, S.C.; Gollin, S.M.; Saunders, W.S. Resolution of Anaphase Bridges in Cancer Cells. Chromosoma 2004, 112, 389-397.
6. Pampalona, J.; Soler, D.; Genesca, A.; Tusell, L. Whole Chromosome Loss is Promoted by Telomere Dysfunction in Primary Cells. Genes Chromosomes Cancer 2010, 49, 368-378.
7. Pampalona, J.; Soler, D.; Genesca, A.; Tusell, L. Telomere Dysfunction and Chromosome Structure Modulate the Contribution of Individual Chromosomes in Abnormal Nuclear Morphologies. Mutat. Res. 2010, 683, 16-22.
8. McClintock, B. The Stability of Broken Ends of Chromosomes in Zea Mays. Genetics 1941, 26, 234-282.
9. Cimini, D.; Fioravanti, D.; Salmon, E.D.; Degrassi, F. Merotelic Kinetochore Orientation versus Chromosome Mono-Orientation in the Origin of Lagging Chromosomes in Human Primary Cells. J. Cell. Sci. 2002, 115, 507-515.
10. Shimizu, N. Molecular Mechanisms of the Origin of Micronuclei from Extrachromosomal Elements. Mutagenesis 2011, 26, 119-123.
11. Kanda, T.; Wahl, G.M. The Dynamics of Acentric Chromosomes in Cancer Cells Revealed by GFP-Based Chromosome Labeling Strategies. J. Cell. Biochem. 2000, Suppl 35, 107-114.
12. Shimizu, N.; Itoh, N.; Utiyama, H.; Wahl, G.M. Selective Entrapment of Extrachromosomally Amplified DNA by Nuclear Budding and Micronucleation during S Phase. J. Cell Biol. 1998, 140, 1307-1320.
13. Lengauer, C.; Kinzler, K.W.; Vogelstein, B. Genetic Instabilities in Human Cancers. Nature 1998, 396, 643-649.
14. Stratton, M.R.; Campbell, P.J.; Futreal, P.A. The Cancer Genome. Nature 2009, 458, 719-724.
15. Duffaud, F.; Orsiere, T.; Digue, L.; Villani, P.; Volot, F.; Favre, R.; Botta, A. Micronucleated Lymphocyte Rates from Head-and-Neck Cancer Patients. Mutat. Res. 1999, 439, 259-266.
16. Bonassi, S.; Znaor, A.; Ceppi, M.; Lando, C.; Chang, W.P.; Holland, N.; Kirsch-Volders, M.; Zeiger, E.; Ban, S.; Barale, R. et al. An Increased Micronucleus Frequency in Peripheral Blood Lymphocytes Predicts the Risk of Cancer in Humans. Carcinogenesis 2007, 28, 625-631.
17. Bonassi, S.; El-Zein, R.; Bolognesi, C.; Fenech, M. Micronuclei Frequency in Peripheral Blood Lymphocytes and Cancer Risk: Evidence from Human Studies. Mutagenesis 2011, 26, 93-100.
18. Abraham, R.T.; Tibbetts, R.S. Cell Biology. Guiding ATM to Broken DNA. Science 2005, 308, 510-511.
19. Stracker, T.H.; Morales, M.; Couto, S.S.; Hussein, H.; Petrini, J.H. The Carboxy Terminus of NBS1 is Required for Induction of Apoptosis by the MRE11 Complex. Nature 2007, 447, 218-221.
20. Rogakou, E.P.; Pilch, D.R.; Orr, A.H.; Ivanova, V.S.; Bonner, W.M. DNA Double-Stranded Breaks Induce Histone H2AX Phosphorylation on Serine 139. J. Biol. Chem. 1998, 273, 5858-5868.
21. Paull, T.T.; Rogakou, E.P.; Yamazaki, V.; Kirchgessner, C.U.; Gellert, M.; Bonner, W.M. A Critical Role for Histone H2AX in Recruitment of Repair Factors to Nuclear Foci after DNA Damage. Curr. Biol. 2000, 10, 886-895.
22. Rogakou, E.P.; Boon, C.; Redon, C.; Bonner, W.M. Megabase Chromatin Domains Involved in DNA Double-Strand Breaks in Vivo. J. Cell Biol. 1999, 146, 905-916.
23. Bekker-Jensen, S.; Mailand, N. Assembly and Function of DNA Double-Strand Break Repair Foci in Mammalian Cells. DNA Repair (Amst) 2010, 9, 1219-1228.
24. Mailand, N.; Bekker-Jensen, S.; Faustrup, H.; Melander, F.; Bartek, J.; Lukas, C.; Lukas, J. RNF8 Ubiquitylates Histones at DNA Double-Strand Breaks and Promotes Assembly of Repair Proteins. Cell 2007, 131, 887-900.
25. Helleday, T.; Lo, J.; van Gent, D.C.; Engelward, B.P. DNA Double-Strand Break Repair: From Mechanistic Understanding to Cancer Treatment. DNA Repair (Amst) 2007, 6, 923-935.
26. Branzei, D.; Foiani, M. Regulation of DNA Repair Throughout the Cell Cycle. Nat. Rev. Mol. Cell Biol. 2008, 9, 297-308.
27. Shrivastav, M.; de Haro, L.P.; Nickoloff, J.A. Regulation of DNA Double-Strand Break Repair Pathway Choice. Cell Res. 2008, 18, 134-147.
28. Terradas, M.; Martin, M.; Tusell, L.; Genesca, A. DNA Lesions Sequestered in Micronuclei Induce a Local Defective-Damage Response. DNA Repair (Amst) 2009, 8, 1225-1234.
29. Nelson, G.; Buhmann, M.; von Zglinicki, T. DNA Damage Foci in Mitosis are Devoid of 53BP1. Cell. Cycle 2009, 8, 3379-3383.
30. Giunta, S.; Jackson, S.P. Give Me a Break, but Not in Mitosis: The Mitotic DNA Damage Response Marks DNA Double-Strand Breaks with Early Signaling Events. Cell. Cycle 2011, 10, 1215-1221.
31. Yoshikawa, T.; Kashino, G.; Ono, K.; Watanabe, M. Phosphorylated H2AX Foci in Tumor Cells have no Correlation with their Radiation Sensitivities. J. Radiat. Res. (Tokyo) 2009, 50, 151-160.
32. Crasta, K.; Ganem, N.J.; Dagher, R.; Lantermann, A.B.; Ivanova, E.V.; Pan, Y.; Nezi, L.; Protopopov, A.; Chowdhury, D.; Pellman, D. DNA Breaks and Chromosome Pulverization from Errors in Mitosis. Nature 2012, 482, 53-58.
33. Medvedeva, N.G.; Panyutin, I.V.; Panyutin, I.G.; Neumann, R.D. Phosphorylation of Histone H2AX in Radiation-Induced Micronuclei. Radiat. Res. 2007, 168, 493-498.
34. MacPhail, S.H.; Banath, J.P.; Yu, Y.; Chu, E.; Olive, P.L. Cell Cycle-Dependent Expression of Phosphorylated Histone H2AX: Reduced Expression in Unirradiated but Not X-Irradiated G1-Phase Cells. Radiat. Res. 2003, 159, 759-767.
35. Kim, J.A.; Kruhlak, M.; Dotiwala, F.; Nussenzweig, A.; Haber, J.E. Heterochromatin is Refractory to Gamma-H2AX Modification in Yeast and Mammals. J. Cell Biol. 2007, 178, 209-218.
36. Karagiannis, T.C.; Harikrishnan, K.N.; El-Osta, A. Disparity of Histone Deacetylase Inhibition on Repair of Radiation-Induced DNA Damage on Euchromatin and Constitutive Heterochromatin Compartments. Oncogene 2007, 26, 3963-3971.
37. Cowell, I.G.; Sunter, N.J.; Singh, P.B.; Austin, C.A.; Durkacz, B.W.; Tilby, M.J. γH2AX Foci Form Preferentially in Euchromatin after Ionising-Radiation. PLoS One 2007, 2, e1057.
38. Falk, M.; Lukasova, E.; Kozubek, S. Chromatin Structure Influences the Sensitivity of DNA to Gamma-Radiation. Biochim. Biophys. Acta 2008, 1783, 2398-2414.
39. Puerto, S.; Ramirez, M.J.; Marcos, R.; Creus, A.; Surralles, J. Radiation-Induced Chromosome Aberrations in Human Euchromatic (17cen-p53) and Heterochromatic (1cen-1q12) Regions. Mutagenesis 2001, 16, 291-296.
40. Goodarzi, A.A.; Noon, A.T.; Deckbar, D.; Ziv, Y.; Shiloh, Y.; Lobrich, M.; Jeggo, P.A. ATM Signaling Facilitates Repair of DNA Double-Strand Breaks Associated with Heterochromatin. Mol. Cell 2008, 31, 167-177.
41. Goodarzi, A.A.; Jeggo, P.; Lobrich, M. The Influence of Heterochromatin on DNA Double Strand Break Repair: Getting the Strong, Silent Type to Relax. DNA Repair (Amst) 2010, 9, 1273-1282.
42. Cann, K.L.; Dellaire, G. Heterochromatin and the DNA Damage Response: The Need to Relax. Biochem. Cell Biol. 2011, 89, 45-60.
43. Gillet, L.C.; Scharer, O.D. Molecular Mechanisms of Mammalian Global Genome Nucleotide Excision Repair. Chem. Rev. 2006, 106, 253-276.
44. Naegeli, H.; Sugasawa, K. The Xeroderma Pigmentosum Pathway: Decision Tree Analysis of DNA Quality. DNA Repair (Amst) 2011, 10, 673-683.
45. Hoeijmakers, J.H. Genome Maintenance Mechanisms for Preventing Cancer. Nature 2001, 411, 366-374.
46. Sugasawa, K.; Akagi, J.; Nishi, R.; Iwai, S.; Hanaoka, F. Two-Step Recognition of DNA Damage for Mammalian Nucleotide Excision Repair: Directional Binding of the XPC Complex and DNA Strand Scanning. Mol. Cell 2009, 36, 642-653.
47. Coin, F.; Oksenych, V.; Egly, J.M. Distinct Roles for the XPB/p52 and XPD/p44 Subcomplexes of TFIIH in Damaged DNA Opening during Nucleotide Excision Repair. Mol. Cell 2007, 26, 245-256.
48. Jones, C.J.; Wood, R.D. Preferential Binding of the Xeroderma Pigmentosum Group A Complementing Protein to Damaged DNA. Biochemistry 1993, 32, 12096-12104.
49. Mu, D.; Hsu, D.S.; Sancar, A. Reaction Mechanism of Human DNA Repair Excision Nuclease. J. Biol. Chem. 1996, 271, 8285-8294.
50. Moser, J.; Kool, H.; Giakzidis, I.; Caldecott, K.; Mullenders, L.H.; Fousteri, M.I. Sealing of Chromosomal DNA Nicks during Nucleotide Excision Repair Requires XRCC1 and DNA Ligase III Alpha in a Cell-Cycle-Specific Manner. Mol. Cell 2007, 27, 311-323.
51. Pfeifer, G.P.; You, Y.H.; Besaratinia, A. Mutations Induced by Ultraviolet Light. Mutat. Res. 2005, 571, 19-31.
52. Rademakers, S.; Volker, M.; Hoogstraten, D.; Nigg, A.L.; Mone, M.J.; van Zeeland, A.A.; Hoeijmakers, J.H.; Houtsmuller, A.B.; Vermeulen, W. Xeroderma Pigmentosum Group A Protein Loads as a Separate Factor Onto DNA Lesions. Mol. Cell. Biol. 2003, 23, 5755-5767.
53. Hoogstraten, D.; Bergink, S.; Ng, J.M.; Verbiest, V.H.; Luijsterburg, M.S.; Geverts, B.; Raams, A.; Dinant, C.; Hoeijmakers, J.H.; Vermeulen, W. et al. Versatile DNA Damage Detection by the Global Genome Nucleotide Excision Repair Protein XPC. J. Cell. Sci. 2008, 121, 2850-2859.
54. Terradas, M.; Martin, M.; Hernandez, L.; Tusell, L.; Genesca, A. Nuclear Envelope Defects Impede a Proper Response to Micronuclear DNA Lesions. Mutat. Res. 2012, 729, 35-40.
55. Rasala, B.A.; Ramos, C.; Harel, A.; Forbes, D.J. Capture of AT-Rich Chromatin by ELYS Recruits POM121 and NDC1 to Initiate Nuclear Pore Assembly. Mol. Biol. Cell 2008, 19, 3982-3996.
56. Labidi, B.; Gregoire, M.; Frackowiak, S.; Hernandez-Verdun, D.; Bouteille, M. RNA Polymerase Activity in PtK1 Micronuclei Containing Individual Chromosomes. an in vitro and in situ Study. Exp. Cell Res. 1987, 169, 233-244.
57. Geraud, G.; Laquerriere, F.; Masson, C.; Arnoult, J.; Labidi, B.; Hernandez-Verdun, D. Three-Dimensional Organization of Micronuclei Induced by Colchicine in PtK1 Cells. Exp. Cell Res. 1989, 181, 27-39.
58. Huang, Y.; Fenech, M.; Shi, Q. Micronucleus Formation Detected by Live-Cell Imaging. Mutagenesis 2011, 26, 133-138.