Nasal carriage as a source of agr-defective staphylococcus aureus bacteremia

Journal of Infectious Diseases

Volumn 206, Issue 8, 2012, Pages 1168-1177

  Smyth, Davida S ^a   Kafer, Jared M ^a   Wasserman, Gregory A ^a   Velickovic, Lili ^b   Mathema, Barun ^c   Holzman, Robert S ^a   Knipe, Tiffany A ^a   Becker, Karsten ^d   Von Eiff, Christof ^d   Peters, Georg ^d   Chen, Liang ^c   Kreiswirth, Barry N ^c   Novick, Richard P ^a   Shopsin, Bo ^a  

^a NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b KAROLINSKA INSTITUTE   (Sweden)

^c PUBLIC HEALTH RESEARCH INSTITUTE   (United States)

^d UNIVERSITY HOSPITAL MÜNSTER   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

AGR GENE; ARTICLE; BACTEREMIA; BACTERIAL GENE; BACTERIAL STRAIN; BACTERIAL VIRULENCE; BACTERIUM CARRIER; BACTERIUM ISOLATE; BLOOD; CLONE; CONTROLLED STUDY; GENE MUTATION; HEMOLYSIS; NONHUMAN; NOSE; PRIORITY JOURNAL; STAPHYLOCOCCUS AUREUS;

BACTEREMIA; BACTERIAL PROTEINS; CARRIER STATE; GENOTYPE; HUMANS; METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS; MOLECULAR TYPING; NASAL MUCOSA; SEQUENCE ANALYSIS, DNA; STAPHYLOCOCCAL INFECTIONS; TRANS-ACTIVATORS; VIRULENCE;

EID: 84866946867     PISSN: 00221899     EISSN: None     Source Type: Journal    
DOI: 10.1093/infdis/jis483     Document Type: Article

References (27)

1. Novick RP. Autoinduction and signal transduction in the regulation of staphylococcal virulence. Mol Microbiol 2003; 48:1429-49. (Pubitemid 36751052)
2. Wright JS, 3rd, Jin R, Novick RP. Transient interference with staphylococcal quorum sensing blocks abscess formation. Proc Natl Acad Sci USA 2005; 102:1691-6. (Pubitemid 40209229)
3. Fowler VG, Jr, Sakoulas G, McIntyre LM, et al. Persistent bacteremia due to methicillin-resistant Staphylococcus aureus infection is associated with agr dysfunction and low-level in vitro resistance to thrombin-induced platelet microbicidal protein. J Infect Dis 2004; 190:1140-9. (Pubitemid 39186802)
4. Schweizer ML, Furuno JP, Sakoulas G, et al. Increased mortality with accessory gene regulator (agr) dysfunction in Staphylococcus aureus among bacteremic patients. Antimicrob Agents Chemother 2011; 55:1082-7.
5. von Eiff C, Becker K, Machka K, Stammer H, Peters G. Nasal carriage as a source of Staphylococcus aureus bacteremia. Study Group. N Engl J Med 2001; 344:11-6. (Pubitemid 32064839)
6. Recsei P, Kreiswirth B, O'Reilly M, Schlievert P, Gruss A, Novick RP. Regulation of exoprotein gene expression in Staphylococcus aureus by agr. Mol Gen Genet 1986; 202:58-61. (Pubitemid 16150393)
7. Queck SY, Jameson-Lee M, Villaruz AE, et al. RNAIII-independent target gene control by the agr quorum-sensing system: insight into the evolution of virulence regulation in Staphylococcus aureus. Mol Cell 2008; 32:150-8.
8. Cheung GY, Duong AC, Otto M. Direct and synergistic hemolysis caused by Staphylococcus phenol-soluble modulins: implications for diagnosis and pathogenesis. Microbes Infect 2012; 14: 380-6.
9. Elek SD, Levy E. Distribution of haemolysins in pathogenic and nonpathogenic staphylococci. J Pathol Bacteriol 1950; 62:541-54.
10. Traber KE, Lee E, Benson S, et al. agr function in clinical Staphylococcus aureus isolates. Microbiology 2008; 154:2265-74.
11. Laemmli UK. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 1970; 227:680-5.
12. Novick RP. Genetic systems in staphylococci. Methods Enzymol 1991; 204:587-636.
13. Chen L, Shopsin B, Zhao Y, et al. Real-time nucleic acid sequencebased amplification (NASBA) assay for rapid detection and quantification of agr functionality in clinical Staphylococcus aureus isolates. J Clin Microbiol 2012; 50:657-61.
14. Shopsin B, Gomez M, Montgomery SO, et al. Evaluation of protein A gene polymorphic region DNA sequencing for typing of Staphylococcus aureus strains. J Clin Microbiol 1999; 37:3556-63. (Pubitemid 29491091)
15. Harmsen D, Claus H, Witte W, Rothganger J, Turnwald D, Vogel U. Typing of methicillin-resistant Staphylococcus aureus in a university hospital setting by using novel software for spa repeat determination and database management. J Clin Microbiol 2003; 41:5442-8. (Pubitemid 37543228)
16. von Eiff C, Friedrich AW, Peters G, Becker K. Prevalence of genes encoding for members of the staphylococcal leukotoxin family among clinical isolates of Staphylococcus aureus. Diagn Microbiol Infect Dis 2004; 49:157-62. (Pubitemid 38891721)
17. Traber K, Novick R. A slipped-mispairing mutation in AgrA of laboratory strains and clinical isolates results in delayed activation of agr and failure to translate delta-and alpha-haemolysins. Mol Microbiol 2006; 59:1519-30.
18. Ng PC, Henikoff S. SIFT: Predicting amino acid changes that affect protein function. Nucleic Acids Res 2003; 31:3812-4. (Pubitemid 37442253)
19. Hunter PR, Gaston MA. Numerical index of the discriminatory ability of typing systems: an application of Simpson's index of diversity. J Clin Microbiol 1988; 26:2465-6.
20. Shopsin B, Eaton C, Wasserman GA, et al. Mutations in agr do not persist in natural populations of methicillin-resistant Staphylococcus aureus. J Infect Dis 2010; 202:1593-9.
21. Vuong C, Kocianova S, Yao Y, Carmody AB, Otto M. Increased colonization of indwelling medical devices by quorum-sensing mutants of Staphylococcus epidermidis in vivo. J Infect Dis 2004; 190:1498-505. (Pubitemid 39332191)
22. Shopsin B, Drlica-Wagner A, Mathema B, Adhikari RP, Kreiswirth BN, Novick RP. Prevalence of agr dysfunction among colonizing Staphylococcus aureus strains. J Infect Dis 2008; 198:1171-4.
23. Deleo FR, Kennedy AD, Chen L, et al. Molecular differentiation of historic phage-type 80/81 and contemporary epidemic Staphylococcus aureus. Proc Natl Acad Sci USA 2011; 108:18091-6.
24. Boles BR, Horswill AR. agr-mediated dispersal of Staphylococcus aureus biofilms. PLoS Pathog 2008; 4:e1000052.
25. Somerville GA, Beres SB, Fitzgerald JR, et al. In vitro serial passage of Staphylococcus aureus: changes in physiology, virulence factor production, and agr nucleotide sequence. J Bacteriol 2002; 184:1430-7. (Pubitemid 34157567)
26. Sakoulas G. The accessory gene regulator (agr) in methicillinresistant Staphylococcus aureus: role in virulence and reduced susceptibility to glycopeptide antibiotics. Drug Discovery Today 2006; 3:287-94. (Pubitemid 44356306)
27. Tsuji BT, MacLean RD, Dresser LD, McGavin MJ, Simor AE. Impact of accessory gene regulator (agr) dysfunction on vancomycin pharmacodynamics among Canadian community and health-care associated methicillin-resistant Staphylococcus aureus. Ann Clin Microbiol Antimicrob 2011; 10:20.