The Long Path from QTL to Gene

PLoS Genetics

Volumn 8, Issue 9, 2012, Pages

  Drinkwater, Norman R ^a   Gould, Michael N ^a  

^a UNIVERSITY OF WISCONSIN MADISON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; BACKCROSSING; BREEDING METHOD; CANCER RISK; CANCER SURVIVAL; CARCINOGENESIS; CHROMOSOME 9; CHROMOSOME SUBSTITUTION; DISEASE MODEL; GENE IDENTIFICATION; GENE MAPPING; GENE OVEREXPRESSION; GENETIC LINKAGE; GENETIC SUSCEPTIBILITY; GENETIC VARIABILITY; HOMOLOGOUS RECOMBINATION; HUMAN; LINKAGE ANALYSIS; METASTASIS POTENTIAL; MICROARRAY ANALYSIS; NONHUMAN; PHENOTYPE; QUANTITATIVE TRAIT LOCUS; SINGLE NUCLEOTIDE POLYMORPHISM; STRAIN DIFFERENCE; TUMOR SUPPRESSOR GENE;

ANIMALS; DISEASE MODELS, ANIMAL; GENETIC ASSOCIATION STUDIES; HUMANS; MICE; NEOPLASM METASTASIS; NEOPLASMS; QUANTITATIVE TRAIT LOCI; RATS;

EID: 84866946846     PISSN: 15537390     EISSN: 15537404     Source Type: Journal    
DOI: 10.1371/journal.pgen.1002975     Document Type: Article

References (15)

1. Eppig JT, Blake JA, Bult CJ, Kadin JA, Richardson JE, et al. (2012) The Mouse Genome Database (MGD): comprehensive resource for genetics and genomics of the laboratory mouse. Nucleic Acids Res 40: D881-D886.
2. Dwinell MR, Worthey EA, Shimoyama M, Bakir-Gungor B, DePons J, et al. (2009) The Rat Genome Database 2009: variation, ontologies, and pathways. Nucleic Acids Res 37: D744-D749.
3. Weinberg RA (2006) The biology of cancer. New York: Garland Science. 850 p.
4. Faraji F, Pang Y, Walker RC, Borges RN, Yang L, Hunter KW, (2012) Cadm1 is a metastasis susceptibility gene that suppresses metastasis by modifying tumor interaction with the cell-mediated immunity. PLoS Genet 8: e1002926 doi:10.1371/journal.pgen.1002926.
5. Demant P, (2003) Cancer susceptibility in the mouse: Genetics, biology and implications for human cancer. Nature Rev Genetics 4: 721-735.
6. Flint J, Valdar W, Shifman S, Mott R, (2005) Strategies for mapping and cloning quantitative trait genes in rodents. Nature Rev Genetics 6: 271-286.
7. Hunter KW, Broman KW, Le Voyer T, Lukes L, Cozma D, et al. (2001) Predisposition to efficient mammary tumor metastatic progression is linked to the breast cancer metastasis suppressor gene Brms1. Cancer Res 61: 8866-8872.
8. Lancaster M, Rouse J, Hunter KW, (2005) Modifiers of mammary tumor progression and metastasis on mouse chromosomes 7, 9, and 17. Mammalian Genome 16: 120-126.
9. Frazer KA, Eskin E, Kang HM, Bogue MA, Hinds DA, et al. (2007) A sequence-based variation map of 8.27 million SNPs in inbred mouse strains. Nature 448: 1050-1053.
10. Keane TM, Goodstadt L, Danecek P, White MA, Wong K, et al. (2011) Mouse genomic variation and its effect on phenotypes and gene regulation. Nature 477: 289-294.
11. Threadgill DW, Churchill GA, (2012) Ten years of the collaborative cross. G3 2: 153-156.
12. Svenson KL, Gatti DM, Valdar W, Welsh CE, Cheng R, et al. (2012) High-resolution genetic mapping using the Mouse Diversity outbred population. Genetics 190: 437-447.
13. Lloyd KC, (2011) A knockout mouse resource for the biomedical research community. Ann NY Acad Sci 1245: 24-26.
14. Guan C, Ye C, Yang X, Gao J, (2010) A review of current large-scale mouse knockout efforts. Genesis 48: 73-85.
15. Cui X, Ji D, Fisher DA, Wu Y, Briner DM, Weinstein EJ, (2011) Targeted integration in rat and mouse embryos with zinc-finger nucleases. Nature Biotechnol 29: 64-67.