Genetic Variation in the TNF Gene Is Associated with Susceptibility to Severe Sepsis, but Not with Mortality

PLoS ONE

Volumn 7, Issue 9, 2012, Pages

  Song, Zhenju ^a   Song, Yuanlin ^a   Yin, Jun ^a   Shen, Yao ^a   Yao, Chenling ^a   Sun, Zhan ^a   Jiang, Jinjun ^a   Zhu, Duming ^a   Zhang, Yong ^a   Shen, Qinjun ^a   Gao, Lei ^a   Tong, Chaoyang ^a   Bai, Chunxue ^a  

^a FUDAN UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

LIPOPOLYSACCHARIDE; TUMOR NECROSIS FACTOR ALPHA;

ADULT; AGED; ARTICLE; CASE CONTROL STUDY; CHINESE; CONTROLLED STUDY; DISEASE SEVERITY; EX VIVO STUDY; FEMALE; GENE; GENE FREQUENCY; GENETIC ASSOCIATION; GENETIC RISK; GENETIC SUSCEPTIBILITY; GENETIC VARIABILITY; GENOTYPE; HUMAN; HUMAN CELL; LTA GENE; MAJOR CLINICAL STUDY; MALE; MORTALITY; PERIPHERAL BLOOD MONONUCLEAR CELL; PROMOTER REGION; PROTEIN BLOOD LEVEL; SEPSIS; SINGLE NUCLEOTIDE POLYMORPHISM; SUPERNATANT; TNFRSF1A GENE; TNFRSF1B GENE; TUMOR NECROSIS FACTOR GENE;

AGED; ASIAN CONTINENTAL ANCESTRY GROUP; CHINA; FEMALE; GENETIC VARIATION; HUMANS; LYMPHOTOXIN-ALPHA; MALE; MIDDLE AGED; POLYMORPHISM, SINGLE NUCLEOTIDE; RECEPTORS, TUMOR NECROSIS FACTOR, TYPE I; RECEPTORS, TUMOR NECROSIS FACTOR, TYPE II; RISK FACTORS; SEPSIS; SURVIVAL ANALYSIS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84866943490     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0046113     Document Type: Article

References (45)

1. Martin GS, Mannino DM, Eaton S, Moss M, (2003) The epidemiology of sepsis in the United States from 1979 through 2000. N Engl J Med 348: 1546-1554.
2. Dahmer MK, Randolph A, Vitali S, Quasney MW, (2005) Genetic polymorphisms in sepsis. Pediatr Crit Care Med 6: S61-73.
3. Holmes CL, Russell JA, Walley KR, (2003) Genetic polymorphisms in sepsis and septic shock: role in prognosis and potential for therapy. Chest 124: 1103-1115.
4. Song Z, Yin J, Yao C, Sun Z, Shao M, et al. Variants in the Toll-interacting protein gene are associated with susceptibility to sepsis in the Chinese Han population. Crit Care 15: R12.
5. Hamann L, Kumpf O, Schuring RP, Alpsoy E, Bedu-Addo G, et al. (2009) Low frequency of the TIRAP S180L polymorphism in Africa, and its potential role in malaria, sepsis, and leprosy. BMC Med Genet 10: 65.
6. Arcaroli J, Silva E, Maloney JP, He Q, Svetkauskaite D, et al. (2006) Variant IRAK-1 haplotype is associated with increased nuclear factor-kappaB activation and worse outcomes in sepsis. Am J Respir Crit Care Med 173: 1335-1341.
7. Toubiana J, Courtine E, Pene F, Viallon V, Asfar P, et al. (2010) IRAK1 functional genetic variant affects severity of septic shock. Crit Care Med 38: 2287-2294.
8. Ferwerda B, Alonso S, Banahan K, McCall MB, Giamarellos-Bourboulis EJ, et al. (2009) Functional and genetic evidence that the Mal/TIRAP allele variant 180L has been selected by providing protection against septic shock. Proc Natl Acad Sci U S A 106: 10272-10277.
9. Pino-Yanes M, Corrales A, Casula M, Blanco J, Muriel A, et al. (2010) Common variants of TLR1 associate with organ dysfunction and sustained pro-inflammatory responses during sepsis. PLoS ONE 5: e13759.
10. Barber RC, Aragaki CC, Rivera-Chavez FA, Purdue GF, Hunt JL, et al. (2004) TLR4 and TNF-alpha polymorphisms are associated with an increased risk for severe sepsis following burn injury. J Med Genet 41: 808-813.
11. Zheng X, Zheng H, Lan R, Ye C, Wang Y, et al. (2011) Identification of genes and genomic islands correlated with high pathogenicity in Streptococcus suis using whole genome tiling microarrays. PLoS ONE 6: e17987.
12. Jessen KM, Lindboe SB, Petersen AL, Eugen-Olsen J, Benfield T, (2007) Common TNF-alpha, IL-1 beta, PAI-1, uPA, CD14 and TLR4 polymorphisms are not associated with disease severity or outcome from Gram negative sepsis. BMC Infect Dis 7: 108.
13. Reid CL, Perrey C, Pravica V, Hutchinson IV, Campbell IT, (2002) Genetic variation in proinflammatory and anti-inflammatory cytokine production in multiple organ dysfunction syndrome. Crit Care Med 30: 2216-2221.
14. Hotchkiss RS, Karl IE, (2003) The pathophysiology and treatment of sepsis. N Engl J Med 348: 138-150.
15. Debets JM, Kampmeijer R, van der Linden MP, Buurman WA, van der Linden CJ, (1989) Plasma tumor necrosis factor and mortality in critically ill septic patients. Crit Care Med 17: 489-494.
16. Douni E, Kollias G, (1998) A critical role of the p75 tumor necrosis factor receptor (p75TNF-R) in organ inflammation independent of TNF, lymphotoxin alpha, or the p55TNF-R. J Exp Med 188: 1343-1352.
17. Nedwin GE, Naylor SL, Sakaguchi AY, Smith D, Jarrett-Nedwin J, et al. (1985) Human lymphotoxin and tumor necrosis factor genes: structure, homology and chromosomal localization. Nucleic Acids Res 13: 6361-6373.
18. Mira JP, Cariou A, Grall F, Delclaux C, Losser MR, et al. (1999) Association of TNF2, a TNF-alpha promoter polymorphism, with septic shock susceptibility and mortality: a multicenter study. Jama 282: 561-568.
19. Appoloni O, Dupont E, Vandercruys M, Andriens M, Duchateau J, et al. (2001) Association of tumor necrosis factor-2 allele with plasma tumor necrosis factor-alpha levels and mortality from septic shock. Am J Med 110: 486-488.
20. O'Keefe GE, Hybki DL, Munford RS, (2002) The G→A single nucleotide polymorphism at the -308 position in the tumor necrosis factor-alpha promoter increases the risk for severe sepsis after trauma. J Trauma 52: 817-825; discussion 825-816.
21. Calvano JE, Um JY, Agnese DM, Hahm SJ, Kumar A, et al. (2003) Influence of the TNF-alpha and TNF-beta polymorphisms upon infectious risk and outcome in surgical intensive care patients. Surg Infect (Larchmt) 4: 163-169.
22. Wang S, Wei M, Han Y, Zhang K, He L, et al. (2008) Roles of TNF-alpha gene polymorphisms in the occurrence and progress of SARS-Cov infection: a case-control study. BMC Infect Dis 8: 27.
23. Tang GJ, Huang SL, Yien HW, Chen WS, Chi CW, et al. (2000) Tumor necrosis factor gene polymorphism and septic shock in surgical infection. Crit Care Med 28: 2733-2736.
24. Duan ZX, Gu W, Zhang LY, Jiang DP, Zhou J, et al. (2011) Tumor necrosis factor alpha gene polymorphism is associated with the outcome of trauma patients in Chinese Han population. J Trauma 70: 954-958.
25. Majetschak M, Flohe S, Obertacke U, Schroder J, Staubach K, et al. (1999) Relation of a TNF gene polymorphism to severe sepsis in trauma patients. Ann Surg 230: 207-214.
26. Stuber F, Udalova IA, Book M, Drutskaya LN, Kuprash DV, et al. (1995) -308 tumor necrosis factor (TNF) polymorphism is not associated with survival in severe sepsis and is unrelated to lipopolysaccharide inducibility of the human TNF promoter. J Inflamm 46: 42-50.
27. Garnacho-Montero J, Aldabo-Pallas T, Garnacho-Montero C, Cayuela A, Jimenez R, et al. (2006) Timing of adequate antibiotic therapy is a greater determinant of outcome than are TNF and IL-10 polymorphisms in patients with sepsis. Crit Care 10: R111.
28. Duan ZX, Gu W, Zhang LY, Jiang DP, Zhou J, et al. (2011) Tumor necrosis factor alpha gene polymorphism is associated with the outcome of trauma patients in Chinese Han population. J Trauma 70: 954-958.
29. Teuffel O, Ethier MC, Beyene J, Sung L, (2010) Association between tumor necrosis factor-alpha promoter -308 A/G polymorphism and susceptibility to sepsis and sepsis mortality: a systematic review and meta-analysis. Crit Care Med 38: 276-282.
30. Secher T, Vasseur V, Poisson DM, Mitchell JA, Cunha FQ, et al. (2009) Crucial role of TNF receptors 1 and 2 in the control of polymicrobial sepsis. J Immunol 182: 7855-7864.
31. Ebach DR, Riehl TE, Stenson WF, (2005) Opposing effects of tumor necrosis factor receptor 1 and 2 in sepsis due to cecal ligation and puncture. Shock 23: 311-318.
32. Moller M, Flachsbart F, Till A, Thye T, Horstmann RD, et al. (2010) A functional haplotype in the 3′untranslated region of TNFRSF1B is associated with tuberculosis in two African populations. Am J Respir Crit Care Med 181: 388-393.
33. Horiuchi T, Washio M, Kiyohara C, Tsukamoto H, Tada Y, et al. (2009) Combination of TNF-RII, CYP1A1 and GSTM1 polymorphisms and the risk of Japanese SLE: findings from the KYSS study. Rheumatology (Oxford) 48: 1045-1049.
34. Waschke KA, Villani AC, Vermeire S, Dufresne L, Chen TC, et al. (2005) Tumor necrosis factor receptor gene polymorphisms in Crohn's disease: association with clinical phenotypes. Am J Gastroenterol 100: 1126-1133.
35. Constantin A, Dieude P, Lauwers-Cances V, Jamard B, Mazieres B, et al. (2004) Tumor necrosis factor receptor II gene polymorphism and severity of rheumatoid arthritis. Arthritis Rheum 50: 742-747.
36. Gordon AC, Lagan AL, Aganna E, Cheung L, Peters CJ, et al. (2004) TNF and TNFR polymorphisms in severe sepsis and septic shock: a prospective multicentre study. Genes Immun 5: 631-640.
37. Tiancha H, Huiqin W, Jiyong J, Jingfen J, Wei C, (2011) Association between lymphotoxin-alpha intron +252 polymorphism and sepsis: a meta-analysis. Scand J Infect Dis 43: 436-447.
38. Clark MF, Baudouin SV, (2006) A systematic review of the quality of genetic association studies in human sepsis. Intensive Care Med 32: 1706-1712.
39. Louis E, Franchimont D, Piron A, Gevaert Y, Schaaf-Lafontaine N, et al. (1998) Tumour necrosis factor (TNF) gene polymorphism influences TNF-alpha production in lipopolysaccharide (LPS)-stimulated whole blood cell culture in healthy humans. Clin Exp Immunol 113: 401-406.
40. Huizinga TW, Westendorp RG, Bollen EL, Keijsers V, Brinkman BM, et al. (1997) TNF-alpha promoter polymorphisms, production and susceptibility to multiple sclerosis in different groups of patients. J Neuroimmunol 72: 149-153.
41. Menges T, Konig IR, Hossain H, Little S, Tchatalbachev S, et al. (2008) Sepsis syndrome and death in trauma patients are associated with variation in the gene encoding tumor necrosis factor. Crit Care Med 36: 1456-1462, e1451-1456.
42. Song Z, Tong C, Sun Z, Yao C, Shao M, et al. (2009) Association study of TLR4 polymorphisms with severe community-acquired pneumonia susceptibility and outcome. Chinese Journal of Emergency Medicine 18: 956-959.
43. American College of Chest Physicians/Society of Critical Care Medicine Consensus Conference: definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. Crit Care Med 20: 864-874.
44. Barrett JC, Fry B, Maller J, Daly MJ, (2005) Haploview: analysis and visualization of LD and haplotype maps. Bioinformatics 21: 263-265.
45. Purcell S, Cherny SS, Sham PC, (2003) Genetic Power Calculator: design of linkage and association genetic mapping studies of complex traits. Bioinformatics 19: 149-150.