A GxxxG-like motif within HIV-1 fusion peptide is critical to its immunosuppressant activity, structure, and interaction with the transmembrane domain of the T-cell receptor

Journal of Biological Chemistry

Volumn 287, Issue 40, 2012, Pages 33503-33511

  Faingold, Omri ^a   Cohen, Tomer ^a   Shai, Yechiel ^a  

^a WEIZMANN INSTITUTE OF SCIENCE   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

ACID REGION; ACTIVATED MACROPHAGES; AMINO ACID MOTIFS; DATA SUPPORT; EXPERIMENTAL STUDIES; FLUORESCENCE STUDIES; FTIR SPECTROSCOPY; FUSION PEPTIDES; HUMAN BODIES; IMMUNE RESPONSE; INACTIVE MUTANTS; LIPID MIXING; MEMBRANE PROTEINS; N-TERMINALS; NATURAL SELECTION; SHEET STRUCTURE; T CELL ACTIVATION; T CELLS; T-CELL RECEPTORS; TARGET CELLS; TARGET SITES; TRANS-MEMBRANE DOMAINS; TRANS-MEMBRANE PROTEINS; TRANSMEMBRANE DOMAIN;

ACTIVATION ANALYSIS; AMINO ACIDS; BIOACTIVITY; BIOINFORMATICS; CELL MEMBRANES; ENZYME ACTIVITY; FOURIER TRANSFORM INFRARED SPECTROSCOPY;

PEPTIDES;

HYBRID PROTEIN; MEMBRANE PROTEIN; T LYMPHOCYTE RECEPTOR; TUMOR NECROSIS FACTOR ALPHA;

AMINO TERMINAL SEQUENCE; ARTICLE; BETA SHEET; BIOINFORMATICS; COMPLEX FORMATION; CONTROLLED STUDY; CYTOKINE RELEASE; FLUORESCENCE RESONANCE ENERGY TRANSFER; HUMAN IMMUNODEFICIENCY VIRUS 1; IMMUNE RESPONSE; IMMUNOSUPPRESSANT ACTIVITY; INFRARED SPECTROSCOPY; MACROPHAGE; MOUSE; MUTANT; NONHUMAN; PEPTIDE SYNTHESIS; PRIORITY JOURNAL; PROTEIN INTERACTION; PROTEIN MOTIF; PROTEIN STRUCTURE; VIRUS STRAIN;

AMINO ACID MOTIFS; AMINO ACID SEQUENCE; ANIMALS; BINDING SITES; BIOPHYSICS; CELL LINE; CELL PROLIFERATION; COMPUTATIONAL BIOLOGY; FLUORESCENCE RESONANCE ENERGY TRANSFER; HIV ENVELOPE PROTEIN GP120; HIV ENVELOPE PROTEIN GP41; HIV-1; HUMANS; IMMUNOSUPPRESSIVE AGENTS; LIPIDS; MEMBRANE PROTEINS; MICE; MICE, INBRED C57BL; MOLECULAR SEQUENCE DATA; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN INTERACTION MAPPING; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; RECEPTORS, ANTIGEN, T-CELL; SEQUENCE HOMOLOGY, AMINO ACID; T-LYMPHOCYTES;

HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 84866937107     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.370817     Document Type: Article

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