Improved dissolution rate and bioavailability of fenofibrate pellets prepared by wet-milled-drug layering

Drug Development and Industrial Pharmacy

Volumn 38, Issue 11, 2012, Pages 1344-1353

  Wang, Puxiu ^a   Luo, Qing ^a   Miao, Yuqiang ^a   Ying, Lin ^a   He, Haibing ^a   Cai, Cuifang ^a   Tang, Xing ^a  

^a SHENYANG PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

Dissolution rate; Drug layering; Fenofibrate; Oral bioavailability; Wet milled

Indexed keywords

FENOFIBRATE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; CRYSTALLIZATION; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG CAPSULE; DRUG HALF LIFE; DRUG PELLET; DRUG SOLUBILITY; DRUG STABILITY; DRUG STORAGE; DRUG SYNTHESIS; MAXIMUM PLASMA CONCENTRATION; NONHUMAN; PARTICLE SIZE; SUSPENSION; TIME TO MAXIMUM PLASMA CONCENTRATION;

ADMINISTRATION, ORAL; ANIMALS; BIOLOGICAL AVAILABILITY; CALORIMETRY, DIFFERENTIAL SCANNING; DOGS; DRUG COMPOUNDING; DRUG STABILITY; DRUG STORAGE; FENOFIBRATE; HYPOLIPIDEMIC AGENTS; MICROSCOPY, ELECTRON, SCANNING; PARTICLE SIZE; SOLUBILITY; SURFACE PROPERTIES; THERMOGRAPHY; X-RAY DIFFRACTION;

EID: 84866910801     PISSN: 03639045     EISSN: 15205762     Source Type: Journal    
DOI: 10.3109/03639045.2011.650647     Document Type: Article

References (20)

1. Jinno J, Kamada N, Miyake M, Yamada K, Mukai T, Odomi M et al. (2008). In vitro-in vivo correlation for wet-milled tablet of poorly water-soluble cilostazol. J Control Release, 130:29-37.
2. Liu P, Rong X, Laru J, van Veen B, Kiesvaara J, Hirvonen J et al. (2011). Nanosuspensions of poorly soluble drugs: preparation and development by wet milling. Int J Pharm, 411:215-222.
3. Shegokar R, Müller RH. (2010). Nanocrystals: industrially feasible multifunctional formulation technology for poorly soluble actives. Int J Pharm, 399:129-139.
4. Nikowitz K, Kása Jr P, Pintye-Hódi K, Regdon Jr G. 2011. Study of the preparation of a multiparticulate drug delivery system with a layering technique. Powder Technol, 205:155-159.
5. Zhang L, Chai G, Zeng X, He H, Xu H, Tang X. (2010). Preparation of fenofbrate immediate-release tablets involving wet grinding for improved bioavailability. Drug Dev Ind Pharm, 36:1054-1063.
6. Vogt M, Kunath K, Dressman JB. (2008). Dissolution enhancement of fenofbrate by micronization, cogrinding and spray-drying: comparison with commercial preparations. Eur J Pharm Biopharm, 68:283-288.
7. Vasconcelos T, Sarmento B, Costa P. (2007). Solid dispersions as strategy to improve oral bioavailability of poor water soluble drugs. Drug Discov Today, 12:1068-1075.
8. Niwa T, Miura S, Danjo K. (2011). Universal wet-milling technique to prepare oral nanosuspension focused on discovery and preclinical animal studies-Development of particle design method. Int J Pharm, 405:218-227.
9. Szentkuti L. 1997. Light microscopical observations on luminally administered dyes, dextrans, nanospheres and microspheres in the pre-epithelial mucus gel layer of the rat distal colon. J Contr Release, 46:233-242.
10. Kürti L, Kukovecz Á, Kozma G, Ambrus R, Deli MA, Szabó-Révész P. 2011. Study of the parameters infuencing the co-grinding process for the production of meloxicam nanoparticles. Powder Tech, 212:210-217.
11. Sharma P, Denny WA, Garg S. (2009). Efect of wet milling process on the solid state of indomethacin and simvastatin. Int J Pharm, 380:40-48.
12. Van Eerdenbrugh B, Van den Mooter G, Augustijns P. (2008). Top-down production of drug nanocrystals: nanosuspension stabilization, miniaturization and transformation into solid products. Int J Pharm, 364:64-75.
13. Wu L, Zhang J, Watanabe W. (2011). Physical and chemical stability of drug nanoparticles. Adv Drug Deliv Rev, 63:456-469.
14. Merisko-Liversidge E, Liversidge GG. (2011). Nanosizing for oral and parenteral drug delivery: a perspective on formulating poorly-water soluble compounds using wet media milling technology. Adv Drug Deliv Rev, 63:427-440.
15. Florence AT, Hussain N. (2001). Transcytosis of nanoparticle and dendrimer delivery systems: evolving vistas. Adv Drug Deliv Rev, 50 Suppl 1:S69-S89.
16. Jani P, Halbert GW, Langridge J, Florence AT. (1989). The uptake and translocation of latex nanospheres and microspheres after oral administration to rats. J Pharm Pharmacol, 41:809-812.
17. LeFevre ME, Boccio AM, Joel DD. (1989). Intestinal uptake of fuorescent microspheres in young and aged mice. Proc Soc Exp Biol Med, 190:23-27.
18. Wan LSC, Lai W. 1991. Factors afecting drug release from drug-coated granules prepared by fuidized-bed coating. Int J Pharm, 72:163-174.
19. Pearnchob N, Bodmeier R. (2003). Dry polymer powder coating and comparison with conventional liquid-based coatings for Eudragit) RS, ethylcellulose and shellac. Eur J Pharm Biopharm, 56:363-369.
20. Van Eerdenbrugh B, Stuyven B, Froyen L, Van Humbeeck J, Martens JA, Augustijns P et al. (2009). Downscaling drug nanosuspension production: processing aspects and physicochemical characterization. AAPS Pharm Sci Tech, 10:44-53.