Clinicopathological significance of CADM4 expression, and its correlation with expression of E-cadherin and Ki-67 in colorectal adenocarcinomas

Journal of Clinical Pathology

Volumn 65, Issue 10, 2012, Pages 902-906

  Jang, Se Min ^a   Han, Hulin ^a   Jun, Young Jin ^a   Jang, Si Hyong ^a   Min, Kyueng Whan ^a   Sim, Jongmin ^a   Ahn, Hye In ^a   Lee, Kang Hong ^a   Jang, Ki Seok ^a   Paik, Seung Sam ^a  

^a Hanyang University   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

CELL ADHESION MOLECULE; CELL ADHESION MOLECULE 4; KI 67 ANTIGEN; UNCLASSIFIED DRUG; UVOMORULIN;

ADULT; ARTICLE; CANCER GROWTH; CANCER PROGNOSIS; CANCER SIZE; CANCER SURVIVAL; COLORECTAL CARCINOMA; CONTROLLED STUDY; DISEASE FREE SURVIVAL; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LYMPH NODE METASTASIS; MAJOR CLINICAL STUDY; MALE; OVERALL SURVIVAL; PRIORITY JOURNAL; PROTEIN EXPRESSION; TISSUE MICROARRAY; TUMOR DIFFERENTIATION;

ADENOCARCINOMA; CADHERINS; CELL ADHESION MOLECULES; COLORECTAL NEOPLASMS; DISEASE-FREE SURVIVAL; FEMALE; FOLLOW-UP STUDIES; HUMANS; IMMUNOGLOBULINS; IMMUNOHISTOCHEMISTRY; KI-67 ANTIGEN; MALE; MIDDLE AGED; TISSUE ARRAY ANALYSIS; TUMOR MARKERS, BIOLOGICAL;

EID: 84866910784     PISSN: 00219746     EISSN: 14724146     Source Type: Journal    
DOI: 10.1136/jclinpath-2012-200730     Document Type: Article

References (20)

1. Murakami Y, Nobukuni T, Tamura K, et al. Localization of tumor suppressor activity important in non-small cell lung carcinoma on chromosome 11q. Proc Natl Acad Sci USA 1998;95:8153-8. (Pubitemid 28326082)
2. Kuramochi M, Fukuhara H, Nobukuni T, et al. TSLC1 is a tumor-suppressor gene in human non-small cell lung cancer. Nat Genet 2001;27:427-30. (Pubitemid 32268425)
3. Masuda M, Yageta M, Fukuhara H, et al. The tumor suppressor protein TSLC1 is involved in cell-cell adhesion. J Biol Chem 2002;277:31014-19. (Pubitemid 34970805)
4. Murakami Y. Involvement of a cell adhesion molecule, TSLC1/IGSF4, in human oncogenesis. Cancer Sci 2005;96:543-52. (Pubitemid 41488417)
5. Fukuhara H, Kuramochi M, Nobukuni T, et al. Isolation of the TSLL1 and TSLL2 genes, members of the tumor suppressor TSLC1 gene family encoding transmembrane proteins. Oncogene 2001;20:5401-7. (Pubitemid 32844072)
6. Yang S, Weng H, Chen L, et al. Lack of protein 4.1G causes altered expression and localization of the cell adhesion molecule nectin-like 4 in testis and can cause male infertility. Mol Cell Biol 2011;31:2276-86.
7. Uchino K, Ito A, Wakayama T, et al. Clinical implication and prognostic significance of the tumor suppressor TSLC1 gene detected in adenocarcinoma of the lung. Cancer 2003;98:1002-7. (Pubitemid 37022101)
8. Takeichi M. Cadherin cell adhesion receptors as a morphogenetic regulator. Science 1991;251:1451-5. (Pubitemid 121000430)
9. Shimoyama Y, Hirohashi S, Hirano S, et al. Cadherin cell-adhesion molecules in human epithelial tissues and carcinomas. Cancer Res 1989;49:2128-33. (Pubitemid 19106526)
10. Frixen UH, Behrens J, Sachs M, et al. E-cadherin-mediated cell-cell adhesion prevents invasiveness of human carcinoma cells. J Cell Biol 1991;113:173-85. (Pubitemid 21909684)
11. Takeichi M. Cadherins in cancer: implication for invasion and metastasis. Curr Opin Cell Biol 1993;5:806-11.
12. Park JM, Jung CK, Choi YJ, et al. The use of an immunohistochemical diagnostic panel to determine the primary site of cervical lymph node metastases of occult squamous cell carcinoma. Hum Pathol 2010;41:431-7.
13. Williams YN, Masuda M, Sakurai-Yageta M, et al. Cell adhesion and prostate tumor-suppressor activity of TSLL2/IGSF4C, an immunoglobulin superfamily molecule homologous to TSLC1/IGSF4. Oncogene 2006;25:1446-53. (Pubitemid 43361930)
14. Nagata M, Sakurai-Yageta M, Yamada D, et al. Aberrations of a cell adhesion molecule CADM4 in renal clear cell carcinoma. Int J Cancer 2012;130:1329-37.
15. Raveh S, Gavert N, Spiegel I, et al. The cell adhesion nectin-like molecules (Necl) 1 and 4 suppress the growth and tumorigenic ability of colon cancer cells. J Cell Biochem 2009;108:326-36.
16. Goto A, Niki T, Chi-Pin L, et al. Loss of TSLC1 expression in lung adenocarcinoma: relationships with histological subtypes, sex and prognostic significance. Cancer Sci 2005;96:480-6. (Pubitemid 41387300)
17. Lung HL, Cheung AK, Xie D, et al. TSLC1 is a tumor suppressor gene associated with metastasis in nasopharyngeal carcinoma. Cancer Res 2006;66:9385-92. (Pubitemid 44623634)
18. Kikuchi S, Yamada D, Fukami T, et al. Hypermethylation of the TSLC1/IGSF4 promoter is associated with tobacco smoking and a poor prognosis in primary non-small cell lung carcinoma. Cancer 2006;106:1751-8.
19. Sakurai-Yageta M, Masuda M, Tsuboi Y, et al. Tumor suppressor CADM1 is involved in epithelial cell structure. Biochem Biophys Res Commun 2009;390:977-82.
20. Endl E, Gerdes J. The Ki-67 protein: fascinating forms and an unknown function. Exp cell Res 2000;257:231-7. (Pubitemid 30390473)