The Impact of Dietary Folate Intake on Reproductive Function in Premenopausal Women: A Prospective Cohort Study

PLoS ONE

Volumn 7, Issue 9, 2012, Pages

  Gaskins, Audrey J ^a,b   Mumford, Sunni L ^a   Chavarro, Jorge E ^b,c   Zhang, Cuilin ^a   Pollack, Anna Z ^a   Wactawski Wende, Jean ^d   Perkins, Neil J ^a   Schisterman, Enrique F ^a  

^a EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT   (United States)

^b HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^c HARVARD MEDICAL SCHOOL   (United States)

^d UNIVERSITY AT BUFFALO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ESTRADIOL; FOLIC ACID; FOLLITROPIN; LUTEINIZING HORMONE; PROGESTERONE;

ADULT; ANOVULATION; ARTICLE; COHORT ANALYSIS; ESTRADIOL BLOOD LEVEL; FEMALE; FOLLITROPIN BLOOD LEVEL; HUMAN; LUTEAL PHASE; LUTEINIZING HORMONE BLOOD LEVEL; MAJOR CLINICAL STUDY; MENSTRUAL CYCLE; PREMENOPAUSE; PROGESTERONE BLOOD LEVEL; PROSPECTIVE STUDY; REPRODUCTION; UNITED STATES; VITAMIN INTAKE;

ADOLESCENT; ADULT; ANOVULATION; DIETARY SUPPLEMENTS; FEMALE; FOLIC ACID; HUMANS; PREMENOPAUSE; PROGESTERONE; YOUNG ADULT;

EID: 84866881706     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0046276     Document Type: Article

References (37)

1. Czeizel AE, Dudas I, (1992) Prevention of the first occurrence of neural-tube defects by periconceptional vitamin supplementation. N Engl J Med 327: 1832-1835.
2. MRC Vitamin Study Research Group (1991) Prevention of neural tube defects: results of the Medical Research Council Vitamin Study. Lancet 338: 131-137.
3. Administration FaD (1996) Food standards: amendment of standards of identity for enriched grain products to require addition of folic acid. Federal Registry 61: 8781-8797.
4. Ray JG, (2004) Folic acid food fortification in Canada. Nutr Rev 62: S35-39.
5. Chen LT, Rivera MA, (2004) The Costa Rican experience: reduction of neural tube defects following food fortification programs. Nutr Rev 62: S40-43.
6. Hertrampf E, Cortes F (2004) Folic acid fortification of wheat flour: Chile. Nutr Rev 62: S44-48; discussion S49.
7. Ebisch IM, Thomas CM, Peters WH, Braat DD, Steegers-Theunissen RP, (2007) The importance of folate, zinc and antioxidants in the pathogenesis and prevention of subfertility. Hum Reprod Update 13: 163-174.
8. Matte JJ, Girard CL, Brisson GJ, (1984) Folic acid and reproductive performances of sows. J Anim Sci 59: 1020-1025.
9. Willmott M, Bartosik DB, Romanoff EB, (1968) The effect of folic acid on superovulation in the immature rat. J Endocrinol 41: 439-445.
10. Westphal LM, Polan ML, Trant AS, Mooney SB, (2004) A nutritional supplement for improving fertility in women: a pilot study. J Reprod Med 49: 289-293.
11. Czeizel AE, Metneki J, Dudas I, (1996) The effect of preconceptional multivitamin supplementation on fertility. Int J Vitam Nutr Res 66: 55-58.
12. Chavarro JE, Rich-Edwards JW, Rosner BA, Willett WC, (2008) Use of multivitamins, intake of B vitamins, and risk of ovulatory infertility. Fertil Steril 89: 668-676.
13. Forges T, Monnier-Barbarino P, Alberto JM, Gueant-Rodriguez RM, Daval JL, et al. (2007) Impact of folate and homocysteine metabolism on human reproductive health. Hum Reprod Update 13: 225-238.
14. Wactawski-Wende J, Schisterman EF, Hovey KM, Howards PP, Browne RW, et al. (2009) BioCycle study: design of the longitudinal study of the oxidative stress and hormone variation during the menstrual cycle. Paediatr Perinat Epidemiol 23: 171-184.
15. Howards PP, Schisterman EF, Wactawski-Wende J, Reschke JE, Frazer AA, et al. (2009) Timing clinic visits to phases of the menstrual cycle by using a fertility monitor: the BioCycle Study. Am J Epidemiol 169: 105-112.
16. Browne RW, Bloom MS, Schisterman EF, Wactawski-Wende J, Hovey K, et al. (2009) Analytical and biological variation of F2-isoprostanes during the menstrual cycle. Clin Chem 55: 1245-1247.
17. Bailey LB, (1998) Dietary reference intakes for folate: the debut of dietary folate equivalents. Nutr Rev 56: 294-299.
18. Gaskins AJ, Mumford SL, Zhang C, Wactawski-Wende J, Hovey KM, et al. (2009) Effect of daily fiber intake on reproductive function: the BioCycle Study. Am J Clin Nutr 90: 1061-1069.
19. Mumford SL, Schisterman EF, Gaskins AJ, Pollack AZ, Perkins NJ, et al. (2011) Realignment and multiple imputation of longitudinal data: an application to menstrual cycle data. Paediatr Perinat Epidemiol 25: 448-459.
20. Craig CL, Marshall AL, Sjostrom M, Bauman AE, Booth ML, et al. (2003) International physical activity questionnaire: 12-country reliability and validity. Med Sci Sports Exerc 35: 1381-1395.
21. Cole SR, Hernan MA, (2008) Constructing inverse probability weights for marginal structural models. Am J Epidemiol 168: 656-664.
22. Robins JM, Hernan MA, Brumback B, (2000) Marginal structural models and causal inference in epidemiology. Epidemiology 11: 550-560.
23. McMahon JM, Pouget ER, Tortu S, (2006) A guide for multilevel modeling of dyadic data with binary outcomes using SAS PROC NLMIXED. Comput Stat Data Anal 50: 3663-3680.
24. Weng HY, Hsueh YH, Messam LL, Hertz-Picciotto I, (2009) Methods of covariate selection: directed acyclic graphs and the change-in-estimate procedure. Am J Epidemiol 169: 1182-1190.
25. Lewis CJ, Crane NT, Wilson DB, Yetley EA, (1999) Estimated folate intakes: data updated to reflect food fortification, increased bioavailability, and dietary supplement use. Am J Clin Nutr 70: 198-207.
26. Verkleij-Hagoort AC, de Vries JH, Stegers MP, Lindemans J, Ursem NT, et al. (2007) Validation of the assessment of folate and vitamin B12 intake in women of reproductive age: the method of triads. Eur J Clin Nutr 61: 610-615.
27. Haggarty P, McCallum H, McBain H, Andrews K, Duthie S, et al. (2006) Effect of B vitamins and genetics on success of in-vitro fertilisation: prospective cohort study. Lancet 367: 1513-1519.
28. Mohanty D, Das KC, (1982) Effect of folate deficiency on the reproductive organs of female rhesus monkeys: a cytomorphological and cytokinetic study. J Nutr 112: 1565-1576.
29. Westphal LM, Polan ML, Trant AS, (2006) Double-blind, placebo-controlled study of Fertilityblend: a nutritional supplement for improving fertility in women. Clin Exp Obstet Gynecol 33: 205-208.
30. Szymanski W, Kazdepka-Zieminska A, (2003) [Effect of homocysteine concentration in follicular fluid on a degree of oocyte maturity]. Ginekol Pol 74: 1392-1396.
31. Thaler CJ, Budiman H, Ruebsamen H, Nagel D, Lohse P, (2006) Effects of the common 677C>T mutation of the 5,10-methylenetetrahydrofolate reductase (MTHFR) gene on ovarian responsiveness to recombinant follicle-stimulating hormone. Am J Reprod Immunol 55: 251-258.
32. Hecht S, Pavlik R, Lohse P, Noss U, Friese K, et al. (2009) Common 677C->T mutation of the 5,10-methylenetetrahydrofolate reductase gene affects follicular estradiol synthesis. Fertil Steril 91: 56-61.
33. Mohanty D, Dash RJ, Das KC, (1976) Effect of experimentally induced folate deficiency on ovarian hormones. Abstract at the 16th Int Cong Haematol. Kyoto, Japan. 2: 66.
34. McNulty H, Pentieva K, (2004) Folate bioavailability. Proc Nutr Soc 63: 529-536.
35. National Research Council. (1998) Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline: The National Academies Press.
36. Yang Q, Cogswell ME, Hamner HC, Carriquiry A, Bailey LB, et al. (2010) Folic acid source, usual intake, and folate and vitamin B-12 status in US adults: National Health and Nutrition Examination Survey (NHANES) 2003-2006. Am J Clin Nutr 91: 64-72.
37. Flegal KM, Keyl PM, Nieto FJ, (1991) Differential misclassification arising from nondifferential errors in exposure measurement. Am J Epidemiol 134: 1233-1244.