Effects of nitric oxide-releasing nonsteroidal anti-inflammatory drugs (NONO-NSAIDs) on melanoma cell adhesion

Toxicology and Applied Pharmacology

Volumn 264, Issue 2, 2012, Pages 161-166

  Cheng, Huiwen ^a   Mollica, Molly Y ^a   Lee, Shin Hee ^a   Wang, Lei ^a   Velázquez Martínez, Carlos A ^b,c   Wu, Shiyong ^a  

^a OHIO UNIVERSITY   (United States)

^b SAIC FREDERICK INC   (United States)

^c UNIVERSITY OF ALBERTA   (Canada)

Author keywords

Cell adhesion; Integrin; Melanoma; NONO NASAIDs

Indexed keywords

ACETYLSALICYLIC ACID; ALPHA4 INTEGRIN; BETA1 INTEGRIN; FIBRONECTIN; NAPROXEN; NITRIC OXIDE RELEASING ACETYLSALICYLIC ACID; NITRIC OXIDE RELEASING NAPROXEN; UNCLASSIFIED DRUG; VASCULAR CELL ADHESION MOLECULE 1; VERY LATE ACTIVATION ANTIGEN 4;

APOPTOSIS; ARTICLE; BINDING AFFINITY; CELL ADHESION; CONTROLLED STUDY; CYTOFLUOROMETRY; DRUG STRUCTURE; DRUG SYNTHESIS; FLUID FLOW; HUMAN; HUMAN CELL; MELANOMA CELL; PROTEIN EXPRESSION; WOUND HEALING;

ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; APOPTOSIS; ASPIRIN; AZO COMPOUNDS; CELL ADHESION; CELL LINE, TUMOR; CELL MOVEMENT; FIBRONECTINS; FLOW CYTOMETRY; HUMANS; INTEGRINS; MELANOMA; NAPROXEN; NEOPLASM METASTASIS; NITRIC OXIDE; NITRIC OXIDE DONORS; RECEPTORS, VERY LATE ANTIGEN; VASCULAR CELL ADHESION MOLECULE-1; WOUND HEALING;

EID: 84866853719     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2012.07.029     Document Type: Article

References (26)

1. Abdellatif K.R., Chowdhury M.A., Dong Y., Das D., Yu G., Velazquez C.A., Suresh M.R., Knaus E.E. Dinitroglyceryl and diazen-1-ium-1,2-diolated nitric oxide donor ester prodrugs of aspirin, indomethacin and ibuprofen: synthesis, biological evaluation and nitric oxide release studies. Bioorg. Med. Chem. Lett. 2009, 19:3014-3018.
2. Baritaki S., Huerta-Yepez S., Sahakyan A., Karagiannides I., Bakirtzi K., Jazirehi A., Bonavida B. Mechanisms of nitric oxide-mediated inhibition of EMT in cancer: inhibition of the metastasis-inducer Snail and induction of the metastasis-suppressor RKIP. Cell Cycle 2010, 9:4931-4940.
3. Bischofs E., Lubs D., Fritzsche F., Meyer A.S., Bruckner T., Sohn C., Eichbaum M.H. In vitro blockade of adhesion of breast cancer cells to endothelial cells using anti-inflammatory drugs. Anticancer Res. 2012, 32:767-771.
4. Chattopadhyay M., Goswami S., Rodes D.B., Kodela R., Velazquez C.A., Boring D., Crowell J.A., Kashfi K. NO-releasing NSAIDs suppress NF-kappaB signaling in vitro and in vivo through S-nitrosylation. Cancer Lett. 2010, 298:204-211.
5. Flores-Santana W., Moody T., Chen W., Gorczynski M.J., Shoman M.E., Velazquez C., Thetford A., Mitchell J.B., Cherukuri M.K., King S.B., Wink D.A. Nitroxide derivatives of non-steroidal anti-inflammatory drugs exert anti-inflammatory and superoxide dismutase scavenging properties in A459 cells. Br. J. Pharmacol. 2012, 165:1058-1067.
6. Jones D.A., Smith C.W., McIntire L.V. Leucocyte adhesion under flow conditions: principles important in tissue engineering. Biomaterials 1996, 17:337-347.
7. Juliano R.L., Varner J.A. Adhesion molecules in cancer: the role of integrins. Curr. Opin. Cell Biol. 1993, 5:812-818.
8. Lahdenranta J., Hagendoorn J., Padera T.P., Hoshida T., Nelson G., Kashiwagi S., Jain R.K., Fukumura D. Endothelial nitric oxide synthase mediates lymphangiogenesis and lymphatic metastasis. Cancer Res. 2009, 69:2801-2808.
9. Lichtenberger L.M., Zhou Y., Dial E.J., Raphael R.M. NSAID injury to the gastrointestinal tract: evidence that NSAIDs interact with phospholipids to weaken the hydrophobic surface barrier and induce the formation of unstable pores in membranes. J. Pharm. Pharmacol. 2006, 58:1421-1428.
10. Liu W., Wu S. The roles of Akt and NOSs in regulation of VLA-4-mediated melanoma cell adhesion to endothelial VCAM-1 after UVB-irradiation. Arch. Biochem. Biophys. 2011, 508:192-197.
11. Ng S.C., Chan F.K. NSAID-induced gastrointestinal and cardiovascular injury. Curr. Opin. Gastroenterol. 2010, 26:611-617.
12. Noreen Y., Ringbom T., Perera P., Danielson H., Bohlin L. Development of a radiochemical cyclooxygenase-1 and -2 in vitro assay for identification of natural products as inhibitors of prostaglandin biosynthesis. J. Nat. Prod. 1998, 61:2-7.
13. Pillinger M.H., Capodici C., Rosenthal P., Kheterpal N., Hanft S., Philips M.R., Weissmann G. Modes of action of aspirin-like drugs: salicylates inhibit erk activation and integrin-dependent neutrophil adhesion. Proc. Natl. Acad. Sci. U. S. A. 1998, 95:14540-14545.
14. Postovit L.M., Adams M.A., Lash G.E., Heaton J.P., Graham C.H. Nitric oxide-mediated regulation of hypoxia-induced B16F10 melanoma metastasis. Int. J. Cancer 2004, 108:47-53.
15. Potter M.B. NSAIDs alone or with opioids as therapy for cancer pain. Am. Fam. Physician 2005, 72:436-437.
16. Shi Q., Xiong Q., Wang B., Le X., Khan N.A., Xie K. Influence of nitric oxide synthase II gene disruption on tumor growth and metastasis. Cancer Res. 2000, 60:2579-2583.
17. Singh G., Triadafilopoulos G. Epidemiology of NSAID induced gastrointestinal complications. J. Rheumatol. Suppl. 1999, 56:18-24.
18. Tang X.P., Xian M., Trikha M., Honn K.V., Wang P.G. Synthesis of peptide-diazeniumdiolate conjugates: towards enzyme activated antitumor agents. Tetrahedron Lett. 2001, 42:2625-2629.
19. Tsai W.H., Chang C.W., Lin Y.S., Chuang W.J., Wu J.J., Liu C.C., Tsai P.J., Lin M.T. Streptococcal pyrogenic exotoxin B-induced apoptosis in A549 cells is mediated through alpha(v)beta(3) integrin and Fas. Infect. Immun. 2008, 76:1349-1357.
20. Tschugguel W., Pustelnik T., Lass H., Mildner M., Weninger W., Schneeberger C., Jansen B., Tschachler E., Waldhor T., Huber J.C., Pehamberger H. Inducible nitric oxide synthase (iNOS) expression may predict distant metastasis in human melanoma. Br. J. Cancer 1999, 79:1609-1612.
21. Velazquez C., Rao P.N.P., Knaus E.E. Novel nonsteroidal antiinflammatory drugs possessing a nitric oxide donor diazen-1-ium-1,2-diolate moiety: design, synthesis, biological evaluation, and nitric oxide release studies. J. Med. Chem. 2005, 48:4061-4067.
22. Velazquez C.A., Praveen Rao P.N., Citro M.L., Keefer L.K., Knaus E.E. O2-acetoxymethyl-protected diazeniumdiolate-based NSAIDs (NONO-NSAIDs): synthesis, nitric oxide release, and biological evaluation studies. Bioorg. Med. Chem. 2007, 15:4767-4774.
23. Velazquez C.A., Chen Q.H., Citro M.L., Keefer L.K., Knaus E.E. Second-generation aspirin and indomethacin prodrugs possessing an O(2)-(acetoxymethyl)-1-(2-carboxypyrrolidin-1-yl)diazenium-1,2-diolate nitric oxide donor moiety: design, synthesis, biological evaluation, and nitric oxide release studies. J. Med. Chem. 2008, 51:1954-1961.
24. Wallace J.L., McKnight W., Del Soldato P., Baydoun A.R., Cirino G. Anti-thrombotic effects of a nitric oxide-releasing, gastric-sparing aspirin derivative. J. Clin. Invest. 1995, 96:2711-2718.
25. Wang L., Shirure V.S., Burdick M.M., Wu S. UVB-irradiation regulates VLA-4-mediated melanoma cell adhesion to endothelial VCAM-1 under flow conditions. Mol. Carcinog. 2011, 50:58-65.
26. Yang Y.C., Ho T.C., Chen S.L., Lai H.Y., Wu J.Y., Tsao Y.P. Inhibition of cell motility by troglitazone in human ovarian carcinoma cell line. BMC Cancer 2007, 7:216.