Gβ2 and Gβ4 participate in the opioid and adrenergic receptor-mediated Ca2+ channel modulation in rat sympathetic neurons

Journal of Physiology

Volumn 590, Issue 19, 2012, Pages 4673-4689

  Mahmoud, Saifeldin ^a   Yun, Jong K ^a   Ruiz Velasco, Victor ^a  

^a PENN STATE COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADRENERGIC RECEPTOR; CALCIUM CHANNEL; CALCIUM ION; GUANINE NUCLEOTIDE BINDING PROTEIN BETA SUBUNIT; GUANINE NUCLEOTIDE BINDING PROTEIN BETA1 SUBUNIT; GUANINE NUCLEOTIDE BINDING PROTEIN BETA2 SUBUNIT; GUANINE NUCLEOTIDE BINDING PROTEIN BETA4 SUBUNIT; NOCICEPTIN; NOCICEPTIN RECEPTOR; NORADRENALIN; OPIATE; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CALCIUM CURRENT; CALCIUM SIGNALING; CHANNEL GATING; CONTROLLED STUDY; EMBRYO; GENE SILENCING; HUMAN; HUMAN CELL; MALE; NEUROMODULATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; RAT; RNA INTERFERENCE; STELLATE GANGLION;

ANIMALS; CALCIUM CHANNELS; GENE KNOCKDOWN TECHNIQUES; GTP-BINDING PROTEIN BETA SUBUNITS; HEK293 CELLS; HUMANS; MALE; NEURONS; RATS; RATS, WISTAR; RECEPTORS, ADRENERGIC; RECEPTORS, OPIOID; RNA, SMALL INTERFERING; STELLATE GANGLION;

EID: 84866840074     PISSN: 00223751     EISSN: 14697793     Source Type: Journal    
DOI: 10.1113/jphysiol.2012.237644     Document Type: Article

References (36)

1. 1A calcium channels by different G protein β subunit isoforms. J Physiol 527, 203-212.
2. Blumer JB, Smrcka AV & Lanier SM. Mechanistic pathways and biological roles for receptor-independent activators of G-protein signaling (2007). Pharmacol Ther 113, 488-506.
3. 2+ current via Gαo in rat sympathetic neurones. J Physiol 477, 415-422.
4. Chen P-S, Chen LS, Cao J-M, Sharifi B, Karagueuzian HS & Fishbein MC (2001). Sympathetic nerve sprouting, electrical remodeling and the mechanisms of sudden cardiac death. Cardiovasc Res 50, 409-416.
5. 2+ channels in rat sympathetic neurones. J Physiol 518, 23-36.
6. 2+ channels in mammalian central neurons. Trends Neurosci 18, 89-98.
7. Fuller BC, Sumner AD, Kutzler MA & Ruiz-Velasco V (2004). A novel approach employing ultrasound guidance for percutaneous cardiac muscle injection to retrograde label rat stellate ganglion neurons. Neurosci Lett 363, 252-256.
8. 2+ channels. J Neurosci 18, 9163-9170.
9. Giuliani S & Maggi CA (1997). Prejunctional modulation by nociceptin of nerve-mediated inotropic responses in guinea-pig left atrium. Eur J Pharmacol 332, 231-236.
10. Haunstetter A, Icking BS, Backs J, Kruger C & Haass M (2002). Differential effects of acidosis, high potassium concentrations, and metabolic inhibition on noradrenaline release and its presynaptic muscarinic regulation. Pharmacol Res 45, 221-228.
11. Hwang J-I, Fraser IDC, Choi S, Qin X-F & Simon MI (2004). Analysis of C5a-mediated chemotaxis by lentiviral delivery of small interfering RNA. Proc Natl Acad Sci U S A 101, 488-493.
12. Hwang J-I, Choi S, Fraser IDC, Chang MIS & Simon MI (2005). Silencing the expression of multiple Gβ-subunits eliminates signaling mediated by all four families of G proteins. Proc Natl Acad Sci U S A 102, 9493-9498.
13. Jayaraman M, Zhou H, Jia L, Cain MD & Blumer KJ (2009). R9AP and R7BP: traffic cops for the RGS7 family in phototransduction and neuronal GPCR signaling. Trends Pharmacol Sci 30, 17-24.
14. Ikeda SR (1991). Double-pulse calcium channel current facilitation in adult rat sympathetic neurones. J Physiol 439, 181-214.
15. 2+ channel modulation in sympathetic neurons. Proc Natl Acad Sci U S A 97, 907-912.
16. Kammermeier PJ, Davis MI & Ikeda SR (2003). Specificity of metabotropic glutamate receptor 2 coupling to G proteins. Mol Pharm 63, 183-191.
17. Kleuss C, Hescheler J, Ewel C, Rosenthal W, Schultz G & Wittig B (1991). Assignment of G-protein subtypes to specific receptors inducing inhibition of calcium currents. Nature 353, 43-48.
18. Krummins AM & Gilman AG (2006). Targeted knockdown of G protein subunits selectively prevents receptor-mediated modulation of effectors and reveals complex changes in non-targeted signaling proteins. J Biol Chem 281, 10250-10262.
19. Lambert NA (2008). Dissociation of heterotrimeric G proteins in cells. Sci Signal 1, 1-5.
20. Malinowsk B, Piszcz J, Koneczny B, Hryniewicz A & Schlicker E (2001). Modulation of the cardiac autonomic transmission of pithed rats by presynaptic opioid OP4 and cannabinoid CB1 receptors. Naunyn Schmiedebergs Arch Pharmacol 364, 233-241.
21. Margas W, Sedeek K & Ruiz-Velasco V (2008). Coupling specificity of NOP opioid receptors to pertussis-toxin-sensitive Gα proteins in adult rat stellate ganglion neurons using small interference RNA. J Neurophysiol 100, 1420-1432.
22. Okae H & Iwakura Y (2010). Neural tube defects and impaired neural progenitor cell proliferation in Gβ1-deficient mice. Dev Dyn 239, 1089-1101.
23. Oldham WM & Hamm HE (2008). Heterotrimeric G protein activation by G-protein-coupled receptors. Nat Rev Mol Cell Biol 9, 60-71.
24. Pardini BJ, Lund DD & Schmid PG (1990). Innervation patterns of the middle cervical-stellate ganglion complex in the rat. Neurosci Lett 117, 300-306.
25. Reynolds A, Leake D, Boese Q, Scaringe S, Marshall WS & Khvorova A (2004). Rational siRNA design for RNA interference. Nat Biotechnol 22, 326-330.
26. Ruiz-Velasco V & Ikeda SR (2000). Multiple G-protein βγ combinations produce voltage-dependent inhibition of N-type calcium channels in rat superior cervical ganglion neurons. J Neurosci 20, 2183-2191.
27. Ruiz-Velasco V & Ikeda SR (2003). A splice variant of the G protein β3-subunit implicated in disease states does not modulate ion channels. Physiol Genomics 13, 85-95.
28. 2+ channels by opioid receptor-like 1 receptors natively expressed in rat stellate ganglion neurons innervating cardiac muscle. J Pharmacol Exp Ther 314, 987-994.
29. Schomig A & Richardt G (1990). Cardiac sympathetic activity in myocardial ischemia: Release and effects of noradrenaline. Basic Res Cardiol 85, 9-30.
30. Siffert W, Rosskopf D, Siffert G, Busch S, Moritz A, Erbel R, Sharma AM, Ritz E, Wichmann EH, Jakobs KH & Horsthemke B (1998). Association of a human G-protein β3 subunit variant with hypertension. Nat Genet 18, 45-48.
31. Siffert W (2005). G protein polymorphisms in hypertension, atherosclerosis, and diabetes. Annu Rev Med 56, 17-28.
32. Smrcka AV (2008). G protein βγ subunits: Central mediators of G protein-coupled receptor signaling. Cell Mol Life Sci 65, 2191-2214.
33. Straiker AJ, Borden CR & Sullivan JM (2002). G-protein alpha subunit isoforms couple differentially to receptors that mediate presynaptic inhibition at rat hippocampal synapses. J Neurosci 22, 2460-2468.
34. Zamponi GW (2001). Determinants of G protein inhibition of presynaptic calcium channels. Cell Biochem Biophys 34, 79-94.
35. Zhang Y, Tang W, Jones MC, Xu W, Halene S & Wu D (2010). Different roles of G protein subunits β1 and β2 in neutrophil function revealed by gene expression silencing in primary mouse neutrophils. J Biol Chem 285, 24 805-24 814.
36. Zhou JY, Siderovski DP & Miller RJ (2000). Selective regulation of N-type Ca channels by different combinations of G-protein β/γ subunits and RGS proteins. J Neurosci 20, 7143-7148.