Toward real-time virtual biopsy of oral lesions using confocal laser endomicroscopy interfaced with embedded computing

Journal of Biomedical Optics

Volumn 17, Issue 5, 2012, Pages

  Thong, Patricia S P ^a   Tandjung, Stephanus S ^b   Movania, Muhammad Mobeen ^b   Chiew, Wei Ming ^b   Olivo, Malini ^a,c   Bhuvaneswari, Ramaswamy ^a   Seah, Hock Soon ^b   Lin, Feng ^b   Qian, Kemao ^b   Soo, Khee Chee ^a  

^a DIVISION OF MEDICAL ONCOLOGY   (Singapore)

^b NANYANG TECHNOLOGICAL UNIVERSITY   (Singapore)

^c Agency for Science   (Singapore)

Author keywords

3 D fluorescence imaging; Confocal laser endomicroscopy; Embedded computing; Oral cancer; Virtual biopsy; Volume rendering

Indexed keywords

ANIMAL; ARTICLE; BAGG ALBINO MOUSE; CAPSULE ENDOSCOPY; COMPUTER ASSISTED DIAGNOSIS; COMPUTER ASSISTED SURGERY; COMPUTER INTERFACE; COMPUTER SYSTEM; CONFOCAL MICROSCOPY; HUMAN; IMAGE ENHANCEMENT; INSTRUMENTATION; MOUSE; MOUTH TUMOR; NEEDLE BIOPSY; NUDE MOUSE; PATHOLOGY; REPRODUCIBILITY; SENSITIVITY AND SPECIFICITY; SIGNAL PROCESSING;

ANIMALS; BIOPSY, NEEDLE; CAPSULE ENDOSCOPY; COMPUTER SYSTEMS; HUMANS; IMAGE ENHANCEMENT; IMAGE INTERPRETATION, COMPUTER-ASSISTED; MICE; MICE, INBRED BALB C; MICE, NUDE; MICROSCOPY, CONFOCAL; MOUTH NEOPLASMS; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; SIGNAL PROCESSING, COMPUTER-ASSISTED; SURGERY, COMPUTER-ASSISTED; USER-COMPUTER INTERFACE;

EID: 84866781750     PISSN: 10833668     EISSN: 15602281     Source Type: Journal    
DOI: 10.1117/1.JBO.17.5.056009     Document Type: Article

References (54)

1. M. Garcia et al., Global Cancer Facts and Figures 2007, American Cancer Society, Atlanta, GA, 1-46 (2007).
2. A. Jernel et al., "Global cancer statistics," CA Cancer J. Clin. 61(2), 69-90 (2011).
3. B. W. Neville and T. A. Day, "Oral cancer and precancerous lesions," CA Cancer J. Clin. 52(4), 195-215 (2002).
4. B. A. Flusberg et al., "Fiber-optic fluorescence imaging," Nat. Methods 2(12), 941-950 (2005). (Pubitemid 43108730)
5. R. Kiesslich and M. I. Canto, "Confocal laser endomicroscopy," Gastrointest. Endosc. Clin. North Am. 19(2), 261-272 (2009).
6. H. Neumann et al., "Confocal laser endomicroscopy: technical advances and clinical applications," Gastroenterology 139(2), 388-392 (2010).
7. R. Kiesslich, M. Goetz, and M. F. Neurath, "Virtual histology," Best Pract. Res. Clin. Gastroenterol. 22(5), 883-897 (2008).
8. R. Singh et al., "Real-time histology with the endocytoscope," World J. Gastroenterol. 16(40), 5016-5019 (2010).
9. A. L. Carlson et al., "Confocal microscopy and molecular-specific optical contrast agents for the detection of oral neoplasia," Technol. Cancer Res. Treat. 6(5), 361-374 (2007). (Pubitemid 47613284)
10. P. Delaney and M. Harris, "Fiber-optics in scanning optical microscopy," in Handbook of Biological Confocal Microscopy, 3rd ed., J. B. Pawley, Ed., pp. 501-515, Springer Science+Business Media, New York, NY (2006).
11. G. Le Goualher et al., "Towards optical biopsies with an integrated fibered confocal fluorescence microscope," in Proc. of the MICCAI'04, Springer-Verlag, Berlin/Heidelberg, 761-768 (2004). (Pubitemid 40787294)
12. L. Thiberville et al., "Confocal fluorescence endomicroscopy of the human airways," in Proc. Am. Thorac. Soc. 6(5), pp. 444-449 (2009).
13. L. Thiberville and M. Salaün, "Bronchoscopic advances: on the way to the cells," Respiration 79(6), 441-449 (2010).
14. F. S. Fuchs et al., "Fluorescein-aided confocal laser endomicroscopy of the lung," Respiration 81(1), 32-38 (2011).
15. A. L. Polglase, W. J. McLaren, and P. M. Delaney, "Pentax confocal endomicroscope: a novel imaging device for in vivo histology of the upper and lower gastrointestinal tract," Expert Rev. Med. Devices 3(5), 549-556 (2006). (Pubitemid 44650444)
16. M. Goetz and R. Kiesslich, "Advances of endomicroscopy for gastrointestinal physiology and diseases," Am. J. Physiol. Gastrointest. Liver Physiol. 298(6), G797-G806 (2010).
17. M. I. Canto, "Endomicroscopy of Barrett's Esophagus," Gastroenterol. Clin. North Am. 39(4), 759-769 (2010).
18. R. Kiesslich, "Screening: Endomicroscopy for a reliable diagnosis of colorectal neoplasia," Nat. Rev. Gastroenterol. Hepatol. 7(8), 422-423 (2010).
19. K. Venkatesh et al., "Role of confocal endomicroscopy in the diagnosis of celiac disease," J. Pediatr. Gastroenterol. Nutr. 51(3), 274-279 (2010).
20. Z. Li et al., "Confocal laser endomicroscopy for in vivo diagnosis of gastric intraepithelial neoplasia: a feasibility study," Gastrointest. Endosc. 72(6), 1146-1153 (2010).
21. M. Goetz, A. Watson, and R. Kiesslich, "Confocal laser endomicroscopy in gastrointestinal diseases," J. Biophotonics 4(7-8), 498-508 (2011).
22. X. J. Xie et al., "Differentiation of colonic polyps by confocal laser endomicroscopy," Endoscopy 43(2), 87-93 (2011).
23. P. Sharma et al., "Real-time increased detection of neoplastic tissue in Barrett's esophagus with probe-based confocal laser endomicroscopy: final results of an international multicenter, prospective, randomized, controlled trial," Gastrointest. Endosc. 74(3), 465-472 (2011).
24. G. A. Sonn et al., "Optical biopsy of human bladder neoplasia with in vivo confocal laser endomicroscopy," J. Urol. 182(4), 1299-1305 (2009).
25. C. Wiesner et al., "Confocal laser endomicroscopy for the diagnosis of urothelial bladder neoplasia: a technology of the future?," BJU Int. 107(3), 399-403 (2011).
26. J. Tan, P. Delaney, and W. J. McLaren, "Confocal endomicroscopy: a novel imaging technique for in vivo histology of cervical intraepithelial neoplasia," Expert Rev. Med. Devices 4(6), 863-871 (2007).
27. J. Tan et al., "Detection of cervical intraepithelial neoplasia in vivo using confocal endomicroscopy," BJOG 116(12), 1663-1670 (2009).
28. W. Zheng et al., "Confocal endomicroscopic imaging of normal and neoplastic human tongue tissue using ALA-induced-PPIX fluorescence: a preliminary study," Oncol. Rep. 12(2), 397-401 (2004).
29. P. S. Thong et al., "Development of a laser confocal endomicroscope for in vivo fluorescence imaging," J. Mech. Med. Biol. 7(1), 1-8 (2007).
30. P. S. Thong et al., "Laser confocal endomicroscopy as a novel technique for fluorescence diagnostic imaging of the oral cavity," J. Biomed. Opt. 12(1), 014007 (2007).
31. B. R. Haxel et al., "Confocal endomicroscopy: a novel application for imaging of oral and oropharyngeal mucosa in human," Eur. Arch. Otorhinolaryngol. 267(3), 443-448 (2010).
32. U Günther et al., "Surveillance colonoscopy in patients with inflammatory bowel disease: comparison of random biopsy vs. targeted biopsy protocols," Int. J. Colorectal Dis. 26(5), 667-672 (2011).
33. N. Q. Nguyen, "Real time intraoperative confocal laser microscopyguided surgery," Ann. Surg. 249(5), 735-737 (2009).
34. M. B.Wallace et al., "The safety of intravenous fluorescein for confocal laser endomicroscopy in the gastrointestinal tract," Aliment. Pharmacol. Ther. 31(5), 548-552 (2010).
35. M. A. D'Hallewin, L. Bezdetnaya, and F. Guillemin, "Fluorescence detection of bladder cancer: a review," Eur. Urol. 42(5), 417-425 (2002). (Pubitemid 35396724)
36. D. L. Campbell et al., "Detection of early stages of carcinogenesis in adenomas of murine lung by 5-aminolevulinic acid-induced protoporphyrin IX fluorescence," Photochem. Photobiol. 64(4), 676-682 (1996). (Pubitemid 27004985)
37. L. S. Cheong et al., "Embedded computing for fluorescence confocal endomicroscopy imaging," J. Signal Process. Syst. 55(1-3), 217-228 (2009).
38. P. S. Thong et al., "Detection and diagnosis of human oral cancer using hypericin fluorescence endoscopic imaging interfaced with embedded computing," in Proc. SPIE 7380, 73806U (2009).
39. S. S. Tandjung et al., "Synchronized volumetric cell image acquisition with FPGA-controlled endomicroscope," in Proceeding of the International Conference on Embedded Systems and Applications, pp. 61-67, ESA'09, CSREA Press, USA (2009).
40. P. S. Thong et al., "Hypericin fluorescence imaging of oral cancer: From endoscopy to real-time 3-dimensional endomicroscopy," J. Med. Imag. Health Inf. 1(2), 139-143 (2011).
41. M. Goetz et al., "In-vivo confocal real-time mini-microscopy in animal models of human inflammatory and neoplastic diseases," Endoscopy 39(4), 350-356 (2007). (Pubitemid 46605935)
42. T. J. Cullip and U. Neumann, Accelerating Volume Reconstruction with 3-D Texture Hardware, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA (1994).
43. B. Cabral, N. Cam, and J. Foran, "Accelerated volume rendering and tomographic reconstruction using texture mapping hardware," in Proc. of the 1994 Symposium on Volume Visualization Tysons Corner, ACM, Virginia, USA (1994).
44. A. Van Gelder and K. Kim, "Direct volume rendering with shading via three-dimensional textures," in Proc. of the 1996 Symposium on Volume Visualization, IEEE Press, San Francisco, CA (1996).
45. R. Westermann and T. Ertl, "Efficiently using graphics hardware in volume rendering applications," in Proc. of the 25th Annual Conference on Computer Graphics and Interactive Techniques, ACM, New York, NY, USA (1998).
46. F. Dachille et al., "High-quality volume rendering using texture mapping hardware," in Proc. of the ACM SIGGRAPH/EUROGRAPHICS Workshop on Graphics Hardware, ACM, Lisbon, Portugal(1998).
47. B. Lichtenbelt, R. Crane, and S. Naqvi, Introduction to Volume Rendering, Hewlett-Packard Professional Books, Prentice-Hall, Inc., New Jersey, pp. 1-120 (1998).
48. K. Engel et al., Real-Time Volume Graphics, A. K. Peters, Ltd., USA, 47-273, (2006).
49. B. Preim and D. Bartz, "Algorithms for direct volume visualization," Chapter 9, in Visualization in Medicine: Theory, Algorithm and ApplicationsB. Preim and D. Bartz, Eds. pp. 197-288, Elsevier, Inc., Burlington, MA (2007).
50. M. Meissner, U. Hoffmann, and W. Strasser, "Enabling classification and shading for 3-D texture mapping based volume rendering using openGL and extensions," in Proc. of the Conference on Visualization '99: Celebrating Ten Years, IEEE Computer Society Press, San Francisco, CA (1999).
51. C. Rezk-Salama et al., "Interactive volume on standard PC graphics hardware using multi-textures and multi-stage rasterization," in Proc. of the ACM SIGGRAPH/EUROGRAPHICS Workshop on Graphics Hardware, ACM, Interlaken, Switzerland (2000).
52. M. M. Movania et al., "Automated local adaptive thresholding for real-time feature detection and rendering of 3-D endomicroscopy images on GPU," Proc. of the 2009 Int. Conf. on Computer Graphics and Virtual Reality, CGVR 2009, CSREA Press, USA (2009).
53. M. M. Movania et al., "GPU-based surface oriented interslice directional interpolation for volume visualization," Proc. of the 2nd Int. Symposium on Applied Sciences in Biomedical and Communication Technologies, Isabel pp. 1-5 (2009).
54. M. Levoy, "Display of surfaces from volume data," Comput. Graph. Appl. IEEE 8(3), 29-37 (1988).