Overcoming the low relaxivity of gadofosveset at high field with spin locking

Magnetic Resonance in Medicine

Volumn 68, Issue 4, 2012, Pages 1234-1238

  Richardson, O C ^a   Scott, M L J ^b   Tanner, S F ^a   Waterton, J C ^b   Buckley, D L ^a  

^a UNIVERSITY OF LEEDS   (United Kingdom)

^b ASTRAZENECA   (United Kingdom)

Author keywords

gadofosveset; relaxivity; spin locking

Indexed keywords

ALBUMIN BINDINGS; BOUND MOLECULES; CONTRAST AGENT; FIELD STRENGTHS; GADOFOSVESET; RELAXATION RATES; RELAXIVITY; SPIN-LOCKING;

BINDING ENERGY;

GADOFOSVESET; GADOLINIUM PENTETATE; GADOLINIUM PENTETATE MEGLUMINE; SERUM ALBUMIN;

ARTICLE; DRUG PROTEIN BINDING; IN VITRO STUDY; MAGNETIC FIELD; MEASUREMENT; RADIOLOGICAL PROCEDURES; SPIN LOCKING; STRENGTH;

EID: 84866740491     PISSN: 07403194     EISSN: 15222594     Source Type: Journal    
DOI: 10.1002/mrm.23316     Document Type: Article

References (28)

1. Aime S, Caravan P,. Biodistribution of gadolinium-based contrast agents, including gadolinium deposition. J Magn Reson Imaging 2009; 30: 1259-1267.
2. Lauffer RB, Parmelee DJ, Dunham SU, Ouellet HS, Dolan RP, Witte S, McMurry TJ, Walovitch RC,. MS-325: albumin-targeted contrast agent for MR angiography. Radiology 1998; 207: 529-538.
3. Caravan P, Cloutier NJ, Greenfield MT, McDermid SA, Dunham SU, Bulte JWM, Amedio JC Jr, Looby RJ, Supkowski RM, Horrocks Jr WD, McMurry TJ, Lauffer RB,. The interaction of MS-325 with human serum albumin and its effect on proton relaxation rates. J Am Chem Soc 2002; 124: 3152-3162.
4. Eldredge HB, Spiller M, Chasse JM, Greenwood MT, Caravan P,. Species dependence on plasma protein binding and relaxivity of the gadolinium-based MRI contrast agent MS-325. Invest Radiol 2006; 41: 229-243.
5. Barrett T, Kobayashi H, Brechbiel M, Choyke PL,. Macromolecular MRI contrast agents for imaging tumor angiogenesis. Eur J Radiol 2006; 60: 353-366.
6. Bremerich J, Bilecen D, Reimer P,. MR angiography with blood pool contrast agents. Eur Radiol 2007; 17: 3017-3024.
7. Muller RN, Raduchel B, Laurent S, Platzek J, Pierart C, Mareski P, Vander Elst L,. Physicochemical characterization of MS-325, a new gadolinium complex, by multinuclear relaxometry. Eur J Inorg Chem 1999: 1949-1955.
8. Rohrer M, Bauer H, Mintorovitch J, Requardt M, Weinmann H-J,. Comparison of magnetic properties of MRI contrast media solutions at different magnetic field strengths. Invest Radiol 2005; 40: 715-724.
9. 1 contrast agents. Contrast Media Mol Imaging 2009; 4: 89-100.
10. 1-rho imaging. J Comput Assist Tomogr 1985; 9: 1007-1011.
11. Redfield AG,. Nuclear magnetic resonance saturation and rotary saturation in solids. Phys Rev 1955; 98: 1787-1809.
12. Martirosian P, Rommel E, Schick F, Deimling M,. Control of susceptibility-related image contrast by spin-lock techniques. Magn Reson Imaging 2008; 26: 1381-1387.
13. Santyr GE, Henkelman RM, Bronskill MJ,. Spin locking for magnetic-resonance imaging with application to human-breast. Magn Reson Med 1989; 12: 25-37.
14. Aronen HJ, Abo Ramadan U, Peltonen TK, Markkola AT, Tanttu JI, Jääskeläinen J, Häkkinen A-M, Sepponen R,. 3D spin-lock imaging of human gliomas. Magn Reson Imaging 1999; 17: 1001-1010.
15. 1 rho magnetic resonance imaging of RIF-1 tumors in vivo: detection of early response to cyclophosphamide therapy. Cancer Res 2001; 61: 7747-7753.
16. 1 relaxation in the rotating frame as a sensitive MR imaging marker for gene therapy treatment response in rat glioma. Radiology 2007; 243: 796-803.
17. 1(rho)-weighted MR imaging-initial experience. Radiology 2004; 232: 606-610.
18. 1(rho) MRI of Alzheimer's disease. Neuroimage 2008; 41: 1199-1205.
19. Dixon WT, Oshinski JN, Trudeau JD, Arnold BC, Pettigrew RI,. Myocardial suppression in vivo by spin locking with composite pulses. Magn Reson Med 1996; 36: 90-94.
20. 1 rho, dGEMRIC and contrast-enhanced computed tomography. Magn Reson Imaging 2009; 27: 779-784.
21. 1Ï dispersion in a tissue model. Magn Reson Med 2011; 66: 1563-1571.
22. 1-rho dispersion weighted NMR-spectroscopy. Magn Reson Med 1989; 12: 390-399.
23. Henkelman RM,. Measurement of signal intensities in the presence of noise in MR images. Med Phys 1985; 12: 232-233.
24. 1 rho relaxation and its application to MR histology. Magn Reson Med 1996; 35: 781-786.
25. Santyr GE, Fairbanks EJ, Kelcz F, Sorenson JA,. Off-resonance spin locking for MR-imaging. Magn Reson Med 1994; 32: 43-51.
26. 1(rho) imaging of murine brain tumors at 4 T. Acad Radiol 2001; 8: 42-47.
27. Borthakur A, Wheaton AJ, Gougoutas AJ, Akella SV, Regatte RR, Charagundla SR, Reddy R,. In vivo measurement of T1rho dispersion in the human brain at 1.5 tesla. J Magn Reson Imaging 2004; 19: 403-409.
28. Wang Y, Spiller M, Caravan P,. Evidence for weak protein binding of commercial extracellular gadolinium contrast agents. Magn Reson Med 2010; 63: 609-616.