Partial nephrectomy after neoadjuvant administration of sunitinib facilitates preservation of a solitary kidney;Partielle Nephrektomie nach neoadjuvanter Therapie mit Sunitinib ermöglicht den Nierenerhalt bei Einzelniere

Aktuelle Urologie

Volumn 43, Issue 5, 2012, Pages 337-339

  Von Klot, C ^a   Becker, J U ^a   Grunwald V ^a   Peters, I ^a   Kuczyk, M A ^a   Merseburger, A S ^a  

^a HANNOVER MEDICAL SCHOOL   (Germany)

Author keywords

clear cell renal cell carcinoma; neoadjuvant therapy; partial nephrectomy; sunitinib; TKI

Indexed keywords

ANTINEOPLASTIC AGENT; INDOLE DERIVATIVE; PYRROLE DERIVATIVE; SUNITINIB;

ADJUVANT THERAPY; AGED; ARTICLE; CANCER STAGING; COMPUTER ASSISTED DIAGNOSIS; COMPUTER ASSISTED TOMOGRAPHY; CONSERVATIVE TREATMENT; FEMALE; HUMAN; KIDNEY CARCINOMA; KIDNEY TUMOR; METHODOLOGY; MULTIMODALITY CANCER THERAPY; NEPHRECTOMY; PATHOLOGY; RADIOGRAPHY;

AGED; ANTINEOPLASTIC AGENTS; CARCINOMA, RENAL CELL; COMBINED MODALITY THERAPY; FEMALE; HUMANS; IMAGE INTERPRETATION, COMPUTER-ASSISTED; INDOLES; KIDNEY NEOPLASMS; NEOADJUVANT THERAPY; NEOPLASM STAGING; NEPHRECTOMY; ORGAN SPARING TREATMENTS; PYRROLES; TOMOGRAPHY, X-RAY COMPUTED;

EID: 84866738517     PISSN: 00017868     EISSN: 14388820     Source Type: Journal    
DOI: 10.1055/s-0032-1314879     Document Type: Article

References (16)

1. Kirchner H., Merseburger A. S. Nebenwirkungen von zielgerichteten Medikamenten bei der Behandlung des metastasierenden Nierenzellkarzinoms. Onkologe: 2011; 17 155 162
2. Harshman Lc, Yu Rj, Allen Gi et al. Surgical outcomes and complications associated with presurgical tyrosine kinase inhibition for advanced renal cell carcinoma (RCC). Urol Oncol: 2011
3. Hellenthal Nj, Underwood W., Penetrante R. et al. Prospective clinical trial of preoperative sunitinib in patients with renal cell carcinoma. J Urol: 2010; 184 859 864
4. Huang Wc, Elkin Eb, Levey As et al. Partial nephrectomy versus radical nephrectomy in patients with small renal tumors is there a difference in mortality and cardiovascular outcomes? J Urol: 2009; 181 55 61 discussion 6152
5. Je Y., Schutz Fa, Choueiri Tk. Risk of bleeding with vascular endothelial growth factor receptor tyrosine-kinase inhibitors sunitinib and sorafenib: a systematic review and meta-analysis of clinical trials. Lancet Oncol: 2009; 10 967 974
6. Kamba T., Mcdonald Dm. Mechanisms of adverse effects of anti-VEGF therapy for cancer. Br J Cancer: 2007; 96 1788 1795 (Pubitemid 46912024)
7. Klatte T., Patard Jj, Wunderlich H. et al. Metachronous bilateral renal cell carcinoma: risk assessment, prognosis and relevance of the primary-free interval. J Urol: 2007; 177 2081 2086 discussion 20862087
8. Kramer M., Krege S., Peters I. et al. Targeted therapy of urological tumours. Experimental field or established therapeutic approach? Urologe A: 2010; 49 1260 1265
9. Miller Dc, Schonlau M., Litwin Ms et al. Renal and cardiovascular morbidity after partial or radical nephrectomy. Cancer: 2008; 112 511 520 (Pubitemid 351186192)
10. Motzer Rj, Michaelson Md, Redman Bg et al. Activity of SU11248, a multitargeted inhibitor of vascular endothelial growth factor receptor and platelet-derived growth factor receptor, in patients with metastatic renal cell carcinoma. J Clin Oncol: 2006; 24 16 24 (Pubitemid 46630489)
11. Motzer Rj, Rini Bi, Bukowski Rm et al. Sunitinib in patients with metastatic renal cell carcinoma. JAMA: 2006; 295 2516 2524 (Pubitemid 43854967)
12. Thomas Aa, Rini Bi, Lane Br et al. Response of the primary tumor to neoadjuvant sunitinib in patients with advanced renal cell carcinoma. J Urol: 2009; 181 518 523 discussion 523
13. Thomas Aa, Rini Bi, Stephenson Aj et al. Surgical resection of renal cell carcinoma after targeted therapy. J Urol: 2009; 182 881 886
14. Thompson Rh, Boorjian S. A., Lohse C. M. et al. Radical nephrectomy for pT1a renal masses may be associated with decreased overall survival compared with partial nephrectomy. J Urol: 2008; 179 468 471 discussion 463472
15. Van der Veldt Aa, Meijerink Mr, Van den Eertwegh Aj et al. Sunitinib for treatment of advanced renal cell cancer: primary tumor response. Clin Cancer Res: 2008; 14 2431 2436 (Pubitemid 351551077)
16. Weight Cj, Larson Bt, Fergany Af et al. Nephrectomy induced chronic renal insufficiency is associated with increased risk of cardiovascular death and death from any cause in patients with localized cT1b renal masses. J Urol: 2010; 183 1317 1323