Sitagliptin exerts anti-inflammatory and anti-allergic effects in ovalbumin-induced murine model of allergic airway disease

Naunyn-Schmiedeberg's Archives of Pharmacology

Volumn 385, Issue 9, 2012, Pages 909-919

  Nader, Manar A ^a   El Awady, Mohammed S ^a   Shalaby, Asem A ^b   El Agamy, Dina S ^a  

^a MANSOURA UNIVERSITY   (Egypt)

^b MANSOURA UNIVERSITY   (Egypt)

Author keywords

Allergic airway inflammation; Asthma; Cytokines; Nitric oxide; Sitagliptin

Indexed keywords

CYTOKINE; GLUTATHIONE; IMMUNOGLOBULIN E; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 13; MALONALDEHYDE; MESSENGER RNA; NITRIC OXIDE; OVALBUMIN; SITAGLIPTIN; SUPEROXIDE DISMUTASE; TRANSFORMING GROWTH FACTOR BETA1;

ALLERGIC ASTHMA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CELL COUNT; CELL INFILTRATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; DRUG EFFECT; ENZYME ACTIVITY; EOSINOPHIL; HISTOPATHOLOGY; IMMUNOGLOBULIN BLOOD LEVEL; INFLAMMATORY CELL; LUNG HOMOGENATE; LUNG LAVAGE; MALE; MOUSE; NONHUMAN; OXIDATIVE STRESS; PROTEIN EXPRESSION;

ANIMALS; ANTI-ALLERGIC AGENTS; ANTI-ASTHMATIC AGENTS; ANTI-INFLAMMATORY AGENTS; ASTHMA; BRONCHOALVEOLAR LAVAGE FLUID; CYTOKINES; DIPEPTIDYL-PEPTIDASE IV INHIBITORS; DISEASE MODELS, ANIMAL; INFLAMMATION; LUNG; MALE; MICE; NITRIC OXIDE SYNTHASE TYPE II; OVALBUMIN; PYRAZINES; RNA, MESSENGER; TRIAZOLES;

EID: 84866728804     PISSN: 00281298     EISSN: 14321912     Source Type: Journal    
DOI: 10.1007/s00210-012-0772-9     Document Type: Article

References (35)

1. Beckman JS, Koppenol WH (1996) Nitric oxide, superoxide, and peroxynitrite: the good, the bad, and the ugly. Am J Physiol 271:C1424-C1437
2. Berger P, Girodet PO, Tunon-de-Lara JM (2005) Mast cell myositis: a new feature of allergic asthma. Allergy 60:1238-1240
3. Boldogh I, Bacsi A, Choudhury BK, Dharajiya N, Alam R, Hazra TK, Mitra S, Goldblum RM, Surs S (2005) ROS generated by pollen NADPH oxidase provide a signal that augments antigen-induced allergic airway inflammation. J Clin Invest 115:2169-2179
4. Brightling CE, Symon FA, Birring SS, Bradding P, Pavord ID, Wardlaw AJ (2002) Th2 cytokine expression in bronchoalveolar lavage fluid T lymphocytes and bronchial submucosa is a feature of asthma and eosinophilic bronchitis. J Allergy Clin Immunol 110:899-905
5. Chomczynski P, Sacchi N (1987) Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem 162:156-159
6. Ciencewicki J, Trivedi S, Kleeberger SR (2008) Oxidants and the pathogenesis of lung diseases. J Allergy Clin Immunol 122:456-468
7. Ellman GL (1959) Tissue sulfhydryl groups. Arch Biochem Biophys 82:70-77
8. Hamelmann E, Tadeda K, Oshiba A, Gelfand EW (1999) Role of IgE in the development of allergic airway inflammation and airway hyperresponsiveness-a murine model. Allergy 54:297-305
9. Holgate ST (2008) The airway epithelium is central to the pathogenesis of asthma. Allergol Int 57:1-10
10. Ishii S, Nagase T, Shindou H, Takizawa H, Ouchi Y, Shimizu T (2004) Platelet-activating factor receptor develops airway hyperresponsiveness independently of airway inflammation in a murine asthma model. J Immunol 172:7095-7102
11. Kharitonov SA, Yates D, Robbins RA, Logan-Sinclair R, Shinebourne EA, Barnes PJ (1994) Increased nitric oxide in exhaled air of asthmatic patients. Lancet 343:133-135
12. Kruschinski C, Skripuletz T, Bedoui S, Tschernig T, Pabst R, Nassenstein C, Braun A, von Hörsten S (2005) CD26 (dipeptidyl-peptidase IV)- dependent recruitment of T cells in a rat asthma model. Clin Exp Immunol 139:17-24
13. Lee MY, Seo CS, Lee NH, Ha H, Lee JA, Lee H, Lee KY, Shin HK (2010) Anti-asthmatic effect of schizandrin on OVA-induced airway inflammation in a murine asthma model. Int Immunopharmacol 10:1374-1379
14. Mest HJ,Mentlein R (2005) Dipeptidyl peptidase inhibitors as new drugs for the treatment of type 2 diabetes. Diabetologia 48:616-620
15. Misra HP, Fridovich I (1972) The role of superoxide anion in the autoxidation of epinephrine and simple assay for superoxide dismutase. J Biol Chem 247:3170-3175
16. Moon DO, Kim MO, Lee HJ, Choi YH, Park YM, Heo MS, Kim GY (2008) Curcumin attenuates ovalbumin-induced airway inflammation by regulating nitric oxide. Biochem Biophys Res Commun 375:275-279
17. Morimoto C, Schlossman SF (1998) The structure and function of CD26 in the T-cell immune response. Immunol Rev 161:55-70
18. Myou S, Leff AR,Myo S, Boetticher E, Tong J, Meliton AY, Liu J,Munoz NM, Zhu X (2003) Blockade of inflammation and airway hyperresponsiveness in immunesensitized mice by dominant-negative phosphoinositide 3-kinase-TAT. J Exp Med 198:1573-1582
19. Nader MA (2011) Inhibition of anaphylaxis like reaction and mast cell activation by sitagliptin. Int Immunopharmacol 11:1052-1056
20. Nakajima H, Takatsu K (2007) Role of cytokines in allergic airway inflammation. Int Arch Allergy Immunol 142:265-273
21. Ohkawa H, Ohishi N, Yagi K (1979) Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal Biochem 95:351-358
22. Pope SM, Brandt EB, Mishra A, Hogan SP, Zimmermann N, Matthaei KI, Foster PS, Rothenberg ME (2001) IL-13 induces eosinophil recruitment into the lung by an IL-5- and eotaxin-dependent mechanism. J Allergy Clin Immunol 108:594-601
23. Ricciardolo FLM (2003) Multiple roles of nitric oxide in the airways. Thorax 58:175-182
24. Roh SS, Kim SH, Lee YC, Seo YB (2008) Effects of radix adenophorae and cyclosporine A on an OVA-induced murine model of asthma by suppressing to T cells activity, eosinophilia, and bronchial hyper-responsiveness. Mediat Inflamm 781425:1-11
25. Sadeghi-Hashjin G, Folkerts G, Henricks PA, Verheyen AK, van der Linde HJ, van Ark I, Coene A, Nijkamp FP (1996) Peroxynitrite induces airway hyperresponsiveness in guinea pigs in vitro and in vivo. Am J Respir Crit Care Med 153:1697-1701
26. Secor ER Jr, Carson WF, Cloutier MM, Guernsey LA, Schramm CM, Wu CA, Thrall RS (2005) Bromelain exerts anti-inflammatory effects in an ovalbumin-induced murine model of allergic airway disease. Cell Immunol 237:68-75
27. Skripuletz T, Schmiedl A, Schade J, Bedoui S, Glaab T, Pabst R, von Hörsten S, Stephan M (2007) Dose-dependent recruitment of CD251 and CD261 T cells in a novel F344 rat model of asthma. Am J Physiol Lung Cell Mol Physiol 292:L1564-L1571
28. Teramoto S, Shu CY, Ouchi Y, Fukuchi Y (1996) Increased spontaneous production and generation of superoxide anion by blood neutrophils in patients with asthma. J Asthma 33:149-155
29. Thomas PS (2001) Tumour necrosis factor-alpha: the role of this multifunctional cytokine in asthma. Immunol Cell Biol 79:132-140
30. van der Velden VH, Wierenga-Wolf AF, Adriaansen-Soeting PW, Overbeek SE, Moller GM, Hoogsteden HC, Versnel MA (1998) Expression of aminopeptidase N and dipeptidyl peptidase IV in the healthy and asthmatic bronchus. Clin Exp Allergy 28:110-120
31. van der Velden VH, Naber BA, van Hal PT, Overbeek SE, Hoogsteden HC, Versnel MA (1999) Peptidase activities in serum and bronchoalveolar lavage fluid from allergic asthmatics-comparison with healthy non-smokers and smokers and effects of inhaled glucocorticoids. Clin Exp Allergy 29:813-823
32. Williams YN, Baba H, Hayashi S, Ikai H, Sugita T, Tanaka S, Miyasaka N, Kubota T (2003) Dipeptidyl peptidase IVon activated Tcells as a target molecule for therapy of rheumatoid arthritis. Clin Exp Immunol 131:68-74
33. Wills-Karp M (1999) Immunologic basis of antigen-induced airway hyperresponsiveness. Annu Rev Immunol 17:255-281
34. Xie S, Sukkar MB, Issa R, Khorasani NM, Chung KF (2007) Mechanisms of induction of airway smooth muscle hyperplasia by transforming growth factor-beta. Am J Physiol Lung Cell Mol Physiol 293:245-253
35. Yuk JE,Woo JS, Yun CY, Lee JS, Kim JH, Song GY, Yang EJ, Hur IK, Kim IS (2007) Effects of lactose-beta-sitosterol and beta-sitosterol on ovalbumin induced lung inflammation in actively sensitized mice. Int Immunopharmacol 7:1517-1527