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Volumn 126, Issue 13, 2012, Pages 1630-1639

Periprocedural heparin bridging in patients receiving vitamin K antagonists: Systematic review and meta-analysis of bleeding and thromboembolic rates

Author keywords

anticoagulants; bridging; heparin; periprocedural; thromboembolism; warfarin

Indexed keywords

ANTIVITAMIN K; ARDEPARIN; DALTEPARIN; ENOXAPARIN; LOW MOLECULAR WEIGHT HEPARIN; TINZAPARIN;

EID: 84866698766     PISSN: 00097322     EISSN: 15244539     Source Type: Journal    
DOI: 10.1161/CIRCULATIONAHA.112.105221     Document Type: Review
Times cited : (355)

References (50)
  • 1
    • 84856804836 scopus 로고    scopus 로고
    • Perioperative management of antithrombotic therapy: Antithrombotic therapy and prevention of thrombosis, 9th edi-tion: American College of Chest Physicians evidence-based clinical practice guidelines
    • Douketis JD, Spyropoulos AC, Spencer FA, Mayr M, Jaffer AK, Eckman MH, Dunn AS, Kunz R. Perioperative management of antithrombotic therapy: Antithrombotic therapy and prevention of thrombosis, 9th edi-tion: American College of Chest Physicians evidence-based clinical practice guidelines. Chest. 2012;141:e326S-e350S.
    • (2012) Chest. , vol.141
    • Douketis, J.D.1    Spyropoulos, A.C.2    Spencer, F.A.3    Mayr, M.4    Jaffer, A.K.5    Eckman, M.H.6    Dunn, A.S.7    Kunz, R.8
  • 2
    • 0031583322 scopus 로고    scopus 로고
    • Management of anticoagulation before and after elective surgery
    • Kearon C, Hirsh J. Management of anticoagulation before and after elective surgery. N Engl J Med. 1997;336:1506-1511.
    • (1997) N Engl J Med. , vol.336 , pp. 1506-1511
    • Kearon, C.1    Hirsh, J.2
  • 3
    • 0037471544 scopus 로고    scopus 로고
    • Perioperative management of patients receiving oral anticoagulants: A systematic review
    • DOI 10.1001/archinte.163.8.901
    • Dunn AS, Turpie AG. Perioperative management of patients receiving oral anticoagulants: A systematic review. Arch Intern Med. 2003;163: 901-908. (Pubitemid 36522737)
    • (2003) Archives of Internal Medicine , vol.163 , Issue.8 , pp. 901-908
    • Dunn, A.S.1    Turpie, A.G.G.2
  • 4
    • 77955918007 scopus 로고    scopus 로고
    • Bridging therapy and oral anticoagulation: Current and future prospects
    • Spyropoulos AC. Bridging therapy and oral anticoagulation: Current and future prospects. Curr Opin Hematol. 2010;17:444-449.
    • (2010) Curr Opin Hematol. , vol.17 , pp. 444-449
    • Spyropoulos, A.C.1
  • 6
    • 9644259108 scopus 로고    scopus 로고
    • Tips for learners of evidence-based medicine: 3. Measures of observer variability (kappa statistic)
    • DOI 10.1503/cmaj.1031981
    • McGinn T, Wyer PC, Newman TB, Keitz S, Leipzig R, Guyatt G; Evidence-Based Medicine Teaching Tips Work Group. Tips for learners of evidence-based medicine, 3: Measures of observer variability (kappa statistic). CMAJ. 2004;171:1369-1373. (Pubitemid 39573841)
    • (2004) Canadian Medical Association Journal , vol.171 , Issue.11 , pp. 1369-1373
    • McGinn, T.1    Wyer, P.C.2    Newman, T.B.3    Keitz, S.4    Leipzig, R.5    Guyatt, G.6
  • 7
    • 84959801619 scopus 로고
    • Statistical aspects of the analysis of data from retrospective studies of disease
    • Mantel N, Haenszel W. Statistical aspects of the analysis of data from retrospective studies of disease. J Natl Cancer Inst. 1959;22:719-748.
    • (1959) J Natl Cancer Inst. , vol.22 , pp. 719-748
    • Mantel, N.1    Haenszel, W.2
  • 11
    • 64349124745 scopus 로고    scopus 로고
    • Randomized, prospective trial comparing bridging therapy using low-molecular-weight heparin with maintenance of oral anticoagulation during extraction of teeth
    • Bajkin BV, Popovic SL, Selakovic SDJ. Randomized, prospective trial comparing bridging therapy using low-molecular-weight heparin with maintenance of oral anticoagulation during extraction of teeth. J Oral Maxillofac Surg. 2009;67:990-995.
    • (2009) J Oral Maxillofac Surg. , vol.67 , pp. 990-995
    • Bajkin, B.V.1    Popovic, S.L.2    Selakovic, S.D.J.3
  • 12
    • 67549096387 scopus 로고    scopus 로고
    • Elective inguinal hernioplasty in patients on chronic anticoagulation therapy: Management and outcome
    • Bombuy E, Mans E, Hugue A, Plensa E, Rodriguez L, Prats M, Sunol X. Elective inguinal hernioplasty in patients on chronic anticoagulation therapy: Management and outcome. Cir Esp. 2009;86:38-42.
    • (2009) Cir Esp. , vol.86 , pp. 38-42
    • Bombuy, E.1    Mans, E.2    Hugue, A.3    Plensa, E.4    Rodriguez, L.5    Prats, M.6    Sunol, X.7
  • 13
    • 72049125866 scopus 로고    scopus 로고
    • Comparison of safety of subcutaneous enoxaparin as outpatient anticoagulation bridging therapy in patients with a mechanical heart valve versus patients with nonvalvular atrial fibrillation
    • Bui HT, Krisnaswami A, Le C-U, Chan J, Shenoy B-N. Comparison of safety of subcutaneous enoxaparin as outpatient anticoagulation bridging therapy in patients with a mechanical heart valve versus patients with nonvalvular atrial fibrillation. Am J Cardiol. 2009;104:1429-1433.
    • (2009) Am J Cardiol. , vol.104 , pp. 1429-1433
    • Bui, H.T.1    Krisnaswami, A.2    Le C-U Chan, J.3    Shenoy, B.-N.4
  • 14
    • 70349472807 scopus 로고    scopus 로고
    • Perioperative anticoagulation for patients with mechanic heart valve(s) undertaking pacemaker implantation
    • Cheng M, Hua W, Chen K, Pu J, Ren X, Zhao X, Liu Z, Wang F, Chen X, Zhang S. Perioperative anticoagulation for patients with mechanic heart valve(s) undertaking pacemaker implantation. Europace. 2009;11: 1183-1187.
    • (2009) Europace. , vol.11 , pp. 1183-1187
    • Cheng, M.1    Hua, W.2    Chen, K.3    Pu, J.4    Ren, X.5    Zhao, X.6    Liu, Z.7    Wang, F.8    Chen, X.9    Zhang, S.10
  • 15
    • 33847027686 scopus 로고    scopus 로고
    • Low-molecular-weight heparin as bridging therapy during interruption of oral anticoagulation in patients undergoing colonoscopy or gastroscopy
    • Constans M, Santamaria A, Mateo J, Pujol N, Souto JC, Fontcuberta J. Low-molecular-weight heparin as bridging therapy during interruption of oral anticoagulation in patients undergoing colonoscopy or gastroscopy. Int J Clin Pract. 2007;61:212-217.
    • (2007) Int J Clin Pract. , vol.61 , pp. 212-217
    • Constans, M.1    Santamaria, A.2    Mateo, J.3    Pujol, N.4    Souto, J.C.5    Fontcuberta, J.6
  • 17
    • 0036077241 scopus 로고    scopus 로고
    • The efficacy and safety of perioperative low molecular weight heparin substitution in patients on chronic oral anticoagulant therapy undergoing transurethral prostatectomy for bladder outlet obstruction
    • discussion 614
    • Dotan ZA, Mor Y, Leibovitch I, Varon D, Golomb J, Duvdevani M, Ramon J. The efficacy and safety of perioperative low molecular weight heparin substitution in patients on chronic oral anticoagulant therapy undergoing transurethral prostatectomy for bladder outlet obstruction. J Urol. 2002;168:610-613, discussion 614.
    • (2002) J Urol. , vol.168 , pp. 610-613
    • Dotan, Z.A.1    Mor, Y.2    Leibovitch, I.3    Varon, D.4    Golomb, J.5    Duvdevani, M.6    Ramon, J.7
  • 18
    • 3042639769 scopus 로고    scopus 로고
    • Low-molecular-weight heparin as bridging anticoagulation during interruption of warfarin: Assessment of a standardized periprocedural anticoagulation regimen
    • DOI 10.1001/archinte.164.12.1319
    • Douketis JD, Johnson JA, Turpie AG. Low-molecular-weight heparin as bridging anticoagulation during interruption of warfarin: Assessment of a standardized periprocedural anticoagulation regimen. Arch Intern Med. 2004;164:1319-1326. (Pubitemid 38828883)
    • (2004) Archives of Internal Medicine , vol.164 , Issue.12 , pp. 1319-1326
    • Douketis, J.D.1    Johnson, J.A.2    Turpie, A.G.3
  • 19
    • 24944436352 scopus 로고    scopus 로고
    • Bridging anticoagulation with low-molecular-weight heparin after interruption of warfarin therapy is associated with a residual anticoagulant effect prior to surgery
    • DOI 10.1160/TH05-01-0064
    • Douketis JD, Woods K, Foster GA, Crowther MA. Bridging anticoagulation with low-molecular-weight heparin after interruption of warfarin therapy is associated with a residual anticoagulant effect prior to surgery. Thromb Haemost. 2005;94:528-531. (Pubitemid 41300847)
    • (2005) Thrombosis and Haemostasis , vol.94 , Issue.3 , pp. 528-531
    • Douketis, J.D.1    Woods, K.2    Foster, G.A.3    Crowther, M.A.4
  • 20
    • 35448944887 scopus 로고    scopus 로고
    • Bridging therapy in patients on long-term oral anticoagulants who require surgery: The Prospective Peri-operative Enoxaparin Cohort Trial (PROSPECT)
    • DOI 10.1111/j.1538-7836.2007.02729.x
    • Dunn AS, Spyropoulos AC, Turpie AGG. Bridging therapy in patients on long-term oral anticoagulants who require surgery: The Prospective Perioperative Enoxaparin Cohort Trial (PROSPECT). J Thromb Haemost. 2007;5:2211-2218. (Pubitemid 47617873)
    • (2007) Journal of Thrombosis and Haemostasis , vol.5 , Issue.11 , pp. 2211-2218
    • Dunn, A.S.1    Spyropoulos, A.C.2    Turpie, A.G.G.3
  • 21
    • 77954683828 scopus 로고    scopus 로고
    • Postoperative hemorrhagic complications after elective laparoscopic cholecystectomy in patients receiving long-term anticoagulant therapy
    • Ercan M, Bostanci EB, Ozer I, Ulas M, Ozogul YB, Teke Z, Akoglu M. Postoperative hemorrhagic complications after elective laparoscopic cholecystectomy in patients receiving long-term anticoagulant therapy. Langenbecks Arch Surg. 2010;395:247-253.
    • (2010) Langenbecks Arch Surg. , vol.395 , pp. 247-253
    • Ercan, M.1    Bostanci, E.B.2    Ozer, I.3    Ulas, M.4    Ozogul, Y.B.5    Teke, Z.6    Akoglu, M.7
  • 24
    • 29244492317 scopus 로고    scopus 로고
    • Bridging anticoagulation for patients on long-term vitamin-K-antagonists. A prospective 1 year registry of 311 episodes
    • DOI 10.1111/j.1538-7836.2005.01674.x
    • Halbritter KM, Wawer A, Beyer J, Oettler W, Schellong SM. Bridging anticoagulation for patients on long-term vitamin-K-antagonists: A prospective 1 year registry of 311 episodes. J Thromb Haemost. 2005;3: 2823-2825. (Pubitemid 41819819)
    • (2005) Journal of Thrombosis and Haemostasis , vol.3 , Issue.12 , pp. 2823-2825
    • Halbritter, K.M.1    Wawer, A.2    Beyer, J.3    Oettler, W.4    Schellong, S.M.5
  • 25
    • 24944565416 scopus 로고    scopus 로고
    • Low-molecular-weight-heparins as periprocedural anticoagulation for patients on long-term warfarin therapy: A standardized bridging therapy protocol
    • DOI 10.1007/s11239-005-3120-9
    • Jaffer AK, Ahmed M, Brotman DJ, Bragg L, Seshadri N, Qadeer MA, Klein A. Low-molecular-weight-heparins as periprocedural anticoagulation for patients on long-term warfarin therapy: A standardized bridging therapy protocol. J Thromb Thrombolysis. 2005;20:11-16. (Pubitemid 41300615)
    • (2005) Journal of Thrombosis and Thrombolysis , vol.20 , Issue.1 , pp. 11-16
    • Jaffer, A.K.1    Ahmed, M.2    Brotman, D.J.3    Bragg, L.4    Seshadri, N.5    Qadeer, M.A.6    Klein, A.7
  • 26
    • 74549217800 scopus 로고    scopus 로고
    • Variations in perioperative warfarin management: Outcomes and practice patterns at nine hospitals
    • Jaffer AK, Brotman DJ, Bash LD, Mahmood SK, Lott B, White RH. Variations in perioperative warfarin management: Outcomes and practice patterns at nine hospitals. Am J Med. 2010;123:141-150.
    • (2010) Am J Med. , vol.123 , pp. 141-150
    • Jaffer, A.K.1    Brotman, D.J.2    Bash, L.D.3    Mahmood, S.K.4    Lott, B.5    White, R.H.6
  • 27
    • 20844440527 scopus 로고    scopus 로고
    • Single-arm study of bridging therapy with low-molecular-weight heparin for patients at risk of arterial embolism who require temporary interruption of warfarin
    • DOI 10.1161/01.CIR.0000142859.77578.C9
    • Kovacs MJ, Kearon C, Rodger M, Anderson DR, Turpie AGG, Bates SM, Desjardins L, Douketis J, Kahn SR, Solymoss S, Wells PS. Single-arm study of bridging therapy with low-molecular-weight heparin for patients at risk of arterial embolism who require temporary interruption of warfarin. Circulation. 2004;110:1658-1663. (Pubitemid 39297990)
    • (2004) Circulation , vol.110 , Issue.12 , pp. 1658-1663
    • Kovacs, M.J.1    Kearon, C.2    Rodger, M.3    Anderson, D.R.4    Turpie, A.G.G.5    Bates, S.M.6    Desjardins, L.7    Douketis, J.8    Kahn, S.R.9    Solymoss, S.10    Wells, P.S.11
  • 28
    • 73049105008 scopus 로고    scopus 로고
    • Patients requiring interruption of long-term oral anticoagulant therapy: The use of fixed sub-therapeutic doses of lowmolecular-weight heparin
    • Malato A, Saccullo G, Lo Coco L, Caramazza D, Abbene I, Pizzo G, Casuccio A, Siragusa S. Patients requiring interruption of long-term oral anticoagulant therapy: The use of fixed sub-therapeutic doses of lowmolecular-weight heparin. J Thromb Haemost. 2010;8:107-113.
    • (2010) J Thromb Haemost. , vol.8 , pp. 107-113
    • Malato, A.1    Saccullo, G.2    Lo Coco, L.3    Caramazza, D.4    Abbene, I.5    Pizzo, G.6    Casuccio, A.7    Siragusa, S.8
  • 31
    • 33847067931 scopus 로고    scopus 로고
    • Brief communication: Preoperative anticoagulant activity after bridging low-molecular-weight heparin for temporary interruption of warfarin
    • O'Donnell MJ, Kearon C, Johnson J, Robinson M, Zondag M, Turpie I, Turpie AG. Brief communication: Preoperative anticoagulant activity after bridging low-molecular-weight heparin for temporary interruption of warfarin [summary for patients in Ann Intern Med. 2007;146:I35]. Ann Intern Med. 2007;146:184-187. (Pubitemid 351650631)
    • (2007) Annals of Internal Medicine , vol.146 , Issue.3 , pp. 184-187
    • O'Donnell, M.J.1    Kearon, C.2    Johnson, J.3    Robinson, M.4    Zondag, M.5    Turpie, I.6    Turpie, A.G.7
  • 32
    • 67649497925 scopus 로고    scopus 로고
    • Standardized low-molecularweight heparin bridging regimen in outpatients on oral anticoagulants undergoing invasive procedure or surgery: An inception cohort management study
    • Italian Federation of Centers for the Diagnosis of Thrombosis and Management of Antithrombotic Therapies (FCSA)
    • Pengo V, Cucchini U, Denas G, Erba N, Guazzaloca G, La Rosa L, De Micheli V, Testa S, Frontoni R, Prisco D, Nante G, Iliceto S; Italian Federation of Centers for the Diagnosis of Thrombosis and Management of Antithrombotic Therapies (FCSA). Standardized low-molecularweight heparin bridging regimen in outpatients on oral anticoagulants undergoing invasive procedure or surgery: An inception cohort management study. Circulation. 2009;119:2920-2927.
    • (2009) Circulation. , vol.119 , pp. 2920-2927
    • Pengo, V.1    Cucchini, U.2    Denas, G.3    Erba, N.4    Guazzaloca, G.5    La Rosa, L.6    De Micheli, V.7    Testa, S.8    Frontoni, R.9    Prisco, D.10    Nante, G.11    Iliceto, S.12
  • 34
    • 2342598333 scopus 로고    scopus 로고
    • A Disease management protocol for outpatient perioperative bridge therapy with enoxaparin in patients requiring temporary interruption of long-term oral anticoagulation
    • DOI 10.1592/phco.24.6.649.34740
    • Spyropoulos AC, Jenkins P, Bornikova L. A disease management protocol for outpatient perioperative bridge therapy with enoxaparin in patients requiring temporary interruption of long-term oral anticoagulation. Pharmacotherapy. 2004;24:649-658. (Pubitemid 38585959)
    • (2004) Pharmacotherapy , vol.24 , Issue.5 , pp. 649-658
    • Spyropoulos, A.C.1    Jenkins, P.2    Bornikova, L.3
  • 35
    • 2442486457 scopus 로고    scopus 로고
    • Costs and clinical outcomes associated with low-molecular-weight heparin vs unfractionated heparin for perioperative bridging in patients receiving long-term oral anticoagulant therapy
    • DOI 10.1378/chest.125.5.1642
    • Spyropoulos AC, Frost FJ, Hurley JS, Roberts M. Costs and clinical outcomes associated with low-molecular-weight heparin vs unfractionated heparin for perioperative bridging in patients receiving long-term oral anticoagulant therapy. Chest. 2004;125:1642-1650. (Pubitemid 38648392)
    • (2004) Chest , vol.125 , Issue.5 , pp. 1642-1650
    • Spyropoulos, A.C.1    Frost, F.J.2    Hurley, J.S.3    Roberts, M.4
  • 36
    • 33646764900 scopus 로고    scopus 로고
    • Clinical outcomes with unfractionated heparin or low-molecular-weight heparin as bridging therapy in patients on long-term oral anticoagulants: The REGIMEN registry
    • Spyropoulos AC, Turpie AGG, Dunn AS, Spandorfer J, Douketis J, Jacobson A, Frost FJ; REGIMEN Investigators. Clinical outcomes with unfractionated heparin or low-molecular-weight heparin as bridging therapy in patients on long-term oral anticoagulants: The REGIMEN registry. J Thromb Haemost. 2006;4:1246-1252.
    • (2006) J Thromb Haemost. , vol.4 , pp. 1246-1252
    • Spyropoulos, A.C.1    Turpie, A.G.G.2    Dunn, A.S.3    Spandorfer, J.4    Douketis, J.5    Jacobson, A.6    Frost, F.J.7    Regimen, I.8
  • 37
    • 52349113109 scopus 로고    scopus 로고
    • Perioperative bridging therapy with unfractionated heparin or low-molecular-weight heparin in patients with mechanical prosthetic heart valves on long-term oral anticoagulants (from the REGIMEN Registry)
    • Spyropoulos AC, Turpie AGG, Dunn AS, Kaatz S, Douketis J, Jacobson A, Petersen H, Investigators R. Perioperative bridging therapy with unfractionated heparin or low-molecular-weight heparin in patients with mechanical prosthetic heart valves on long-term oral anticoagulants (from the REGIMEN Registry). Am J Cardiol. 2008;102:883-889.
    • (2008) Am J Cardiol. , vol.102 , pp. 883-889
    • Spyropoulos, A.C.1    Turpie, A.G.G.2    Dunn, A.S.3    Kaatz, S.4    Douketis, J.5    Jacobson, A.6    Petersen, H.7    Investigators, R.8
  • 38
    • 0035010396 scopus 로고    scopus 로고
    • Dalteparin as periprocedure anticoagulation for patients on warfarin and at high risk of thrombosis
    • Tinmouth AH, Morrow BH, Cruickshank MK, Moore PM, Kovacs MJ. Dalteparin as periprocedure anticoagulation for patients on warfarin and at high risk of thrombosis. Ann Pharmacother. 2001;35:669-674. (Pubitemid 32523598)
    • (2001) Annals of Pharmacotherapy , vol.35 , Issue.6 , pp. 669-674
    • Tinmouth, A.H.1    Morrow, B.H.2    Cruickshank, M.K.3    Moore, P.M.4    Kovacs, M.J.5
  • 39
    • 67650541562 scopus 로고    scopus 로고
    • Implantation of cardiac rhythm devices without interruption of oral anticoagu-lation compared with perioperative bridging with low-molecular weight heparin
    • Tischenko A, Gula LJ, Yee R, Klein GJ, Skanes AC, Krahn AD. Implantation of cardiac rhythm devices without interruption of oral anticoagu-lation compared with perioperative bridging with low-molecular weight heparin. Am Heart J. 2009;158:252-256.
    • (2009) Am Heart J. , vol.158 , pp. 252-256
    • Tischenko, A.1    Gula, L.J.2    Yee, R.3    Klein, G.J.4    Skanes, A.C.5    Krahn, A.D.6
  • 42
    • 36549078144 scopus 로고    scopus 로고
    • Atrial fibrillation ablation in patients with therapeutic international normalized ratio: Comparison of strategies of anticoagulation management in the periprocedural period
    • DOI 10.1161/CIRCULATIONAHA.107.727784, PII 0000301720071127000008
    • Wazni OM, Beheiry S, Fahmy T, Barrett C, Hao S, Patel D, Di Biase L, Martin DO, Kanj M, Arruda M, Cummings J, Schweikert R, Saliba W, Natale A. Atrial fibrillation ablation in patients with therapeutic international normalized ratio: Comparison of strategies of anticoagulation management in the periprocedural period. Circulation. 2007;116:2531-2534. (Pubitemid 350179218)
    • (2007) Circulation , vol.116 , Issue.22 , pp. 2531-2534
    • Wazni, O.M.1    Beheiry, S.2    Fahmy, T.3    Barrett, C.4    Hao, S.5    Patel, D.6    Di Biase, L.7    Martin, D.O.8    Kanj, M.9    Arruda, M.10    Cummings, J.11    Schweikert, R.12    Saliba, W.13    Natale, A.14
  • 43
    • 0035179199 scopus 로고    scopus 로고
    • A model for perioperative outpatient management of anticoagulation in high-risk patients: An evaluation of effectiveness and safety
    • Wilson SJ, Morgan J, Gray L, Newman V, Anderson DR. A model for perioperative outpatient management of anticoagulation in high-risk patients: An evaluation of effectiveness and safety. Can J Hosp Pharm. 2001;54:269-277. (Pubitemid 33094821)
    • (2001) Canadian Journal of Hospital Pharmacy , vol.54 , Issue.4 , pp. 269-277
    • Wilson, S.J.-A.1    Morgan, J.2    Gray, L.3    Newman, V.4    Anderson, D.R.5
  • 44
    • 44949133339 scopus 로고    scopus 로고
    • Periprocedural anticoagulation management of patients with nonvalvular atrial fibrillation
    • DOI 10.4065/83.6.639
    • Wysokinski WE, McBane RD, Daniels PR, Litin SC, Hodge DO, Dowling NF, Heit JA. Periprocedural anticoagulation management of patients with nonvalvular atrial fibrillation [erratum appears in Mayo Clin Proc. 2008;83:851]. Mayo Clin Proc. 2008;83:639-645. (Pubitemid 351810563)
    • (2008) Mayo Clinic Proceedings , vol.83 , Issue.6 , pp. 639-645
    • Wysokinski, W.E.1    Mcbane, R.D.2    Daniels, P.R.3    Litin, S.C.4    Hodge, D.O.5    Dowling, N.F.6    Heit, J.A.7
  • 45
    • 80055083430 scopus 로고    scopus 로고
    • Net clinical benefit of adding clopidogrel to aspirin therapy in patients with atrial fibrillation for whom vitamin K antagonists are unsuitable
    • Connolly SJ, Eikelboom JW, Ng J, Hirsh J, Yusuf S, Pogue J, de Caterina R, Hohnloser S, Hart RG. Net clinical benefit of adding clopidogrel to aspirin therapy in patients with atrial fibrillation for whom vitamin K antagonists are unsuitable. Ann Intern Med. 2011;155:579-586.
    • (2011) Ann Intern Med. , vol.155 , pp. 579-586
    • Connolly, S.J.1    Eikelboom, J.W.2    Ng, J.3    Hirsh, J.4    Yusuf, S.5    Pogue, J.6    De Caterina, R.7    Hohnloser, S.8    Hart, R.G.9
  • 46
    • 77953168824 scopus 로고    scopus 로고
    • Dabigatran etexilate-A novel, reversible, oral direct thrombin inhibitor: Interpretation of coagulation assays and reversal of anticoagulant activity
    • van Ryn J, Stangier J, Haertter S, Liesenfeld KH, Wienen W, Feuring M, Clemens A. Dabigatran etexilate-A novel, reversible, oral direct thrombin inhibitor: Interpretation of coagulation assays and reversal of anticoagulant activity. Thromb Haemost. 2010;103:1116-1127.
    • (2010) Thromb Haemost. , vol.103 , pp. 1116-1127
    • Van Ryn, J.1    Stangier, J.2    Haertter, S.3    Liesenfeld, K.H.4    Wienen, W.5    Feuring, M.6    Clemens, A.7
  • 48
    • 84859186769 scopus 로고    scopus 로고
    • Periprocedural antithrombotic and bridging therapy: Recommendations for standardized reporting in patients with arterial indications for chronic oral anticoagulant therapy
    • Spyropoulos AC, Douketis J, Gerotziafas G, Kaatz S, Ortel T, Schulman S. Periprocedural antithrombotic and bridging therapy: Recommendations for standardized reporting in patients with arterial indications for chronic oral anticoagulant therapy. J Thromb Haemost. 2012;10:692-694.
    • (2012) J Thromb Haemost. , vol.10 , pp. 692-694
    • Spyropoulos, A.C.1    Douketis, J.2    Gerotziafas, G.3    Kaatz, S.4    Ortel, T.5    Schulman, S.6


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