Phosphodiesterase 5 inhibition protects against increased intra-abdominal pressure-induced renal dysfunction in experimental congestive heart failure

European Journal of Heart Failure

Volumn 14, Issue 10, 2012, Pages 1104-1111

  Bishara, Bishara ^a   Abu Saleh, Niroz ^b   Awad, Hoda ^b   Ghrayeb, Nabil ^a   Goltsman, Ilia ^a   Aronson, Doron ^a   Khamaysi, Iyad ^a   Assady, Suhair ^a   Armaly, Zaher ^c   Haddad, Saleem ^a   Haddad, Elias ^d   Abassi, Zaid ^a,b  

^a RAMBAM MEDICAL CENTER   (Israel)

^b TECHNION ISRAEL INSTITUTE OF TECHNOLOGY   (Israel)

^c Anglican Hospital   (Israel)

^d HAEMEK MEDICAL CENTER   (Israel)

Author keywords

Cardio renal syndrome; Experimental heart failure; Intra abdominal pressure; Phosphodiesterase 5 inhibitor

Indexed keywords

PHOSPHODIESTERASE V; TADALAFIL;

ABDOMINAL PRESSURE; ANIMAL EXPERIMENT; ANIMAL MODEL; AORTOCAVAL FISTULA; ARTERY LIGATION; ARTICLE; CONGESTIVE HEART FAILURE; CONTROLLED STUDY; ENZYME INHIBITION; GLOMERULUS FILTRATION; HEART INFARCTION; HEART PROTECTION; HEMODYNAMICS; KIDNEY BLOOD FLOW; KIDNEY CLEARANCE; KIDNEY DYSFUNCTION; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; SODIUM EXCRETION; URINARY EXCRETION; VASODILATATION;

ANIMALS; CARBOLINES; CARDIO-RENAL SYNDROME; DISEASE MODELS, ANIMAL; GLOMERULAR FILTRATION RATE; HEART FAILURE; HEMODYNAMICS; INTRA-ABDOMINAL HYPERTENSION; KIDNEY; MALE; PHOSPHODIESTERASE 5 INHIBITORS; RATS; RATS, SPRAGUE-DAWLEY; RENAL INSUFFICIENCY; RENAL PLASMA FLOW;

EID: 84866674831     PISSN: 13889842     EISSN: 18790844     Source Type: Journal    
DOI: 10.1093/eurjhf/hfs102     Document Type: Article

References (30)

1. Ronco C, Haapio M, House AA, Anavekar N, Bellomo R. Cardiorenal syndrome. J Am Coll Cardiol 2008;52:1527-1539.
2. Scrutinio D, Passantino A, Santoro D, Catanzaro R. The cardiorenal anaemia syndrome in systolic heart failure: prevalence, clinical correlates, and long-term survival. Eur J Heart Fail 2011;13:61-67.
3. Damman K, Navis G, Voors AA, Asselbergs FW, Smilde TD, Cleland JG, van Veldhuisen DJ, Hillege HL. Worsening renal function and prognosis in heart failure: systematic review and meta-analysis. J Card Fail 2007;13:599-608.
4. Mohmand H, Goldfarb S. Renal dysfunction associated with intra-abdominal hypertension and the abdominal compartment syndrome. J Am Soc Nephrol 2011;22:615-621.
5. Abassi Z, Bishara B, Karram T, Khatib S, Winaver J, Hoffman A. Adverse effects of pneumoperitoneum on renal function: involvement of the endothelin and nitric oxide systems. Am J Physiol Regul Integr Comp Physiol 2008;294:R842-R850.
6. Bishara B, Karram T, Khatib S, Ramadan R, Schwartz H, Hoffman A, Abassi Z. Impact of pneumoperitoneum on renal perfusion and excretory function: beneficial effects of nitroglycerine. Surg Endosc 2009;23:568-576.
7. Mullens W, Abrahams Z, Skouri HN, Francis GS, Taylor DO, Starling RC, Paganini E, Tang WH. Elevated intra-abdominal pressure in acute decompensated heart failure: a potential contributor to worsening renal function? J Am Coll Cardiol 2008;51:300-306.
8. Mullens W, Abrahams Z, Francis GS, Taylor DO, Starling RC, Tang WH. Prompt reduction in intra-abdominal pressure following large-volume mechanical fluid removal improves renal insufficiency in refractory decompensated heart failure. J Card Fail 2008;14:508-514.
9. Bishara B, Abu-Saleh N, Awad H, Goltsman I, Ramadan R, Khamaysi I, Abassi Z. Pneumoperitoneum aggravates renal function in decompensated, but not compensated experimental congestive heart failure: role of nitric oxide. J Urol 2011; 186:310-317.
10. Hamet P, Tremblay J, Pang SC, Skuherska R, Schiffrin EL, Garcia R, Cantin M, Genest J, Palmour R, Ervin FR. Cyclic GMP as mediator and biological marker of atrial natriuretic factor. J Hypertens Suppl 1986;4:S49-S56.
11. Reffelmann T, Kloner RA. Phosphodiesterase 5 inhibitors: are they cardioprotective? Cardiovasc Res 2009;83:204-212.
12. Forfia PR, Lee M, Tunin RS, Mahmud M, Champion HC, Kass DA. Acute phosphodiesterase 5 inhibition mimics hemodynamic effects of B-type natriuretic peptide and potentiates B-type natriuretic peptide effects in failing but not normal canine heart. J Am Coll Cardiol 2007;49:1079-1088.
13. Abassi ZA, Brodsky S, Karram T, Dobkin I, Winaver J, Hoffman A. Temporal changes in natriuretic and antinatriuretic systems after closure of a large arteriovenous fistula. Cardiovasc Res 2001;51:567-576.
14. Abassi ZA, Gurbanov K, Mulroney SE, Potlog C, Opgenorth TJ, Hoffman A, Haramati A, Winaver J. Impaired nitric oxide-mediated renal vasodilation in rats with experimental heart failure: role of angiotensin II. Circulation 1997;96: 3655-3664.
15. Bhindi R, Witting PK, McMahon AC, Khachigian LM, Lowe HC. Rat models of myocardial infarction. Pathogenetic insights and clinical relevance. Thromb Haemost 2006;96:602-610.
16. Cisek LJ, Gobet RM, Peters CA. Pneumoperitoneum produces reversible renal dysfunction in animals with normal and chronically reduced renal function. J Endourol 1998;2:95-100.
17. Colombo JR Jr, Haber GP, Gill IS. Laparoscopic partial nephrectomy in patients with compromised renal function. Urology 2008;71:1043-1048.
18. Abassi Z, Goltsman I, Karram T, Winaver J, Hoffman A. Aortocaval fistula in rat: a unique model of volume-overload congestive heart failure and cardiac hypertrophy. J Biomed Biotechnol 2011;2011:729497.
19. Numabe A, Nishikimi T, Komatsu K, Frohlich ED. Intrarenal hemodynamics in low-and high-output cardiac failure in rats. Am J Med Sci 1994;308: 331-337.
20. Chaney E, Shaw A. Pathophysiology of fluid retention in heart failure. Contrib Nephrol 2010;164:46-53.
21. Dzau VJ. Renal and circulatory mechanisms in congestive heart failure. Kidney Int 1987;31:1402-1415.
22. Mullens W, Abrahams Z, Francis GS, Sokos G, Taylor DO, Starling RC, Young JB, Tang WH. Importance of venous congestion for worsening of renal function in advanced decompensated heart failure. J Am Coll Cardiol 2009;53: 589-596.
23. Damman K, Voors AA, Hillege HL, Navis G, Lechat P, van Veldhuisen DJ, Dargie HJ. Congestion in chronic systolic heart failure is related to renal dysfunction and increased mortality. Eur J Heart Fail 2010;12:974-982.
24. Uthoff H, Breidthardt T, Klima T, Aschwanden M, Arenja N, Socrates T, Heinisch C, Noveanu M, Frischknecht B, Baumann U, Jaeger KA, Mueller C. Central venous pressure and impaired renal function in patients with acute heart failure. Eur J Heart Fail 2011;13:432-439.
25. De Waele JJ, De Laet I, Kirkpatrick AW, Hoste E. Intra-abdominal hypertension and abdominal compartment syndrome. Am J Kidney Dis 2011;57:159-169.
26. Elsamra S, Pareek G. Complications of laparoscopic renal surgery. Int J Urol 2010; 17:206-214.
27. Winaver J, Hoffman A, Burnett JC Jr, Haramati A. Hormonal determinants of sodium excretion in rats with experimental high-output heart failure. Am J Physiol 1988;254:R776-R784.
28. Abassi Z, Karram T, Ellaham S, Winaver J, Hoffman A. Implications of the natriuretic peptide system in the pathogenesis of heart failure: diagnostic and therapeutic importance. Pharmacol Ther 2004;102:223-241.
29. Fülle HJ, Garbers DL. Guanylyl cyclases: a family of receptor-linked enzymes. Cell Biochem Funct 1994;12:157-165.
30. Guazzi M, Vicenzi M, Arena R, Guazzi MD. PDE5 inhibition with sildenafil improves left ventricular diastolic function, cardiac geometry, and clinical status in patients with stable systolic heart failure: results of a 1-year, prospective, randomized, placebo-controlled study. Circ Heart Fail 2011;4:8-17.