Treponema pallidum azithromycin resistance in Dublin, Ireland

Sexually Transmitted Diseases

Volumn 39, Issue 10, 2012, Pages 784-786

  Muldoon, Eavan G ^a   Walsh, Anne ^a   Crowley, Brendan ^a   Mulcahy, Fiona ^a  

^a ST JAMES S HOSPITAL   (Ireland)

Author keywords

[No Author keywords available]

Indexed keywords

AZITHROMYCIN; BACTERIAL DNA;

ADULT; ANTIBIOTIC RESISTANCE; ARTICLE; BACTERIAL GENE; BACTERIUM ISOLATE; DNA SEQUENCE; DRUG WITHDRAWAL; GENE MUTATION; HUMAN; IRELAND; NONHUMAN; NUCLEOTIDE SEQUENCE; POLA GENE; POLYMERASE CHAIN REACTION; SYPHILIS; TREPONEMA PALLIDUM;

ADULT; ANTI-BACTERIAL AGENTS; AZITHROMYCIN; DNA, BACTERIAL; DRUG RESISTANCE, BACTERIAL; FEMALE; HUMANS; IRELAND; MALE; MIDDLE AGED; MUTATION; RNA, RIBOSOMAL, 23S; SYPHILIS; TREPONEMA PALLIDUM; YOUNG ADULT;

EID: 84866664750     PISSN: 01485717     EISSN: 15374521     Source Type: Journal    
DOI: 10.1097/OLQ.0b013e318269995f     Document Type: Article

References (21)

1. Mahoney JF, Arnold RC, Harris A. Penicillin treatment of early syphilisVA preliminary report. Am J Public Health Nations Health 1943; 33:1387-1391.
2. Smith CA, Kamp M, Olansky S, et al. Benzathine penicillin G in the treatment of syphilis. Bull World Health Organ 1956; 15: 1087-1096.
3. Workowski KA, Berman S, Centers for Disease Control and Prevention. Sexually transmitted diseases treatment guidelines, 2010. MMWR Recomm Rep 2010; 59:1-110.
4. Kingston M, French P, Goh B, et al. UK National Guidelines on the Management of Syphilis 2008. Int J STD AIDS 2008; 19:729-740.
5. Hook EW 3rd, Martin DH, Stephens J, et al. A randomized, comparative pilot study of azithromycin versus benzathine penicillin G for treatment of early syphilis. Sex Transm Dis 2002; 29:486-490. (Pubitemid 34851786)
6. Kiddugavu MG, Kiwanuka N, Wawer MJ, et al. Effectiveness of syphilis treatment using azithromycin and/or benzathine penicillin in Rakai, Uganda. Sex Transm Dis 2005; 32:1-6. (Pubitemid 40054154)
7. Lukehart SA, Fohn MJ, Baker-Zander SA. Efficacy of azithromycin for therapy of active syphilis in the rabbit model. J Antimicrob Chemother 1990; 25(suppl A):91-99. (Pubitemid 20043954)
8. Verdon MS, Handsfield HH, Johnson RB. Pilot study of azithromycin for treatment of primary and secondary syphilis. Clin Infect Dis 1994; 19:486-488. (Pubitemid 24286953)
9. GeislerWM. Management of uncomplicated Chlamydia trachomatis infections in adolescents and adults: Evidence reviewed for the 2006 Centers for Disease Control and Prevention sexually transmitted diseases treatment guidelines. Clin Infect Dis 2007; 44 (suppl 3): S77-S83. (Pubitemid 46452041)
10. Lukehart SA, Godornes C, Molini BJ, et al. Macrolide resistance in Treponema pallidum in the United States and Ireland. N Engl J Med 2004; 351:154-158.
11. Mitchell SJ, Engelman J, Kent CK, et al. Azithromycin-resistant syphilis infection: San Francisco, California, 2000-2004. Clin Infect Dis 2006; 42:337-345. (Pubitemid 43122308)
12. Morshed MG, Jones HD. Treponema pallidum macrolide resistance in BC. CMAJ 2006; 174:349.
13. Marra CM, Colina AP, Godornes C, et al. Antibiotic selection may contribute to increases in macrolide-resistant Treponema pallidum. J Infect Dis 2006; 194:1771-1773. (Pubitemid 44902010)
14. Van Damme K, Behets F, Ravelomanana N, et al. Evaluation of azithromycin resistance in Treponema pallidum specimens from Madagascar. Sex Transm Dis 2009; 36:775-776.
15. Martin IE, Tsang RS, Sutherland K, et al. Molecular characterization of syphilis in patients in Canada: Azithromycin resistance and detection of Treponema pallidum DNA in whole-blood samples versus ulcerative swabs. J Clin Microbiol 2009; 47:1668-1673.
16. Martin IE, Gu W, Yang Y, et al. Macrolide resistance and molecular types of Treponema pallidum causing primary syphilis in Shanghai, China. Clin Infect Dis 2009; 49:515-521.
17. Muldoon E, Mulcahy F. Syphilis resurgence in Dublin, Ireland. Int J STD AIDS; 22:493-497.
18. Leslie DEA, Karapanagiotidis F, Leydon T, et al. Development of a Real-Time PCR Assay to detect Treponema pallidum in clinical specimens and assessment of the assay's performance by comparison with serological testing. J Clin Microbiol 2006; 45:93-96.
19. Pandori MW, Gordones C, Castro L, et al. Detection of azithromycin resistance in Treponema pallidum by real-Time PCR. Antimicrob Agents Chemother 2007; 51:3425-3430. (Pubitemid 350067571)
20. Centers for Disease Control and Prevention. Azithromycin treatment failures in syphilis infectionsVSan Francisco, California, 2002-2003. MMWR Morb Mortal Wkly Rep 2004; 53:197-198.
21. Stamm LV, Bergen HL. A point mutation associated with bacterial macrolide resistance is present in both 23S rRNA genes of an erythromycin-resistant Treponema pallidum clinical isolate. Antimicrob Agents Chemother 2000; 44:806-807. (Pubitemid 30117989)