메뉴 건너뛰기




Volumn 1, Issue 3, 2011, Pages 213-221

A shining light in the darkness for the treatment of pancreatic neuroendocrine tumors

Author keywords

[No Author keywords available]

Indexed keywords

8 [4 (1 AMINOCYCLOBUTYL) PHENYL] 9 PHENYL 1, 2, 4 TRIAZOLO [3, 4 F] [1, 6] NAPHTHYRIDIN 3 (2H) ONE; ALPHA INTERFERON; ATIPRIMOD; BEVACIZUMAB; BORTEZOMIB; CIXUTUMUMAB; ERLOTINIB; EVEROLIMUS; GANITUMAB; GROWTH FACTOR; HYPOXIA INDUCIBLE FACTOR 1ALPHA; MAMMALIAN TARGET OF RAPAMYCIN; MOTESANIB; OCTREOTIDE; PASIREOTIDE; PAZOPANIB; PEGINTERFERON ALPHA2B; PERTUZUMAB; PLACEBO; PROTEIN KINASE B; RECOMBINANT ENDOSTATIN; ROMIDEPSIN; SORAFENIB; SUNITINIB; TEMOZOLOMIDE; TEMSIROLIMUS; THALIDOMIDE; UNCLASSIFIED DRUG; UNINDEXED DRUG; VATALANIB; VON HIPPEL LINDAU PROTEIN;

EID: 84866655972     PISSN: 21598274     EISSN: 21598290     Source Type: Journal    
DOI: 10.1158/2159-8290.CD-11-0151     Document Type: Review
Times cited : (20)

References (41)
  • 1
    • 46449110634 scopus 로고    scopus 로고
    • One hundred years after "carcinoid": Epidemiology of and prognostic factors for neuroendocrine tumors in 35,825 cases in the United States
    • Yao JC, Hassan M, Phan A, Dagohoy C, Leary C, Mares JE, et al. One hundred years after "carcinoid": epidemiology of and prognostic factors for neuroendocrine tumors in 35,825 cases in the United States. J Clin Oncol 2008;26:3063-72.
    • (2008) J Clin Oncol , vol.26 , pp. 3063-3072
    • Yao, J.C.1    Hassan, M.2    Phan, A.3    Dagohoy, C.4    Leary, C.5    Mares, J.E.6
  • 2
    • 78649819705 scopus 로고    scopus 로고
    • Molecular markers associated with response to chemotherapy in gastro-entero-pancreatic neuroendocrine tumors
    • O' Toole D, Couvelard A, Rebours V, Zappa M, Hentic O, Hammel P, et al. Molecular markers associated with response to chemotherapy in gastro-entero-pancreatic neuroendocrine tumors. Endocr Relat Cancer 2010;17:847-56.
    • (2010) Endocr Relat Cancer , vol.17 , pp. 847-856
    • O' Toole, D.1    Couvelard, A.2    Rebours, V.3    Zappa, M.4    Hentic, O.5    Hammel, P.6
  • 3
  • 4
    • 0037389850 scopus 로고    scopus 로고
    • Expression of molecular targets for tyrosine kinase receptor antagonists in malignant endocrine pancreatic tumors
    • Fjällskog ML, Lejonklou MH, Oberg KE, Eriksson BK, Janson ET. Expression of molecular targets for tyrosine kinase receptor antagonists in malignant endocrine pancreatic tumors. Clin Cancer Res 2003;9:1469-73.
    • (2003) Clin Cancer Res , vol.9 , pp. 1469-1473
    • Fjällskog, M.L.1    Lejonklou, M.H.2    Oberg, K.E.3    Eriksson, B.K.4    Janson, E.T.5
  • 5
    • 14644413806 scopus 로고    scopus 로고
    • Fluorouracil, doxorubicin, and streptozocin in the treatment of patients with locally advanced and metastatic pancreatic endocrine carcinomas
    • Kouvaraki MA, Ajani JA, Hoff P, Wolff R, Evans DB, Lozano R, et al. Fluorouracil, doxorubicin, and streptozocin in the treatment of patients with locally advanced and metastatic pancreatic endocrine carcinomas. J Clin Oncol 2004;22:4762-71.
    • (2004) J Clin Oncol , vol.22 , pp. 4762-4771
    • Kouvaraki, M.A.1    Ajani, J.A.2    Hoff, P.3    Wolff, R.4    Evans, D.B.5    Lozano, R.6
  • 7
    • 0026530547 scopus 로고
    • Streptozocin-doxorubicin, streptozocin-fluorouracil or chlorozotocin in the treatment of advanced islet-cell carcinoma
    • Moertel CG, Lefkopoulo M, Lipsitz S, Hahn RG, Klaassen D. Streptozocin-doxorubicin, streptozocin-fluorouracil or chlorozotocin in the treatment of advanced islet-cell carcinoma. N Engl J Med 1992;326:519-23.
    • (1992) N Engl J Med , vol.326 , pp. 519-523
    • Moertel, C.G.1    Lefkopoulo, M.2    Lipsitz, S.3    Hahn, R.G.4    Klaassen, D.5
  • 8
    • 41649114168 scopus 로고    scopus 로고
    • Targeting vascular endothelial growth factor in advanced carcinoid tumor: A random assignment phase II study of depot octreotide with bevacizumab and pegylated interferon alfa-2b
    • Yao JC, Phan A, Hoff PM, Chen HX, Charnsangavej C, Yeung SC, et al. Targeting vascular endothelial growth factor in advanced carcinoid tumor: a random assignment phase II study of depot octreotide with bevacizumab and pegylated interferon alfa-2b. J Clin Oncol 2008;26:1316-23.
    • (2008) J Clin Oncol , vol.26 , pp. 1316-1323
    • Yao, J.C.1    Phan, A.2    Hoff, P.M.3    Chen, H.X.4    Charnsangavej, C.5    Yeung, S.C.6
  • 9
    • 33644847440 scopus 로고    scopus 로고
    • Safety, pharmacokinetic, and antitumor activity of SU11248, a novel oral multitarget tyrosine kinase inhibitor, in patients with cancer
    • Faivre S, Delbaldo C, Vera K, Robert C, Lozahic S, Lassau N, et al. Safety, pharmacokinetic, and antitumor activity of SU11248, a novel oral multitarget tyrosine kinase inhibitor, in patients with cancer. J Clin Oncol 2006;24:25-35.
    • (2006) J Clin Oncol , vol.24 , pp. 25-35
    • Faivre, S.1    Delbaldo, C.2    Vera, K.3    Robert, C.4    Lozahic, S.5    Lassau, N.6
  • 12
    • 33747819801 scopus 로고    scopus 로고
    • MTOR and cancer: Insights into a complex relationship
    • Sabatini DM. MTOR and cancer: insights into a complex relationship. Nat Rev Cancer 2006;6:729-34.
    • (2006) Nat Rev Cancer , vol.6 , pp. 729-734
    • Sabatini, D.M.1
  • 13
    • 79952279828 scopus 로고    scopus 로고
    • DAXX/ATRX, MEN1, and mTOR pathway genes are frequently altered in pancreatic neuroendocrine tumors
    • Jiao Y, Shi C, Edil BH, et al. DAXX/ATRX, MEN1, and mTOR pathway genes are frequently altered in pancreatic neuroendocrine tumors. Science 2011;331:1199-203.
    • (2011) Science , vol.331 , pp. 1199-1203
    • Jiao, Y.1    Shi, C.2    Edil, B.H.3
  • 14
    • 52049125970 scopus 로고    scopus 로고
    • Efficacy of RAD001 (everolimus) and octreotide LAR in advanced low-to intermediate-grade neuroendocrine tumors: Results of a phase II study
    • Yao JC, Phan AT, Chang DZ, Wolff RA, Hess K, Gupta S, et al. Efficacy of RAD001 (everolimus) and octreotide LAR in advanced low-to intermediate-grade neuroendocrine tumors: results of a phase II study. J Clin Oncol 2008;26:4311-8.
    • (2008) J Clin Oncol , vol.26 , pp. 4311-4318
    • Yao, J.C.1    Phan, A.T.2    Chang, D.Z.3    Wolff, R.A.4    Hess, K.5    Gupta, S.6
  • 15
    • 73949088959 scopus 로고    scopus 로고
    • Daily oral everolimus activity in patients with metastatic pancreatic neuroendocrine tumors after failure of cytotoxic chemotherapy: A phase II trial
    • Yao JC, Lombard-Bohas C, Baudin E, Kvols LK, Rougier P, Ruszniewski P, et al. Daily oral everolimus activity in patients with metastatic pancreatic neuroendocrine tumors after failure of cytotoxic chemotherapy: a phase II trial. J Clin Oncol 2010;28:69-76.
    • (2010) J Clin Oncol , vol.28 , pp. 69-76
    • Yao, J.C.1    Lombard-Bohas, C.2    Baudin, E.3    Kvols, L.K.4    Rougier, P.5    Ruszniewski, P.6
  • 16
    • 78650443861 scopus 로고    scopus 로고
    • A randomized, double-blind, placebo-controlled, multicenter phase III trial of everolimus + octeotride LAR vs placebo + octeotride LAR in patients with advanced neuroendocrine tumors (NET) (RADIANT-2)
    • Pavel M, Hainsworth J, Baudin E, Peeters M, Hoersch D, Anthony L, et al. A randomized, double-blind, placebo-controlled, multicenter phase III trial of everolimus + octeotride LAR vs placebo + octeotride LAR in patients with advanced neuroendocrine tumors (NET) (RADIANT-2). Ann Oncol 2010;21(Suppl 8):LBA8.
    • (2010) Ann Oncol , vol.21 , Issue.SUPPL. 8
    • Pavel, M.1    Hainsworth, J.2    Baudin, E.3    Peeters, M.4    Hoersch, D.5    Anthony, L.6
  • 18
    • 0037108750 scopus 로고    scopus 로고
    • Tuberous sclerosis complex-1 and-2 gene products function together to inhibit mammalian target of rapamycin (mTOR)-mediated downstream signaling
    • Tee AR, Fingar DC, Manning BD, Kwiatkowski DJ, Cantley LC, Blenis J. Tuberous sclerosis complex-1 and-2 gene products function together to inhibit mammalian target of rapamycin (mTOR)-mediated downstream signaling. Proc Natl Acad Sci U S A 2002;99:13571-6.
    • (2002) Proc Natl Acad Sci U S A , vol.99 , pp. 13571-13576
    • Tee, A.R.1    Fingar, D.C.2    Manning, B.D.3    Kwiatkowski, D.J.4    Cantley, L.C.5    Blenis, J.6
  • 20
    • 0030974683 scopus 로고    scopus 로고
    • Allelic deletions on chromosome 11q13 in multiple endocrine neoplasia type 1-associated and sporadic gastrinomas and pancreatic endocrine tumors
    • Debelenko LV, Zhuang Z, Emmert-Buck MR, Chandrasekharappa SC, Manickam P, Guru SC, et al. Allelic deletions on chromosome 11q13 in multiple endocrine neoplasia type 1-associated and sporadic gastrinomas and pancreatic endocrine tumors. Cancer Res 1997;57:2238-43.
    • (1997) Cancer Res , vol.57 , pp. 2238-2243
    • Debelenko, L.V.1    Zhuang, Z.2    Emmert-Buck, M.R.3    Chandrasekharappa, S.C.4    Manickam, P.5    Guru, S.C.6
  • 22
    • 33750600178 scopus 로고    scopus 로고
    • MicroRNA expression abnormalities in pancreatic endocrine and acinar tumors are associated with distinctive pathologic features and clinical behavior
    • Roldo C, Missiaglia E, Hagan JP, Falconi M, Capelli P, Bersani S, et al. MicroRNA expression abnormalities in pancreatic endocrine and acinar tumors are associated with distinctive pathologic features and clinical behavior. J Clin Oncol 2006;24:4677-84.
    • (2006) J Clin Oncol , vol.24 , pp. 4677-4684
    • Roldo, C.1    Missiaglia, E.2    Hagan, J.P.3    Falconi, M.4    Capelli, P.5    Bersani, S.6
  • 23
    • 77956354202 scopus 로고    scopus 로고
    • MEN1 in pancreatic endocrine tumors: Analysis of gene and protein status in 169 sporadic neoplasms reveals alterations in the vast majority of cases
    • Corbo V, Dalai I, Scardoni M, Barbi S, Beghelli S, Bersani S, et al. MEN1 in pancreatic endocrine tumors: analysis of gene and protein status in 169 sporadic neoplasms reveals alterations in the vast majority of cases. Endocr Relat Cancer 2010;17:771-83.
    • (2010) Endocr Relat Cancer , vol.17 , pp. 771-783
    • Corbo, V.1    Dalai, I.2    Scardoni, M.3    Barbi, S.4    Beghelli, S.5    Bersani, S.6
  • 24
    • 78751554804 scopus 로고    scopus 로고
    • The tumor suppressor protein menin inhibits AKT activation by regulating its cellular localization
    • Wang Y, Ozawa A, Zaman S, Prasad NB, Chandrasekharappa SC, et al. The tumor suppressor protein menin inhibits AKT activation by regulating its cellular localization. Cancer Res 2011;71:371-82.
    • (2011) Cancer Res , vol.71 , pp. 371-382
    • Wang, Y.1    Ozawa, A.2    Zaman, S.3    Prasad, N.B.4    Chandrasekharappa, S.C.5
  • 25
    • 80052632136 scopus 로고    scopus 로고
    • Pancreatic endocrine tumours: Mutational and immunohistochemical survey of protein kinases reveals alterations in targetable kinases in cancer cell lines and rare primaries
    • Mar 29. [Epub ahead of print]
    • Corbo V, Beghelli S, Bersani S, Antonello D, Talamini G, Brunelli M, et al. Pancreatic endocrine tumours: mutational and immunohistochemical survey of protein kinases reveals alterations in targetable kinases in cancer cell lines and rare primaries. Ann Oncol 2011 Mar 29. [Epub ahead of print].
    • (2011) Ann Oncol
    • Corbo, V.1    Beghelli, S.2    Bersani, S.3    Antonello, D.4    Talamini, G.5    Brunelli, M.6
  • 26
    • 79951864002 scopus 로고    scopus 로고
    • Survival benefit with proapoptotic molecular and pathologic responses from dual targeting of mammalian target of rapamycin and epidermal growth factor receptor in a preclinical model of pancreatic neuroendocrine carcinogenesis
    • Chiu CW, Nozawa H, Hanahan D. Survival benefit with proapoptotic molecular and pathologic responses from dual targeting of mammalian target of rapamycin and epidermal growth factor receptor in a preclinical model of pancreatic neuroendocrine carcinogenesis. J Clin Oncol 2010;28:4425-33.
    • (2010) J Clin Oncol , vol.28 , pp. 4425-4433
    • Chiu, C.W.1    Nozawa, H.2    Hanahan, D.3
  • 27
    • 58849093671 scopus 로고    scopus 로고
    • O6-Methylguanine DNA methyltransferase deficiency and response to temozolomide-based therapy in patients with neuroendocrine tumors
    • Kulke MH, Hornick JL, Frauenhoffer C, Hooshmand S, Ryan DP, Enzinger PC, et al. O6-Methylguanine DNA methyltransferase deficiency and response to temozolomide-based therapy in patients with neuroendocrine tumors. Clin Cancer Res 2009;15:338-45.
    • (2009) Clin Cancer Res , vol.15 , pp. 338-345
    • Kulke, M.H.1    Hornick, J.L.2    Frauenhoffer, C.3    Hooshmand, S.4    Ryan, D.P.5    Enzinger, P.C.6
  • 28
    • 79551600015 scopus 로고    scopus 로고
    • Targeting cancer stem cells by inhibiting Wnt, Notch, and Hedgehog pathways
    • Takebe N, Harris PJ, Warren RQ, Ivy SP. Targeting cancer stem cells by inhibiting Wnt, Notch, and Hedgehog pathways. Nat Rev Clin Oncol 2011;8:97-106.
    • (2011) Nat Rev Clin Oncol , vol.8 , pp. 97-106
    • Takebe, N.1    Harris, P.J.2    Warren, R.Q.3    Ivy, S.P.4
  • 29
    • 17444423289 scopus 로고    scopus 로고
    • Wnt signaling in the intestinal epithelium: From endoderm to cancer
    • Gregorieff A, Clevers H. Wnt signaling in the intestinal epithelium: from endoderm to cancer. Genes Dev 2005;19:877-90.
    • (2005) Genes Dev , vol.19 , pp. 877-890
    • Gregorieff, A.1    Clevers, H.2
  • 30
    • 33847058103 scopus 로고    scopus 로고
    • Notch-1 regulates pulmonary neuroendocrine cell differentiation in cell lines and in transgenic mice
    • Shan L, Aster JC, Sklar J, Sunday ME. Notch-1 regulates pulmonary neuroendocrine cell differentiation in cell lines and in transgenic mice. Am J Physiol Lung Cell Mol Physiol 2007;292:500-9.
    • (2007) Am J Physiol Lung Cell Mol Physiol , vol.292 , pp. 500-509
    • Shan, L.1    Aster, J.C.2    Sklar, J.3    Sunday, M.E.4
  • 31
    • 64349087319 scopus 로고    scopus 로고
    • Phase II trial of FOLFOX plus bevacizumab in advanced, progressive neuroendocrine tumors
    • Venook AP, Ko AH, Tempero MA, Uy J, Weber T, Korn M, et al. Phase II trial of FOLFOX plus bevacizumab in advanced, progressive neuroendocrine tumors. Proc Am Soc Clin Oncol 2008;26:15545.
    • (2008) Proc Am Soc Clin Oncol , vol.26 , pp. 15545
    • Venook, A.P.1    Ko, A.H.2    Tempero, M.A.3    Uy, J.4    Weber, T.5    Korn, M.6
  • 32
    • 64349110644 scopus 로고    scopus 로고
    • A phase II study of capecitabine, oxaliplatin, and bevacizumab for metastatic or unresectable neuroendocrine tumors: Preliminary results
    • Kunz PL, Kuo T, Kaiser HL, Norton JA, Longacre TA, Ford JM, et al. A phase II study of capecitabine, oxaliplatin, and bevacizumab for metastatic or unresectable neuroendocrine tumors: preliminary results. Proc Am Soc Clin Oncol 2008;26:15502.
    • (2008) Proc Am Soc Clin Oncol , vol.26 , pp. 15502
    • Kunz, P.L.1    Kuo, T.2    Kaiser, H.L.3    Norton, J.A.4    Longacre, T.A.5    Ford, J.M.6
  • 34
    • 41349094931 scopus 로고    scopus 로고
    • MC044h, a phase II trial of sorafenib in patients (pts) with metastatic neuroendocrine tumors (NET): A phase II consortium (P2C) study
    • Hobday TJ, Rubin J, Holen K, Picus J, Donehower R, Marschke R, et al. MC044h, a phase II trial of sorafenib in patients (pts) with metastatic neuroendocrine tumors (NET): a phase II consortium (P2C) study. Proc Am Soc Clin Oncol 2007;25:4504.
    • (2007) Proc Am Soc Clin Oncol , vol.25 , pp. 4504
    • Hobday, T.J.1    Rubin, J.2    Holen, K.3    Picus, J.4    Donehower, R.5    Marschke, R.6
  • 35
    • 79960201832 scopus 로고    scopus 로고
    • Sorafenib and bevacizumab combination targeted therapy in advanced neuroendocrine tumor: A phase II study of the Spanish Neuroendocrine Tumor Group (GETNE0801)
    • Castellano D, Capdevila J, Salazar R, Sastre J, Alonso V, Llanos M, et al. Sorafenib and bevacizumab combination targeted therapy in advanced neuroendocrine tumor: a phase II study of the Spanish Neuroendocrine Tumor Group (GETNE0801). Proc Am Soc Clin Oncol 2011;29:4113.
    • (2011) Proc Am Soc Clin Oncol , vol.29 , pp. 4113
    • Castellano, D.1    Capdevila, J.2    Salazar, R.3    Sastre, J.4    Alonso, V.5    Llanos, M.6
  • 36
    • 78049425681 scopus 로고    scopus 로고
    • A prospective, multi-institutional phase II study of GW786034 (pazopanib) and depot octreotide (sandostatin LAR) in advanced low-grade neuroendocrine carcinoma (LGNEC)
    • Phan AT, Yao JC, Fogelman DR, Hess KR, Ng CS, Bullock SA, et al. A prospective, multi-institutional phase II study of GW786034 (pazopanib) and depot octreotide (sandostatin LAR) in advanced low-grade neuroendocrine carcinoma (LGNEC). Proc Am Soc Clin Oncol 2010;28:4001.
    • (2010) Proc Am Soc Clin Oncol , vol.28 , pp. 4001
    • Phan, A.T.1    Yao, J.C.2    Fogelman, D.R.3    Hess, K.R.4    Ng, C.S.5    Bullock, S.A.6
  • 37
    • 59349089380 scopus 로고    scopus 로고
    • Phase II proof-of-concept study of atiprimod in patients with advanced low-to intermediate-grade neuroendocrine carcinoma
    • Sung MW, Kvols L, Wolin E, Jacob G, Talluto C, Torres JC, et al. Phase II proof-of-concept study of atiprimod in patients with advanced low-to intermediate-grade neuroendocrine carcinoma. Proc Am Soc Clin Oncol 2008;26:4611.
    • (2008) Proc Am Soc Clin Oncol , vol.26 , pp. 4611
    • Sung, M.W.1    Kvols, L.2    Wolin, E.3    Jacob, G.4    Talluto, C.5    Torres, J.C.6
  • 39
    • 33644846851 scopus 로고    scopus 로고
    • Phase II study of temozolomide and thalidomide in patients with metastatic neuroendocrine tumors
    • Kulke MH, Stuart K, Enzinger PC, Ryan DP, Clark JW, Muzikansky A, et al. Phase II study of temozolomide and thalidomide in patients with metastatic neuroendocrine tumors. J Clin Oncol 2006; 24:401-6.
    • (2006) J Clin Oncol , vol.24 , pp. 401-406
    • Kulke, M.H.1    Stuart, K.2    Enzinger, P.C.3    Ryan, D.P.4    Clark, J.W.5    Muzikansky, A.6
  • 40
    • 33747072903 scopus 로고    scopus 로고
    • Phase II study of recombinant human endostatin in patients with advanced neuroendocrine tumors
    • Kulke MH, Bergsland EK, Ryan DP, Enzinger PC, Lynch TJ, Zhu AX, et al. Phase II study of recombinant human endostatin in patients with advanced neuroendocrine tumors. J Clin Oncol 2006;24:3555-61.
    • (2006) J Clin Oncol , vol.24 , pp. 3555-3561
    • Kulke, M.H.1    Bergsland, E.K.2    Ryan, D.P.3    Enzinger, P.C.4    Lynch, T.J.5    Zhu, A.X.6
  • 41
    • 77954789459 scopus 로고    scopus 로고
    • Randomized run-in study of bevacizumab and everolimus in low-to intermediate-grade neuroendocrine tumors using perfusion CT as functional biomarker
    • Yao JC, Phan AT, Fogleman D, Ng C, Jacobs C, Dagohoy CD, et al. Randomized run-in study of bevacizumab and everolimus in low-to intermediate-grade neuroendocrine tumors using perfusion CT as functional biomarker. Proc Am Soc Clin Oncol 2010;28:4002.
    • (2010) Proc Am Soc Clin Oncol , vol.28 , pp. 4002
    • Yao, J.C.1    Phan, A.T.2    Fogleman, D.3    Ng, C.4    Jacobs, C.5    Dagohoy, C.D.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.