HtrA3 as an Early Marker for Preeclampsia: Specific Monoclonal Antibodies and Sensitive High-Throughput Assays for Serum Screening

PLoS ONE

Volumn 7, Issue 9, 2012, Pages

  Dynon, Kemperly ^a   Heng, Sophea ^a   Puryer, Michelle ^a   Li, Ying ^a   Walton, Kelly ^a   Endo, Yaeta ^b   Nie, Guiying ^a,c  

^a HUDSON INSTITUTE OF MEDICAL RESEARCH   (Australia)

^b EHIME UNIVERSITY   (Japan)

^c MONASH UNIVERSITY   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

HIGH TEMPERATURE REQUIREMENT A3 PROTEIN; ISOENZYME; MONOCLONAL ANTIBODY; SERINE PROTEINASE; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ANTIBODY SPECIFICITY; ARTICLE; BLOOD ANALYSIS; CONTROLLED STUDY; DISEASE ASSOCIATION; EARLY DIAGNOSIS; ENZYME ASSAY; FEMALE; GESTATIONAL AGE; HIGH THROUGHPUT SCREENING; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOADSORBENT; IMMUNOASSAY; IMMUNOHISTOCHEMISTRY; MOUSE; NONHUMAN; PREECLAMPSIA; SENSITIVITY ANALYSIS; VALIDATION PROCESS; WESTERN BLOTTING;

ADULT; ANIMALS; ANTIBODIES, MONOCLONAL; ENDOMETRIUM; EPITOPE MAPPING; EPITOPES; FEMALE; GESTATIONAL AGE; HUMANS; IMMUNOASSAY; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; PRE-ECLAMPSIA; PREGNANCY; PREGNANCY TRIMESTER, SECOND; PROTEIN ISOFORMS; PROTEIN STRUCTURE, TERTIARY; RECOMBINANT PROTEINS; SERINE ENDOPEPTIDASES; TISSUE DISTRIBUTION; TROPHOBLASTS; UTERUS;

MAMMALIA;

EID: 84866650557     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0045956     Document Type: Article

References (41)

1. Clausen T, Kaiser M, Huber R, Ehrmann M, (2011) HTRA proteases: regulated proteolysis in protein quality control. Nat Rev Mol Cell Biol 12: 152-162.
2. Clausen T, Southan C, Ehrmann M, (2002) The HtrA family of proteases: implications for protein composition and cell fate. Mol Cell 10: 443-455.
3. Chien J, Campioni M, Shridhar V, Baldi A, (2009) HtrA serine proteases as potential therapeutic targets in cancer. Curr Cancer Drug Targets 9: 451-468.
4. Wang LJ, Cheong ML, Lee YS, Lee MT, Chen H (2012) High Temperature Requirement A4 (HtrA4) Suppresses the Fusogenic Activity of Syncytin-1 and Promotes Trophoblast Invasion. Mol Cell Biol.
5. Nie GY, Hampton A, Li Y, Findlay JK, Salamonsen LA, (2003) Identification and cloning of two isoforms of human high-temperature requirement factor A3 (HtrA3), characterization of its genomic structure and comparison of its tissue distribution with HtrA1 and HtrA2. Biochem J 371: 39-48.
6. Nie GY, Li Y, Minoura H, Batten L, Ooi GT, et al. (2003) A novel serine protease of the mammalian HtrA family is up-regulated in mouse uterus coinciding with placentation. Mol Hum Reprod 9: 279-290.
7. Nie G, Li Y, Hale K, Okada H, Manuelpillai U, et al. (2006) Serine peptidase HTRA3 is closely associated with human placental development and is elevated in pregnancy serum. Biol Reprod 74: 366-374.
8. Nie G, Li Y, He H, Findlay JK, Salamonsen LA, (2006) HtrA3, a serine protease possessing an IGF-binding domain, is selectively expressed at the maternal-fetal interface during placentation in the mouse. Placenta 27: 491-501.
9. Singh H, Endo Y, Nie G, (2011) Decidual HtrA3 negatively regulates trophoblast invasion during human placentation. Hum Reprod 26: 748-757.
10. Singh H, Makino SI, Endo Y, Nie G, (2010) Inhibition of HTRA3 stimulates trophoblast invasion during human placental development. Placenta 31: 1085-1092.
11. Bowden M, Drummond AE, Salamonsen LA, Findlay JK, Nie G, (2009) Evolutionary conservation of mammalian HTRA3 and its developmental regulation in the rat ovary. J Exp Zool B Mol Dev Evol 312: 701-713.
12. Bowden MA, Li Y, Liu YX, Findlay JK, Salamonsen LA, et al. (2008) HTRA3 expression in non-pregnant rhesus monkey ovary and endometrium, and at the maternal-fetal interface during early pregnancy. Reprod Biol Endocrinol 6: 22.
13. Tocharus J, Tsuchiya A, Kajikawa M, Ueta Y, Oka C, et al. (2004) Developmentally regulated expression of mouse HtrA3 and its role as an inhibitor of TGF-beta signaling. Dev Growth Differ 46: 257-274.
14. Kato MV, (2000) A secreted tumor-suppressor, mac25, with activin-binding activity. Mol Med 6: 126-135.
15. Beleford D, Rattan R, Chien J, Shridhar V, (2010) High temperature requirement A3 (HtrA3) promotes etoposide- and cisplatin-induced cytotoxicity in lung cancer cell lines. J Biol Chem 285: 12011-12027.
16. Beleford D, Liu Z, Rattan R, Quagliuolo L, Boccellino M, et al. (2010) Methylation induced gene silencing of HtrA3 in smoking-related lung cancer. Clin Cancer Res 16: 398-409.
17. Bowden MA, Di Nezza-Cossens LA, Jobling T, Salamonsen LA, Nie G, (2006) Serine proteases HTRA1 and HTRA3 are down-regulated with increasing grades of human endometrial cancer. Gynecol Oncol 103: 253-260.
18. Bowden MA, Drummond AE, Fuller PJ, Salamonsen LA, Findlay JK, et al. (2010) High-temperature requirement factor A3 (HtrA3): a novel serine protease and its potential role in ovarian function and ovarian cancers. Mol Cell Endocrinol 327: 13-18.
19. Narkiewicz J, Klasa-Mazurkiewicz D, Zurawa-Janicka D, Skorko-Glonek J, Emerich J, et al. (2008) Changes in mRNA and protein levels of human HtrA1, HtrA2 and HtrA3 in ovarian cancer. Clin Biochem 41: 561-569.
20. Narkiewicz J, Lapinska-Szumczyk S, Zurawa-Janicka D, Skorko-Glonek J, Emerich J, et al. (2009) Expression of human HtrA1, HtrA2, HtrA3 and TGF-beta1 genes in primary endometrial cancer. Oncol Rep 21: 1529-1537.
21. Theoleyre S, Mottier S, Masson D, Denis MG, (2010) HtrA3 is regulated by 15-deoxy-Delta12,14-prostaglandin J2 independently of PPARgamma in clear cell renal cell carcinomas. Biochem Biophys Res Commun 394: 453-458.
22. Li Y, Puryer M, Lin E, Hale K, Salamonsen LA, et al. (2011) Placental HtrA3 is regulated by oxygen tension and serum levels are altered during early pregnancy in women destined to develop preeclampsia. J Clin Endocrinol Metab 96: 403-411.
23. Than NG, Romero R, Hillermann R, Cozzi V, Nie G, et al. (2008) Prediction of preeclampsia- a workshop report. Placenta 29 Suppl A: S83-85.
24. Osungbade KO, Ige OK (2011) Public health perspectives of preeclampsia in developing countries: implication for health system strengthening. J Pregnancy 2011: 6 pages, article number 481095.
25. Dolea C, Abu Zahr C (2003) Global burden of hypertensive disorders of pregnancy in the year 2000. Geneva: World Health Organization.
26. Kajantie E, Eriksson JG, Osmond C, Thornburg K, Barker DJ, (2009) Pre-eclampsia is associated with increased risk of stroke in the adult offspring: the Helsinki birth cohort study. Stroke 40: 1176-1180.
27. Wu CS, Nohr EA, Bech BH, Vestergaard M, Catov JM, et al. (2009) Health of children born to mothers who had preeclampsia: a population-based cohort study. Am J Obstet Gynecol 201: 269 e261-e210.
28. Bellamy L, Casas JP, Hingorani AD, Williams DJ, (2007) Pre-eclampsia and risk of cardiovascular disease and cancer in later life: systematic review and meta-analysis. BMJ 335: 974.
29. Singh H, Makino S, Endo Y, Li Y, Stephens AN, et al. (2012) Application of the wheat-germ cell-free translation system to produce high temperature requirement A3 (HtrA3) proteases. Biotechniques 52: 23-28.
30. Graham CH, Hawley TS, Hawley RG, MacDougall JR, Kerbel RS, et al. (1993) Establishment and characterization of first trimester human trophoblast cells with extended lifespan. Exp Cell Res 206: 204-211.
31. Roberts JM, Pearson GD, Cutler JA, Lindheimer MD, (2003) Summary of the NHLBI Working Group on Research on Hypertension During Pregnancy. Hypertens Pregnancy 22: 109-127.
32. Huang B, Xiao H, Zhang J, Zhang L, Yang H, et al. (2009) Dual-label time-resolved fluoroimmunoassay for simultaneous detection of aflatoxin B1 and ochratoxin A. Arch Toxicol. 83: 619-624.
33. Gasteiger E, Hoogland C, Gattiker A, Duvaud S, Wilkins MR, et al. (2005) Protein Identification and Analysis Tools on the ExPASy Server. In: Walker JM, editor. The Proteomics Protocols Handbook: Humana Press. 571-607.
34. The UniProt C, (2012) Reorganizing the protein space at the Universal Protein Resource (UniProt). Nucleic Acids Research 40: D71-D75.
35. Petersen SB, Lovmand JM, Honore L, Jeppesen CB, Pridal L, et al. (2010) Comparison of a luminescent oxygen channeling immunoassay and an ELISA for detecting insulin aspart in human serum. J Pharm Biomed Anal 51: 217-224.
36. Golla R, Seethala R, (2004) A sensitive, robust high-throughput electrochemiluminescence assay for rat insulin. J Biomol Screen 9: 62-70.
37. McGiven JA, Sawyer J, Perrett LL, Brew SD, Commander NJ, et al. (2008) A new homogeneous assay for high throughput serological diagnosis of brucellosis in ruminants. J Immunol Methods 337: 7-15.
38. Poulsen F, Jensen KB, (2007) A luminescent oxygen channeling immunoassay for the determination of insulin in human plasma. J Biomol Screen 12: 240-247.
39. Hadker N, Garg S, Costanzo C, Miller JD, Foster T, et al. (2009) Financial impact of a novel pre-eclampsia diagnostic test versus standard practice: a decision-analytic modeling analysis from a UK healthcare payer perspective. J Med Econ 13: 728-737.
40. Cetin I, Huppertz B, Burton G, Cuckle H, Gonen R, et al. (2011) Pregenesys pre-eclampsia markers consensus meeting: What do we require from markers, risk assessment and model systems to tailor preventive strategies? Placenta 32 (Suppl):: S4-16.
41. Levine RJ, Lam C, Qian C, Yu KF, Maynard SE, et al. (2006) Soluble endoglin and other circulating antiangiogenic factors in preeclampsia. N Engl J Med 355: 992-1005.