Long-term prognosis of diabetic foot patients and their limbs: Amputation and death over the course of a decade

Diabetes Care

Volumn 35, Issue 10, 2012, Pages 2021-2027

  Morbach, Stephan ^a   Furchert, Heike ^a   Gröblinghoff, Ute ^a   Hoffmeier, Heribert ^a   Kersten, Kerstin ^a   Klauke, Gerd Thomas ^a   Klemp, Ulrike ^a   Roden, Thomas ^b   Icks, Andrea ^c   Haastert, Burkhard ^a   Rümenapf, Gerhard ^d   Abbas, Zulfiqarali G ^e,f   Bharara, Manish ^g   Armstrong, David G ^g  

^a Marienkrankenhaus ^*  (Germany)

^b Center for Diabetology   (Germany)

^c HEINRICH HEINE UNIVERSITY   (Germany)

^d Diakonissen Stiftungs Krankenhaus Speyer   (Germany)

^e MUHIMBILI UNIVERSITY OF HEALTH AND ALLIED SCIENCES   (Tanzania)

^f Abbas Medical Centre   (Tanzania)

^g UNIVERSITY OF ARIZONA COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

INSULIN;

ADULT; AGE DISTRIBUTION; AGED; ANKLE BRACHIAL INDEX; ARTICLE; CHRONIC KIDNEY FAILURE; COHORT ANALYSIS; DEATH; DIABETIC FOOT; DIABETIC NEUROPATHY; DISEASE SEVERITY; FEMALE; FOLLOW UP; FOOT AMPUTATION; HUMAN; LIMB SALVAGE; MAJOR CLINICAL STUDY; MALE; MORTALITY; NON INSULIN DEPENDENT DIABETES MELLITUS; OUTCOME ASSESSMENT; PERIPHERAL OCCLUSIVE ARTERY DISEASE; PROGNOSIS; PROSPECTIVE STUDY; RENAL REPLACEMENT THERAPY; SEX DIFFERENCE; SURVIVAL RATE;

ADULT; AGED; AGED, 80 AND OVER; AMPUTATION; ANKLE BRACHIAL INDEX; DIABETIC FOOT; FEMALE; GERMANY; HUMANS; LIMB SALVAGE; MALE; MIDDLE AGED; PERIPHERAL ARTERIAL DISEASE; PROGNOSIS; RISK FACTORS; TREATMENT OUTCOME;

EID: 84866641630     PISSN: 01495992     EISSN: 19355548     Source Type: Journal    
DOI: 10.2337/dc12-0200     Document Type: Article

References (29)

1. Boulton AJ, Vileikyte L, Ragnarson-Tennvall G, Apelqvist J. The global burden of diabetic foot disease. Lancet 2005;366:1719-1724
2. Apelqvist J, Larsson J, Agardh CD. Long-term prognosis for diabetic patients with foot ulcers. J Intern Med 1993;233:485-491
3. Faglia E, Favales F, Morabito A. New ulceration, new major amputation, and survival rates in diabetic subjects hospitalized for foot ulceration from 1990 to 1993: a 6.5-year follow-up. Diabetes Care 2001;24:78-83
4. Moulik PK, Mtonga R, Gill GV. Amputation and mortality in new-onset diabetic foot ulcers stratified by etiology. Diabetes Care 2003;26:491-494
5. Ghanassia E, Villon L, Thuan Dit Dieudonné JF, Boegner C, Avignon A, Sultan A. Long-term outcome and disability of diabetic patients hospitalized for diabetic foot ulcers: a 6.5-year follow-up study. Diabetes Care 2008;31:1288-1292
6. Izumi Y, Satterfield K, Lee S, Harkless LB. Risk of reamputation in diabetic patients stratified by limb and level of amputation: a 10-year observation. Diabetes Care 2006; 29:566-570
7. Izumi Y, Satterfield K, Lee S, Harkless LB, Lavery LA. Mortality of first-time amputees in diabetics: a 10-year observation. Diabetes Res Clin Pract 2009;83:126-131
8. Iversen MM, Tell GS, Riise T, et al. History of foot ulcer increases mortality among individuals with diabetes: ten-year follow-up of the Nord-Trøndelag Health Study, Norway. Diabetes Care 2009;32:2193-2199
9. Hiatt WR. Medical treatment of peripheral arterial disease and claudication. N Engl J Med 2001;344:1608-1621
10. Chantelau E, Lee KM. Ankle/arm pressure index in diabetes mellitus. Diabetologia 1994;37:223
11. Morbach S, Lutale JK, Viswanathan V, et al. Regional differences in risk factors and clinical presentation of diabetic foot lesions. Diabet Med 2004;21:91-95
12. Morbach S, Quante C, Ochs HR, Gaschler F, Pallast JM, Knevels U. Increased risk of lower-extremity amputation among Caucasian diabetic patients on dialysis. Diabetes Care 2001;24:1689-1690
13. Prompers L, Schaper N, Apelqvist J, et al. Prediction of outcome in individuals with diabetic foot ulcers: focus on the differences between individuals with and without peripheral arterial disease. The EURODIALE Study. Diabetologia 2008;51:747-755
14. Gershater MA, Löndahl M, Nyberg P, et al. Complexity of factors related to outcome of neuropathic and neuroischaemic/ ischaemic diabetic foot ulcers: a cohort study. Diabetologia 2009;52:398-407
15. Winkley K, Stahl D, Chalder T, Edmonds ME, Ismail K. Risk factors associated with adverse outcomes in a population-based prospective cohort study of people with their first diabetic foot ulcer. J Diabetes Complications 2007;21:341-349
16. Winkley K, Sallis H, Kariyawasam D, et al. Five-year follow-up of a cohort of people with their first diabetic foot ulcer: the persistent effect of depression on mortality. Diabetologia 2012;55:303-310
17. Young MJ, McCardle JE, Randall LE, Barclay JI. Improved survival of diabetic foot ulcer patients 1995-2008: possible impact of aggressive cardiovascular risk management. Diabetes Care 2008;31:2143-2147
18. Jeffcoate WJ, Chipchase SY, Ince P, Game FL. Assessing the outcome of the management of diabetic foot ulcers using ulcer-related and person-related measures. Diabetes Care 2006;29:1784-1787
19. Graziani L, Silvestro A, Bertone V, et al. Vascular involvement in diabetic subjects with ischemic foot ulcer: a new morphologic categorization of disease severity. Eur J Vasc Endovasc Surg 2007;33:453-460
20. Apelqvist J, Elgzyri T, Larsson J, Löndahl M, Nyberg P, Thörne J. Factors related to outcome of neuroischemic/ischemic foot ulcer in diabetic patients. J Vasc Surg 2011; 53:1582-1588, e2
21. Boyko EJ, Ahroni JH, Smith DG, Davignon D. Increased mortality associated with diabetic foot ulcer. Diabet Med 1996;13:967-972
22. Subramaniam B, Pomposelli F, Talmor D, Park KW. Perioperative and long-term morbidity and mortality after above-knee and below-knee amputations in diabetics and nondiabetics. Anesth Analg 2005; 100:1241-1247
23. Tentolouris N, Al-Sabbagh S, Walker MG, Boulton AJ, Jude EB. Mortality in diabetic and nondiabetic patients after amputations performed from 1990 to 1995: a 5-year follow-up study. Diabetes Care 2004;7: 1598-1604
24. Icks A, Scheer M, Morbach S, et al. Time-dependent impact of diabetes on mortality in patients after major lower extremity amputation: survival in apopulation-based 5-year cohort in Germany. Diabetes Care 2011;34:1350-1354
25. Junrungsee S, Kosachunhanun N, Wongthanee A, Rerkasem K. History of foot ulcers increases mortality among patients with diabetes in Northern Thailand. Diabet Med 2011;28:608-611
26. Morbach S, Gröblinghoff U, Schulze H, et al. All-cause mortality after diabetes-related amputation in Barbados: a prospective case-control study: response to Hambleton et Al. Diabetes Care 2009;32: e100; author reply e101
27. Forsblom CM, Sane T, Groop PH, et al. Risk factors for mortality in Type II (non-insulin-dependent) diabetes: evidence of a role for neuropathy and a protective effect of HLA-DR4. Diabetologia 1998;41:1253-1262
28. Coppini DV, Bowtell PA, Weng C, Young PJ, Sönksen PH. Showing neuropathy is related to increased mortality in diabetic patients - a survival analysis using an accelerated failure time model. J Clin Epidemiol 2000;53:519-523
29. Chammas NK, Hill RL, Foster AV, Edmonds ME. Is neuropathic ulceration the key to understanding increased mortality due to ischaemic heart disease in diabetic foot ulcer patients? A population approach using a proportionate model. J Int Med Res 2002;30:553-559