Intravenous multipotent adult progenitor cell therapy after traumatic brain injury: Modulation of the resident microglia population

Journal of Neuroinflammation

Volumn 9, Issue , 2012, Pages

  Walker, Peter A ^a   Bedi, Supinder S ^a   Shah, Shinil K ^a,b   Jimenez, Fernando ^a   Xue, Hasen ^a   Hamilton, Jason A ^c   Smith, Philippa ^a   Thomas, Chelsea P ^a   Mays, Robert W ^c   Pati, Shibani ^a   Cox Jr, Charles S ^a,b  

^a UNIVERSITY OF TEXAS MEDICAL SCHOOL   (United States)

^b TEXAS A AND M UNIVERSITY   (United States)

^c ATHERSYS INC   (United States)

Author keywords

Blood brain barrier; Microglia; Multipotent adult progenitor cells; Splenocytes; Stem cells; Traumatic brain injury

Indexed keywords

CD206 ANTIGEN; CD4 ANTIGEN; CD86 ANTIGEN; INTERLEUKIN 2 RECEPTOR ALPHA; LYMPHOCYTE ANTIGEN; TRANSCRIPTION FACTOR FOXP3; UNCLASSIFIED DRUG;

ADULT STEM CELL; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BLOOD BRAIN BARRIER; CELL CONTACT; CELL PROLIFERATION; COCULTURE; CONTROLLED STUDY; IN VITRO STUDY; IN VIVO STUDY; MACROPHAGE; MACROPHAGE ACTIVATION; MICROGLIA; MOUSE; MULTIPOTENT STEM CELL; NEUROPROTECTION; NONHUMAN; REGULATORY T LYMPHOCYTE; SPLEEN CELL; TRAUMATIC BRAIN INJURY;

ADMINISTRATION, INTRAVENOUS; ADULT STEM CELLS; ANALYSIS OF VARIANCE; ANIMALS; ANTIGENS, CD; BLOOD-BRAIN BARRIER; BRAIN INJURIES; CELL COMMUNICATION; CELL PROLIFERATION; CELLS, CULTURED; COCULTURE TECHNIQUES; DISEASE MODELS, ANIMAL; FLOW CYTOMETRY; FORKHEAD TRANSCRIPTION FACTORS; HUMANS; LIVER; LYMPHOCYTES; MACROPHAGES; MICE; MICE, INBRED C57BL; MICROGLIA; MULTIPOTENT STEM CELLS; TISSUE THERAPY;

EID: 84866635677     PISSN: None     EISSN: 17422094     Source Type: Journal    
DOI: 10.1186/1742-2094-9-228     Document Type: Article

References (18)

1. Thurman DJ, Alverson C, Dunn KA, Guerrero J, Sniezek JE. Traumatic brain injury in the United States: A public health perspective. J Head Trauma Rehabil 1999, 14:602-615. 10.1097/00001199-199912000-00009, 10671706.
2. Olson JK, Miller SD. Microglia initiate central nervous system innate and adaptive immune responses through multiple TLRs. J Immunol 2004, 173:3916-3924.
3. Chirumamilla S, Sun D, Bullock MR, Colello RJ. Traumatic brain injury induced cell proliferation in the adult mammalian central nervous system. J Neurotrauma 2002, 19:693-703. 10.1089/08977150260139084, 12165131.
4. Beck KD, Nguyen HX, Galvan MD, Salazar DL, Woodruff TM, Anderson AJ. Quantitative analysis of cellular inflammation after traumatic spinal cord injury: evidence for a multiphasic inflammatory response in the acute to chronic environment. Brain 2010, 133:433-447. 10.1093/brain/awp322, 2858013, 20085927.
5. Smith HS. Activated microglia in nociception. Pain Physician 2010, 13:295-304.
6. Loane DJ, Byrnes KR. Role of microglia in neurotrauma. Neurotherapeutics 2010, 7:366-377. 10.1016/j.nurt.2010.07.002, 2948548, 20880501.
7. Kigerl KA, Gensel JC, Ankeny DP, Alexander JK, Donnelly DJ, Popovich PG. Identification of two distinct macrophage subsets with divergent effects causing either neurotoxicity or regeneration in the injured mouse spinal cord. J Neurosci 2009, 29:13435-13444. 10.1523/JNEUROSCI.3257-09.2009, 2788152, 19864556.
8. Gordon S. Alternative activation of macrophages. Nat Rev Immunol 2003, 3:23-35. 10.1038/nri978, 12511873.
9. Graeber MB. Changing face of microglia. Science 2010, 330:783-788. 10.1126/science.1190929, 21051630.
10. Jiang Y, Vaessen B, Lenvik T, Blackstad M, Reyes M, Verfaillie CM. Multipotent progenitor cells can be isolated from postnatal murine bone marrow, muscle, and brain. Exp Hematol 2002, 30:896-904. 10.1016/S0301-472X(02)00869-X, 12160841.
11. Walker PA, Shah SK, Jimenez F, Gerber MH, Xue H, Cutrone R, Hamilton JA, Mays RW, Deans R, Pati S, et al. Intravenous multipotent adult progenitor cell therapy for traumatic brain injury: preserving the blood brain barrier via an interaction with splenocytes. Exp Neurol 2010, 225:341-352. 10.1016/j.expneurol.2010.07.005, 20637752.
12. Kovacsovics-Bankowski M, Mauch K, Raber A, Streeter PR, Deans RJ, Maziarz RT, Van't Hof W. Pre-clinical safety testing supporting clinical use of allogeneic multipotent adult progenitor cells. Cytotherapy 2008, 10:730-742. 10.1080/14653240802320245, 18985479.
13. Kovacsovics-Bankowski M, Streeter PR, Mauch KA, Frey MR, Raber A, van't Hof W, Deans R, Maziarz RT. Clinical scale expanded adult pluripotent stem cells prevent graft-versus-host disease. Cell Immunol 2009, 255:55-60. 10.1016/j.cellimm.2008.10.004, 19022422.
14. Lighthall JW. Controlled cortical impact: a new experimental brain injury model. J Neurotrauma 1988, 5:1-15. 10.1089/neu.1988.5.1, 3193461.
15. Harting MT, Jimenez F, Adams SD, Mercer DW, Cox CS. Acute, regional inflammatory response after traumatic brain injury: Implications for cellular therapy. Surgery 2008, 144:803-813. 10.1016/j.surg.2008.05.017, 19081024.
16. Lakhan SE, Kirchgessner A, Hofer M. Inflammatory mechanisms in ischemic stroke: therapeutic approaches. J Transl Med 2009, 7:97. 10.1186/1479-5876-7-97, 2780998, 19919699.
17. Fischer UM, Harting MT, Jimenez F, Monzon-Posadas WO, Xue H, Savitz SI, Laine GA, Cox CS. Pulmonary passage is a major obstacle for intravenous stem cell delivery: the pulmonary first-pass effect. Stem Cells Dev 2009, 18:683-692. 10.1089/scd.2008.0253, 3190292, 19099374.
18. Aloisi F. Immune function of microglia. Glia 2001, 36:165-179. 10.1002/glia.1106, 11596125.