Regulation and Function of Adiponectin Receptors in Skeletal Muscle

Vitamins and Hormones

Volumn 90, Issue , 2012, Pages 95-123

  Lustig, Yaniv ^a   Hemi, Rina ^a   Kanety, Hannah ^a  

^a SHEBA MEDICAL CENTER   (Israel)

Author keywords

Adiponectin; AdipoR1; AdipoR2; Diabetes; Insulin resistance; Posttranscriptional regulation; Skeletal muscle; Transcriptional regulation

Indexed keywords

EID: 84866627407     PISSN: 00836729     EISSN: None     Source Type: Book Series    
DOI: 10.1016/B978-0-12-398313-8.00004-X     Document Type: Chapter

References (124)

1. Adeli K. Translational control mechanisms in metabolic regulation: Critical role of RNA binding proteins, microRNAs, and cytoplasmic RNA granules. American Journal of Physiology. Endocrinology and Metabolism 2011, 301:E1051-E1064.
2. Amin R.H., Mathews S.T., Camp H.S., Ding L., Leff T. Selective activation of PPARgamma in skeletal muscle induces endogenous production of adiponectin and protects mice from diet-induced insulin resistance. American Journal of Physiology. Endocrinology and Metabolism 2010, 298:E28-E37.
3. Anavi S., Ilan E., Tirosh O., Madar Z. Infusion of a lipid emulsion modulates AMPK and related proteins in rat liver, muscle, and adipose tissues. Obesity (Silver Spring) 2010, 18:1108-1115.
4. Andersen J.L., Schjerling P., Andersen L.L., Dela F. Resistance training and insulin action in humans: Effects of de-training. The Journal of Physiology 2003, 551:1049-1058.
5. Ando D., Hosaka Y., Suzuki K., Yamagata Z. Effects of exercise training on circulating high molecular weight adiponectin and adiponectin oligomer composition: A randomized controlled trial. Journal of Atherosclerosis and Thrombosis 2009, 16:733-739.
6. Arita Y., Kihara S., Ouchi N., Takahashi M., Maeda K., Miyagawa J., et al. Paradoxical decrease of an adipose-specific protein, adiponectin, in obesity. Biochemical and Biophysical Research Communications 1999, 257:79-83.
7. Ashwal R., Hemi R., Tirosh A., Gordin R., Yissachar E., Cohen-Dayag A., et al. Differential expression of novel adiponectin receptor-1 transcripts in skeletal muscle of subjects with normal glucose tolerance and type 2 diabetes. Diabetes 2011, 60:936-946.
8. Barnea M., Shamay A., Stark A.H., Madar Z. A high-fat diet has a tissue-specific effect on adiponectin and related enzyme expression. Obesity (Silver Spring) 2006, 14:2145-2153.
9. Bartel D.P. MicroRNAs: Target recognition and regulatory functions. Cell 2009, 136:215-233.
10. Berg A.H., Combs T.P., Du X., Brownlee M., Scherer P.E. The adipocyte-secreted protein Acrp30 enhances hepatic insulin action. Nature Medicine 2001, 7:947-953.
11. Beylot M., Pinteur C., Peroni O. Expression of the adiponectin receptors AdipoR1 and AdipoR2 in lean rats and in obese Zucker rats. Metabolism 2006, 55:396-401.
12. Bjursell M., Ahnmark A., Bohlooly Y., William-Olsson L., Rhedin M., Peng X.R., et al. Opposing effects of adiponectin receptors 1 and 2 on energy metabolism. Diabetes 2007, 56:583-593.
13. Bluher M., Bullen J.W., Lee J.H., Kralisch S., Fasshauer M., Kloting N., et al. Circulating adiponectin and expression of adiponectin receptors in human skeletal muscle: Associations with metabolic parameters and insulin resistance and regulation by physical training. The Journal of Clinical Endocrinology and Metabolism 2006, 91:2310-2316.
14. Bonnard C., Durand A., Vidal H., Rieusset J. Changes in adiponectin, its receptors and AMPK activity in tissues of diet-induced diabetic mice. Diabetes & Metabolism 2008, 34:52-61.
15. Brochu-Gaudreau K., Rehfeldt C., Blouin R., Bordignon V., Murphy B.D., Palin M.F. Adiponectin action from head to toe. Endocrine 2010, 37:11-32.
16. Buechler C., Wanninger J., Neumeier M. Adiponectin receptor binding proteins-Recent advances in elucidating adiponectin signalling pathways. FEBS Letters 2010, 584:4280-4286.
17. Bullen J.W., Bluher S., Kelesidis T., Mantzoros C.S. Regulation of adiponectin and its receptors in response to development of diet-induced obesity in mice. American Journal of Physiology. Endocrinology and Metabolism 2007, 292:E1079-E1086.
18. Burr J.F., Rowan C.P., Jamnik V.K., Riddell M.C. The role of physical activity in type 2 diabetes prevention: Physiological and practical perspectives. The Physician and Sportsmedicine 2010, 38:72-82.
19. Ceddia R.B., Somwar R., Maida A., Fang X., Bikopoulos G., Sweeney G. Globular adiponectin increases GLUT4 translocation and glucose uptake but reduces glycogen synthesis in rat skeletal muscle cells. Diabetologia 2005, 48:132-139.
20. Chang S.P., Chen Y.H., Chang W.C., Liu I.M., Cheng J.T. Increase of adiponectin receptor gene expression by physical exercise in soleus muscle of obese Zucker rats. European Journal of Applied Physiology 2006, 97:189-195.
21. Choudhary S., Sinha S., Zhao Y., Banerjee S., Sathyanarayana P., Shahani S., et al. NF-kappaB-inducing kinase (NIK) mediates skeletal muscle insulin resistance: Blockade by adiponectin. Endocrinology 2011, 152:3622-3627.
22. Christiansen T., Paulsen S.K., Bruun J.M., Ploug T., Pedersen S.B., Richelsen B. Diet-induced weight loss and exercise alone and in combination enhance the expression of adiponectin receptors in adipose tissue and skeletal muscle, but only diet-induced weight loss enhanced circulating adiponectin. The Journal of Clinical Endocrinology and Metabolism 2010, 95:911-919.
23. Civitarese A.E., Jenkinson C.P., Richardson D., Bajaj M., Cusi K., Kashyap S., et al. Adiponectin receptors gene expression and insulin sensitivity in non-diabetic Mexican Americans with or without a family history of Type 2 diabetes. Diabetologia 2004, 47:816-820.
24. Civitarese A.E., Ukropcova B., Carling S., Hulver M., DeFronzo R.A., Mandarino L., et al. Role of adiponectin in human skeletal muscle bioenergetics. Cell Metabolism 2006, 4:75-87.
25. Coletta D.K., Sriwijitkamol A., Wajcberg E., Tantiwong P., Li M., Prentki M., et al. Pioglitazone stimulates AMP-activated protein kinase signalling and increases the expression of genes involved in adiponectin signalling, mitochondrial function and fat oxidation in human skeletal muscle in vivo: A randomised trial. Diabetologia 2009, 52:723-732.
26. Combs T.P., Berg A.H., Obici S., Scherer P.E., Rossetti L. Endogenous glucose production is inhibited by the adipose-derived protein Acrp30. The Journal of Clinical Investigation 2001, 108:1875-1881.
27. Combs T.P., Pajvani U.B., Berg A.H., Lin Y., Jelicks L.A., Laplante M., et al. A transgenic mouse with a deletion in the collagenous domain of adiponectin displays elevated circulating adiponectin and improved insulin sensitivity. Endocrinology 2004, 145:367-383.
28. Crunkhorn S., Dearie F., Mantzoros C., Gami H., da Silva W.S., Espinoza D., et al. Peroxisome proliferator activator receptor gamma coactivator-1 expression is reduced in obesity: Potential pathogenic role of saturated fatty acids and p38 mitogen-activated protein kinase activation. The Journal of Biological Chemistry 2007, 282:15439-15450.
29. de Oliveira C., de Mattos A.B., Biz C., Oyama L.M., Ribeiro E.B., do Nascimento C.M. High-fat diet and glucocorticoid treatment cause hyperglycemia associated with adiponectin receptor alterations. Lipids in Health and Disease 2011, 10:11.
30. Debard C., Laville M., Berbe V., Loizon E., Guillet C., Morio-Liondore B., et al. Expression of key genes of fatty acid oxidation, including adiponectin receptors, in skeletal muscle of Type 2 diabetic patients. Diabetologia 2004, 47:917-925.
31. Deckert C.M., Heiker J.T., Beck-Sickinger A.G. Localization of novel adiponectin receptor constructs. Journal of Receptor and Signal Transduction Research 2006, 26:647-657.
32. DeFronzo R.A., Gunnarsson R., Bjorkman O., Olsson M., Wahren J. Effects of insulin on peripheral and splanchnic glucose metabolism in noninsulin-dependent (type II) diabetes mellitus. The Journal of Clinical Investigation 1985, 76:149-155.
33. Delaigle A.M., Jonas J.C., Bauche I.B., Cornu O., Brichard S.M. Induction of adiponectin in skeletal muscle by inflammatory cytokines: in vivo and in vitro studies. Endocrinology 2004, 145:5589-5597.
34. Delaigle A.M., Senou M., Guiot Y., Many M.C., Brichard S.M. Induction of adiponectin in skeletal muscle of type 2 diabetic mice: in vivo and in vitro studies. Diabetologia 2006, 49:1311-1323.
35. Denzel M.S., Scimia M.C., Zumstein P.M., Walsh K., Ruiz-Lozano P., Ranscht B. T-cadherin is critical for adiponectin-mediated cardioprotection in mice. The Journal of Clinical Investigation 2010, 120:4342-4352.
36. Du M., Shen Q.W., Zhu M.J., Ford S.P. Leucine stimulates mammalian target of rapamycin signaling in C2C12 myoblasts in part through inhibition of adenosine monophosphate-activated protein kinase. Journal of Animal Science 2007, 85:919-927.
37. Eriksson K.F., Lindgarde F. Prevention of type 2 (non-insulin-dependent) diabetes mellitus by diet and physical exercise. The 6-year Malmo feasibility study. Diabetologia 1991, 34:891-898.
38. Fang X., Fetros J., Dadson K.E., Xu A., Sweeney G. Leptin prevents the metabolic effects of adiponectin in L6 myotubes. Diabetologia 2009, 52:2190-2200.
39. Fang X., Palanivel R., Zhou X., Liu Y., Xu A., Wang Y., et al. Hyperglycemia- and hyperinsulinemia-induced alteration of adiponectin receptor expression and adiponectin effects in L6 myoblasts. Journal of Molecular Endocrinology 2005, 35:465-476.
40. Fiaschi T., Cirelli D., Comito G., Gelmini S., Ramponi G., Serio M., et al. Globular adiponectin induces differentiation and fusion of skeletal muscle cells. Cell Research 2009, 19:584-597.
41. Fruebis J., Tsao T.S., Javorschi S., Ebbets-Reed D., Erickson M.R., Yen F.T., et al. Proteolytic cleavage product of 30-kDa adipocyte complement-related protein increases fatty acid oxidation in muscle and causes weight loss in mice. Proceedings of the National Academy of Sciences of the United States of America 2001, 98:2005-2010.
42. Ghosh N., Patel N., Jiang K., Watson J.E., Cheng J., Chalfant C.E., et al. Ceramide-activated protein phosphatase involvement in insulin resistance via Akt, serine/arginine-rich protein 40, and ribonucleic acid splicing in L6 skeletal muscle cells. Endocrinology 2007, 148:1359-1366.
43. Heiker J.T., Kosel D., Beck-Sickinger A.G. Molecular mechanisms of signal transduction via adiponectin and adiponectin receptors. Biological Chemistry 2010, 391:1005-1018.
44. Heiker J.T., Wottawah C.M., Juhl C., Kosel D., Morl K., Beck-Sickinger A.G. Protein kinase CK2 interacts with adiponectin receptor 1 and participates in adiponectin signaling. Cellular Signalling 2009, 21:936-942.
45. Heilbronn L.K., Gregersen S., Shirkhedkar D., Hu D., Campbell L.V. Impaired fat oxidation after a single high-fat meal in insulin-sensitive nondiabetic individuals with a family history of type 2 diabetes. Diabetes 2007, 56:2046-2053.
46. Henstridge D.C., Febbraio M.A. Adiponectin sparks an interest in calcium. Cell Metabolism 2010, 11:447-449.
47. Holland W.L., Miller R.A., Wang Z.V., Sun K., Barth B.M., Bui H.H., et al. Receptor-mediated activation of ceramidase activity initiates the pleiotropic actions of adiponectin. Nature Medicine 2011, 17:55-63.
48. Holmes R.M., Yi Z., De Filippis E., Berria R., Shahani S., Sathyanarayana P., et al. Increased abundance of the adaptor protein containing pleckstrin homology domain, phosphotyrosine binding domain and leucine zipper motif (APPL1) in patients with obesity and type 2 diabetes: Evidence for altered adiponectin signalling. Diabetologia 2011, 54:2122-2131.
49. Hotta K., Funahashi T., Arita Y., Takahashi M., Matsuda M., Okamoto Y., et al. Plasma concentrations of a novel, adipose-specific protein, adiponectin, in type 2 diabetic patients. Arteriosclerosis, Thrombosis, and Vascular Biology 2000, 20:1595-1599.
50. Hu E., Liang P., Spiegelman B.M. AdipoQ is a novel adipose-specific gene dysregulated in obesity. The Journal of Biological Chemistry 1996, 271:10697-10703.
51. Huang H., Iida K.T., Sone H., Yokoo T., Yamada N., Ajisaka R. The effect of exercise training on adiponectin receptor expression in KKAy obese/diabetic mice. The Journal of Endocrinology 2006, 189:643-653.
52. Hug C., Wang J., Ahmad N.S., Bogan J.S., Tsao T.S., Lodish H.F. T-cadherin is a receptor for hexameric and high-molecular-weight forms of Acrp30/adiponectin. Proceedings of the National Academy of Sciences of the United States of America 2004, 101:10308-10313.
53. Inoue N., Nagao K., Wang Y.M., Noguchi H., Shirouchi B., Yanagita T. Dietary conjugated linoleic acid lowered tumor necrosis factor-alpha content and altered expression of genes related to lipid metabolism and insulin sensitivity in the skeletal muscle of Zucker rats. Journal of Agricultural and Food Chemistry 2006, 54:7935-7939.
54. Inukai K., Nakashima Y., Watanabe M., Takata N., Sawa T., Kurihara S., et al. Regulation of adiponectin receptor gene expression in diabetic mice. American Journal of Physiology. Endocrinology and Metabolism 2005, 288:E876-E882.
55. Iwabu M., Yamauchi T., Okada-Iwabu M., Sato K., Nakagawa T., Funata M., et al. Adiponectin and AdipoR1 regulate PGC-1alpha and mitochondria by Ca(2+) and AMPK/SIRT1. Nature 2010, 464:1313-1319.
56. Jortay J., Senou M., Delaigle A., Noel L., Funahashi T., Maeda N., et al. Local induction of adiponectin reduces lipopolysaccharide-triggered skeletal muscle damage. Endocrinology 2010, 151:4840-4851.
57. Kadowaki T., Yamauchi T., Kubota N., Hara K., Ueki K., Tobe K. Adiponectin and adiponectin receptors in insulin resistance, diabetes, and the metabolic syndrome. The Journal of Clinical Investigation 2006, 116:1784-1792.
58. Kaltenbach S., Staiger H., Weisser M., Haas C., Stumvoll M., Machicao F., et al. Adiponectin receptor gene expression in human skeletal muscle cells is not regulated by fibrates and thiazolidinediones. International Journal of Obesity 2005, 29:760-765.
59. Kelly K.R., Blaszczak A., Haus J.M., Patrick-Melin A., Fealy C.E., Solomon T.P., et al. A 7-d exercise program increases high-molecular weight adiponectin in obese adults. Medicine & Science in Sports & Exercise 2012, 44:69-74.
60. Kishida K., Funahashi T., Shimomura I. Molecular mechanisms of diabetes and atherosclerosis: Role of adiponectin. Endocrine, Metabolic & Immune Disorders Drug Targets 2012, 12:118-131.
61. Knowler W.C., Barrett-Connor E., Fowler S.E., Hamman R.F., Lachin J.M., Walker E.A., et al. Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin. The New England Journal of Medicine 2002, 346:393-403.
62. Kosel D., Heiker J.T., Juhl C., Wottawah C.M., Bluher M., Morl K., et al. Dimerization of adiponectin receptor 1 is inhibited by adiponectin. Journal of Cell Science 2010, 123:1320-1328.
63. Krause M.P., Liu Y., Vu V., Chan L., Xu A., Riddell M.C., et al. Adiponectin is expressed by skeletal muscle fibers and influences muscle phenotype and function. American Journal of Physiology. Cell Physiology 2008, 295:C203-C212.
64. Kubota N., Terauchi Y., Yamauchi T., Kubota T., Moroi M., Matsui J., et al. Disruption of adiponectin causes insulin resistance and neointimal formation. The Journal of Biological Chemistry 2002, 277:25863-25866.
65. Li W., Tonelli J., Kishore P., Owen R., Goodman E., Scherer P.E., et al. Insulin-sensitizing effects of thiazolidinediones are not linked to adiponectin receptor expression in human fat or muscle. American Journal of Physiology. Endocrinology and Metabolism 2007, 292:E1301-E1307.
66. Li L., Wu L., Wang C., Liu L., Zhao Y. Adiponectin modulates carnitine palmitoyltransferase-1 through AMPK signaling cascade in rat cardiomyocytes. Regulatory Peptides 2007, 139:72-79.
67. Liu Y., Chewchuk S., Lavigne C., Brule S., Pilon G., Houde V., et al. Functional significance of skeletal muscle adiponectin production, changes in animal models of obesity and diabetes, and regulation by rosiglitazone treatment. American Journal of Physiology. Endocrinology and Metabolism 2009, 297:E657-E664.
68. Liu Y., Michael M.D., Kash S., Bensch W.R., Monia B.P., Murray S.F., et al. Deficiency of adiponectin receptor 2 reduces diet-induced insulin resistance but promotes type 2 diabetes. Endocrinology 2007, 148:683-692.
69. Liu B.H., Wang P.H., Wang Y.C., Cheng W.M., Mersmann H.J., Ding S.T. Fasting regulates the expression of adiponectin receptors in young growing pigs. Journal of Animal Science 2008, 86:3377-3384.
70. Maeda K., Okubo K., Shimomura I., Funahashi T., Matsuzawa Y., Matsubara K. cDNA cloning and expression of a novel adipose specific collagen-like factor, apM1 (AdiPose Most abundant Gene transcript 1). Biochemical and Biophysical Research Communications 1996, 221:286-289.
71. Maeda N., Shimomura I., Kishida K., Nishizawa H., Matsuda M., Nagaretani H., et al. Diet-induced insulin resistance in mice lacking adiponectin/ACRP30. Nature Medicine 2002, 8:731-737.
72. Maeda N., Takahashi M., Funahashi T., Kihara S., Nishizawa H., Kishida K., et al. PPARgamma ligands increase expression and plasma concentrations of adiponectin, an adipose-derived protein. Diabetes 2001, 50:2094-2099.
73. Magkos F., Mohammed B.S., Mittendorfer B. Enhanced insulin sensitivity after acute exercise is not associated with changes in high-molecular weight adiponectin concentration in plasma. European Journal of Endocrinology 2010, 162:61-66.
74. Mao X., Kikani C.K., Riojas R.A., Langlais P., Wang L., Ramos F.J., et al. APPL1 binds to adiponectin receptors and mediates adiponectin signalling and function. Nature Cell Biology 2006, 8:516-523.
75. Metais C., Forcheron F., Abdallah P., Basset A., Del Carmine P., Bricca G., et al. Adiponectin receptors: Expression in Zucker diabetic rats and effects of fenofibrate and metformin. Metabolism 2008, 57:946-953.
76. Mullen K.L., Tishinsky J.M., Robinson L.E., Dyck D.J. Skeletal muscle inflammation is not responsible for the rapid impairment in adiponectin response with high-fat feeding in rats. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology 2010, 299:R500-R508.
77. Nakano Y., Tobe T., Choi-Miura N.H., Mazda T., Tomita M. Isolation and characterization of GBP28, a novel gelatin-binding protein purified from human plasma. Journal of Biochemistry 1996, 120:803-812.
78. Nawrocki A.R., Rajala M.W., Tomas E., Pajvani U.B., Saha A.K., Trumbauer M.E., et al. Mice lacking adiponectin show decreased hepatic insulin sensitivity and reduced responsiveness to peroxisome proliferator-activated receptor gamma agonists. The Journal of Biological Chemistry 2006, 281:2654-2660.
79. Numao S., Suzuki M., Matsuo T., Nomata Y., Nakata Y., Tanaka K. Effects of acute aerobic exercise on high-molecular-weight adiponectin. Medicine & Science in Sports & Exercise 2008, 40:1271-1276.
80. O'Leary V.B., Jorett A.E., Marchetti C.M., Gonzalez F., Phillips S.A., Ciaraldi T.P., et al. Enhanced adiponectin multimer ratio and skeletal muscle adiponectin receptor expression following exercise training and diet in older insulin-resistant adults. American Journal of Physiology. Endocrinology and Metabolism 2007, 293:E421-E427.
81. Ordelheide A.M., Heni M., Gommer N., Gasse L., Haas C., Guirguis A., et al. The myocyte expression of adiponectin receptors and PPARdelta is highly coordinated and reflects lipid metabolism of the human donors. Experimental Diabetes Research 2011, 2011:692536.
82. Pajvani U.B., Du X., Combs T.P., Berg A.H., Rajala M.W., Schulthess T., et al. Structure-function studies of the adipocyte-secreted hormone Acrp30/adiponectin. Implications fpr metabolic regulation and bioactivity. The Journal of Biological Chemistry 2003, 278:9073-9085.
83. Pajvani U.B., Hawkins M., Combs T.P., Rajala M.W., Doebber T., Berger J.P., et al. Complex distribution, not absolute amount of adiponectin, correlates with thiazolidinedione-mediated improvement in insulin sensitivity. The Journal of Biological Chemistry 2004, 279:12152-12162.
84. Pan X.R., Li G.W., Hu Y.H., Wang J.X., Yang W.Y., An Z.X., et al. Effects of diet and exercise in preventing NIDDM in people with impaired glucose tolerance. The Da Qing IGT and Diabetes Study. Diabetes Care 1997, 20:537-544.
85. Park H.J., Kang Y.M., Kim C.H., Jung M.H. ATF3 negatively regulates adiponectin receptor 1 expression. Biochemical and Biophysical Research Communications 2010, 400:72-77.
86. Patel N.A., Kaneko S., Apostolatos H.S., Bae S.S., Watson J.E., Davidowitz K., et al. Molecular and genetic studies imply Akt-mediated signaling promotes protein kinase CbetaII alternative splicing via phosphorylation of serine/arginine-rich splicing factor SRp40. The Journal of Biological Chemistry 2005, 280:14302-14309.
87. Pedersen B.K., Febbraio M.A. Muscle as an endocrine organ: Focus on muscle-derived interleukin-6. Physiological Reviews 2008, 88:1379-1406.
88. Pihlajamaki J., Lerin C., Itkonen P., Boes T., Floss T., Schroeder J., et al. Expression of the splicing factor gene SFRS10 is reduced in human obesity and contributes to enhanced lipogenesis. Cell Metabolism 2011, 14:208-218.
89. Pita J., Panadero A., Soriano-Guillen L., Rodriguez E., Rovira A. The insulin sensitizing effects of PPAR-gamma agonist are associated to changes in adiponectin index and adiponectin receptors in Zucker fatty rats. Regulatory Peptides 2012, 174:18-25.
90. Prior L.J., Velkoska E., Watts R., Cameron-Smith D., Morris M.J. Undernutrition during suckling in rats elevates plasma adiponectin and its receptor in skeletal muscle regardless of diet composition: A protective effect?. International Journal of Obesity 2008, 32:1585-1594.
91. Qiao L., Kinney B., Yoo H.S., Lee B., Schaack J., Shao J. Adiponectin increases skeletal muscle mitochondrial biogenesis by suppressing mitogen-activated protein kinase phosphatase-1. Diabetes 2012, 61:1463-1470.
92. Rodriguez A., Catalan V., Becerril S., Gil M.J., Mugueta C., Gomez-Ambrosi J., et al. Impaired adiponectin-AMPK signalling in insulin-sensitive tissues of hypertensive rats. Life Sciences 2008, 83:540-549.
93. Sanchez-Gurmaches J., Cruz-Garcia L., Gutierrez J., Navarro I. Adiponectin effects and gene expression in rainbow trout: An in vivo and in vitro approach. The Journal of Experimental Biology 2012, 215:1373-1383.
94. Satoh H., Nguyen M.T., Trujillo M., Imamura T., Usui I., Scherer P.E., et al. Adenovirus-mediated adiponectin expression augments skeletal muscle insulin sensitivity in male Wistar rats. Diabetes 2005, 54:1304-1313.
95. Scherer P.E., Williams S., Fogliano M., Baldini G., Lodish H.F. A novel serum protein similar to C1q, produced exclusively in adipocytes. The Journal of Biological Chemistry 1995, 270:26746-26749.
96. Shetty S., Kusminski C.M., Scherer P.E. Adiponectin in health and disease: Evaluation of adiponectin-targeted drug development strategies. Trends in Pharmacological Sciences 2009, 30:234-239.
97. Sigal R.J., Kenny G.P., Wasserman D.H., Castaneda-Sceppa C., White R.D. Physical activity/exercise and type 2 diabetes: A consensus statement from the American Diabetes Association. Diabetes Care 2006, 29:1433-1438.
98. Sixt S., Beer S., Bluher M., Korff N., Peschel T., Sonnabend M., et al. Long- but not short-term multifactorial intervention with focus on exercise training improves coronary endothelial dysfunction in diabetes mellitus type 2 and coronary artery disease. European Heart Journal 2010, 31:112-119.
99. Staiger H., Kaltenbach S., Staiger K., Stefan N., Fritsche A., Guirguis A., et al. Expression of adiponectin receptor mRNA in human skeletal muscle cells is related to in vivo parameters of glucose and lipid metabolism. Diabetes 2004, 53:2195-2201.
100. Sun X., He J., Mao C., Han R., Wang Z., Liu Y., et al. Negative regulation of adiponectin receptor 1 promoter by insulin via a repressive nuclear inhibitory protein element. FEBS Letters 2008, 582:3401-3407.
101. Tan G.D., Debard C., Funahashi T., Humphreys S.M., Matsuzawa Y., Frayn K.N., et al. Changes in adiponectin receptor expression in muscle and adipose tissue of type 2 diabetic patients during rosiglitazone therapy. Diabetologia 2005, 48:1585-1589.
102. Tang Y.T., Hu T., Arterburn M., Boyle B., Bright J.M., Emtage P.C., et al. PAQR proteins: A novel membrane receptor family defined by an ancient 7-transmembrane pass motif. Journal of Molecular Evolution 2005, 61:372-380.
103. Tomas E., Tsao T.S., Saha A.K., Murrey H.E., Zhang C.C., Itani S.I., et al. Enhanced muscle fat oxidation and glucose transport by ACRP30 globular domain: Acetyl-CoA carboxylase inhibition and AMP-activated protein kinase activation. Proceedings of the National Academy of Sciences of the United States of America 2002, 99:16309-16313.
104. Trujillo M.E., Scherer P.E. Adiponectin-journey from an adipocyte secretory protein to biomarker of the metabolic syndrome. Journal of Internal Medicine 2005, 257:167-175.
105. Tsao T.S., Murrey H.E., Hug C., Lee D.H., Lodish H.F. Oligomerization state-dependent activation of NF-kappa B signaling pathway by adipocyte complement-related protein of 30 kDa (Acrp30). The Journal of Biological Chemistry 2002, 277:29359-29362.
106. Tsuchida A., Yamauchi T., Ito Y., Hada Y., Maki T., Takekawa S., et al. Insulin/Foxo1 pathway regulates expression levels of adiponectin receptors and adiponectin sensitivity. The Journal of Biological Chemistry 2004, 279:30817-30822.
107. Tuomilehto J., Lindstrom J., Eriksson J.G., Valle T.T., Hamalainen H., Ilanne-Parikka P., et al. Prevention of type 2 diabetes mellitus by changes in lifestyle among subjects with impaired glucose tolerance. The New England Journal of Medicine 2001, 344:1343-1350.
108. Van Berendoncks A.M., Garnier A., Beckers P., Hoymans V.Y., Possemiers N., Fortin D., et al. Functional adiponectin resistance at the level of the skeletal muscle in mild to moderate chronic heart failure. Circulation. Heart Failure 2010, 3:185-194.
109. Van Berendoncks A.M., Garnier A., Beckers P., Hoymans V.Y., Possemiers N., Fortin D., et al. Exercise training reverses adiponectin resistance in skeletal muscle of patients with chronic heart failure. Heart 2011, 97:1403-1409.
110. Vu V., Riddell M.C., Sweeney G. Circulating adiponectin and adiponectin receptor expression in skeletal muscle: Effects of exercise. Diabetes/Metabolism Research and Reviews 2007, 23:600-611.
111. Waki H., Yamauchi T., Kamon J., Kita S., Ito Y., Hada Y., et al. Generation of globular fragment of adiponectin by leukocyte elastase secreted by monocytic cell line THP-1. Endocrinology 2005, 146:790-796.
112. Wang E.T., Sandberg R., Luo S., Khrebtukova I., Zhang L., Mayr C., et al. Alternative isoform regulation in human tissue transcriptomes. Nature 2008, 456:470-476.
113. Wang C., Xin X., Xiang R., Ramos F.J., Liu M., Lee H.J., et al. Yin-Yang regulation of adiponectin signaling by APPL isoforms in muscle cells. The Journal of Biological Chemistry 2009, 284:31608-31615.
114. Wasserman D.H. Four grams of glucose. American Journal of Physiology. Endocrinology and Metabolism 2009, 296:E11-E21.
115. Yamauchi T., Kadowaki T. Physiological and pathophysiological roles of adiponectin and adiponectin receptors in the integrated regulation of metabolic and cardiovascular diseases. International Journal of Obesity 2008, 32(Suppl 7):S13-S18.
116. Yamauchi T., Kamon J., Ito Y., Tsuchida A., Yokomizo T., Kita S., et al. Cloning of adiponectin receptors that mediate antidiabetic metabolic effects. Nature 2003, 423:762-769.
117. Yamauchi T., Kamon J., Minokoshi Y., Ito Y., Waki H., Uchida S., et al. Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase. Nature Medicine 2002, 8:1288-1295.
118. Yamauchi T., Kamon J., Waki H., Imai Y., Shimozawa N., Hioki K., et al. Globular adiponectin protected ob/ob mice from diabetes and ApoE-deficient mice from atherosclerosis. The Journal of Biological Chemistry 2003, 278:2461-2468.
119. Yamauchi T., Kamon J., Waki H., Terauchi Y., Kubota N., Hara K., et al. The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity. Nature Medicine 2001, 7:941-946.
120. Yamauchi T., Nio Y., Maki T., Kobayashi M., Takazawa T., Iwabu M., et al. Targeted disruption of AdipoR1 and AdipoR2 causes abrogation of adiponectin binding and metabolic actions. Nature Medicine 2007, 13:332-339.
121. Yao H., Ling H., Wang H., Zhang L., Huang X., Xia Z. Gene expression of adiponectin and adiponectin receptor 1 in type 2 diabetic rats and the relationship with the parameters of glucose and lipid metabolism. Journal of Huazhong University of Science and Technology. Medical Sciences 2005, 25:285-288.
122. Yoon M.J., Lee G.Y., Chung J.J., Ahn Y.H., Hong S.H., Kim J.B. Adiponectin increases fatty acid oxidation in skeletal muscle cells by sequential activation of AMP-activated protein kinase, p38 mitogen-activated protein kinase, and peroxisome proliferator-activated receptor alpha. Diabetes 2006, 55:2562-2570.
123. Zeng Q., Isobe K., Fu L., Ohkoshi N., Ohmori H., Takekoshi K., et al. Effects of exercise on adiponectin and adiponectin receptor levels in rats. Life Sciences 2007, 80:454-459.
124. Zhou Q., Du J., Hu Z., Walsh K., Wang X.H. Evidence for adipose-muscle cross talk: Opposing regulation of muscle proteolysis by adiponectin and Fatty acids. Endocrinology 2007, 148:5696-5705.