DOR undergoes nucleo-cytoplasmic shuttling, which involves passage through the nucleolus

FEBS Letters

Volumn 586, Issue 19, 2012, Pages 3179-3186

  Mauvezin, Caroline ^a,b,c   Sancho, Ana ^a,b,c   Ivanova, Saska ^a,b,c   Palacin, Manuel ^a,b   Zorzano, Antonio ^a,b,c  

^a INSTITUTE FOR RESEARCH IN BIOMEDICINE   (Spain)

^b UNIVERSITY OF BARCELONA   (Spain)

^c INSTITUTO DE SALUD CARLOS III   (Spain)

Author keywords

Basal autophagy; DOR; Nucleo cytoplasmic shuttle; Nucleolus; TP53inp2

Indexed keywords

DIABETES AND OBESITY RELATED PROTEIN; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

ARTICLE; AUTOPHAGY; CELL NUCLEUS; CONTROLLED STUDY; HUMAN; HUMAN CELL; NUCLEOCYTOPLASMIC SHUTTLING; NUCLEOLUS; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN TRANSPORT; TRANSPORT KINETICS;

ACTIVE TRANSPORT, CELL NUCLEUS; AUTOPHAGY; CELL NUCLEOLUS; CHROMOSOMAL PROTEINS, NON-HISTONE; HELA CELLS; HUMANS; MICROSCOPY, CONFOCAL; MUTAGENESIS, SITE-DIRECTED; NUCLEAR PROTEINS; PROTEIN TRANSPORT; RECOMBINANT FUSION PROTEINS; TRANSFECTION;

EID: 84866623644     PISSN: 00145793     EISSN: 18733468     Source Type: Journal    
DOI: 10.1016/j.febslet.2012.06.032     Document Type: Article

References (19)

1. M. Martinez-Vicente, and A.M. Cuervo Autophagy and neurodegeneration: when the cleaning crew goes on strike Lancet Neurol. 6 2007 352 361
2. I. Beau, M. Mehrpour, and P. Codogno Autophagosomes and human diseases Int. J. Biochem. Cell Biol. 43 2011 460 464
3. L. Shang, S. Chen, F. Du, S. Li, L. Zhao, and X. Wang Nutrient starvation elicits an acute autophagic response mediated by Ulkl dephosphorylation and its subsequent dissociation from AMPK Proc. Natl. Acad. Sci. USA 108 2011 4788 4793
4. H.Y. Chen, and E. White Role of autophagy in cancer prevention Cancer Prev. Res. 4 2011 973 983
5. C. Behrends, M.E. Sowa, S.P. Gygi, and J.W. Harper Network organization of the human autophagy system Nature 466 2010 68 76
6. S. Boulon, B.J. Westman, S. Hutten, F.M. Boisvert, and A.I. Lamond The nucleolus under stress Mol. Cell 40 2010 216 227
7. J. Nowak, C. Archange, J. Tardivel-Lacombe, P. Pontarotti, M.J. Pebusque, M.I. Vaccaro, J.C. Velasco, Q. Dagorn, and J.L. Iovanna The TP53INP2 protein is required for autophagy in mammalian cells Mol. Biol. Cell 20 2009 870 881
8. C. Mauvezin, M. Orpinell, V.A. Francis, F. Mansilla, J. Duran, V. Ribas, M. Palacin, P. Boya, A.A. Teleman, and A. Zorzano The nuclear cofactor DOR regulates autophagy in mammalian and Drosophila cells EMBO Rep. 11 2010 37 44
9. B.Q. Baumgartner, M. Orpinell, J. Duran, V. Ribas, H.E. Burghardt, D. Bach, A.V. Villar, J.C. Paz, M. Gonzalez, M. Camps, J. Oriola, F. Rivera, M. Palacin, and A. Zorzano Identification of a novel modulator of thyroid hormone receptor-mediated action PLoS One 2 2007 el 183
10. V.A. Francis, A. Zorzano, and A.A. Teleman dDOR is an EcR coactivator that forms a feed-forward loop connecting insulin and ecdysone signaling Curr. Biol. 20 2010 1799 1808
11. A. Sancho, J. Duran, A. Garcia-Espafia, C. Mauvezin, E.A. Alemu, T. Lamark, M.J. Macias, R. Desalle, M. Royo, D. Sala, J.U. Chicote, M. Palacin, T. Johansen, and A. Zorzano DOR/Tp53inp2 and Tp53inpl constitute a metazoan gene family encoding dual regulators of autophagy and transcription Plos One 7 3 2012 e34034
12. F.M. Boisvert, S. van Koningsbruggen, J. Navascues, and A.I. Lamond The multifunctional nucleolus Nat. Rev. Mol. Cell Biol. 8 2007 574 585
13. L.B. Maggi Jr.; M. Kuchenruether, D.Y. Dadey, R.M. Schwope, S. Grisendi, R.R. Townsend, P.P. Pandolfi, and J.D. Weber Nucleophosmin serves as a rate-limiting nuclear export chaperone for the mammalian ribosome Mol. Cell. Biol. 28 2008 7050 7065
14. N. Abella, S. Brun, M. Calvo, O. Tapia, J.D. Weber, M.T. Berciano, M. Lafarga, O. Bachs, and N. Agell Nucleolar disruption ensures nuclear accumulation of p21 upon DNA damage Traffic 11 2010 743 755
15. S. Kobayashi, P. Volden, D. Timm, K. Mao, X. Xu, and Q. Liang Transcription factor GATA4 inhibits doxorubicin-induced autophagy and cardiomyocyte death J. Biol. Chem. 285 l 2010 793 804
16. D.A. Freedman, L. Wu, and A.J. Levine Functions of the MDM2 oncoprotein Cell. Mol. Life Sci. 55 1999 96 107
17. M. Kodiha, A. Chu, O. Lazrak, and U. Stochaj Stress inhibits nucleocytoplasmic shuttling of heat shock protein hsc70 Am. J. Physiol. Cell Physiol. 289 2005 C1034 C1041
18. R. Bernardi, P.P. Scaglioni, S. Bergmann, H.F. Horn, K.H. Vousden, and P.P. Pandolfi PML regulates p53 stability by sequestering Mdm2 to the nucleolus Nat. Cell Biol. 6 2004 665 672
19. A. Vazquez-Martin, S. Cufi, C. Oliveras-Ferraros, and J.A. Menendez Raptor, a positive regulatory subunit of mTOR complex 1, is a novel phosphoprotein of the rDNA transcription machinery in nucleoli and chromosomal nucleolus organizer regions (NORs) Cell Cycle 10 2011 3140 3152