Clinical translation of cell-based pharmacogenomic discovery

Clinical Pharmacology and Therapeutics

Volumn 92, Issue 4, 2012, Pages 425-427

  Cox, N J ^a   Gamazon, E R ^a   Wheeler, H E ^a   Dolan, M E ^a  

^a UNIVERSITY OF CHICAGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARBOPLATIN; CISPLATIN; CYTARABINE;

ACUTE GRANULOCYTIC LEUKEMIA; ARTICLE; CANCER CHEMOTHERAPY; CANCER SURVIVAL; CELL GROWTH; CELL THERAPY; CLINICAL TRIAL (TOPIC); CYTOTOXICITY; GENE EXPRESSION; GENE FREQUENCY; GENETIC ASSOCIATION; GENETIC VARIABILITY; GERM LINE GENE THERAPY; HUMAN; IN VITRO STUDY; LOSS OF FUNCTION MUTATION; LUNG NON SMALL CELL CANCER; LUNG SMALL CELL CANCER; LYMPHOBLASTOID CELL LINE; NONHUMAN; OVARY CANCER; OVERALL SURVIVAL; PHARMACOGENOMICS; PRIORITY JOURNAL; PROTEIN EXPRESSION; SINGLE NUCLEOTIDE POLYMORPHISM; TREATMENT RESPONSE;

ANIMALS; CELL LINE, TUMOR; DRUG DISCOVERY; GENOMICS; HUMANS; PHARMACOGENETICS; POLYMORPHISM, SINGLE NUCLEOTIDE; TRANSLATIONAL MEDICAL RESEARCH;

EID: 84866617047     PISSN: 00099236     EISSN: 15326535     Source Type: Journal    
DOI: 10.1038/clpt.2012.115     Document Type: Article

References (4)

1. Wheeler, H.E. & Dolan, M.E. Lymphoblastoid cell lines in pharmacogenomic discovery and clinical translation. Pharmacogenomics 13, 55-70 (2012).
2. Duan, S. et al. Genetic architecture of transcript-level variation in humans. Am. J. Hum. Genet. 82, 1101-1113 (2008).
3. Gamazon, E.R., Huang, R.S., Cox, N.J. & Dolan, M.E. chemotherapeutic drug susceptibility associated SNPs are enriched in expression quantitative trait loci. Proc. Natl. Acad. Sci. U.S.A. 107, 9287-9292 (2010).
4. Ding, J. et al. Gene expression in skin and lymphoblastoid cells: Refned statistical method reveals extensive overlap in cis-eQtL signals. Am. J. Hum. Genet. 87, 779-789 (2010).