An Exploration of Depressive Symptoms in Hepatitis C Patients Taking Interferon-alpha: Increase in Sickness Behaviors but not Negative Cognitions

Journal of Clinical and Experimental Hepatology

Volumn 2, Issue 3, 2012, Pages 218-223

  Smith, Kimberley J ^a,b   Norris, Suzanne ^c   McKiernan, Susan ^c   Hynes, Barbara ^c   O'Dwyer, Anne M ^c   O'Mara, Shane M ^a  

^a TRINITY COLLEGE DUBLIN   (Ireland)

^b DOUGLAS MENTAL HEALTH UNIVERSITY INSTITUTE   (Canada)

^c ST JAMES S HOSPITAL   (Ireland)

Author keywords

Depression; Hepatitis C; Interferon alpha; Sickness behavior

Indexed keywords

PEGINTERFERON ALPHA2B; RIBAVIRIN;

ADULT; ARTICLE; BEHAVIOR DISORDER; CLINICAL ARTICLE; CLINICAL FEATURE; COGNITIVE DEFECT; DEPRESSION; DISEASE ASSOCIATION; DISEASE EXACERBATION; DRUG TOLERABILITY; DRUG WITHDRAWAL; FEMALE; HAMILTON SCALE; HEPATITIS C; HUMAN; ILLNESS BEHAVIOR; MAJOR DEPRESSION; MALE; MOOD DISORDER; PRIORITY JOURNAL; PSYCHOLOGIC ASSESSMENT; PSYCHOSOMATIC DISORDER; SCORING SYSTEM; STRUCTURED CLINICAL INTERVIEW FOR DSM DISORDERS; TREATMENT OUTCOME;

EID: 84866561571     PISSN: 09736883     EISSN: 22133453     Source Type: Journal    
DOI: 10.1016/j.jceh.2012.03.001     Document Type: Article

References (18)

1. Dafny N., Yang P.B. Interferon and the central nervous system. Eur J of Pharmacol 2005, 523:1-15.
2. Cotler S.J., Wartelle C.F., Larson A.M., Gretch D.R., Jensen D.M., Carithers R.L. Pretreatment symptoms and dosing regimen predict side-effects of interferon therapy for hepatitis C. J Viral Hepat 2000, 7:211-217.
3. Davis G.L., Esteban-Mur R., Rustgi V., et al. Interferon alfa-2b alone or in combination with ribavirin for the treatment of relapse of chronic hepatitis C. International Hepatitis Interventional Therapy Group. N Engl J Med 1998, 339:1493-1499.
4. Fried M.W., Shiffman M.L., Reddy K.R., et al. Peginterferon alfa-2a plus ribavirin for chronic hepatitis C virus infection. N Engl J Med 2002, 347:975-982.
5. Dantzer R., Bluthe R.M., Gheusi G., et al. Molecular basis of sickness behavior. Ann N Y Acad Sci 1998, 856:132-138.
6. Dantzer R., O'Connor J.C., Freund G.G., Johnson R.W., Kelley K.W. From inflammation to sickness and depression: when the immune system subjugates the brain. Nat Rev Neurosci 2008, 9:46-56.
7. Konsman J.P., Parnet P., Dantzer R. Cytokine-induced sickness behavior: mechanisms and implications. Trends Neurosci 2002, 25:154-159.
8. Carr A., McNulty M. Depression. The Handbook of Adult Clinical Psychology: An Evidence-based Practice Approach 2006, 291-345. Routledge, Suffolk. A. Carr, M. McNulty (Eds.).
9. Loftis J.M., Huckans M., Morasco B.J. Neuroimmune mechanisms of cytokine-induced depression: current theories and novel treatment strategies. Neurobiol Dis 2010, 37:519-533.
10. Smith K.J., Norris S., O'Farrelly C., O'Mara S.M. Risk factors for the development of depression in patients with hepatitis C taking interferon-α. Neuropsychiatric Dis Treat 2011, 7:275-292.
11. Schaefer M., Schmidt F., Folwaczny C., et al. Adherence and mental side effects during hepatitis C treatment with interferon alfa and ribavirin in psychiatric risk groups. Hepatology 2003, 37:443-451.
12. Bonaccorso S., Marino V., Biondi M., Grimaldi F., Ippoliti F., Maes M. Depression induced by treatment with interferon-alpha in patients affected by hepatitis C virus. J Affect Disord 2002, 72:237-241.
13. Dieperink E., Ho S.B., Thuras P., Willenbring M.L. A prospective study of neuropsychiatric symptoms associated with interferon-alpha-2b and ribavirin therapy for patients with chronic hepatitis C. Psychosomatics 2003, 44:104-112.
14. Hauser P., Khosla J., Aurora H., et al. A prospective study of the incidence and open-label treatment of interferon-induced major depressive disorder in patients with hepatitis C. Mol Psychiatry 2002, 7:942-947.
15. Majer M., Welberg L.A., Capuron L., Pagnoni G., Raison C.L., Miller A.H. IFN-alpha-induced motor slowing is associated with increased depression and fatigue in patients with chronic hepatitis C. Brain Behav Immun 2008, 22:870-880.
16. Trask P.C., Esper P., Riba M., Redman B. Psychiatric side effects of interferon therapy: prevalence, proposed mechanisms, and future directions. J Clin Oncol 2000, 18:2316-2326.
17. Pasquini M., Speca A., Mastroeni S., Delle Chiaie R., Sternberg C.N., Biondi M. Differences in depressive thoughts between major depressive disorder, IFN-alpha-induced depression, and depressive disorders among cancer patients. J Psychosom Res 2008, 65:153-156.
18. Capuron L., Fornwalt F.B., Knight B.T., Harvey P.D., Ninan P.T., Miller A.H. Does cytokine-induced depression differ from idiopathic major depression in medically healthy individuals?. J Affect Disord 2009, 119:181-185.