Self-regulation of the head-inducing properties of the Spemann organizer

Proceedings of the National Academy of Sciences of the United States of America

Volumn 109, Issue 38, 2012, Pages 15354-15359

  Inui, Masafumi ^a   Montagner, Marco ^a   Ben Zvi, Danny ^b   Martello, Graziano ^a   Soligo, Sandra ^a   Manfrin, Andrea ^a   Aragona, Mariaceleste ^a   Enzo, Elena ^a   Zacchigna, Luca ^a   Zanconato, Francesca ^a   Azzolin, Luca ^a   Dupont, Sirio ^a   Cordenonsi, Michelangelo ^a   Piccolo, Stefano ^a  

^a UNIVERSITY OF PADOVA   (Italy)

^b WEIZMANN INSTITUTE OF SCIENCE   (Israel)

Author keywords

Morphogen gradients; Xenopus leavis

Indexed keywords

BONE MORPHOGENETIC PROTEIN; PEPTIDES AND PROTEINS; PROTEIN ADMP; PROTEIN NODAL; SMAD PROTEIN; UNCLASSIFIED DRUG; WNT PROTEIN;

ARTICLE; CONTROLLED STUDY; EMBRYO; EMBRYO DEVELOPMENT; EMBRYONIC STRUCTURES; HEAD; NONHUMAN; PRIORITY JOURNAL; SPEMANN ORGANIZER; XENOPUS;

ACTIVIN RECEPTORS, TYPE I; ACTIVIN RECEPTORS, TYPE II; ANIMALS; BODY PATTERNING; BONE MORPHOGENETIC PROTEINS; CELL LINE; CHICKENS; GENE EXPRESSION REGULATION, DEVELOPMENTAL; HUMANS; IN SITU HYBRIDIZATION; LIGANDS; MODELS, BIOLOGICAL; ORGANIZERS, EMBRYONIC; SIGNAL TRANSDUCTION; TIME FACTORS; TRANSFECTION; XENOPUS LAEVIS;

VERTEBRATA; XENOPUS LAEVIS;

EID: 84866558681     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1203000109     Document Type: Article

References (33)

1. De Robertis EM (2006) Spemann's organizer and self-regulation in amphibian embryos. Nat Rev Mol Cell Biol 7:296-302.
2. Harland R, Gerhart J (1997) Formation and function of Spemann's organizer. Annu Rev Cell Dev Biol 13:611-667. (Pubitemid 28034535)
3. Niehrs C (2004) Regionally specific induction by the Spemann-Mangold organizer. Nat Rev Genet 5:425-434.
4. Spemann H, Mangold H (2001) Induction of embryonic primordia by implantation of organizers from a different species. 1923. Int J Dev Biol 45:13-38. (Pubitemid 33730577)
5. De Robertis EM, Larraín J, Oelgeschläger M, Wessely O (2000) The establishment of Spemann's organizer and patterning of the vertebrate embryo. Nat Rev Genet 1:171-181.
6. Martello G, et al. (2007) MicroRNA control of Nodal signalling. Nature 449:183-188. (Pubitemid 47402367)
7. Sudou N, Yamamoto S, Ogino H, Taira M (2012) Dynamic in vivo binding of transcription factors to cis-regulatory modules of cer and gsc in the stepwise formation of the Spemann-Mangold organizer. Development 139:1651-1661.
8. Ben-Zvi D, Shilo BZ, Fainsod A, Barkai N (2008) Scaling of the BMP activation gradient in Xenopus embryos. Nature 453:1205-1211. (Pubitemid 351913602)
9. Inomata H, Haraguchi T, Sasai Y (2008) Robust stability of the embryonic axial pattern requires a secreted scaffold for chordin degradation. Cell 134:854-865.
10. Khokha MK, Yeh J, Grammer TC, Harland RM (2005) Depletion of three BMP antagonists from Spemann's organizer leads to a catastrophic loss of dorsal structures. Dev Cell 8:401-411. (Pubitemid 40309810)
11. Piccolo S, Sasai Y, Lu B, De Robertis EM (1996) Dorsoventral patterning in Xenopus: Inhibition of ventral signals by direct binding of chordin to BMP-4. Cell 86:589-598. (Pubitemid 26299490)
12. Reversade B, De Robertis EM (2005) Regulation of ADMP and BMP2/4/7 at opposite embryonic poles generates a self-regulating morphogenetic field. Cell 123:1147-1160. (Pubitemid 41785427)
13. Zimmerman LB, De Jesús-Escobar JM, Harland RM (1996) The Spemann organizer signal noggin binds and inactivates bone morphogenetic protein 4. Cell 86:599-606. (Pubitemid 26299491)
14. Glinka A, et al. (1998) Dickkopf-1 is a member of a new family of secreted proteins and functions in head induction. Nature 391:357-362. (Pubitemid 28093502)
15. Glinka A, Wu W, Onichtchouk D, Blumenstock C, Niehrs C (1997) Head induction by simultaneous repression of Bmp and Wnt signalling in Xenopus. Nature 389:517-519. (Pubitemid 27435330)
16. Piccolo S, et al. (1999) The head inducer Cerberus is a multifunctional antagonist of Nodal, BMP and Wnt signals. Nature 397:707-710.
17. Dosch R, Niehrs C (2000) Requirement for anti-dorsalizing morphogenetic protein in organizer patterning. Mech Dev 90:195-203. (Pubitemid 30042925)
18. Moos M, Jr., Wang S, Krinks M (1995) Anti-dorsalizing morphogenetic protein is a novel TGF-beta homolog expressed in the Spemann organizer. Development 121:4293-4301. (Pubitemid 26007577)
19. Vodicka MA, Gerhart JC (1995) Blastomere derivation and domains of gene expression in the Spemann Organizer of Xenopus laevis. Development 121:3505-3518.
20. Miyazono K, Kamiya Y, Morikawa M (2010) Bone morphogenetic protein receptors and signal transduction. J Biochem 147:35-51.
21. Lavery K, Swain P, Falb D, Alaoui-Ismaili MH (2008) BMP-2/4 and BMP-6/7 differentially utilize cell surface receptors to induce osteoblastic differentiation of human bone marrow-derived mesenchymal stem cells. J Biol Chem 283:20948-20958.
22. Takahashi M, et al. (2008) Bone morphogenetic protein 6 (BMP6) and BMP7 inhibit estrogen-induced proliferation of breast cancer cells by suppressing p38 mitogen-activated protein kinase activation. J Endocrinol 199:445-455.
23. Brennan J, et al. (2001) Nodal signalling in the epiblast patterns the early mouse embryo. Nature 411:965-969. (Pubitemid 32601495)
24. Nomura M, Li E (1998) Smad2 role in mesoderm formation, left-right patterning and craniofacial development. Nature 393:786-790. (Pubitemid 28299489)
25. Zorn AM, Butler K, Gurdon JB (1999) Anterior endomesoderm specification in Xenopus by Wnt/beta-catenin and TGF-beta signalling pathways. Dev Biol 209:282-297. (Pubitemid 29230880)
26. Song J, et al. (1999) The type II activin receptors are essential for egg cylinder growth, gastrulation, and rostral head development in mice. Dev Biol 213:157-169. (Pubitemid 29409953)
27. Bouwmeester T, Kim S, Sasai Y, Lu B, De Robertis EM (1996) Cerberus is a head-inducing secreted factor expressed in the anterior endoderm of Spemann's organizer. Nature 382:595-601. (Pubitemid 26268946)
28. Schneider VA, Mercola M (1999) Spatially distinct head and heart inducers within the Xenopus organizer region. Curr Biol 9:800-809. (Pubitemid 29375182)
29. Tam PP, Steiner KA (1999) Anterior patterning by synergistic activity of the early gastrula organizer and the anterior germ layer tissues of the mouse embryo. Development 126:5171- 5179.
30. Feng XH, Derynck R (2005) Specificity and versatility in tgf-beta signaling through Smads. Annu Rev Cell Dev Biol 21:659-693.
31. Itoh S, ten Dijke P (2007) Negative regulation of TGF-beta receptor/Smad signal transduction. Curr Opin Cell Biol 19:176-184. (Pubitemid 46386411)
32. Gerhart J (2001) Evolution of the organizer and the chordate body plan. Int J Dev Biol 45:133- 153.
33. Dupont S, et al. (2009) FAM/USP9x, a deubiquitinating enzyme essential for TGFbeta signaling, controls Smad4 monoubiquitination. Cell 136:123-135.