Kupffer cells suppress perfluorononanoic acid-induced hepatic peroxisome proliferator-activated receptor a expression by releasing cytokines

Archives of Toxicology

Volumn 86, Issue 10, 2012, Pages 1515-1525

  Fang, Xuemei ^a,b   Zou, Shanshan ^a   Zhao, Yuanyuan ^c   Cui, Ruina ^a   Zhang, Wei ^a   Hu, Jiayue ^a   Dai, Jiayin ^a  

^a INSTITUTE OF ZOOLOGY   (China)

^b Suzhou Teachers' College   (China)

^c Peking University   (China)

Author keywords

Hepatotoxicity; Lipid metabolism; NF jB; Perfluorinated compound; Peroxisome proliferator activated receptors

Indexed keywords

CYTOKINE; GADOLINIUM CHLORIDE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1BETA; PERFLUORONONANOIC ACID; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; STEROL REGULATORY ELEMENT BINDING PROTEIN 1C; TRIACYLGLYCEROL; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOKINE RELEASE; GENE EXPRESSION; IN VITRO STUDY; KUPFFER CELL; LIPID METABOLISM; LIPID STORAGE; LIVER CELL; LIVER METABOLISM; LIVER TOXICITY; LIVER WEIGHT; MALE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; RAT; UPREGULATION;

ANIMALS; DOSE-RESPONSE RELATIONSHIP, DRUG; FATTY ACIDS; GADOLINIUM; GENE EXPRESSION REGULATION; HEPATOCYTES; INTERLEUKIN-1BETA; KUPFFER CELLS; LIPID METABOLISM; LIVER; MALE; NF-KAPPA B; PPAR ALPHA; RATS; RATS, SPRAGUE-DAWLEY; TRIGLYCERIDES; TUMOR NECROSIS FACTOR-ALPHA; UP-REGULATION;

RATTUS;

EID: 84866548567     PISSN: 03405761     EISSN: 14320738     Source Type: Journal    
DOI: 10.1007/s00204-012-0877-4     Document Type: Article

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